Hepatitis B virus infection in Latin America:A genomic medicine approach

作     者：Sonia Roman Alexis Jose-Abrego Nora Alma Fierro Griselda Escobedo-Melendez Claudia Ojeda-Granados Erika Martinez-Lopez Arturo Puro 

作者机构：Department of Molecular Biology in MedicineCivil Hospital of Guadalajara "Fray Antonio Alcalde" and University of GuadalajaraGuadalajaraJalisco 44280Mexico Immunovirology UnitDepartment of Molecular Biology in MedicineCivil Hospital of Guadalajara "Fray Antonio Alcalde" and University of GuadalajaraGuadalajaraJalisco 44280Mexico Viral Hepatitis ClinicPediatric Infectious Disease UnitDepartment of Pediatric Hematology and OncologyCivil Hospital of Guadalajara "Juan I.Menchaca" and University of GuadalajaraGuadalajaraJalisco 44280Mexico 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第23期

页      面：7181-7196页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by The National Council of Science and Technology,Fondo Sectorial Salud-2010-1-139085 the Jalisco State Council of Science and Technology,COECYTJAL-Universidad de Guadalajara 5-2010-1-1041 to Roman S,Guadalajara,Jalisco,Mexico 

主　　题：Genomic medicine Hepatitis B virus Hepatitis B virus genotypes Latin America Mexico Central America South America 

摘      要：Hepatitis B virus(HBV)infection is the leading cause of severe chronic liver *** article provides a critical view of the importance of genomic medicine for the study of HBV infection and its clinical outcomes in Latin *** levels of evolutionary adaptation may correlate with the clinical outcomes of HBV *** in Latin America are predominantly of genotype H in Mexico and genotype F in Central and South America;these strains have historically circulated among the indigenous *** genotypes appear to be linked to a benign course of disease among the native and mestizo Mexicans and native South *** contrast,genotypes F,A and D are common in acute and chronic infections among mestizos with Caucasian *** carcinoma is rare in Mexicans,but it has been associated with genotype F1b among *** observation illustrates the significance of ascertaining the genetic and environmental factors involved in the development of HBV-related liver disease in Latin America,which contrast with those reported in other regions of the world.