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Aggressive Angiomyxoma: An Unusual Female Pelvic Tumour. Report of Three Cases and Review of the Literature

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Surgical Science 2010年第2期1卷 40-45页

作者： juan antonio Martin-Cartes Manuel Bustos-Jimenez Maria Jesus Tamayo-lopez Maria del Carmen Palacios-Gonzalez Virginia Gomez-Cabeza de Vaca antonio Muñoz Ortega Division of Surgery Abdominal Wall Surgery UnitSevilleSpain

Aggressive angiomyxoma was first described in 1983 by Steeper and Rosai, and fewer than 150 cases have been reported in the world medical literature. It is a soft-tissue tumour of the pelvis and perineum. The recurrence rate is high, and often extensive resections are performed with considerable morbidity. These tumours are benign, locally infiltrative mesenchymal neoplasms with a predilection for the female pelvis and perineum and they usually tend to recur. Furthermore, these tumours often reach too large dimensions before becoming clinically symptomatic;their incidence is higher in women of the reproductive age group;however a few cases of its occurrence outside the pelvis have also been reported. In this study, we reported three cases with aggressive pelvic angiomyxoma treated with surgical methods and used an approach that described by Kraske in order to get access to lower rectal cancers. Accurate preoperative diagnosis should alert the surgeon to the need for wide excision, which is essential for prevention of local recurrence.

关键词： Aggressive Angiomyxoma Soft Tissue Tumour Perineum and Pelvis Tumour

Analysis of the therapeutic evolution in the management of airway infantile hemangioma

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World Journal of Clinical Pediatrics 2016年第1期5卷 95-101页

作者： Grecia V Vivas-Colmenares Israel Fernandez-Pineda juan Carlos lopez-Gutierrez Miguel Angel Fernandez-Hurtado Maria Antonia Garcia-Casillas Jose antonio Matute de Cardenas Department of Pediatric Surgery Virgen del Rocio Children’s Hospital Department of Pediatric Surgery La Paz’s Children’s Hospital Department of Pediatric Surgery Gregorio Mara?on Children’s Hospital

AIM: To analyze the evolution in the management of airway infantile hemangioma(AIH) and to report the results from 3 pediatric tertiary care ***: A retrospective study of patients with diagnosis of AIH and treated in 3 pediatric tertiary care institutions from 1996 to 2014 was performed. RESULTS: Twenty-three patients with diagnosis of AIH were identified. Mean age at diagnosis was 6 mo(range, 1-27). Single therapy was indicated in 16 patients and 7 patients received combined therapy. Two therapeutic groups were identified: Group A included 14 patients who were treated with steroids, interferon, laser therapy and/or surgery; group B included 9 patients treated with oral propranolol. In group A, oral corticosteroids were used in 9 patients with a good response in 3 cases(no requiring other therapeutic option), the other patients required additional treatment options. Cushing syndrome was observed in 3 patients. One patient died of a fulminant sepsis. Open surgical excision and endoscopic therapy were performed in 11 patients(in 5 of them as a single treatment) with a response rateof 54.5%. Stridor persisted in 2 cases, and one patient died during the clinical course of bronchial aspiration. In group B, oral propranolol was used in 9 patients(in 8 of them as a single treatment) with a response rate of 100%, with an mean treatment duration of 7 mo(range, 5-10); complications were not observed. CONCLUSION: Our experience and the medical literature support the use of propranolol as a first line of treatment in AIH.

关键词： Infantile hemangioma Propranolol Surgery Airway Fibrobronchoscopy

Effect of Citric Acid, Phytase and Calcium Levels on the Calcium and Phosphorus Content in Egg: Yolk-Albumen and Shell, Yolk Color and Egg Quality in Diets of Laying Hens

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Food and Nutrition Sciences 2016年第14期7卷 1364-1374页

作者： Lily M. Vargas-Rodríguez Jesús E. morales-Barrera José G. Herrera-Haro juan antonio-Bautista Roberto López-Pozos David Hernández-Sánchez Instituto de Recursos Genéticos y Productividad (IREGEP) Colegio de Postgraduados Texcoco México Departamento de Medicina Veterinaria y Zootecnia Universidad Autónoma Metropolitana Xochimilco D.F. México México División de Ingeniería en Procesos Bioalimentarios Universidad Tecnológica de los Valles Centrales de Oaxaca Oaxaca México Licenciatura en Zootecnia Universidad del Mar. Puerto Escondido Oaxaca México

To evaluate the effect of different levels of citric acid (CA) combined with phytase and calcium levels in the diets of laying hens on the calcium and phosphorus (P) contents of eggs: yolk-albumen and shell, yolk color and egg quality. A study was conducted with 24-week-old laying hens fed with a diet based on sorghum and soybean meal with 2.7 Mcal of EM/kg, 15% crude protein, 3.25% calcium and 0.25% available P. The levels of CA, phytase and calcium were 0%, 0.6% and 1.2%;0 and 300 units of phytase (PHYU)/kg;and 3.0% and 3.25%, respectively. Phytase was added as an ingredient into to the diets, contributing 0.1% P and 0.3% calcium. A completely randomized factorial experiment was performed with a 3 × 2 × 2 design and 4 replications. The CA increased (P < 0.05) the P in the shell, and the combination of 1.2% CA, 300 PHYU phytase and 3.25% calcium increased (P < 0.05) the calcium in the eggshell. There was a CA × phytase × calcium interaction (P < 0.05) affecting egg yolk pigmentation;there were no differences in egg quality. It was concluded that adding CA to the diets of laying hens increases eggshell calcium content, and improves the phytase response. 1.2% CA × Phytase × 3.25% calcium significantly increases shell calcium by 0.56 g. Under the conditions of the present investigation, it would imply greater resistance of the eggs to be broken in the handling from the farm to the sales centers and consumer. Phytase interacts negatively with 0.6% CA at low calcium levels to degrade the yellow pigmentation of the yolk.

关键词： Citric Acid Phytase Calcium Laying Hens Eggshell

Antinociceptive and Anti-inflammatory Activities of Methanol Extract of Ormosia coccinea （Aubl,） Jacks in vivo

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Journal of Pharmacy and Pharmacology 2017年第6期5卷 289-298页

作者： Miguel Angel Diaz C. Lorena H. Cruz M. Mahabir P. Gupta Dionisio Olmedo Jose Luis lopez-Perez Estela Guerrero De Leon juan antonio Moran-Pinzon Direccidn Nacional de Farmacia y Drogas Ministerio de Salud Panama Apartado 06812-0816 Republica de Panama Centro de lnvestigaciones Farmacognosticas de la Flora Panamena (CIFLORPAN) Facultad de Farmacia Universidad de Panama Panama Apartado 0824-00172 Republica de Panama Departamento de Quimica FarmacOutica Facultad de Farmacia Universidad de Salamanca Salamanca Apartado 37007 Spain Departamento de Farmacologla Facultad de Medicina Universidad de Panama Panama Apartado 0824 Panama

The present study was conducted to evaluate the antinociceptive and anti-inflammatory activities of methanol extract of rachis of Ormosia coccinea （Aubl.） Jacks （MEOC） using animal models of nociception and inflammation. The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin tests. Oral administration of MEOC （500 mg/kg） produced significant （t7 〈 0.05） antinociceptive effects when tested in mice using acetic acid-induced abdominal writhing test and on the inflammatory phase of the formalin test. It was also demonstrated that MEOC had no significant effect on the response latency time to the heat stimulus in the thermal model of the hot plate test. The anti-inflammatory activity of the extract was assessed using carrageenan, histamine and serotonin induced oedema in rat paw. The oral administration of MEOC showed maximum inhibition （64.29%） at 1 h on carrageenan edema, but it did not modify the edema induced by histamine and serotonin. The present results suggest that MEOC has a peripheral antinoeiceptive and anti-inflammatory action.

关键词： Ormosia coccinea antinociceptive anti-inflammatory fabaceae.

Risk perception and knowledge of COVID-19 in patients with celiac disease

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World Journal of Gastroenterology 2021年第12期27卷 1213-1225页

作者： Jamie Zhen juan Pablo Stefanolo María de la Paz Temprano Caroline L Seiler Alberto Caminero Enrique de-Madaria Miguel Montoro Huguet Vivas Santiago Sonia Isabel Niveloni Edgardo Gustavo Smecuol Luis Uzcanga Dominguez Elena Trucco Virginia lopez Carolina Olano Pasquale Mansueto antonio Carroccio Peter H Green Donald Duerksen Andrew S Day Jason A Tye-Din Julio César Bai Carolina Ciacci Elena F Verdú Benjamin Lebwohl M Ines Pinto-Sanchez Department of Medicine Farncombe Family Digestive Health Research InstituteMcMaster University Medical CenterHamilton Health SciencesHamilton L8S4K1ONCanada Department of Medicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Department of Pancreatic Unit Hospital General Universitario de AlicanteAlicante 03010Spain Department of Medicine Instituto Aragonés de Ciencias de la Salud(IACS)Zaragoza 50009Spain Department of Medicine Hospital Universitario San Jorge.HuescaZaragoza 50004Spain Department of Gastroenterology Univ Hosp LeonGastroenterol UnitAltos de Nava S-NLeon 24071Spain Department of Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico DF 14080Mexico Department of Medicine Universidad de la RepublicMontevideo 11800Uruguay Department of Internal Medicine PROMISE DepartmentUniversity of PalermoPalermo 90127Italy Department of Internal Medicine V.Cervello HospitalPROMISE DepartmentUniversity of PalermoPalermo 90127Italy Celiac Disease Center Columbia University Medical CenterColumbia UnivCeliac Dis CtrDiv Digest and Liver DisNew YorkNY 10032United States Department of Medicine St Boniface Gen HospUniversity of ManitobaWinnipeg R2H 2A6Canada Department of Paediatrics University of Otago ChristchurchChristchurch 8041New Zealand Department of Gastroenterology Royal Melbourne HospitalImmunology DivisionWalter and Eliza Hall InstituteMelbourne 3052Australia Department of Medicine Surgery and DentryScuola Medica SalernitanaUniversity of SalernoCeliac Center at the University Hospital San Giovanni di Dio e Ruggi di AragonaSalerno 84131Italy Department of Medicine Farncombe Family Digestive Research InstituteMcMaster UniversityHamilton L8S4K1ONCanada The Celiac Disease Center Columbia UniversityNew YorkNY 10032United States

BACKGROUND We recently demonstrated that the odds of contracting coronavirus disease 2019(COVID-19)in patients with celiac disease(CeD)is similar to that of the general ***,how patients with CeD perceive their COVID-19 risk may differ from their actual *** To investigate risk perceptions of contracting COVID-19 in patients with CeD and determine the factors that may influence their *** We distributed a survey throughout 10 countries between March and June 2020 and collected data on demographics,diet,COVID-19 testing,and risk perceptions of COVID-19 in patients with *** were recruited through various celiac associations,clinic visits,and social *** perception was assessed by asking individuals whether they believe patients with CeD are at an increased risk of contracting COVID-19 when compared to the general *** regression was used to determine the influencing factors associated with COVID-19 risk perception,such as age,sex,adherence to a gluten-free diet(GFD),and comorbidities such as cardiac conditions,respiratory conditions,and *** was presented as adjusted odds ratios(aORs)RESULTS A total of 10737 participants with CeD completed the *** them,6019(56.1%)patients with CeD perceived they were at a higher risk or were unsure if they were at a higher risk of contracting COVID-19 compared to the non-CeD population.A greater proportion of patients with CeD perceived an increased risk of contracting COVID-19 when compared to infections in general due to their CeD(56.1%vs 26.7%,P<0.0001).Consequently,34.8%reported taking extra COVID-19 precautions as a result of their *** of celiac associations were less likely to perceive an increased risk of COVID-19 when compared to non-members(49.5%vs 57.4%,P<0.0001).Older age(aOR:0.99;95%CI:0.99 to 0.99,P<0.001),male sex(aOR:0.84;95%CI:0.76 to 0.93,P=0.001),and strict adherence to a GFD(aOR:0.89;95%CI:0.82 to 0.96,P=0.007)were associated

关键词： Celiac disease Gluten Risk Infection Knowledge Perception Coronavirus COVID-19

Alginate Encapsulation as a Preservation Method of Pitaya Fruit Juice （Stenocereus spp.）

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Journal of Food Science and Engineering 2017年第3期7卷 127-134页

作者： juan antonio Rodriguez-Sanchez Maria Isabel Cuatzo-Lozano Maria Guadalupe Perez-Loredo Diana ImeldaAbarca-Sarro Yoja Gallardo Navarro Department of Environmental Systems Engineering Escuela Nacional de Ciencias Biol6gicas Instituto Politecnico Nacional.Wilfrido Massieu s/n Ave. Unidad Profesional Adolfo Lopez Mateos Mexico City 07738 Mexico Department of Biochemical Engineering Escuela Nacional de Ciencias Biologicas Instituto Politecnico Nacional. WilfridoMassieu s/n Ave. Unidad Profesional Adolfo Lopez Mateos Mexico City 07738 Mexico

Alginate is a widely used polymer matrix in food industry since it allows formation of spherical, soft, and strong membranes adequate for encapsulation of a large amount of products, including food. The flow rate of alginate solutions and the permeability of the capsules were evaluated within an acidic-low acidic pH range and different alginate concentrations. In solutions adjusted at different pH （3.0 to 7.0） with concentrations of alginate of 0.8, 1.0, and 1.2% w/v, flow rates at 20 ℃ were 6.95 to 10.00, 4.54-5.35, and 2.60-2.80 mL sl, respectively. Permeability of the capsules was evaluated in terms of the diffusion of H＋ions （expressed as pH） and soluble solids （~Brix）. Meanwhile both diffusions were minor at 4.0 〈 pH 〈 7.0 and were significantly superior at more acidic pH （P 〈 0.05）, alginate concentration did not present significant effect. Yellow, purple, and red juices from Stenocereus spp. fruits （pitayas） were encapsulated using 1.0% of alginate and stored with isotonic solution （3 mL g^-1） at 4 ℃ in the dark. The capsules were spherical with diameter between 4.59 and 470 mm, weight from 82.60 to 97.50 rag, and volume of 0.075-0.098 mL. Pigment （total betalains content） diffusion reached equilibrium at 24 h of storage, at which point retentions of total betalains in the yellow, purple, and red capsules were 87.79, 96.13, and 85.13%, respectively. Also, changes in the color of the capsules were observed during storage.

关键词： Stenocereus pitaya betalains alginate encapsulation color stability.

Innovate combination of sevoflurane dilution in dimethyl sulfoxide: A stability study by gas chromatography and nuclear magnetic resonance

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World Journal of Pharmacology 2016年第3期5卷 59-67页

作者： F Dámaso Fernández-Ginés Sergio García-Mu?oz Héctor Mateo-Carrasco Miguel ángel Rincón-Cervera Manuel Corti?as-Sáenz José antonio morales-Molina Carmen Fernández-Sánchez juan Miguel Expósito-López Ignacio Rodríguez-García Department of Pharmacy Torrecárdenas Hospital University of Almería Aseptic Services Unit Department of Pharmacy Northampton General Hospital Institute of Nutrition and Food Technology University of Chile Department of Anesthesiology and Pain Management Torrecárdenas Hospital Department of Pharmacy Agencia Pública Empresarial Sanitaria Hospital de Poniente Department of Chemistry and Physics University of Almería

To investigate physicochemical stability of sevofuranein dimethyl sulfoxide using gas chromatography with a fame ionization detector and nuclear magnetic reso-nance （NMR）.METHODSUndiluted sevoflurane, plus dilutions 1：2, 1：5, 1：10, 1：25, and 1：50 in dimethyl sulfoxide were prepared in a vertical laminar fow cabinet class Ⅱ type B and stored at different temperatures （23 ℃, 6 ℃, and -10 ℃） for 45 d. Sterile 1 mL polypropylene amber syringes to minimize light degradation, caps and needles were used. The presence of sevofurane and its degradation products in the samples was determined by gas chroma-tography with flame ionization detector （260 ℃, 40min）, and by 1H, 19F, and proton-decoupled 19F nuclearmagnetic *** The gas chromatography analysis showed sevofluraneand dimethyl sulfoxide （DMSO） retention times were 2.7and 13.0 min, respectively. Pure DMSO injection into thecolumn resulted in two additional peaks at 2.1 and 2.8min. The same sevofurane peak at 2.7 min was observedin all the dilutions at -10 ℃, 4 ℃ and 25 ℃. The NMRspectra showed signals consistent with the sevoflurane structure in all the dilutions at -10 ℃, 4 ℃ and 25 ℃. In the 1H spectrum, two signals corresponding to the sevoflurane molecule were observed at 5.12 and 4.16 parts per million （ppm5）. In the 19F-NMR spectrum, two signals were observed at -76.77 ppm and -157.13 ppm. In the 19F NMR CPD, two signals were observed at -76.77 ppm and -157.13 ppm. The first one showed a doublet （JF-F = 3.1 Hz） which integrated by six fluorine nuclei from the hexafluoro-isopropyl group. The second signal was integrated by a fuorine atom and showed a septuplet （JF-F = 3.1 Hz）.CONCLUSIONThis study shows that different concentrations ofsevofurane in dimethyl sulfoxide retain their chemicalcomposition after exposure to different temperaturesfor a period of 45 d.

关键词： Sevoflurane Dimethyl sulfoxide Uclear magnetic resonance Gas chromatography Skin ulcers Drug stability

αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

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Protein & Cell 2020年第3期11卷 219-226页

作者： Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo juan Manuel lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityCambridgeMA 02115USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San antonio de Murcia(UCAM) Campus de los JeronimosNo 1351230107 GuadalupeSpain Hospital Clinic of Barcelona Career Villarroel17008036 BarcelonaSpain Department of Traumatology and Research Unit Clinica CEMTRO28035 MadridSpain National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Translational Medical Center for Stem Cell Therapy Shanghai East HospitalTongji University School of MedicineShanghai 200120China

Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular *** regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with *** aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016).

关键词： aging treatment critical

Hepatitis B virus infection in Latin America:A genomic medicine approach

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World Journal of Gastroenterology 2014年第23期20卷 7181-7196页

作者： Sonia Roman Alexis Jose-Abrego Nora Alma Fierro Griselda Escobedo-Melendez Claudia Ojeda-Granados Erika Martinez-lopez Arturo Puro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" and University of GuadalajaraGuadalajaraJalisco 44280Mexico Immunovirology Unit Department of Molecular Biology in MedicineCivil Hospital of Guadalajara "Fray Antonio Alcalde" and University of GuadalajaraGuadalajaraJalisco 44280Mexico Viral Hepatitis Clinic Pediatric Infectious Disease UnitDepartment of Pediatric Hematology and OncologyCivil Hospital of Guadalajara "Juan I.Menchaca" and University of GuadalajaraGuadalajaraJalisco 44280Mexico

Hepatitis B virus(HBV)infection is the leading cause of severe chronic liver *** article provides a critical view of the importance of genomic medicine for the study of HBV infection and its clinical outcomes in Latin *** levels of evolutionary adaptation may correlate with the clinical outcomes of HBV *** in Latin America are predominantly of genotype H in Mexico and genotype F in Central and South America;these strains have historically circulated among the indigenous *** genotypes appear to be linked to a benign course of disease among the native and mestizo Mexicans and native South *** contrast,genotypes F,A and D are common in acute and chronic infections among mestizos with Caucasian *** carcinoma is rare in Mexicans,but it has been associated with genotype F1b among *** observation illustrates the significance of ascertaining the genetic and environmental factors involved in the development of HBV-related liver disease in Latin America,which contrast with those reported in other regions of the world.

关键词： Genomic medicine Hepatitis B virus Hepatitis B virus genotypes Latin America Mexico Central America South America