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Advancing and demonstrating the Impact Indices method to screen the sensitivity of building energy use to occupant behaviour

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Building Simulation 2023年第7期16卷 1257-1272页

作者： juan mahecha zambrano Isabella Gaetani Ulrich Filippi Oberegger Graziano Salvalai Zurich University of Applied Sciences Centre for Building Technologies and Processes8400 WinterthurSwitzerland Politecnico di Milano Department of ArchitectureBuilt Environment and Construction Engineering20133 MilanItaly Arup Smart BuildingsLondonW1T 4BQUK European Academy of Bolzano/Bozen Institute for Renewable Energy39100 Bolzano/BozenItaly

A critical gap between the occupant behaviour research field and the building engineering practice limits the integration of occupant-centric strategies into simulation-aided building design and *** this gap would contribute to the implementation of strategies that improve the occupants’well-being while reducing the buildings’environmental *** this view,it is urgent to develop guidelines,standardised methods,and supporting tools that facilitate the integration of advanced occupant behaviour models into the simulation *** important step that needs to be fully integrated into the simulation workflow is the identification of influential and non-influential occupant behaviour aspects for a given simulation ***,this article advances and demonstrates the application of the Impact Indices method,a fast and efficient method for screening the potential impact of occupant behaviour on the heating and cooling ***,the method now allows the calculation of Impact Indices quantifying the sensitivity of building energy use to occupancy,lighting use,plug-load appliances use,and blind operation at any spatial and temporal ***,users can apply it in more detailed heating and cooling scenarios without losing ***,they can identify which components in building design and operation require more sophisticated occupant behaviour *** office building is used as a real case study to illustrate the application of the method and asses its performance against a one-factor-at-a-time sensitivity *** Impact Indices method indicates that occupancy,lighting use and plug-load appliances have the greatest impact on the annual cooling demand of the studied office building;blind operation is influential only in the west and south façades of the ***,potential applications of the method in building design and operation practice are discussed.

关键词： occupant behaviour building simulation occupant-centric building design building performance

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Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado Francisco J.Llorente-Cantarero juan Francisco Pascual-Gázquez Kirsten K.Ness Vicente Martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

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Impact of device resistances in the performance of graphene-based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期 89-99页

作者： óscar Castelló Sofía M.López Baptista Kenji Watanabe Takashi Taniguchi Enrique Diez Jesús Enrique Velázquez-Pérez Yahya M.Meziani José M.Caridad juan A.Delgado-Notario Department of Applied Physics University of Salamanca Unidad de Excelencia en Luz y Materia Estructurada(LUMES) University of Salamanca Research Center for Electronic and Optical Materials National Institute for Materials Science Research Center for Materials Nanoarchitectonics National Institute for Materials Science Nanotechnology Group USAL–Nanolab University of Salamanca

In recent years, graphene field-effect-transistors(GFETs) have demonstrated an outstanding potential for terahertz(THz) photodetection due to their fast response and high-sensitivity. Such features are essential to enable emerging THz applications, including 6G wireless communications, quantum information, bioimaging and security. However, the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device, so-called access or parasitic resistances. In this work, we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET detectors. Such dual-gate architectures allow us to fine tune(decrease) the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector, respectively. Our results can be well understood by a series resistance model, as shown by the excellent agreement found between the experimental data and theoretical calculations. These findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

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Arabidopsis SWC4 Binds DNA and Recruits the SWR1 Complex to Modulate Histone H2A.Z Deposition at Key Regulatory Genes

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Molecular Plant 2018年第6期11卷 815-832页

作者： Angeles Gomez-zambrano Pedro Crevillen Jose M. Franco-Zorrilla juan A. Lopez Jordi Moreno-Romero Pawel Roszak juan Santos-Gonzalez Silvia Jurado Jesus Vazquez Claudia Kohler Roberto Solano Manuel Pineiro Jose A. Jarillo Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid (UPM) - Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA) Campus Montegancedo UPM Pozuelo de Alarcon 28223 Madrid Spain Plant Molecular Genetics Department and Genomics Unit Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientfficas 28049 Madrid Spain Proteomics Unit Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) 28029 Madrid Spain Department of Plant Biology Uppsala BioCenter Swedish University of Agricultural Sciences and Linnean Center for Plant Biology Uppsala 75652 Sweden Laboratory of Cardiovascular Proteomics Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) 28029 Madrid Spain Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientfficas and Universidad de Sevilla 41092 Sevilla Spain Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB Campus UAB Bellaterra Barcelona Spain The Sainsbury Laboratory Cambridge CB2 1LR UK

Deposition of the H2A.Z histone variant by the SWR1 complex （SWRI-C） in regulatory regions of specific loci modulates transcription. Characterization of mutations in Arabidopsis thaliana homologs of yeast SWRI-C has revealed a role for H2A.Z exchange in a variety of developmental processes. Nevertheless, the exact composition of plant SWRI-C and how it is recruited to target genes remains to be established. Here we show that SWC4, the Arabidopsis homolog of yeast SANT domain protein Swc4/Eaf2, is a DNA-binding protein that interacts with SWR1-C subunits. We demonstrate that the swc4-1 knockout mutant is embryo- lethal, while SWC4 RNAi knockdown lines display pleiotropic phenotypic alterations in vegetative and repro- ductive traits, including acceleration of flowering time, indicating that SWC4 controls post-embryonic processes. Transcriptomic analyses and genome-wide profiling of H2A.Z indicate that SWC4 represses tran- scription of a number of genes, including the floral integrator FT and key transcription factors, mainly by modulating H2A.Z deposition. Interestingly, SWC4 silencing does not affect H2A.Z deposition at the FLC locus nor expression of this gene, a master regulator of flowering previously shown to be controlled by SWR1-C. Importantly, we find that SWC4 recognizes specific AT-rich DNA elements in the chromatin regions of target genes and that SWC4 silencing impairs SWRI-C binding at FT. Collectively, our data suggest that SWC4 regulates plant growth and development by aiding SWR1-C recruitment and modulating H2A.Z deposition.

关键词： Arabidopsis SWC4 chromatin SWR1 complex H2A.Z deposition flowering time

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Outcomes of abdominal surgery in patients with liver cirrhosis

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World Journal of Gastroenterology 2016年第9期22卷 2657-2667页

作者： juan C Lopez-Delgado Josep Ballus Francisco Esteve Nelson L Betancur-zambrano Vicente Corral-Velez Rafael Manez Antoni J Betbese Joan A Roncal Casimiro Javierre Hospital Universitari de Bellvitge Intensive Care Department L'Hospitalet de Llobregat 08907 Barcelona Spain IDIBELL (Institut d'Investigacio Biomedica Bellvitge Biomedical Investigation Institute of Bellvitge) Research Team of Area of Innate Immunity and Pathology of the Critical Patient L'Hospitalet de Llobregat 08908 Barcelona Spain Hospital de la Santa Creu i Sant Pau Intensive Care Department 08041 Barcelona Spain Physiological Sciences II Department Universitat de Barcelona Campus Bellvitge 08907 Barcelona Spain

Patients suffering from liver cirrhosis(LC) frequently require non-hepatic abdominal surgery,even before liver *** is an important risk factor itself for surgery,due to the higher than average associated morbidity and *** high surgical risk occurs because of the pathophysiology of liver disease itself and to the presence of contributing factors,such as coagulopathy,poor nutritional status,adaptive immune dysfunction,cirrhotic cardiomyopathy,and renal and pulmonary dysfunction,which all lead to poor *** evaluation of these factors and the degree of liver disease can help to reduce the development of complications both during and after abdominal *** the emergency setting,with the presence of decompensated LC,alcoholic hepatitis,severe/advanced LC,and significant extrahepatic organ dysfunction conservative management is preferred.A multidisciplinary,individualized,and specialized approach can improve outcomes;preoperative optimization after risk stratification and careful management are mandatory before *** techniques can also improve *** review the impact of LC on surgical outcome in non-hepatic abdominal surgeries required in this cirrhotic population before,during,and after surgery.

关键词： Liver cirrhosis Outcomes Coagulopathy Nutritional status Abdominal surgery Adaptive immune dysfuncti

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Cesarean Scar Pregnancy with Iniencephaly and Progression to Placenta Accreta Due to Early Management Rejection

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Maternal-Fetal Medicine 2020年第1期2卷 56-58页

作者： Albaro José Nieto-Calvache María Camila López-Girón Jaime López-Tenorio juan Carlos Quintero-Mejía María Andrea zambrano-Regalado Harry Pachajoa-Londoño María Fernanda Escobar-Vidarte Abnormally Invasive Placenta Clinic Fundación Valle del LiliCali 760032Colombia Clinical postgraduate department Universidad IcesiCali 760032Colombia Clinical Research Center Fundación Valle del LiliCali 760032Colombia Department of Ginecology and Obstetrics Centro médico ImbanacoCali 760032Colombia Department of Genetics Fundación Valle del LiliCali 760032Colombia

To editor:Cesarean scar pregnancy(CSP)is a rare pathology,with an increasingly clear association with morbidly adherent placenta(MAP).1 Although the most recommended treatment is pregnancy termination by cesarean section and scar resection shortly after diagnosis.2 The final decision regarding management depends on the patient's choice,medical advice,the fertility desire,and the social,religious and emotional background that should also be taken into account.

关键词： Placenta accreta Cesarean scar pregnancy Morbidity adherent placenta Pregnancy termination Ultrasonography Prenatal

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