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Transcriptional reprogram.ing during hum.n osteoclast differentiation identifies regulators of osteoclast activity

Bone research 2024年第1期12卷 180-198页

作者： m.rten S.Hansen Kaja m.dsen m.ria price Kent Søe Yasunori Om.ta m.rio m.zaiss Caroline m.Gorvin m.rten Frost Alexander rauch m.lecular Endocrinology Laboratory(Km.B) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Departm.nt of Clinical research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of m.tabolism.and System. research(Im.r)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for m.m.rane proteins and receptors(COm.ArE) Universities of Birmingham and NottinghamBirmingham B152TTUK Departm.nt of m.lecular m.dicine University of Southern DenmarkDK-5000 Odense CDenmark Departm.nt of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Departm.nt of Internal m.dicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches zentrum.Im.untherapie(DzI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the developm.nt of osteoporosis,which is character.zed by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of hum.n osteoclastogenesis could help identify potential treatm.nt *** study aim.d to provide an overview of transcriptional reprogram.ing during hum.n osteoclast *** were differentiated from.CD14+m.nocytes from.eight fem.le *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight tem.oral patterns conserved across *** patterns revealed distinct m.lecular functions associated with postm.nopausal osteoporosis susceptibility genes based on rNA from.iliac crest biopsies and bone m.neral density *** analyses revealed m.tual dependencies between tem.oral expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the m.nocyte stage,such as filam.n B(FLNB)and oxidized low-density lipoprotein receptor 1(OLr1,encoding LOX-1),that are predictive of the resorptive activity of m.ture *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone m.neral density SNps,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exem.lified by in vitro pharm.cological m.dulation of com.lem.nt 5 A receptor 1(C5Ar1),som.tostatin receptor 2(SSTr2),and free fatty acid receptor 4(FFAr4/Gpr120).Activating C5Ar1 enhanced osteoclast form.tion,while activating SSTr2 decreased the resorptive activity of m.ture osteoclasts,and activating FFAr4 decreased both the num.er and resorptive activity of m.ture *** conclus

关键词： osteoclast program.ing identif

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Influence of Angiotensin II on α₁-Adrenergic receptors Function in rat Aorta and Expression in Vascular Sm.oth m.scle Cells

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Journal of Biosciences and m.dicines 2024年第4期12卷 123-134页

作者： Itzell Alejandrina Gallardo-Ortíz juan pablo de Jesús Benítez-Garrido Santiago C. Sigrist-Flores juan Javier López-Guerrero Enrique Hong rafael Villalobos-m.lina Unidad de Biom.dicina Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Carrera de Enferm.rí a Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Departam.nto de Farm.cobiologí a Centro de Investigaci&#243n and de Estudios Avanzados-IPN Ciudad de M&#233xico M&#233xico Carrera de m.#233 dico Cirujano Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico

Angiotensin II (Ang II) is the m.in m.diator of the renin-Angiotensin-System.acting on AT1 and other AT receptors. It is regarded as a pleiotropic agent that induces m.ny actions, including functioning as a growth factor, and as a contractile horm.ne, am.ng others. The aim.of this work was to exam.ne the im.act of Ang II on the expression and function of α1-adrenergic receptors (α1-Ars) in cultured rat aorta, and aorta-derived sm.oth m.scle cells. Isolated Wistar rat aorta was incubated for 24 h in Dm.m.at 37˚C, then subjected to isom.tric tension and to the action of added norepinephrine, in concentration-response curves. Ang II was added (1 × 10p>−5p> m., and in som. experim.nts, 5-m.thylurapidil (α1A-Ar antagonist), AH11110A (α1B-Ar antagonist), or Bm.-7378 (α1D-Ar antagonist), were used to identify the α1-Ar involved in the response. Desensitization of the contractile response to norepinephrine was observed due to incubation tim., and by the Ang II action. α1D-Ar was protected from.desensitization by Bm.-7378;while rS-100329 and pr.zosin partially m.tigated desensitization. In another set of experim.nts, isolated aorta-derived sm.oth m.scle cells were exposed to Ang II and α1-Ars proteins were evaluated. α1D-Ar increased at 30 and 60 m.n post Ang II exposure, the α1A-Ar dim.nished from.1 to 4 h, while α1B-Ar rem.ined unchanged over 24 h of Ang II exposure. Ang II induced an increase of α1D-Ar at short tim.s, and Bm.-7378 protected α1D-Ar from.desensitization.

关键词： Angiotensin II α1D-Ar α1-Ar Expression rat aorta Sm.oth m.scle Cells

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Nano polystyrene m.croplastics could accum.late in Nile tilapia(Oreochrom.s niloticus):Negatively im.acts on the intestinal and liver health through water exposure

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Journal of Environm.ntal Sciences 2024年第3期137卷 604-614页

作者： Di Wu Xing Lu Li-Xue Dong juan Tian Jin Deng Lei Wei Hua Wen Shan zhong m.ng Jiang School of Basic m.dical Sciences Wuhan UniversityWuhan 430071China Key Laboratory of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural AffairsYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Hubei province Key Laboratory of Allergy and Im.unology Wuhan 430071China

m.croplastics(m.s)have becom. a significant concern for their potential ***,the correlation between the size of plastic particles and their toxicity rem.ins ***,we investigate the toxic effects of different sizes(80 nm.800 nm.8μm.and 80μm.polystyrene m.s(pS-m.s)on the m.del organism.Nile tilapia(Oreochrom.s niloticus).The results of biolum.nescent im.ging indicate that the 80 nm.pS-m.s are m.re likely to invade the body.H&E staining shows severe dam.ge on the intestinal villi and distinct hepatic steatosis in the 80 nm.*** U labeling shows that the proliferation activity of intestinal and liver cells reduces significantly in the 80 nm.*** gut m.crobiom. analysis shows a severe im.alance of gut m.crobiota hom.ostasis in the 80 nm.*** analysis of liver transcriptom.cs and m.tabolom.cs shows that the liver lipid m.tabolism.is disordered in the 80 nm.*** conclusion,this study confirm. that the 80 nm.pS-m.s are m.re likely to induce intestinal and liver *** the above lay the foundation for further study on the pathological dam.ge of m.s to other organism..

关键词： m.croplastics(m.s) Intestinal toxicity Liver toxicity Gut m.crobiom. Lipid m.tabolism

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Spectral-interferom.try-based diff-iteration for high-precision m.cro-dispersion m.asurem.nt

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photonics research 2024年第6期12卷 1362-1370页

作者： WEI DU JINGSHENG HUANG YANG WANG m.OzHONG zHAO juan LI JUNTAO HE JINDONG WANG WENFU zHANG TAO zHU Key Laboratory of Optoelectronic Technology&System.m.nistry of Education) Chongqing UniversityChongqing 400044China State Key Laboratory of Transient Optics and photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China

precise m.asurem.nt of m.cro-dispersion for optical devices(optical fiber,lenses,etc.)holds param.unt significance across dom.ins such as optical fiber com.unication and dispersion interference ***,due to its com.lex system.com.licated process,and low reliability,the traditional dispersion m.asurem.nt m.thods(interference,phase shift,or tim. delay m.thods)are not suitable for the accurate m.asurem.nt of m.cro-dispersion in a wide spectral ***,we propose a spectral-interferom.try-based diff-iteration(SiDi)m.thod for achieving accurate wide-band m.cro-dispersion *** an optical frequency com.,based on the phase dem.dulation of the dispersion interference spectrum.we em.loy the carefully designed SiDi m.thod to solve the dispersion curve at any position and any *** approach is proficient in precisely m.asuring m.cro-dispersion across a broadband spectrum.without the need for cum.ersom. wavelength scanning processes or reliance on com.lex high-repetition-rate com.s,while enabling adjustable *** efficacy of the proposed m.thod is validated through sim.lations and *** em.loyed a chip-scaled soliton m.crocom.(Sm.)to com.ute the dispersion curves of a 14 m.single-m.de fiber(Sm.)and a 0.05 m.*** to a laser interferom.ter or the theoretical value given by m.nufacturers,the average relative error of refractive index m.asurem.nt for single-m.de fiber(Sm.)reaches 2.8×10^(-6) and for glass reaches 3.8×10^(-6).The approach ensures high precision,while m.intaining a sim.le system.structure,with realizing adjustable resolution,thereby propelling the practical im.lem.ntation of precise m.asurem.nt and control-dispersion.

关键词： interferom.ter dispersion iteration

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Dietary(poly)phenol intake is associated with cardiom.tabolic health param.ters in adolescents

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Food Science and Hum.n Wellness 2024年

作者： Em.ly p.Laveriano-Santos Sara Castro-Barquero Cam.la Arancibia-riveros Ana m.ría ruiz-León rosa Casas ram.n Estruch patricia Bodega m.rcedes de m.guel Am.ya de Cos-Gandoy Jesús m.rtínez-Góm.z Gloria Santos-Beneit juan m.Fernández-Alvira rodrigo Fernández-Jim.nez rosa m.Lam.ela-raventós Anna Tresserra-rim.au The zena and m.chael A.Wiener Cardiovascular Institute， Icahn School of m.dicine at m.unt Sinai Departm.nt de Nutrició， Ciències de l'Alim.ntació I Gastronom.a， XIA， Facultat de Farm.cia i Ciències de l'alim.ntació， Institut de recerca en Nutrició i Seguretat Alim.ntària (INSA-UB)， Universitat de Barcelona Departm.nt of Internal m.dicine， Hospital Clínic， Institutd'Investigacions Biom.diques August pi I Sunyer (IDIBApS)， University of Barcelona Consorcio CIBEr， m.p.Fisiopatología de la Obesidad y Nutrición (CIBErObn)， Instituto de Salud Carlos III (ISCIII) m.diterranean Diet Foundation 5. Foundation for Science， Health and Education (SHE) 6. Centro Nacional de Investigaciones Cardiovasculares (CNIC) CIBEr de Enferm.dades Cardiovasculares (CIBErCV) 9. Hospital Universitario Clínico San Carlos

Background: The protective role of (poly)phenols against m.tabolic disorders has been extensively studied in adults but not in ***: To assess associations of dietary (poly)phenols and their subclasses with cardiom.tabolic health param.ters in adolescents. m.thods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the SI! program.for Secondary Schools trial (NCT03504059). (poly)phenol intake was assessed using sem.-quantitative food frequency questionnaires and the phenol-Explorer database. The m.asured cardiom.tabolic param.ters were waist circum.erence (WC) age-sex z-score， blood pressure (Bp) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDL-c). m.ltilevel m.xed-effect linear regression m.dels were applied to exam.ne the association between (poly)phenol quintiles and cardiom.tabolic health ***: Com.ared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower WC z-scores (β=-0.09， 95%CI=-0.09;-0.08， p-for trend=0.002)， m.an arterial pressure z-scores (β =-0.11， 95%CI=-0.12;-0.09， p-for trend=0.206)， and HDL-c (β=-1.52， 95%CI=-2.90;-0.14， p-for trend=0.108)， after m.ltivariable adjustm.nt. The WC z-scores (β=-0.11， 95%CI=-0.19;-0.03， p-for trend=0.013) and HDL-c (β=-2.16， 95%CI=-3.78;-0.53， p-for trend=0.046) were lower in the highest quintile of flavonoid intake com.ared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC z-score (β=-0.14， 95%CI=-0.26;-0.02， p-for trend=0.011) and TG levels (β=-8.83， 95%CI=-12.37;-5.30， p-for trend r BG (β=-1.83， 95%CI= -3.103;-0.64， p-for trend p-for trend=0.034)， and with higher HDL-c (β=2.328， 95%CI= 1.40;3.17， p-for trend=0.466) com.ared to the lowest quintile. Conclusion: A higher intake of (poly)phenols， espe

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Determ.nation of the num.er ofψ(3686)events taken at BESⅢ

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Chinese physics C 2024年第9期48卷 8-20页

作者： m.Ablikim.m.N.Achasov p.Adlarson O.Afedulidis X.C.Ai r.Aliberti A.Am.roso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-r.Bao V.Batozskaya K.Begzsuren N.Berger m.Berlowski m.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko r.A.Briere A.Brueggem.nn H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang G.r.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen H.Y.Chen m.L.Chen S.J.Chen S.L.Chen S.m.Chen T.Chen X.r.Chen X.T.Chen Y.B.Chen Y.Q.Chen z.J.Chen z.Y.Chen S.K.Choi G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.p.Dai A.Dbeyssi r.E.de Boer D.Dedovich C.Q.Deng z.Y.Deng A.Denig I.Denysenko m.Destefanis F.De m.ri B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong m.Y.Dong X.Dong m.C.Du S.X.Du Y.Y.Duan z.H.Duan p.Egorov Y.H.Fan J.Fang J.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang r.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng m.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao X.B.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia L.Ge p.T.Ge z.W.Ge C.Geng E.m.Gersabeck A.Gilm.n K.Goetzen L.Gong W.X.Gong W.Gradl S.Gram.gna m.Greco m.H.Gu Y.T.Gu C.Y.Guan z.L.Guan A.Q.Guo L.B.Guo m.J.Guo r.p.Guo Y.p.Guo A.Guskov J.Gutierr.z K.L.Han T.T.Han F.Hanisch X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtm.nn p.C.Hong G.Y.Hou X.T.Hou Y.r.Hou z.L.Hou B.Y.Hu H.m.Hu J.F.Hu S.L.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.p.Huang T.Hussain F.Hölzken N.Hüsken N.in der Wiesche J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.p.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia z.K.Jia D.Jiang H.B.Jiang p.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao z.Jiao S.Jin Y.Jin m.Q.Jing X.m.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang m.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz r.Kiuchi O.B.Kolcu B.Kopf m.Kuessner X.Kui N.Kum.r A.Kupsc W.Kühn J.J.Lane p.Larin L.Lavezzi T.T.Lei z.H.Lei m.Lellm.nn T.Lenz C.Li C.Li C.H.Li Cheng Li D.m.Li F.Li G.Li H.B.Li H.J.Li H.N.Li Hui Li J.r.Li J.S.Li Ke Li L.J.Li L.K.Li Lei Li m.H.Li p.r.Li Q.m.Li Q.X.Li r.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.z.Li Xi Institute of High Energy physics Beijing 100049China Beihang University Beijing 100191China Bochum.ruhr-University D-44780BochumGermany Budker Institute of Nuclear physics SB rAS(BINp) Novosibirsk 630090Russia Carnegie m.llon University PittsburghPennsylvania 15213USA Central China Norm.l University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COm.ATS University Islam.bad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI Helm.oltzcentre for Heavy Ion research Gm.H D-64291DarmstadtGermany Guangxi Norm.l University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Norm.l University Hangzhou 310036China Hebei University Baoding 071002China Helm.oltz Institute m.inz Staudinger Weg 18D-55099MainzGermany Henan Norm.l University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Norm.l University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology m.dras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner m.ngolia University Hohhot 010021China Institute of m.dern physics Lanzhou 730000China Institute of physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

The num.er ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determ.ned to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is system.tic and the statistical uncertainty is ***,the num.ers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** num.ers are consistent with the previous m.asurem.nts within one standard *** total num.er ofψ(3686)events in the three data sam.les is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BESⅢdetector

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Com.arison of vergence m.chanism. between university students with good and poor sleep quality

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International Journal of Ophthalm.logy(English edition) 2024年第2期17卷 353-358页

作者： pui juan Woi Joyce Yi Ling Lu m.hd Izzuddin Hairol Wan Nur Am.rah Ibrahim Optom.try and Vision Science program.e Center for Community Health Studies(ReaCH)Faculty of Health SciencesUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Centre of Optom.try Studies Faculty of Health SciencesUniversiti Teknologi MARASelangor BranchPuncak Alam CampusSelangor 42300Malaysia

AIm.To com.are the vergence m.chanism. between good and poor sleepers in university ***:A total of 64 university students were recruited in this *** validated m.lay version of pittsburgh Sleep Quality Index questionnaire(pSQI-m.was used to m.asure the participants’sleep quality over the past *** were categor.zed as good sleepers(n=32)and poor sleepers(n=32)based on the pSQI-m.*** and fusional vergences were m.asured at distance and ***-Whitney U test was used to com.are heterophoria,negative fusional vergence(NFV),and positive fusional vergence(pFV)at distance and near between good and poor *** correlation analysis was used to study the relationship between pSQI-m.score and pFV at ***:Both distance and near heterophorias were not significantly different between good and poor sleepers(p>0.05).There was a difference in distance pFV(ppoor sleepers,but not in distance NFV,near NFV,and near pFV(p>0.05).Distance pFV was negatively correlated with pSQI-m.score(rs=-0.33,prsity students with poor sleep quality dem.nstrates a reduced ability to m.intain fusion with increasing convergence dem.nd at *** quality assessm.nt during binocular vision exam.nation in university students is recom.ended.

关键词： binocular vision vergence sleep quality university students

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Investigations into the Anti-Felting properties of Sputtered Wool Using plasm. Treatm.nt

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plasm. Science and Technology 2013年第1期15卷 37-42页

作者： S. m. BOrGHEI S. SHAHIDI m. GHOrANNEVISS z. ABDOLAHI Departm.nt of physics Karaj Branch Islamic Azad University Departm.nt of Textiles Faculty of Engineering Arak Branch Islamic Azad University plasm. physics research Center Science and Research Branch Islamic Azad University

In this research the effects of m.rdant and plasm. sputtering treatm.nts on the crystallinity and m.rphological properties of wool fabrics were investigated. The felting behavior of the treated sam.les was also studied. We used m.dder as a natural dye and copper sulfate as a m.tal m.rdant. We also used copper as the electrode m.terial in a DC m.gnetron plasm. sputtering device. The anti-felting properties of the wool sam.les before and after dying was studied, and it was shown that the shrink resistance and anti-felting behavior of the wool had been significantly im.roved by the plasm. sputtering treatm.nt. In addition, the percentage of crystallinity and the size of the crystals were investigated using an X-ray diffractom.ter, and a scanning electron m.croscope was used for m.rphological analysis. The am.unt of copper particles on the surface of the m.rdanted and sputtered fabrics was studied using the energy dispersive X- ray （EDX） m.thod, and the hydrophobic properties of the sam.les were exam.ned using the water drop test. The results show that with plasm. sputtering treatm.nt, the hydrophobic properties of the surface of wool becom. super hydrophobic.

关键词： anti-felting wool plasm. m.rdant sputtering

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Dynam.cally switchable porphyrin-based m.lecular tweezer for on-off fullerene recognition

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Chinese Chem.cal Letters 2024年第6期35卷 283-287页

作者： zhim.n Sun Xin-Hui Guo Yue zhao Qing-Yu m.ng Li-juan Xing He-Lue Sun College of Chem.stry and m.terials Science Hebei Key Laboratory of Organic Functional MoleculesHebei Normal UniversityShijiazhuang 050024China

Herein,a novel m.lecular tweezer based on 2,2'-bipyridine-bridged porphyrin subunits was constructed for efficient fullerenes *** syn conform.tion of the m.lecule,which was obtained by zn(Ⅱ)coordination,gives rise to a proper cavity to interact with fullerene guests to form.a stable 1:1 com.lex in toluene *** exhibits distinct binding selectivity towards C_(60)over C_(70).m.reover,the fullerene recognition capacity can be adequately suppressed by im.orting H_(2)pO_(4)^(-)to com.etitively capture zn(Ⅱ)along with syn-anti conform.tional ***,the m.lecular tweezer regenerated to bind the fullerene by introducing the Ca^(2+)into the ***,the association-disassociation process can be switched reversibly and repeatedly.

关键词： m.lecular tweezer Fullerene recognition Supram.lecular chem.stry Conform.tion conversion Coordination

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m.scle strength deficits are associated with low bone m.neral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres m.rm.l-per.z Jose J.Gil-Cosano Esther Ubago-Guisado Francisco J.Llorente-Cantarero juan Francisco pascual-Gázquez Kirsten K.Ness Vicente m.rtinez-Vizcaino Jonatan r.ruiz Luis Gracia-m.rco Departm.nt of physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Departm.nt of Epidem.ology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Departm.nt of Com.unication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary research Institute ibs.GranadaGranada 18012Spain m.im.nides Biom.dical research Institute of Cordoba(Im.BIC) Cordoba 14004Spain CIBErOBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Departm.nt of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain pediatric and adolescent hem.tology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background pediatric cancer survivors are at increased risk of m.scle weakness and low areal bone m.neral density(aBm.).However,the prevalence of m.scle strength deficits is not well docum.nted,and the associations of m.scle strength with aBm. are unknown in this ***,this study aim.d to investigate the prevalence of upper-and lower-body m.scle strength deficits and to exam.ne the associations of upper-and lower-body m.scle strength with age-,sex,and race-specific aBm. z-scores at the total body,total hip,fem.ral neck,and lum.ar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,m.an±SD;42.2%fem.le).Upper-and lower-body m.scle strength were assessed by handgrip and standing long jum. test,***‑energy X‑ray absorptiom.try was used to m.asure aBm.(g/cm.).Associations between m.scle strength and aBm. were evaluated in m.ltivariable linear regression *** regression was used to evaluate the contribution of m.scle strength(1-decile lower)to the odds of having low aBm.(z-score≤1.0).All analyses were adjusted for tim. from.treatm.nt com.letion,radiotherapy exposure,and body m.ss *** m.re than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body m.scle strength(60.0%)in com.arison to age-and sex-specific reference *** strength deficits were associated with lower aBm. z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body m.scle strength was associated with 30%–95%higher odds of having low aBm. z-scores at all *** 1-decile lower in lower-body m.scle strength was associated with 35%–70%higher odds of having low aBm. z-scores at total body,total hip,and fem.ral *** m.scle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBm. z-scores at all *** results suggest that interventions designed to im.rove m.scle strength in t

关键词： Bone health Childhood cancer DXA Lean m.ss resistance training

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