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未来食品学报(英文) 2024年第3期4卷 258-266页

作者： juan bai Linzhao He Jinfu Zhang Xiangyue Gu Beiqi Wu Anlin Wang Ying Zhu Jiayan Zhang Yansheng Zhao Jie Yuan Xiang Xiao School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China

Highland barley is a well-known cereal in Qinghai-Tibet Plateau area with high nutritional value,which has been reported to be a health-promoting grain for the obesity and the diabetes.Fermentation by certain microbiota can improve the flavor property and nutritional characteristics.In the present study,Lactiplantibacillus plantarum and Saccharomyces cerevisiae were singly or jointly applied to ferment highland barley,and the profile of volatile substances and lipid-lowering effects of the respective extracts were analyzed.Results indicated that either L.plantarum or S.cerevisiae or co-fermentation could consume the polysaccharides of highland barley to provide energy,and dramatically increase the contents of total protein and polyphenol.Gas chromatography-mass spectrometry(GC-MS)analysis revealed that the presence of S.cerevisiae was critical for production of the pleasant flavors,especially for the ethyl ester substances including hexadecanoic acid ethyl,hexanoic acid ethyl ester and so on.Meanwhile,we found that fermented highland barley extracts by L.plantarum exhibited stronger lipid-lowering effects in Caenorhabditis elegans than that by S.cerevisiae,while the co-fermentation not only emitted pleasant odors but also exerted high hypolipidemic function.In all,co-fermentation by L.plantarum and S.cerevisiae was proposed to be a promising processing to improve the flavor and functional properties of highland barley.

关键词： Highland barley Lactiplantibacillus plantarum Saccharomyces cerevisiae Fermentation Flavor property Lipid-lowering

Progress in MXene-based catalysts for oxygen evolution reaction

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Electron 2024年第1期2卷 48-67页

作者： Jieli Chen Xiaohong Gao Jing Li Zhenye Kang juan bai Tianjiao Wang Yuliang Yuan Chenghang You Yu Chen Bao Yu Xia Xinlong Tian School of Marine Science and Engineering Hainan Provincial Key Lab of Fine ChemistrySchool of Chemistry and Chemical EngineeringHainan UniversityHaikouChina School of Chemistry and Physics Queensland University of TechnologyBrisbaneQueenslandAustralia Key Laboratory of Macromolecular Science of Shaanxi Province School of Materials Science and EngineeringShaanxi Normal UniversityXi'anChina School of Chemistry and Chemical Engineering State Key Laboratory of Materials Processing and Die&Mould TechnologyKey Laboratory of Material Chemistry for Energy Conversion and Storage(Ministry of Education)Hubei Key Laboratory of Material Chemistry and Service FailureWuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology(HUST)WuhanChina

Electrochemical water splitting for hydrogen generation is considered one of the most promising strategies for reducing the use of fossil fuels and storing renewable electricity in hydrogen fuel.However,the anodic oxygen evolution process remains a bottleneck due to the remarkably high overpotential of about 300 mV to achieve a current density of 10 mA cm^(−2).The key to solving this dilemma is the development of highly efficient catalysts with minimized overpotential,long-term stability,and low cost.As a new 2D material,MXene has emerged as an intriguing material for future energy conversion technology due to its benefits,including superior conductivity,excellent hydrophilic properties,high surface area,versatile chemical composition,and ease of processing,which make it a potential constituent of the oxygen evolution catalyst layer.This review aims to summarize and discuss the recent development of oxygen evolution catalysts using MXene as a component,emphasizing the synthesis and synergistic effect of MXene-based composite catalysts.Based on the discussions summarized in this review,we also provide future research directions regarding electronic interaction,stability,and structural evolution of MXene-based oxygen evolution catalysts.We believe that a broader and deeper research in this area could accelerate the discovery of efficient catalysts for electrochemical oxygen evolution.

关键词： MXene-based catalysts oxygen evolution reaction water splitting

Barley Protein LFBEP-C1 from Lactiplantibacillus plantarum dy-1 Fermented Barley Extracts by Inhibiting Lipid Accumulation in a Caenorhabditis elegans Model

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Biomedical and Environmental Sciences 2024年第4期37卷 377-386页

作者： ZHANG Jia Yan LIU Meng Ting LIU Yu Hao DENG Huan bai juan XIE Jian Hua XIAO Xiang School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047JiangxiChina

Objective This study aimed to investigate the lipid-lowering activity of LFBEP-C1 in high glucose-fed Caenorhabditis elegans(C.elegans).Methods In this study,the fermented barley protein LFBEP-C1 was prepared and tested for its potential anti-obesity effects on C.elegans.The worms were fed Escherichia coli OP50(E.coli OP50),glucose,and different concentrations of LFBEP-C1.Body size,lifespan,movement,triglyceride content,and gene expression were analyzed.The results were analyzed using ANOVA and Tukey's multiple comparison test.Results Compared with the model group,the head-swing frequency of C.elegans in the group of LFBEP-C1 at 20μg/mL increased by 33.88%,and the body-bending frequency increased by 27.09%.This indicated that LFBEP-C1 improved the locomotive ability of C.elegans.The average lifespan of C.elegans reached 13.55 days,and the body length and width of the C.elegans decreased after LFBEP-C1 intake.Additionally,LFBEP-C1 reduced the content of lipid accumulation and triglyceride levels.The expression levels of sbp-1,daf-2,and mdt-15 significantly decreased,while those of daf-16,tph-1,mod-1,and ser-4 significantly increased after LFBEP-C1 intake.Changes in these genes explain the signaling pathways that regulate lipid metabolism.Conclusion LFBEP-C1 significantly reduced lipid deposition in C.elegans fed a high-glucose diet and alleviated the adverse effects of a high-glucose diet on the development,lifespan,and exercise behavior of C.elegans.In addition,LFBEP-C1 regulated lipid metabolism mainly by mediating the expression of genes in the sterol regulatory element-binding protein,insulin,and 5-hydroxytryptamine signaling pathways.

关键词： LFBEP-C1 Fermentation Protein Caenorhabditis elegans Lipid accumulation Signaling pathway

Analysis of the successful clinical treatment of 140 patients with parathyroid adenoma:A retrospective study

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World Journal of Clinical Cases 2022年第28期10卷 10031-10041页

作者： Zhen-Xing Peng Yong Qin juan bai Jin-Shu Yin Bo-Jun Wei Department of Otorhinolaryngology Head and Neck Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Otorhinolaryngology and Head and Neck Surgery Peking University First HospitalBeijing 100034China Department of Thyroid and Neck Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND Parathyroid adenoma(PA) sometimes recurs after surgery,how to improve the surgical success rate of PA is the key to the treatment of this disease.AIM To investigate the clinical features,diagnosis,and surgical treatment of patients with PA.METHODS Patients who were pathologically confirmed with PA and had undergone surgery for the first time between January 2010 and December 2017 at the Beijing Shijitan Hospital affiliated to Capital Medical University were included in the study.The clinical features,localization diagnosis,and surgical treatment of these patients were analyzed.RESULTS Of the 140 patients,32 were male and 108 were female;132 cases had one adenoma,and 8 had two adenomas.In addition,114 cases had clinical symptoms,among which 51,28,23,8,and 4 had urinary system,skeletal system,digestive system,neuromuscular system,and neuropsychiatric symptoms,respectively,while 26 cases had no obvious symptoms.The median level of preoperative parathyroid hormone(PTH) was 201.0 pg/m L.The positive detection rate of technetium-99m sestamibi(Tc-99m MIBI) single-photon emission computed tomography/computed tomography(SPECT/CT),ultrasound examination,and the combined use of Tc-99m MIBI SPECT/CT and ultrasound examination was 92.9%,85.5%,and 96.4%,respectively.Open surgery was performed in all patients,and PTH was monitored during surgery.The success rate of surgery was 98.6%.After surgery,21 cases developed hypocalcemia,1 case developed temporary hoarseness,and 19 cases had transient hypoparathyroidism but there was no permanent hypoparathyroidism,postoperative hemorrhage,or hematoma in the surgical area.CONCLUSION For patients with clinically unexplained skeletal system,urinary system,and neuropsychiatric symptoms,the possibility of PA should be considered.Imaging examinations such as ultrasound and Tc-99m MIBI SPECT/CT could be integrated before surgery to obtain accurate localization diagnosis.Precise preoperative localization,intraoperative PTH monitoring,and delicate surgery to protect the integrity of t

关键词： Primary hyperparathyroidism Parathyroid adenoma Technetium-99m sestamibi SPECT/CT Surgical treatment Localization diagnosis Intraoperative parathyroid hormone monitoring

Network Pharmacology and Experimental Study of MomordicineⅠand MomordicineⅡfrom Bitter Melon Saponins in Inhibiting Fat Accumulation

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Biomedical and Environmental Sciences 2024年第5期37卷 526-530页

作者： HUANG Shi Ting LI Shang Yuan LI Xin Yu ZHU Ying ZHU Lin ZHANG Jia Yan ZHAO Yan Sheng DAGLIA Maria XIAO Xiang bai juan School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina Department of Pharmacy University of Napoli FedericoⅡVia D.Montesano 4980131 NaplesItaly International Research Center for Food Nutrition and Safety Jiangsu UniversityZhenjiang 212013JiangsuChina

Bitter melon(Momordica Charania L.),a member of the Cucurbitaceae family,is widely distributed across tropical and subtropical regions.Saponin,an important functional component of bitter melon,has been proven to exert hypoglycemic effects similarly to insulin,and also possesses lipid-lowering properties inhibiting preadipocyte differentiation and fat synthesis^([1]).

关键词： melon Momordica subtropical

Primary primitive neuroectodermal tumor in the pericardium-a focus on imaging findings:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4336-4341页

作者： Shu-Ming Xu juan bai Jin-Hua Cai Department of Radiology Children’s Hospital of ShanxiTaiyuan 030013Shanxi ProvinceChina Department of Medical Imaging Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Radiology Children’s HospitalChongqing Medical UniversityChongqing 400014China

BACKGROUND Primitive neuroectodermal tumors(PNETs)are rare,sporadic malignant tumors of the peripheral nervous system,bone,or soft tissues.However,to the best of our knowledge,only three cases of PNET in the pericardium have been reported in the English literature,and their magnetic resonance imaging findings have not previously been described.CASE SUMMARY A 3-year-old boy was hospitalized with a 1-wk history of recurrent vomiting and weakness.Detailed history-taking revealed no evidence of heart disease.Computed tomography demonstrated a soft tissue mass in the left pericardial cavity with heterogeneous contrast enhancement.The border between the mass and the heart was poorly defined.Thoracotomy revealed a mass invading the left ventricle,with a high risk of bleeding.The mass was considered inoperable.A biopsy was performed,and the histological and immunohistochemical findings confirmed the diagnosis of primary PNET of the pericardium.The patient received four cycles of standard chemotherapy.Chest magnetic resonance imaging 3 mo after the initiation of chemotherapy revealed that the tumor in the pericardium still existed,but its volume had slightly decreased.The patient was lost to follow-up,and the final outcome was therefore unknown.CONCLUSION Medical imaging plays an important role in defining the pericardial origin of PNET and understanding its characteristics.Magnetic resonance imaging can provide more information on the tumor than computed tomography and may thus aid therapeutic planning.

关键词： Primary primitive neuroectodermal tumors Pericardium Tumor Computed tomography Magnetic resonance imaging Case report

Interactive response of photosynthetic characteristics in Haloxylon ammodendron and Hedysarum scoparium exposed to soil water and air vapor pressure deficits

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Journal of Environmental Sciences 2015年第8期27卷 184-196页

作者： Chunmei Gong Jiajia Wang Congxia Hu Junhui Wang Pengbo Ning juan bai College of Life Sciences Northwest A&F University College of Veterinary Medicine Northwest A&F University

C4 plants possess better drought tolerance than C3 plants. However, Hedysarum scoparium, a C3 species, is dominant and widely distributed in the desert areas of northwestern China due to its strong drought tolerance. This study compared it with Haloxylon ammodendron, a C4 species, regarding the interactive effects of drought stress and different leaf–air vapor pressure deficits. Variables of interest included gas exchange, the activity levels of key C4 photosynthetic enzymes, and cellular anatomy. In both species, gas exchange parameters were more sensitive to high vapor pressure deficit than to strong water stress, and the net CO2 assimilation rate（A n） was enhanced as vapor pressure deficits increased. A close relationship between A n and stomatal conductance（g s） suggested that the species shared a similar response mechanism. In H. ammodendron, the activity levels of key C4 enzymes were higher, including those of phosphoenolpyruvate carboxylase（PEPC） and nicotinamide adenine dinucleotide phosphate-malate enzyme（NADP-ME）, whereas in H. scoparium, the activity level of nicotinamide adenine dinucleotide-malate enzyme（NAD-ME） was higher.Meanwhile, H. scoparium utilized adaptive structural features, including a larger relative vessel area and a shorter distance from vein to stomata, which facilitated the movement of water. These findings implied that some C4 biochemical pathways were present in H. scoparium to respond to environmental challenges.

关键词： C4photosynthesis Gas exchange H.ammodendron H.scoparium Water stress Vapor pressure deficit

Enhanced ethanol oxidation over Pd nanoparticles supported porous graphene-doped MXene using polystyrene particles as sacrificial templates

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Rare Metals 2022年第9期41卷 3170-3179页

作者： Yi-Zhe Chen Ming Zhou Yu-Fu Huang Yan-Yun Ma Luo-Yi Yan Xin-Wen Zhou Xin-Zhou Ma Xue-Ling Zhao Cheng Chen juan bai Dong-Hai Lin Shanghai Engineering Research Center of Advanced Thermal Functional Materials Shanghai Key Laboratory of Engineering Materials Application and EvaluationSchool of Energy and MaterialsShanghai Polytechnic UniversityShanghai201209China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China College of Biological and Pharmaceutical Sciences China Three Gorges UniversityYichang443002China School of Materials Science and Hydrogen Energy Foshan UniversityFoshan528000China School of Chemistry and Physics Queensland University of TechnologyBrisbaneQLD4000Australia

Fabrication of superior catalytic performance palladium-based catalysts with affordable cost is the key to develop direct ethanol fuel cell.Herein,Pd-decorated three-dimensional(3D)porous constructed from graphene oxide(GO)and MXene combining with polystyrene(PS)particles as sacrificial templates(Pd/GO-MXene-PS)to elevate the catalytic performance for ethanol oxidation was proposed.The 3D porous interconnected structure of Pd/GO-MXene-PS was characterized by scanning electron microscope(SEM),transmission electron microscope(TEM)and Brunner−Emmet−Teller(BET).By optimizing the doping ratio of MXene to GO,the mass activity of Pd/GO_(5)-MXene_(5)-PS(2944.0 mA·mg^(−1))was 3.0 times higher than that of commercial Pd/C(950.4 mA·mg^(−1))toward ethanol oxidation in base solution.Meanwhile,the rotating disk electrode(RDE)results demonstrated that Pd/GO5-MXene5-PS had a faster kinetics of ethanol oxidation.The enhanced ethanol oxidation over Pd/GO5-MXene5-PS could attribute to the excellent 3D interconnected porous structure,large surface area,good conductivity and homogeneous Pd distribution.This work provided a new idea for creating 3D porous MXene composite materials in electrocatalysis.

关键词： Pd nanoparticles Ethanol oxidation Graphene MXene Polystyrene(PS)template Rotating disk electrode(RDE)

Inhibition of neurite outgrowth using commercial myelin associated glycoprotein-Fc in neuro-2a cells

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Neural Regeneration Research 2018年第11期13卷 1893-1899页

作者： Fu Liu Mei-Ling Gao juan bai Ya-Fang Wang Xia-Qing Li Department of Pathophysiology Shanxi Medical University Taiyuan Shanxi Province China Department of Vascular Surgery People's Hospital of Gansu Province Lanzhou Gansu Province China

Myelin-associated glycoprotein（MAG） inhibits the growth of neurites from nerve cells. Extraction and purification of MAG require complex operations; therefore, we attempted to determine whether commercially available MAG-Fc can replace endogenous MAG for research purposes. Immunofluorescence using specific antibodies against MAG, Nogo receptor（NgR） and paired immunoglobulin-like receptor B（PirB） was used to determine whether MAG-Fc can be endocytosed by neuro-2a cells. In addition, neurite outgrowth of neuro-2a cells treated with different doses of MAG-Fc was evaluated. Enzyme linked immunosorbent assays were used to measure RhoA activity. Western blot assays were conducted to assess Rho-associated protein kinase（ROCK） phosphorylation. Neuro-2a cells expressed NgR and PirB, and MAG-Fc could be endocytosed by binding to NgR and PirB. This activated intracellular signaling pathways to increase RhoA activity and ROCK phosphorylation, ultimately inhibiting neurite outgrowth. These findings not only verify that MAG-Fc can inhibit the growth of neural neurites by activating RhoA signaling pathways, similarly to endogenous MAG, but also clearly demonstrate that commercial MAG-Fc is suitable for experimental studies of neurite outgrowth.

关键词： nerve regeneration myelin growth inhibitors myelin-associated glycoprotein MAG-Fc cell culture receptors for myelin-associatedglycoprotein neuro-2a cell line RhoA/ROCK signaling pathways neurite outgrowth neural regeneration

高职院校生产性实训基地“三全育人”创新实践研究——以杨凌职业技术学院旅游与管理学院旅苑创咖实训室为例

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黑龙江教师发展学院学报 2024年第4期43卷 101-104页

作者：白娟利杨凌职业技术学院陕西咸阳712100

在高职院校开展“三全育人”工作,需要构建全方位、全过程、全员参与的实践育人机制。当前高职院校通过构建生产实训性基地,进一步提升了高职院校实践育人的能力。基于此,以杨凌职业技术学院旅游与管理学院旅苑创咖实训室为例,分析当前... 详细信息

在高职院校开展“三全育人”工作,需要构建全方位、全过程、全员参与的实践育人机制。当前高职院校通过构建生产实训性基地,进一步提升了高职院校实践育人的能力。基于此,以杨凌职业技术学院旅游与管理学院旅苑创咖实训室为例,分析当前我国高职院校生产性实训基地建设过程中面临的挑战,并提出高职院校生产性实训基地“三全育人”创新实践策略,以期进一步强化人才培养评价机制,优化生产性实训基地师资队伍,促进高职院校生产性实训基地“三全育人”创新实践能力的提升。

关键词：高职院校生产性实训基地 “三全育人” 创新实践