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Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats

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World Journal of Gastroenterology 2009年第15期15卷 1821-1828页

作者： Hai-Qiang zhang Tomas T Ding Jun-Sheng Zhao Xin Yang Hai-Xia zhang juan-juan zhang Yun-Long Cui Qingdao Research Center of Microecology-Engineering Technology Jiaonan 266400 Shandong Province China BRITE/Department of Pharmaceutical Sciences North Carolina Central University Durham NC27707 United States Pathology Department of People's Hospital Jiaonan 266400 Shandong Province China Qingdao East Sea Pharmaceutical Co. Ltd Jiaonan 266400 Shandong Province China

AIM： To evaluate the therapeutic effects of a probiotic supplement （Clostridium butyricum, CGMCC0313 ） in a chemically-induced rat model of experimental colitis. METHODS： An experimental ulcerative colitis model was established by rectal injection of oxazolone into the colon of 40 Wistar rats randomly divided into four groups. The positive control group was sacrificed 3 d after colitis onset. The remaining groups were fed daily with either 2 mL of C. butyricum （2.3 × 10^11 CFU/L）, 2 mL of mesalamine （100 g/L）, or 1 mL of sodium butyrate （50 mmol/L） for 21 d. The animals＇ body weight, behavior, and bowel movements were recorded weekly. After sacrifice, visual and microscopic observations of pathological changes of colon tissue were made, body weight and wet colon mass index were measured and recorded, and serum levels of interleukin-23 （IL-23） and TNF-α were measured using ELISA. Expression of calcitonin gene-related peptide in colon tissue was measured by RT-PCR. Finally, changes in rat intestinal microflora status were measured in all *** the serum levels of both IL-23 and tumor necrosis factor-α （TNF-α） with similar or even better efficiency than that of mesalamine or sodium butyrate. The rat intestinal flora appeared to recover more quickly in the group treated with C. butyricum than in the mesalamine and sodium butyrate groups. Finally, we found that the expression level of calcitonin gene related peptide was elevated in colon tissue in the sodium butyrate treated group but not in the C. butyricum or mesalamine treated groups, indicating a sensitization of colon following sodium butyrate treatment. CONCLUSION： In our experimental colitis model, treatment with C. butyricum CGMCC0313, a probiotic supplement, is at least as efficient as treatment with mesalamine.

关键词： Clostridium butyricum Interleukin-23 Tumor necrosis factor-m Calcitonin gene relatedpeptide Colitis

Alström syndrome with a novel mutation of ALMS1 and Graves’hyperthyroidism:A case report and review of the literature

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World Journal of Clinical Cases 2021年第13期9卷 3200-3211页

作者： juan-juan zhang Jun-Qi Wang Man-Qing Sun De Xu Yuan Xiao Wen-Li Lu Zhi-Ya Dong Department of Pediatrics Ruijin HospitalShanghai Jiao-Tong UniversitySchool of MedicineShanghai 200025China

BACKGROUND Alström syndrome(AS,OMIM ID 203800)is a rare disease involving multiple organs in children and is mostly reported in non-Chinese *** the Chinese population,there are few reports on the clinical manifestations and pathogenesis of *** is the first report on the association between AS and Graves’*** SUMMARY An 8-year-old Chinese girl was diagnosed with *** years later,Graves’hyperthyroidism developed with progressive liver *** patient’s clinical data were collected;DNA from peripheral blood of the proband,parents and sibling was collected for gene mutation detection using the second-generation sequencing method and gene panel for *** association between the patient’s genotype and clinical phenotype was *** carried the pathogenic compound heterozygous mutation of ALMS1(c.2296_2299del4 and c.11460C>A).These stop-gain mutations likely caused truncation of the ALMS1 *** The manifestation of hyperthyroidism may suggest rapid progression of AS.

关键词： ALMS1 Alström syndrome Stop-gain mutations Protein truncation Graves’hyperthyroidism Case report

Evaluation of the effectiveness of preventive nursing measures for pressure injuries in patients in the neurology intensive care unit

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World Journal of Clinical Cases 2024年第19期12卷 3807-3814页

作者： Rong zhang Peng-Xin Ma juan-juan zhang Intensive Medicine Department The First People’s Hospital of Jiangxia DistrictWuhan 430000Hubei ProvinceChina Department of Neurology The First People’s Hospital of Jiangxia DistrictWuhan 430000Hubei ProvinceChina

BACKGROUND Patients in neurology intensive care units(ICU)are prone to pressure injuries(PU)due to factors such as severe illness,long-term bed rest,and physiological *** not only causes pain and complications to patients,but also increases medical burden,prolongs hospitalization time,and affects the recovery *** To evaluate and optimize the effectiveness of pressure injury prevention nursing measures in neurology ICU *** A retrospective study was conducted,and 60 patients who were admitted to the ICU of the Department of Neurology were selected and divided into an observation group and a control group according to the order of admission,with 30 people in each *** observation group implemented pressure injury prevention and nursing measures,while the control group adopted routine *** Comparison between observation and control groups following pressure injury prevention nursing intervention revealed significantly lower incidence rates in the observation group compared to the control group at 48 h(8.3%vs 26.7%),7 d(16.7%vs 43.3%),and 14 d(20.0%vs 50.0%).This suggests a substantial reduction in pressure injury incidence in the observation group,with the gap widening over ***,patients in the observation group exhibited quicker recovery,with a shorter average time to get out of bed(48 h vs 72 h)and a shorter average length of stay(12 d vs 15 d)compared to the control ***,post-intervention,patients in the observation group reported significantly improved quality of life scores,including higher scores in body satisfaction,feeling and function,and comfort(both psychological and physiological),indicating enhanced overall well-being and comfort following the implementation of pressure injury prevention nursing *** Implementing pressure injury preventive care measures for neurology ICU patients will have better results.

关键词： Neurology intensive care units Pressure injury Preventive care Effect evaluation Optimization research Prognostic effect

Guideline for the diagnosis and treatment of rheumatoid arthritis with integrated traditional Chinese medicine and Western medicine to increase efficiency and reduce toxicity

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Traditional Medicine Research 2023年第3期8卷 19-35页

作者： Zhi-Jun Xie Wei Cao Lin Huang Yang-Qin Xun Nan Yang Ping Wang Qiao Wang Meng-juan Ren Hai-Chang Li Yun-Lan Liu Yu-Jun Tang Yue Hu Hui Zheng juan-juan zhang Hui Lan Shou-Yuan Wu Qiang-Qiang Guo Ya-Jia Sun Xian-Zhuo zhang Xiao-Hui Wang Xu-Ping Song Yan-Fang Ma Yao-Long Chen Cheng-Ping Wen Basic Medical School Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Rheumatology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Center for Evidence-Based Medicine School of Basic MedicineLanzhou UniversityLanzhou 730000China School of Public Health Lanzhou UniversityLanzhou 730000China The Institutes of Biology and Medical Sciences Soochow UniversitySuzhou 215123China The First Clinical Medical College Lanzhou UniversityLanzhou 730000China Hong Kong Chinese Medicine Clinical Study Center School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Institute of Health Data Science Lanzhou UniversityLanzhou 730000China Research Unit of Evidence-Based Evaluation and Guidelines(2021RU017) Chinese Academy of Medical SciencesSchool of Basic Medical SciencesLanzhou UniversityLanzhou 730000China WHO Collaborating Centre for Guideline Implementation and Knowledge Translation Lanzhou 730000China

Rheumatoid arthritis imposes a huge disease *** practice guidelines do not meet the needs of integrated traditional Chinese medicine and Western medicine in the treatment of rheumatoid *** established a guideline working group consists of a steering committee,a secretary group,an evidence evaluation group,a consensus group and a review group and developed a guideline following the guidance of the World Health Organization Handbook and the Chinese Medical *** guideline includes 35 recommendations which reached consensus by the two rounds Delphi *** recommendations were formulated to address the following themes of most concern to clinician:diagnostic imaging,disease staging,traditional Chinese medicine syndromes,effectiveness and toxicity of integrated traditional Chinese medicine and Western medicine.

关键词： rheumatoid arthritis guideline traditional Chinese medicine toxicity

Application of Percutaneous Endoscopic Gastrojejunostomy in Duodenal Crohn’s Disease-Associated Strictures

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Journal of Nutritional Oncology 2022年第4期7卷 199-203页

作者： juan juan zhang Ying Dong Xie Tian Tian Liu Bin Lin Da Yan Qing Diao Yi Li Zhi Ming Wang Department of General Surgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210002China Ultrasonography Department Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210002China

Background Duodenal Crohn’s disease(CD)-associated strictures are related to a high risk of malnutrition,and effective methods of enteral nutrition(EN)are needed to support these *** purpose of this study was to evaluate the efficacy and safety of percutaneous endoscopic gastrojejunostomy(PEG-J)for the treatment of duodenal CD-associated *** Patients with strictures associated with duodenal CD were *** clinical data,stricture characteristics,nutritional status,duration of PEG-J tube placement,complications,and follow up periods were *** A total of 24 patients with duodenal CD-associated strictures underwent PEG-J tube *** PEG-J tubes were successfully placed in 100%of the patients within an average of 19.04±2.94 *** were no procedure-related *** were no major complications after PEG-J tube placement,and only two minor complications(8.33%)***-J was well tolerated in all *** mean Karnofsky score was 67.50±7.94 points and 83.33±7.02 points(P=0.000),the mean body mass index was 17.02±1.85 kg/m^(2)and 18.10±1.78 kg/m^(2)(P=0.045),and the mean Alb level was 35.28±5.35 g/dl and 38.68±5.10 g/dl(P=0.029)before PEG-J and 3 months after PEG-J,*** median CD Activity Index(CDAI score)was 144(range 87-280)and the median C-reactive protein(CRP)was 1.90 mg/L(0.5-67.9 mg/L)after PEG-J,which were significantly lower than the respective 196 mg/L(range 114-331 mg/L)(P=0.044)and 3.75 mg/L(range 0.5-67 mg/L)(P=0.033)before *** PEG-J was a safe,well-tolerated and effective method for the treatment of duodenal CD-associated ***-J improved the patient’s nutritional status and reduced disease CD *** findings suggest that PEG-J is an option for EN in patients with duodenal CD-associated strictures.

关键词： Percutaneous endoscopic gastrojejunostomy Crohn’s disease Duodenal strictures Enteral nutrition

糖尿病患者HbA1c水平与白内障术后黄斑中心凹视网膜厚度的相关性研究

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国际眼科杂志 2018年第8期18卷 1495-1498页

作者：刘萱张娟娟王敏王妮程橙杜娟中国陕西省咸阳市第一人民医院眼科 712000

目的:探讨糖尿病患者糖化血红蛋白(HbA1c)水平与白内障术后黄斑中心凹视网膜厚度的相关性。方法:回顾性分析2013-09/2016-06在我院眼科行白内障手术的糖尿病视网膜病变患者119例119眼,根据术前HbA1c水平将患者分为低HbA1c组(HbA1c≤7.0%... 详细信息

目的:探讨糖尿病患者糖化血红蛋白(HbA1c)水平与白内障术后黄斑中心凹视网膜厚度的相关性。方法:回顾性分析2013-09/2016-06在我院眼科行白内障手术的糖尿病视网膜病变患者119例119眼,根据术前HbA1c水平将患者分为低HbA1c组(HbA1c≤7.0%,60例60眼)和高HbA1c组(7.0%

关键词：糖尿病糖化血红蛋白白内障黄斑中心凹视网膜厚度

p62/SQSTM1 as an oncotarget mediates cisplatin resistance through activating RIP1-NF-κB pathway in human ovarian cancer cells

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p62/SQSTM1 as an oncotarget mediates cisplatin resistance th...

Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Xiao-Yu Yan Yu zhang juan-juan zhang Li-Chao zhang Ya-Nan Liu Yao Wu Ya-Nan Xue Sheng-Yao Lu Jing Su Lian-Kun Sun Department of Pathophysiology College of Basic Medical SciencesJilin University

Platinum-based therapeutic strategies have been widely used in ovarian cancer treatment. However, drug resistance has greatly limited therapeutic efficacy. Recently, tolerance to cisplatin has been attributed to other factors unrelated to DNA. p62(also known as SQSTM1) functions as a multifunctional hub participating in tumorigenesis and may be a therapeutic target. Our previous study showed that p62 was overexpressed in drug-resistant ovarian epithelial carcinoma and its inhibition increased the sensitivity to cisplatin. In this study, we demonstrate that the activity of the NF-κB signaling pathway and K63-linked ubiquitination of RIP1 was higher in cisplatin-resistant ovarian(SKOV3/DDP) cells compared with parental cells. In addition, cisplatin resistance could be reversed by inhibiting the expression of p62 using siRNA. Furthermore, deletion of the ZZ domain of p62 that interacts with RIP1 in SKOV3 cells markedly decreased K63-linked ubiquitination of RIP1 and inhibited the activation of the NF-κB signaling pathway. Moreover, loss of the ZZ domain from p62 led to poor proliferative capacity and high levels of apoptosis in SKOV3 cells and made them more sensitive to cisplatin treatment. Collectively, we provide evidence that p62 is implicated in the activation of NF-κB signaling that is partly dependent on RIP1. p62 promotes cell proliferation and inhibits apoptosis thus mediating drug resistance in ovarian cancer cells.

关键词： p62/SQSTM1 drug resistance NF-KB pathway RIP1 ovarian cancer

来源： cnki会议评论

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang zhang juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua zhang Lian-Lian Wang Wen-Wen Liu Xin Yang Ming-Zhao Xiao Hao-Ling zhang juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity