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Low Trichorhinophalangeal Syndrome 1 Gene Transcript Levels in Basal-like Breast Cancer Associate with Mesenchymal-to-epithelial Transition

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Chinese Medical Sciences Journal 2013年第3期28卷 129-134页

作者： Yi Bao Ling-juan Ruan juan-fen mo Key Laboratory Jiaxing Second Hospital Jiaxing University

Objective To investigate trichorhinophalangeal syndrome 1 gene （TRPS-1） expression patterns in different subtypes of breast cancer and its correlations with other genes and survival using microarray data sets. Methods The transcripts of TRPS-1 and its role in survival in breast cancer were analyzed using published microarray data sets-Netherlands Cancer Institute （NKI） cohort and Wang cohort.

关键词： ductal epithelial cells trichorhinophalangeal syndrome 1 gene Slug epithelial mesenchymal transition breast cancer

Ezrin Promotes the Proliferation, Migration, and Invasion of Ovarian Cancer Cells

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Biomedical and Environmental Sciences 2021年第2期34卷 139-151页

作者： LI mo juan XIONG Dan HUANG Hao WEN Zhong Yong Department of Obstetrics and Gynecology Nanhai Hospital Affiliated to Southern Medical UniversityFoshan 528200GuangdongChina Department of Hematology Shunde Hospital of Southem Medical University(The First People's Hospital of Shunde)Foshan 528308GuangdongChina

Objective The underlying mechanism of Ezrin in ovarian cancer(OVCA) is far from being ***, this study aimed to assess the role of Ezrin in OVCA cells(SKOV3 and Ca OV3) and investigate the associated molecular *** We performed Western blotting, reverse transcription-quantitative polymerase chain reaction, MTT, cell colony, cell wound healing, transwell migration and invasion, Rho A and Rac active pull down assays, and confocal immunofluorescence experiments to evaluate the functions and molecular mechanisms of Ezrin overexpression or knockdown in the proliferation and metastasis of OVCA *** The ectopic expression of Ezrin significantly increased cell proliferation, invasiveness, and epithelial–mesenchymal transition(EMT) in OVCA cells. By contrast, the knockdown of endogenous Ezrin prevented OVCA cell proliferation, invasiveness, and EMT. Lastly, we observed that Ezrin can positively regulate the active forms of Rho A rather than Rac-1 in OVCA cells, thereby promoting robust stress fiber *** Our results indicated that Ezrin regulates OVCA cell proliferation and invasiveness by modulating EMT and induces actin stress fiber formation by regulating Rho-GTPase activity, which provides novel insights into the treatment of the OVCA.

关键词： Epithelial ovarian cancer Ezrin Proliferation Invasiveness RhoA Stress fiber

Hydrogen bond-assisted 1,2-cis O-glycosylation under mild hydrogenolytic conditions

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Chinese Chemical Letters 2023年第4期34卷 313-317页

作者： Gefei Li Yanlong Luo juan mo Masato Noguchi Jie Jing Zhenyang Luo Shin-ichiro Shoda Xin-Shan Ye College of Science Nanjing Forestry UniversityNanjing 210037China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Biomolecular Engineering Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan

A hydrogen bond-assisted α-selective glycosylation reaction by using 4,6-dibenzyloxy-1,3,5-triazin-2-yl(DBT) β-glycosyl donors was developed for the efficient construction of 1,2-cis-α-glycosidic bond in natural products. This method was applied successfully to the direct synthesis of complex oligosaccharidederived glycolipids with simple protecting chemistry. Mechanistic studies using the NMR spectroscopy and DFT calculation provide a proof of concept for hydrogen bond-assisted glycosylation reaction towardsα-specific construction of O-glycosidic linkage.

关键词： O-Glycosylation Hydrogen bond α-Selectivity Glycolipid Natural product

Protection-Free Site-Directed Peptide or Protein S-Glycosylation and Its Application in the Glycosylation of Glucagon-like Peptide 1

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CCS Chemistry 2022年第6期4卷 1930-1937页

作者： Gefei Li Yuankun Dao juan mo Suwei Dong Shin-ichiro Shoda Xin-Shan Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191 Department of Biomolecular Engineering Graduate School of EngineeringTohoku UniversityAoba-kuSendai 980-8579

The development of a facile cysteine-directed S-glycosylation strategy would facilitate the intensive investigation of the effect of glycosylation on protein translational ***,we introduce glycosyl Bunte salt as an efficient glycosyl donor for site-selective peptide/protein *** coupling reaction with cysteine thiols under alkaline buffer conditions proceeded chemoselectively,delivering homogeneous glycoconjugates and inorganic salt as the only byproduct.A series of sugar moieties,including monosaccharides and oligosaccharides,were successfully conjugated to the peptides and protein via the disulfide ***,this protocol was applied to the glycosylation of the glucagon-like peptide 1(GLP-1)variant,and its glycosylated effect on blood glucose control was also studied.

关键词： site-selective S-glycosylation peptide/protein-modification glycosyl Bunte salt disulfide bond GLP-1

momentum-space crystal in narrow-line cooling of ^(87)Sr

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Chinese Physics B 2019年第1期28卷 360-366页

作者： Jian-Xin Han Ben-Quan Lu mo-juan Yin Ye-Bing Wang Qin-Fang Xu Xiao-Tong Lu Hong Chang Key Laboratory of Time and Frequency Primary Standards National Time Service Center Chinese Academy of Sciences University of Chinese Academy of Sciences

The discovery of the momentum space crystal based on the alkaline-earth atom ^(88)Sr in narrow-line cooling has paved the way to explore this novel physical phenomenon in other cold atom systems. In this paper, a momentum space crystal based on the fermions ^(87)Sr in narrow-line cooling of transition^1S_0–~3P_1 is demonstrated. We theoretically analyze and compare the formation principle of the narrow-line with that of broad-line cooling, and achieve the momentum space crystal in experiment. Beyond that we present a series of numerical calculations of those important parameters which influence the distribution and size of the momentum space crystal. Correspondingly, we vary the values of these parameters in experiment to observe the momentum space crystal evolution and distribution. The experimental results are in conformity with the results of the theoretically numerical calculations. These results and analyses provide a detailed supplementary study on the formation and evolution of momentum space crystal. In addition, this work could also give a guideline on atomic manipulation by narrow-line cooling.

关键词： momentum space crystal narrow-line cooling strontium

Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1449-1460页

作者： Fei Chen Wei-Wei Li juan-Fen mo Min-Jie Chen Su-Hang Wang Shu-Ying Yang Zheng-Wei Song Department of Hepatobiliary Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina The Key Laboratory The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Intensive Medicine The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Neuroendocrine carcinoma(NEC)of the extrahepatic bile duct is very rare,and the treatment and prognosis are ***,we report the case of a middleaged female with primary large cell NEC(LCNEC)of the common hepatic duct combined with distal cholangiocarcinoma(dCCA).Additionally,after a review of the relevant literature,we summarize and compare mixed neuroendocrine-nonneuroendocrine neoplasm(MiNEN)and pure NEC to provide a reference for selecting the appropriate treatment and predicting the prognosis of this rare *** SUMMARY A 62-year-old female presented to the hospital due to recurrent abdominal pain for 2 *** examination showed mild tenderness in the upper abdomen and a positive Courvoisier *** tests showed elevated liver transaminase and carbohydrate antigen 199 *** examination revealed node dissection was performed,and hepatic duct tumours were unexpectedly found during *** suggested poorly differentiated LCNEC(approximately 0.5 cm×0.5 cm×0.4 cm),Ki-67(50%),synaptophysin+,and chromogranin A+.dCCA pathology suggested moderately differentiated *** patient eventually developed lymph node metastasis in the liver,bone,peritoneum,and abdominal cavity and died 24 months after *** sequencing methods were used to compare gene mutations in the two primary bile duct *** The prognosis of MiNEN and pure NEC alone is different,and the selection of treatment options needs to be differentiated.

关键词： Neuroendocrine carcinoma Mixed neuroendocrine-non-neuroendocrine neoplasm Cholangiocarcinoma Extrahepatic bile duct Case report

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变压器去耦覆盖层降噪技术研究

高压电器 2022年第5期58卷 7-14页

作者：莫娟彭宗仁西安交通大学西安710049 中国电力科学研究院有限公司北京100192

传统的低噪声变压器研究主要围绕着降低铁心磁通密度方面开展,但该技术因耗材多、成本高难以普及推广应用。文中基于吸声降噪原理,提出了在变压器内壁增加吸声装置调整变压器箱体声阻抗方法来实现降噪目的,并对声阻抗变化前后的变压器... 详细信息

传统的低噪声变压器研究主要围绕着降低铁心磁通密度方面开展,但该技术因耗材多、成本高难以普及推广应用。文中基于吸声降噪原理,提出了在变压器内壁增加吸声装置调整变压器箱体声阻抗方法来实现降噪目的,并对声阻抗变化前后的变压器噪声特性进行了模拟仿真分析,计算结果表明,适当调整变压器箱体声阻抗后,变压器箱体外噪声可明显降低,声压最小降幅为5 d B。随后借鉴平板吸声器调整声阻抗降噪思路,研制了变压器去耦覆盖层面板,该面板采用模块化设计,多块去耦板独立组装敷设在变压器内壁,并通过球形阻尼器连接在一起。同时开展了变压器噪声测试,结果显示安装去耦覆盖层面板后,测点声压级明显降低,降幅可达7.1 dB(A)。

关键词：变电站变压器噪声去耦覆盖层

Rabi Spectroscopy and Sensitivity of a Floquet Engineered Optical Lattice Clock

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Chinese Physics Letters 2021年第7期38卷 29-33页

作者： mo-juan Yin Tao Wang Xiao-Tong Lu Ting Li Ye-Bing Wang Xue-Feng Zhang Wei-Dong Li Augusto Smerzi Hong Chang Key Laboratory of Time and Frequency Primary Standards National Time Service CenterChinese Academy of SciencesXi'an 710600China Department of Physics and Center of Quantum Materials and DevicesChongqing UniversityChongqing 401331China Department of Physics and Institute of Theoretical Physics Shanxi UniversityTaiyuan 030006China QSTAR INO-CNRand LENSLargo Enrico Fermi 2I-50125 FirenzeItaly School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

We periodically modulate the lattice trapping potential of a ^(87)Sr optical clock to Floquet engineer the clock *** the context of atomic gases in lattices,Floquet engineering has been used to shape the dispersion and topology of Bloch quasi-energy *** from these previous works manipulating the external(spatial)quasi-energies,we target the internal atomic degrees of *** shape Floquet spin quasi-energies and measure their resonance profiles with Rabi *** provide the spectroscopic sensitivity of each band by measuring the Fisher information and show that this is not depleted by the Floquet dynamical *** demonstration that the internal degrees of freedom can be selectively engineered by manipulating the external degrees of freedom inaugurates a novel device with potential applications in metrology,sensing and quantum simulations.

关键词： spectroscopy transition quasi

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电力行业碳排放权的初始分配机制

电力自动化设备 2013年第1期33卷 44-49页

作者：宋旭东莫娟向铁元武汉大学电气工程学院湖北武汉430072

在传统碳排放权分配模式的基础上,结合我国电力行业发展的实际情况以及发电资源分布的特点,提出基于区域比较的两级分配机制,并建立相应的分配模型。该分配机制中,一级区域间分配考虑各区域发展的不平衡性和发电资源分布的不均衡性,保... 详细信息

在传统碳排放权分配模式的基础上,结合我国电力行业发展的实际情况以及发电资源分布的特点,提出基于区域比较的两级分配机制,并建立相应的分配模型。该分配机制中,一级区域间分配考虑各区域发展的不平衡性和发电资源分布的不均衡性,保证分配的公平性;二级区域内分配以发电效率和效益为主,保证分配的高效性。仿真结果表明该分配机制能合理分配碳排放权。

关键词：电力行业碳排放权分配机制公平效率模型