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Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1230-1243页

作者： j.n Zhou j.aqi Liu Bingj.ng Wang Nan Li juan Liu Yanmei Han Xuetao Cao Institute of Immunology Zhejiang University School of MedicineHangzhou 310058China National Key Laboratory of Immunity and Inflammation Institute of ImmunologyNaval Medical UniversityShanghai 200433China Department of Immunology Center for ImmunotherapyInstitute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100005China Institute of Immunology College of Life SciencesNankai UniversityTianjin 300071China

Memory CD8+T cell generation is crucial for pathogen elimination and effective vaccination against *** cellular and molecular circuitry that underlies the generation of memory CD8+T cells remains *** can modulate inflammatory allergic responses and interact with lymphocytes to regulate their functions in immune *** we report that eosinophils are required for the generation of memory CD8+T cells by inhibiting CD8+T cell ***-deficient mice display significantly impaired memory CD8+T cell response and weakened resistance against Listeria monocytogenes(L.m.)***,eosinophils secrete interleukin-4(IL-4)to inhibit j.K/Caspase-3 dependent apoptosis of CD8+T cells upon *** in ***,active eosinophils are recruited into the spleen and secrete more IL-4 to suppress CD8+T cell apoptosis during early stage of *** in *** transfer of wild-type(WT)eosinophils but not IL-4-deficient eosinophils into eosinophil-deficient mice could rescue the impaired CD8+T cell memory ***,our findings suggest that eosinophil-derived IL-4 promotes the generation of CD8+T cell memory and enhances immune defense against *** study reveals a new adj.vant role of eosinophils in memory T cell generation and provides clues for enhancing the vaccine potency via targeting eosinophils and related cytokines.

关键词： impaired immunity spleen

Perspective and challenges of mycorrhizal symbiosis in orchid medicinal plants

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Chinese Herbal Medicines 2024年第2期16卷 172-179页

作者： Chunyan Leng Mengyan Hou Yongmei Xing juan Chen Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

The family Orchidaceae is of the most diverse taxon in the plant kingdom,and most of its members are highly valuable herbal *** have a unique mycorrhizal symbiotic relationship with specific fungi for carbohydrate and nutrient supplies in their whole *** large-scale cultivation of the medicinal plant Gastodia elata is a successful example of using mycorrhizal symbiotic *** this review,we adopted *** and Dendrobium officinale as examples to describe the characteristics of orchid mycorrhiza and mycorrhizal benefits for host plants’growth and health(*** and abiotic stress and secondary metabolite accumulation).The challenges in applying mycorrhizal technology to the cultivation of orchid medicinal plants in the future were also *** review aims to serve as a theoretical guide for the cultivation of mycorrhizal technology in medicinal orchid plants.

关键词： Dendrobium officinale Kimura&Migo ecological cultivation Gastodia elata Blume mycorrhiza orchid medicinal plants symbiosis mechanisms

Safety and efficacy of omalizumab for antihistamine-resistant chronic urticaria in children:a case series and literature review

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World j.urnal of Pediatrics 2024年第3期20卷 294-298页

作者： Wei-Fang Zhu Chen Wang j.an-j.n Qiao Lan-juan Li Department of Dermatology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Chronic urticaria(CU)is a common skin disease characterized by the occurrence of wheals,with or without angioedema,lasting more than 6 *** prevalence of CU is about 0.7%[1],but higher in children,with an incidence of 1.38%[1].The occurrence of severe pruritus and unpredictable wheals may severely impact patients'quality of life,cause psychological problems,including sleep disorders and depression,and lead to economic burden due to limitation on daily life and work[2,3].

关键词： edema prevalence children

Langasite-based SAW high-temperature vibration sensor with temperature decoupling

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Science China(Technological Sciences) 2024年第6期67卷 1946-1956页

作者： ZHANG juan CHENG WenHua WANG Hao ZHANG Lei LI XiangRong MA HongShuai PANG j.nQi TAN QiuLin State Key Laboratory of Dynamic Measurement Technology North University of ChinaTaiyuan030051China Department of Mechanical Engineering Taiyuan Institute of TechnologyTaiyuan030008China

Monitoring high-temperature vibrations is critical in aerospace engineering,industrial manufacturing,and energy production,where harsh conditions necessitate robust vibration sensors for detecting anomalous ***,the accuracy of such sensors is often compromised by crosstalk between temperature and vibration *** study introduces a high-temperature vibration sensor based on langasite(LGS)surface acoustic wave(SAW)technology,designed to withstand temperatures up to 500℃.The sensor demonstrates high sensitivity,ranging from 12.54 kHz/g at 25℃ to 15.63 k Hz/g at 500℃.A comprehensive mechanical and electrical coupling model for the SAW vibration sensor was developed by integrating theoretical equations with numerical simulations to optimize the sensor's ***,a novel decoupling algorithm for temperature and vibration was established,achieving thermomechanical decoupling with precise vibration *** results indicated a maximum relative deviation of 4.67%for the *** conclusion,the proposed LGS SAW vibration sensor emerges as a promising solution for the accurate detection of multiple parameters in high-temperature vibration monitoring.

关键词： high temperature langasite(LGS) surface acoustic wave(SAW) piezoelectric vibration sensor temperature decoupling

Highly crystallization-induced emissive luminophores with mechanoluminescent features for two-photon harvesting fluorescence imaging and latent fingerprint identification

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Nano Research 2024年第7期17卷 6475-6482页

作者： j.an Lu juan Gao Rui-Xuan Qian Shuai-Hua Wang Fa-Kun Zheng Guo-Cong Guo Fuj.an Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Fluorescence imaging can be employed in fields of medical treatment,astronomical exploration,and national defense *** fluorescence imaging often takes the single-photon techniques,which is vulnerable to background interference and ***,two-photon fluorescence imaging can achieve much higher-resolution fluorescence imaging for reducing scattering and deeper ***,by assembling the tetraphenylethylene backbones with nontoxic and non-noble K^(+)ions,compound 1([(Hdma)K(H_(2)ettc)]_(n),H_(4)ettc=4',4''',4''''',4'''''''-(ethene-1,1,2,2-tetrayl)tetrakis(([1,1'-biphenyl]-4-carboxylic acid)))with the crystallization-induced emissions exhibited charming fluorescence imaging under two-photon excitation microscopy(TPEM).Besides,luminescent powders based on compound 1 can achieve high-resolution fingerprint recognition,providing secure access control and identification for a novel authentication *** with the commercial fluorescent dyes coumarin-6,the as-synthesized compound 1 showed great solvent stability,indicating its durability against harsh ***,compound 1 shows mechanoluminescent properties for the perturbation of weak supramolecular interactions within ordered arrangements of the H_(2)ettc^(2−)*** novel compound has provided an important insight to the development of twophoton fluorescence imaging and advanced external-stimuli responsive materials.

关键词： crystallization-induced emission fluorescence imaging two-photon absorption fingerprint recognition mechanoluminescence

Effects of processing parameters on fabrication defects,microstructure and mechanical properties of additive manufactured Mg–Nd–Zn–Zr alloy by selective laser melting process

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j.urnal of Magnesium and Alloys 2024年第6期12卷 2249-2266页

作者： Wenyu Xu Penghuai Fu Nanqing Wang Lei Yang Liming Peng juan Chen Wenj.ang Ding National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Shanghai Light Alloy Net Forming National Engineering Research Center Co. LtdShanghai 201615China

Mg–3Nd–0.2Zn–0.4Zr(NZ30K,wt.%)alloy is a new kind of high-performance metallic *** combination of the NZ30K Magnesium(Mg)alloy and selective laser melting(SLM)process seems to be an ideal solution to produce porous Mg degradable ***,the microstructure evolution and mechanical properties of the SLMed NZ30K Mg alloy were not yet studied ***,the fabrication defects,microstructure,and mechanical properties of the SLMed NZ30K alloy under different processing parameters were *** results show that there are two types of fabrication defects in the SLMed NZ30K alloy,gas pores and unfused *** the increase of the laser energy density,the porosity sharply decreases to the minimum first and then slightly *** minimum porosity is 0.49±0.18%.While the microstructure varies from the large grains with lamellar structure inside under low laser energy density,to the large grains with lamellar structure inside&the equiaxed grains&the columnar grains under middle laser energy density,and further to the fine equiaxed grains&the columnar grains under high laser energy *** lamellar structure in the large grain is a newly observed microstructure for the NZ30K Mg *** laser energy density leads to finer grains,which enhance all the yield strength(YS),ultimate tensile strength(UTS)and elongation,and the best comprehensive mechanical properties obtained are YS of 266±2.1 MPa,UTS of 296±5.2 MPa,with an elongation of 4.9±0.68%.The SLMed NZ30K Mg alloy with a bimodal-grained structure consisting of fine equiaxed grains and coarser columnar grains has better elongation and a yield drop phenomenon.

关键词： Selective laser melting Mg alloy Processing parameter Lamellar structure Bimodal-grained structure

Thermal stability of the Cr-coated zirconium alloy microstructure prepared by pulsed laser deposition

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Tungsten 2024年第2期6卷 333-341页

作者： Bo Li Hui-Long Yang Reuben Holmes Li-juan Cui Sho Kano Hiroaki Abe Department of Nuclear Engineering and Management The University of TokyoTokyo 113-8656Japan School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Nuclear Professional School The University of TokyoIbaraki 319-1188Japan

Cr-coated zirconium alloy was prepared by pulsed laser deposition(PLD)for the application of accident-tolerant fuel cladding in light water *** microstructural characteristics of the Cr coating and its evolution with temperature were investigated using grazing incidence X-ray diff raction and in situ heating transmission electron microscopy(TEM).Results show that the microstructure of the laser-deposited Cr coatings consists mainly of fine and non-specific shaped nano-crystals in the inner layer and columnar crystals in the outer *** recrystallization of the Cr-coating layer starts at 300–400℃ to release the high strain introduced by PLD,and the grain coalescence starts at temperatures>400°*** annealing,the(110)-texture gradually intensifi es because of its high reticular density and low close-packed ***,in situ heating TEM observation shows the presence of cavities on the Cr–Zr interface,which may result from the interdiff usion and/or the transformation from amorphous to crystalline.

关键词： Accident tolerant fuel Crcoating Interface Microstructure Pulsed laser deposition

Evaluation of Well Spacing for Primary Development of Fractured Horizontal Wells in Tight Sandstone Gas Reservoirs

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Fluid Dynamics & Materials Processing 2024年第5期20卷 1015-1030页

作者： Fang Li juan Wu Haiyong Yi Lihong Wu Lingyun Du Yuan Zeng Exploration and Development Research Institute PetroChina Southwest Oil&Gas Field CompanyChengdu610041China Oil and Gas Resources Department PetroChina Southwest Oil&Gas Field CompanyChengdu610000China

Methods for horizontal well spacing calculation in tight gas reservoirs are still adversely affected by the complexity of related control factors,such as strong reservoir heterogeneity and seepage *** this study,the stress sensitivity and threshold pressure gradient of various types of reservoirs are quantitatively evaluated through reservoir seepage *** the basis of these experiments,a numerical simulation model(based on the special seepage mechanism)and an inverse dynamic reserve algorithm(with different equivalent drainage areas)were *** well spacing ranges of Classes I,II,and III wells in the Q gas field are determined to be 802–1,000,600–662,and 285–400 m,respectively,with their average ranges as 901,631,and 342.5 m,*** considering both the pairs of parallel well groups and series well groups as examples,the reliability of the calculation results is *** is shown that the combination of the two models can reduce errors and provide accurate results.

关键词： Well spacing for primary development tight gas reservoir fractured horizontal well threshold pressure gradient stress sensitivity

THE SMOOTHING EFFECT IN SHARP GEVREY SPACE FOR THE SPATIALLY HOMOGENEOUS NON-CUTOFF BOLTZMANN EQUATIONS WITH A HARDPOTENTIAL

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Acta Mathematica Scientia 2024年第2期44卷 455-473页

作者：刘吕桥曾娟 School of Mathematics and Statistics Anhui Normal UniversityWuhu241002China School of Mathematics and Statistics Wuhan UniversityWuhan430072China

In this article, we study the smoothing effect of the Cauchy problem for the spatially homogeneous non-cutoff Boltzmann equation for hard potentials. It has long been suspected that the non-cutoff Boltzmann equation enj.ys similar regularity properties as to whose of the fractional heat equation. We prove that any solution with mild regularity will become smooth in Gevrey class at positive time, with a sharp Gevrey index, depending on the angular singularity. Our proof relies on the elementary L^(2) weighted estimates.

关键词： Boltzmann equation Gevrey regularity non-cutoff hard potential