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Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation

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World Journal of Gastroenterology 2014年第42期20卷 15820-15829页

作者： Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach juan ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria luis Feliz antonio María de lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel Department of Epidemiology Harvard School of Public Health Department of Medical Oncology Hospital Clínic ICMHO IDIBAPS CIBEREHD University of Barcelona Interdisciplinary Tumor Center Mannheim and Ⅲ Medical Clinic University Hospital Mannheim University of Heidelberg Department of Gastroenterology Endoscopy Unit Hospital Clínic ICMDiM IDIBAPS CIBEREHD University of Barcelona Department of Radiology Hospital Clínic CDI IDIBAPS University of Barcelona Department of Pathology Hospital Clínic IDIBAPS University of Barcelona Department of Radiation Oncology Hospital Clínic ICMHO University of Barcelona Department of Gastrointestinal Surgery Hospital Clínic ICMDiM IDIBAPS CIBEREHD University of Barcelona Department of Gastroenterology Hospital Clínic ICMDiM IDIBAPS CIBEREHD University of Barcelona Department of Nursing and Health University of Applied Sciences of the Saarland Department for Hematology and Oncology Clinic for Internal Medicine Ⅱ Jena University Hospital

AIM: To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.

关键词： Exercise Follow-up Gastrointestinal diseases Irritable bowel syndrome Physical activity

Transportation Safety Requirements in the Use of Pushchairs on Buses

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Journal of Traffic and Transportation Engineering 2017年第2期5卷 63-76页

作者： juan Dols Enrique Alcalá Jaime Masiā luis Martinez Angel Martin antonio Garcia Institute for Design and Manufacturing (IDF) Universitat Politècnica de Valencia Spain Camino de Vera s/n. 46022 Valencia Spain University Institute for Automobile Research (INSIA) Universidad Politécnica de Madrid Spain Campus sur de la UPM Ctra. de Valencia km Z 28031 Madrid Spain

The safe use of buses by passengers travelling with pushchairs for young children is a mobility problem that has not yet been satisfactorily resolved. The lack of national and international standards in this area in the past led to the development of a research project developed jointly by the Universitat Politecnica Valencia and the Universidad Politecnica Madrid （Spain）. This paper shows a comparative study to evaluate the dynamic behaviour in case of low-g accidents reproducing frontal impacts resembling real traffic events （deceleration 2g, AV 20 km/h） of a new pushchair restraint system against the use of back-restraint by pushchairs as establishes R 107- 06 series of amendments. In the dynamic trials, three pushchair restraint prototypes and a typical wheelchair back-restraint system combined with two worst-case up-to-date pushchair models in misuse and correct use configurations were tested. The results demonstrated the need for preventing children injuries as a consequence of low-g accidents. The new design meets and improves the latest revision of regulation R 107 regarding the use of restraint systems for the transport of wheelchair and pushchair passengers and represents an advance for pushchairs travelling on buses.

关键词： Transportation safety pushchairs children injury restraint system public transport.

Comparison of Electric load Forecasting between Using SOM and MlP Neural Network

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Journal of Energy and Power Engineering 2012年第3期6卷 411-417页

作者： Sergio Valero Carolina Senabre Miguel lopez juan Aparicio antonio Gabaldon Mario Ortiz Department of Mechanical and Energy Engineering Universidad Miguel Hernandez Elche 03202 Spain Operations Research Center Universidad Miguel Hernandez Elche 03202 Spain Department of Electrical Engineering Universidad Politdenica de Cartagena Murcia 30202 Spain

Electric load forecasting has been a major area of research in the last decade since the production of accurate short-term forecasts for electricity loads has proven to be a key to success for many of the decision makers in the energy sector, from power generation to operation of the system. The objective of this research is to analyze the capacity of the MlP （multilayer perceptron neural network） versus SOM （self-organizing map neural network） for short-term load forecasting. The MlP is one of the most commonly used networks. It can be used for classification problems, model construction, series forecasting and discrete control. On the other hand, the SOM is a type of artificial neural network that is trained using unsupervised data to produce a low-dimensional, discretized representation of an input space of training samples in a cell map. Historical data of real global load demand were used for the research. Both neural models provide good prediction results, but the results obtained with the SOM maps are markedly better Also the main advantage of SOM maps is that they reach good results as a network unsupervised. It is much easier to train and interpret the results.

关键词： Short-term load forecasting SOM (self-organizing map) multilayer perceptron neural network electricity markets.

An Acoustic Modem Featuring a Multi-Receiver and Ultra-low Power

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Circuits and Systems 2015年第1期6卷 1-12页

作者： antonio Sánchez Sara Blanc Pedro Yuste Angel Perles juan José Serrano Institut ITACA Universitat Politècnica de València Edifici 8G Valencia Spain

Wireless technology for underwater communication possesses a wide range of potential application, but it is still a relatively unexplored area in many aspects concerning modems physical design. A step towards future deployment of underwater networks is the reduction of power consumption. Therefore, asynchronous wakeup systems need to be integrated within the physical layer design while avoiding the use of additional transducers. This paper offers a practical and generic solution to adapt data reception and transmission together with asynchronous wakeup sub-systems in acoustic underwater modem architectures using a low power and low cost solution. The proposal has been implemented in a real prototype with success.

关键词： Underwater Acoustic Sensor Networks Electro-Acoustic Transducers Asynchronous Wake-Up Systems Underwater Wireless Communication

(4 + 4)-Dimensional Space-Time as a Dual Scenario for Quantum Gravity and Dark Matter

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Journal of Applied Mathematics and Physics 2022年第3期10卷 688-702页

作者： Brandon Mariano Martínez-Olivas juan antonio Nieto Andrés Sandoval-Rodríguez Facultad de Ciencias Fsico-Matemáticas de la Universidad Autónoma Culiacán Sinaloa México

In this work, we make a number of proposals to explain how a world of (4 + 4)-dimensions can be useful for a better understanding of both dark matter and quantum gravity. The key idea is to look for some advantage of considering self-dual invariants in (4 + 4)-dimensions rather than in a separate context of (1 + 3)-dimensions or (3 + 1)-dimensions. In fact, we show that by considering the duality concept in (4 + 4)-dimensions we may provide an alternative meaning of a framework for loop quantum gravity. Moreover, considering the Dirac equation in (4 + 4)-dimensions for a particle without electric charge and mass, we show that when it is projected into the (1 + 3) and (3 + 1)-worlds may describe a system with electric charge and mass. We also discuss the relation between the three physical scenarios;(4 + 4)-world, black-holes and dark matter.

关键词： (4 + 4)-Dimensions Dark Matter Quantum Gravity

Abscisic Acid Connects Phytohormone Signaling with RNA Metabolic Pathways and Promotes an Antiviral Response that Is Evaded by a Self- Controlled RNA Virus

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Plant Communications 2020年第5期1卷 111-128页

作者： Fabio Pasin Hongying Shan Beatriz García Maren Müller David San león Márta ludman David H.Fresno Károly Fátyol Sergi Munné-Bosch Guillermo Rodrigo juan antonio García Centro Nacional de Biotecnología(CNB-CSIC) 28049 MadridSpain Agricultural Biotechnology Research Center Academia Sinica11529 TaipeiTaiwan Departamento de Biologı´a Evolutiva Ecologı´a y Ciencias AmbientalesFacultad de Biologı´aUniversidad de Barcelona08028 BarcelonaSpain Agricultural Biotechnology Institute National Agricultural Research and Innovation Centre2100 Godoll}oHungary Institute for Integrative Systems Biology(I2SysBio) CSIC-University of Valencia46980 PaternaSpain Present address:College of Horticulture and Gardening Tianjin Agricultural University300384 TianjinChina

A complex network of cellular receptors,RNA targeting pathways,and small-molecule signaling provides robust plant immunity and tolerance to *** maximize their fitness,viruses must evolve control mechanisms to balance host immune evasion and plant-damaging *** genus Potyvirus comprises plant viruses characterized by RNA genomes that encode large polyproteins led by the P1 protease.A P1 autoinhibitory domain controls polyprotein processing,the release of a downstream functional RNAsilencing suppressor,and viral ***,we show that P1Pro,a plum pox virus clone that lacks the P1 autoinhibitory domain,triggers complex reprogramming of the host transcriptome and high levels of abscisic acid(ABA)accumulation.A meta-analysis highlighted ABA connections with host pathways known to control RNA stability,turnover,maturation,and *** changes triggered by P1Pro infection or ABA showed similarities in host RNA abundance and *** and hormone treatment assays showed that ABA promotes plant resistance to potyviral ***,quantitative mathematical modeling of viral replication in the presence of defense pathways supported self-control of polyprotein processing kinetics as a viral mechanism that attenuates the magnitude of the host antiviral ***,our findings indicate that ABA is an active player in plant antiviral immunity,which is nonetheless evaded by a self-controlled RNA virus.

关键词： abscisic acid antiviral immune evasion mathematical modeling viral polyprotein processing Potyvirus RNA metabolism

Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes

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Protein & Cell 2014年第1期5卷 59-68页

作者： Ying Gut Guang-Hui liu Nongluk Plongthongkum' Christopher Benner Fei Yi Jing Qu Keiichiro Suzuki Jiping Yang Weiqi Zhang Mo li Nuria Montserrat Isaac Crespo antonio del Sol Concepcion Rodriguez Esteban Kun Zhang juan Carlos Izpisua Belmonte Gene Expression laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA National laboratory of Biomacromolecules institute of Biophysics Chinese Academy of Sciences Beijing 100101 China ' State key laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Department of Bioengineering University of California at San Diego La Jolla CA 92093 USA center of Regenerative Medicine in Barcelona Dr. Aiguader 88 08003 Barcelona Spain Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN) Poeta MarianoEsquillor s/n 50018 Sargossa Spain luxembourg Centre for Systems Biomedicine (lCSB) University of Luxembourg Walferdange Luxembourg

With defined culture protocol, human embryonic stem cells （hESCs） are able to generate cardiomyocytes in vitro, therefore providing a great model for human heart development, and holding great potential for car- diac disease therapies. In this study, we successfully generated a highly pure population of human cardio- myocytes （hCMs）（〉95% cTnT＋） from hESC line, which enabled us to identify and characterize an hCM-specific signature, at both the gene expression and DNA meth- ylation levels. Gene functional association network and gene-disease network analyses of these hCM-enriched genes provide new insights into the mechanisms of hCM transcriptional regulation, and stand as an informative and rich resource for investigating cardiac gene func- tions and disease mechanisms. Moreover, we show that cardiac-structural genes and cardiac-transcription fac- tors have distinct epigenetic mechanisms to regulate their gene expression, providing a better understandingof how the epigenetic machinery coordinates to regulate gene expression in different cell types.

关键词： human cardiomyocyte DNA methylation,microarray heart development

Risk Groups and Mortality in Patients with SARS-CoV-2 from Family Medicine Unit No. 43 in Southeastern Mexico

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Journal of Biosciences and Medicines 2023年第1期11卷 116-122页

作者： Abel Pérez-Pavón Sigrid lorena Martínez-Vazquez Jorge Iván Martínez-Pérez Jorda Aleiria Albarrán-Melzer juan antonio Córdova-Hernández Sergio De Jesús Romero-Tapia Sergio Quiroz-Gomez Crystell G. Guzmán-Priego Social Security Institute of the State of Tabasco Villahermosa Mexico Cardiometabolism laboratory Academic Division of Health Sciences Juarez Autonomous University of Tabasco Villahermosa México

SARS-CoV-2 infection is a viral disease that causes respiratory infections that can cause multiple complications. Patients with adjacent morbidities have a higher chance of complications and mortality. The National Health and Nutrition Survey (ENSANUT) in 2018 reported that in Mexico, 75.2% of adults aged 20 years and over are overweight and obese, both situations are closely related to the cases reported as severe COVID and even with a higher risk of mortality. The main objective was to evaluate the risk and mortality groups in patients with SARS-CoV-2 from family medicine in the south of México. The study was carried out during the 2020 year, in the Family Medicine Unit No. 43 of Villahermosa, Tabasco, a cross-sectional, retrospective investigation was carried out with an analytical approach, and the sample was obtained using the formula of n for infinite populations that correspond to 215, patients were included who met the selection criteria;3 groups were integrated: DM2, HAS and obesity. Descriptive statistics andχ2 formula were used, using the SPSS version 25 Windows program. The female gender presented the highest number of infections 122 (56.7%) and mortality: 5 (2.32%), obesity comorbidity presented the highest number of infections: 194 (90.2%), HAS: 153 (71.2%), and MD: 44 (20.46%). Complications were observed in 23 (10.69%), distributed in: SIRA: 7 (3.3%), multiple organ failure: 6 (2.8%), heart failure: 6 (2.8%) and pneumonia 4 (1.9%). The observed mortality was 8 (3.72%). The comorbidities of patients with the highest mortality were: SAH: 6 (75%) (χ2 = 9.169;df = 1;p = 0.010) and obesity: 6 (75%) (χ2 = 9.169;df = 1;p = 0.010). The group with the highest risk for SARS-CoV-2 was patients with overweight/obesity comorbidities. Mortality was 3.7%. The patients who died had at least one or more comorbidities. The main complications were ARIS, heart failure, and multiple organ failure.

关键词： Pandemic COVID-19 SARS-CoV-2 Hypertension Diabetes Obesity Mortality

Blood transfusion for the treatment of acute anaemia in inflammatory bowel disease and other digestive diseases

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World Journal of Gastroenterology 2009年第37期15卷 4686-4694页

作者： José antonio García-Erce Fernando Gomollón Manuel Muoz Transfusion Medicine and Apheresis Unit Haematology and Haemotherapy Regional Service "Miguel Servet" University Hospital Zaragoza 50009 Spain Gastroenterology Unit University Clinical Hospital and Biomedical Investigation Center at Digestive and Hepatic Disease Network c/San Juan Bosco 15 Zaragoza 50009 Spain Transfusion Medicine School of Medicine University of Málaga Málaga 29071 Spain

Allogeneic blood transfusion (ABT) is frequently used as the first therapeutic option for the treatment of acute anaemia in patients with inflammatory bowel disease (IBD), especially when it developed due to gastrointestinal or perioperative blood loss, but is not risk-free. Adverse effects of ABT include, but are not limited to, acute hemolytic reaction (wrong blood or wrong patient), febrile non-hemolytic transfusional reaction, bacterial contamination, transfusion-related acute lung injury, transfusion associated circulatory overload, transfusion-related immuno-modulation, and transmission of almost all infectious diseases (bacteria, virus, protozoa and prion), which might result in increased risk of morbidity and mortality. Unfortunately, the main physiological goal of ABT, i.e. to increase oxygen consumption by the hypoxic tissues, has not been well documented. In contrast, the ABT is usually misused only to increase the haemoglobin level within a f ixed protocol [mostly two by two packed red blood cell (PRC) units] independently of the patient' s tolerance to normovolemic anaemia or his clinical response to the transfusion of PRC units according to a "one-by-one" administration schedule. Evidencebased clinical guidelines may promote best transfusion practices by implementing restrictive transfusion protocols, thus reducing variability and minimizing the avoidable risks of transfusion, and the use of autologous blood and pharmacologic alternatives. In this regard, preoperative autologous blood donation (PABD) consistently diminished the frequency of ABT, although its contribution to ABT avoidance is reduced when performed under a transfusion protocol. In addition, interpretation of utility of PABD in surgical IBD patients is hampered by scarcity of published data. However, the role of autologous red blood cells as drug carriers is promising. Finally, it must be stressed that a combination of methods used within wellconstructed protocols will offer better prospe

关键词： Anaemia Blood transfusion Autologous blood transfusion Inflammatory bowel diseases Risk assessment