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Revision anterior cruciate ligament reconstruction:Return to sports at a minimum 5-year follow-up

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World Journal of Orthopedics 2022年第9期13卷 812-824页

作者： Ezequiel Ortiz juan Pablo Zicaro ignacio Garcia Mansilla Carlos Yacuzzi Matias Costa-Paz Knee Division Hospital Italiano de Buenos AiresCiudad Autónoma 1181Buenos AiresArgentina

BACKGROUND Between 43%and 75%of patients who undergo primary anterior cruciate ligament(ACl)surgery return to sport ***,after a revision ACl reconstruction(AClR)the rate of return to sports is variable.A few publications have reported returns to sports incidence between 56%to 100%after revision *** To determine return to sports and functional outcomes after a single-stage revision AClR with a 5-year minimum follow-up at a single *** All patients operated between 2010 and 2016 with a minimum 5 years of followup were *** of sport,intensity,frequency,expectation,time to return to sport and failure rate were ***,Tegner and International Knee Documentation Committee forms were evaluated prior to the first AClR surgery,at 6 mo after primary surgery and after revision AClR at 5 years minimum of *** stability was tested with the knee arthrometer test(KT-1000 knee arthrometer,Medmetric Corp).RESUlTS A total of 41 patients who underwent revision AClR during that period of time were contacted and available for *** patient age at time of revision was 29 years old[interquartile range(IQR):24.0-36.0],and 39(95.0%)were *** median time from revision procedure to follow-up was 70 mo(IQR:58.0-81.0).Regarding return to sports,16(39.0%)were at the same level compared to preinjury period,and 25 patients(61.0%)returned at a lower ***-three percent categorized the sport as very important and 37.0%as *** patient(2.4%)failed with a recurrent ACl *** preoperative lysholm and(SD)16]and 50(SD 11),*** follow-up,mean lysholm and subjective International Knee Documentation Committee scores were 89(SD 8)and 82(SD 9)(P=0.0001).Mean Tegner score prior to primary AClR was 6.7(SD 1.3),5.1(1.5 SD)prior to revision AClR and 5.6(1.6 SD)at follow-up(P=0.0002).Overall,knee arthrometer test measurement showed an average of 6 mm(IQR:4.0-6.0)side-to-side difference of displacement pri

关键词： Return to sport Revision anterior cruciate ligament Arthroscopy Knee Functional outcome

Failure rate,return-to-sports and magnetic resonance imaging after meniscal repair:119 patients with 7 years mean follow up

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世界骨科杂志:英文版 2023年第8期14卷 612-620页

作者： juan Pablo Zicaro Nicolas Garrido ignacio Garcia-Mansilla Carlos Yacuzzi Matias Costa-Paz Department of Knee Hospital Italiano de Buenos AiresBuenos Aires 1109Argentina

BACKGROUND One of the most important factors to consider in relation to meniscal repair is the high failure rate reported in the existing *** To evaluate failure rates,return to sports(RTS)rate,clinical outcomes and magnetic resonance image(MRI)evaluation after meniscus suture repair for longitudinal tears at a minimum *** We conducted a retrospective review of meniscal repairs between January 2004 and December *** patients treated for longitudinal tears associated or not with an anterior cruciate ligament reconstruction(ACl-R)were *** ramp lesions,radial and root tears,associated with multiligament injuries,tibial fracture and meniscal allograft transplants were *** details and failure rate,defined as symptomatic patients who underwent a revision surgery,were *** isolated bucket handle tears(BHTs)were usually associated with higher failure rates,we compared BHTs and not BHTs associated or not with an *** 2014,the inside-out technique using cannulas and suture needles with 2-0 Tycron began to *** addition,the number of stitches per repair was *** view of differences in surgical technique,we compared two different cohorts:before and after *** recorded the RTS according to the level achieved and the time to *** and IKDC scores were *** were studied with x-rays and MRI as standard postoperative *** One hundred and nineteen patients were included with a mean follow up of 7 years(SD:4.08).Overall failure rate was 20.3%at a mean 20.1 *** statistically significant differences were found when comparing failure for medial and lateral meniscal repair(22.7%and 15.3%,P=0.36),BHTs and not BHTs(26%and 17.6%,P=0.27),isolated or associated with an ACl-R(22.9%and 18%,P=0.47),or when comparing only BHTs associated with an ACl-R(23%and 27.7%,P=0.9)or *** comparing cohorts before and after 2014,we found a significant decrease in the overall f

关键词： Meniscus repair Bucket handle tears Meniscal suture Failure rate longitudinal meniscus tears

Effectiveness of statins *** on reducing postprandial hypertriglyceridemia in dyslipidemic population:A systematic review and network meta-analysis

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Journal of Sport and Health Science 2022年第5期11卷 567-577页

作者： laura Alvarez-Jimenez Alfonso moreno-Cabanas Miguel Ramirez-Jimenez Felix Morales-Palomo juan FOrtega Ricardo Mora-Rodriguez Exercise Physiology lab at Toledo Sports Science DepartmentUniversity of Castilla-La ManchaToledo 45004Spain

Background:Individuals at risk of suffering cardiovascular disease(CVD) present with larger increases in blood trigyceride(TG) concentration after a high-fat meal than do healthy *** postprandial hypertriglyceride levels are an independent risk factor for *** of statins and a bout of prolonged exercise are both effective in lowering postprandial hypertriglyceride *** aimed to evaluate the comparative effectiveness of statins vs.a bout of aerobic exercise in reducing fasting and postprandial TG(PPTG) concentrations in indiv、duals at high nsk of developing ***:Thirty-seven sltudies from a systematic literature search of the PubMed,EMBASE,and Cochrane databases were included in this *** selected studies conducted trials involving statin therapy(n=20) or a bout of aerobic exercise(n=19) and measured their impact on PPTG levels as the *** studies analyzed both treatments and were included in *** meta-analysis was constructed using a random-effects model to calculate the mean difference(MD).The Student t test was used to compare the data sets for statins ***:Overall,statin and exercise interventions showed similar reductions in PPTG levels,with an MD of-0.65 mmol/l for statins(95% confidence interval(95%CI):-0.54 to-0.77;p l/l for exercise(95%CI:-0.21 to-0.71;p lowered fasting TG levels more than exercise(MD=-1.54 mmol/l,95%CI:-2.25 to-0.83;p=0.009).Conclusion:Although aerobic exercise is effective in lowering blood TG levels,statins seem to be more efficient,especially in the fasted state.A combination of exercise and statins might reveal a valuable approach to the treatment and prevention of *** studies are required to determine the underlying mechanisms and the possible additive effects of these interventions.

关键词： Aerobic exercise Cardiovascular disease Hydroxymethylglutaryl-CoA reductase inhibitor Meta-analysis Metabolic syndrome

Intravitreal dexamethasone implant in naive and previously treated patients with diabetic macular edema:a retrospective study

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1597-1605页

作者： Marta Medina-Baena Olga Cejudo-Corbalán juan ignacio García-Pulido María Jesús Huertos-Carrillo Eloy Girela-lópez Hospital Universitario Puerto Real Puerto Real 11510CadizSpain University of Cordoba Cordoba 14004Spain

AIM:To assess the effect of the intravitreal dexamethasone implant(DEX)Ozurdex on the best corrected visual acuity(BCVA)and central retinal thickness(CRT)in patients with diabetic macular edema(DME).METHODS:Totally 43 eyes(24 naive and 19 previously treated)were included in the *** and single-center study involved patients with a clinical diagnosed of DME,who received treatment with DEX implant and had a follow-up of at least 12 *** endpoints included changes in BCVA and ***:At month 12,mean improvement in BCVA from baseline was 20.4±20.8 letters and 6.8±6.9 letters in naive and previously treated patients,respectively(P=0.0132).The naive patients achieved the BCVA improvement significantly faster(2.4±1.5 mo)than the previously treated ones(3.5±2.4 mo,P=0.0298;MannWhitney test).The proportion of eyes gaining≥15 letters was 54.2%and 21.1%in the non-previously treated and previously treated groups,respectively(P=0.0293).CRT was significantly reduced from 484.0±119.8 and 487.5±159.9μm to 272.0±39.2 and 233.5±65.7μm in the naive and previously treated patients,respectively;Pl fluid was significantly associated with the proportion of patients achieving a BCVA improvement≥5 letters[HR(95%CI),1.23(1.04 to 1.45),P=0.0145];≥10 letters[HR(95%CI),1.75(1.10 to 2.77),P=0.0182];and≥15 letters[HR(95%CI),2.04(1.03 to 4.02),P=0.0407].Naive patients received less DEX implants throughout the study than the previously treated ones(1.8±0.6 vs 2.3±0.6,P=0.0172,respectively).Totally 9 patients(20.9%)have developed ocular hypertension,which was successfully controlled with topical hypotensive *** the 23 phakic eyes at baseline,5 eyes(21.7%)either had new onset lens opacity or progression of an existing opacity during the study *** of them(2 in the naive group and 2 in the previously treated one)required cataract surgery at months 4,6,6,and 6,***:The results obtained in this

关键词： diabetic macular edema dexamethasone implant Ozurdex visual acuity central retinal thickness naive patients

Use of agents stimulating erythropoiesis in digestive diseases

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World Journal of Gastroenterology 2009年第37期15卷 4675-4685页

作者： Rosario moreno lópez Beatriz Sicilia Aladrén Fernando Gomollón García Department of Nephrology San Juan de Dios Hospital Paseo Colón 14 50006 Zaragoza Spain Department of Medicine Universidad de Zaragoza 50009 Zaragoza Spain Department of Medicine (Gastroenterology) Alcaiz Hospital 44600 Alcaiz (Teruel) Spain Department of Gastroenterology Clinical University Hospital "Lozano Blesa" Department of Medicine University of Zaragoza IACS CIBEREHD 50009 Zaragoza Spain

Anemia is the most common complication of inflammatory bowel disease (IBD). Control and inadequate treatment leads to a worse quality of life and increased morbidity and hospitalization. Blood loss, and to a lesser extent, malabsorption of iron are the main causes of iron def iciency in IBD. There is also a variable component of anemia related to chronic inflammation. The anemia of chronic renal failure has been treated for many years with recombinant human erythropoietin (rHuEPO), which significantly improves quality of life and survival. Subsequently, rHuEPO has been used progressively in other conditions that occur with anemia of chronic processes such as cancer, rheumatoid arthritis or IBD, and anemia associated with the treatment of hepatitis C virus. Erythropoietic agents complete the range of available therapeutic options for treatment of anemia associated with IBD, which begins by treating the basis of the inflammatory disease, along with intravenous iron therapy as f irst choice. In cases of resistance to treatment with iron, combined therapy with erythropoietic agents aims to achieve near-normal levels of hemoglobin/hematocrit (11-12 g/dl). New formulations of intravenous iron (iron carboxymaltose) and the new generation of erythropoietic agents (darbepoetin and continuous erythropoietin receptor activator) will allow better dosing with the same eff icacy and safety.

关键词：人红细胞生成素消化系统疾病慢性肾功能衰竭传染性法氏囊病红细胞生成素受体综合治疗类风湿关节炎丙型肝炎病毒

Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander lucaci Conor loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease juan moreno Andrew Boddicker Junhua Zhao Bryan lajoie Andrew Altomare Semyon Kruglyak Shawn levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(lEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

COVID‑19 and tourism sector stock price in Spain:medium‑term relationship through dynamic regression models

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Financial Innovation 2023年第1期9卷 257-280页

作者： Isabel Carrillo‑Hidalgo juan ignacio Pulido‑Fernández Joséluis Durán‑Román Jairo Casado‑Montilla laboratory of Analysis and Innovation in Tourism University of JaénParaje Las Lagunillas S/ND3‑13423071 JaénSpain laboratory of Analysis and Innovation in Tourism University of JaénParaje Las Lagunillas S/ND3‑27323071 JaénSpain laboratory of Analysis and Innovation in Tourism University of JaénParaje Las Lagunillas S/ND3‑21723071 JaénSpain

The global pandemic,coronavirus disease 2019(COVID-19),has significantly affected tourism,especially in Spain,as it was among the first countries to be affected by the pandemic and is among the world’s biggest tourist *** market values are responding to the evolution of the pandemic,especially in the case of tourist ***,being able to quantify this relationship allows us to predict the effect of the pandemic on shares in the tourism sector,thereby improving the response to the crisis by policymakers and ***,a dynamic regression model was developed to predict the behavior of shares in the Spanish tourism sector according to the evolution of the COVID-19 pandemic in the medium *** has been confirmed that both the number of deaths and cases are good predictors of abnormal stock prices in the tourism sector.

关键词： COVID-19 Stock exchange Tourism stock Dynamic regression models Spain

The labyrinth of nuclear reprogramming

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分子细胞生物学报:英文版 2011年第6期3卷 327-329页

作者： ignacio Sancho-Martinez Emmanuel Nivet juan Carlos Izpisua Belmonte Gene Expression laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Center for Regenerative Medicine in Barcelona Dr Aiguader 88Barcelona 08003Spain

Human embryonic stem cells(ESCs)have the capability to differentiate into all somatic cell types,a process that recapitu-lates the early stages of human ***,the use of ESCs raises several controversies,particularly concern-ing the ethical dilemma regarding the use of human embryonic material and the need for embryo *** discov-ery of induced pluripotent stem cell(iPSC)technology in 2006(Takahashi and Yamanaka,2006)opened the door for possible application of pluripotent stem-cell-related therapies in the clinic as well as for the generation of patient-derived pluripotent stem cells suitable for disease modeling in vitro.

关键词： programming destruction opened

land-use change and windstorms legacies drove the recolonization dynamics of laurel forests in Tenerife, Canary islands

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Forest Ecosystems 2023年第1期10卷 113-124页

作者： Vicente Rozas Maria A.Garcia-lopez Jose M.Olano Gabriel Sanguesa-Barreda Miguel Garcia-Hidalgo Susana Gomez-Gonzalez Roberto lopez-Rubio Jose M.Fernandez-Palacios ignacio Garcia-Gonzalez laura lozano-lopez Paula Garcia-Gonzalez Ana I.Garcia-Cervigon EiFAB-iuFOR Universidad de ValladolidCampus Duques de Soria42004SoriaSpain Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510Puerto RealSpain Center for Climate and Resilience Research(CR)2 Blanco Encalada 20028370449SantiagoChile Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n28933MostolesSpain Grupo de Ecologia y Biogeografia Insular Universidad de La Laguna38206La LagunaTenerifeSpain BIOAPlIC Departamento de BotanicaEscola Politecnica Superior de EnxenariaCampus TerraUniversidade de Santiago de CompostelaLugo27002Spain

laurel forests are quite relevant for biodiversity conservation and are among the island ecosystems most severely damaged by human *** the past,Canary laurel forests have been greatly altered by logging,livestock and *** remains of laurel forests are currently protected in the Canary Islands(Spain).However,we miss basic information needed for their restoration and adaptive management,such as tree longevity,growth potential and responsiveness to natural and anthropogenic *** dendrochronological methods,we studied how forest dynamic is related to land-use change and windstorms in two well-preserved laurel forests on Tenerife *** cores were collected from over 80 trees per stand at three stands per *** used ring-width series to estimate tree ages and calculate annual basal area increments(BAI),cumulative diameter increases,and changes indicative of released and suppressed *** tree species were found in all stands,with laurus novocanariensis,Ilex canariensis and Morella faya being the most common *** some individuals were over 100 years old,61.8%-88.9% of the trees per stand established between 1940 and 1970,coinciding with a post-war period of land abandonment,rural exodus and the onset of a tourism *** trees have shown growth rates larger than 1 cm diameter per year and most species have had increasing BAI trends over the past *** growth releases occurred after windstorms at both sites,but the effects of windstorms were site-dependent,with the 1958 storm affecting mainly the eastern tip of the island(Anaga massif)and the 1991 storm the western tip(Teno massif).Given the great ability of laurel forest trees to establish after land use cessation and to increase growth after local disturbances such as windstorms,passive restoration may be sufficient to regenerate this habitat in currently degraded areas.

关键词： Canary islands Dendroecology Disturbance Forest structure Macaronesia Management cessation Tree rings