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Early pancreatic cancer in Ig G4-related pancreatic mass:A case report

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World Journal of Gastrointestinal Surgery 2019年第12期11卷 443-448页

作者： juan Glinka francisco Calderón Martín de Santibanes Sung Ho Hyon Adrián Gadano Eduardo Mullen Melina Pol juan Spina Eduardo de Santibanes Department of General Surgery Hepato-bilio-pancreatic UnitHospital Italiano de Buenos AiresBuenos Aires C1181ACHArgentina Department of General Surgery Image Guided Minimally Invasive Surgery UnitHospital Italiano de Buenos AiresBuenos Aires C1181ACHArgentina Hepatology Section Hospital Italiano Buenos AiresBuenos Aires C1181ACHArgentina Department of Surgical Pathology Hospital Italiano de Buenos AiresBuenos Aires C1181ACHArgentina Department of Radiology Hospital Italiano de Buenos AiresBuenos Aires C1181ACHArgentina

BACKGROUND IgG4-related disease can manifest diversely,including autoimmune pancreatitis and IgG4-related *** are reporting a very unusual cause of pancreatic cancer triggered in a previously unknown IgG4-related *** SUMMARY A 75-year-old man was diagnosed with a 43 mm×33 mm pancreatic head tumor after consulting for abdominal pain and jaundice.A pancreaticoduodenectomy was carried out uneventfully,and the histopathology report showed an early stage of acinar-cell pancreatic *** patient reconsulted on the 30th postoperative day with fever,jaundice and *** resonance cholangiopancreatography evidenced an extense bile duct stricture.A percutaneous biliary drainage proved to be ineffective,even after exchanging it with larger bore *** the surgical specimen,features compatible with IgG4-related disease were ***,empiric treatment with steroids was initiated achieving excellent *** IgG4-related disease may cause chronic inflammation of the pancreas and can condition pancreatic malignancies.

关键词： Autoimmune pancreatitis Pancreatic adenocarcinoma Pancreatic cancer IgG4 IgG4-related disease Case report

Use of recycled concrete aggregates in asphalt mixtures for pavements:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第5期9卷 725-741页

作者： juan Gabriel Bastidas-Martínez Fredy Alberto Reyes-Lizcano Hugo Alexander Rondón-Quintana Faculty of Engineering Universidad Piloto de ColombiaBogotáDC 110231Colombia Faculty of Engineering Pontificia Universidad JaverianaBogotáDC 110131Colombia Facultad del Medio Ambiente y Recursos Naturales Universidad Distrital Francisco Joséde CaldasBogotáDC 110131Colombia

Large quantities of natural aggregates(NA)are required in the manufacturing of asphalt mixtures for *** extraction of NA generates high environmental impacts that negatively affect environmental preservation and *** alternative materials obtained in construction and demolition processes in civil construction worked have been studies as possible replacements for NA,with the purpose of reducing these environmental *** foregoing study presents a state of knowledge review referring to the use of recycled concrete aggregates(RCA)when these are used in the manufacturing of asphalt mixtures(mainly hot-mix asphalt HMA type).Environmental aspects are presented,as well as possible benefits and limitations of using RCA as replacements for NA in asphalt ***,it is not possible to establish a behavior pattern,since the characteristics of the RCA are very heterogeneous and vary from the original source of the *** is highlighted from the literature that RCA has a wide potential for use in the manufacture of asphalt mixtures,since in most studies,the mixtures with these materials comply the quality requirements contemplated by the construction specifications,mainly in low-volume ***,based on the literature review,some recommendations and suggestions are presented for future research.

关键词： Recycled concrete aggregates Asphalt mixtures Mechanical properties Volumetric composition

Splenic rupture following colonoscopy

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World Journal of Gastroenterology 2008年第41期14卷 6410-6412页

作者： juan francisco Guerra Ignacio San francisco Fernando Pimentel Luis Ibanez Departamento de Cirugía Digestiva Pontificia Universidad Católica de Chile Marcoleta 367

Colonoscopy is a safe and routinely performed diagnostic and therapeutic procedure for different colorectal diseases. Although the most common complications are bleeding and perforation, extracolonic or visceral injuries have also been described. Splenic rupture is a rare complication following colonoscopy, with few cases reported. We report a 60-year-old female who presented to surgical consultation 8 h after a diagnostic colonoscopy. Clinical, laboratory and imaging findings were suggestive for a massive hemoperitoneum. At surgery, an almost complete splenic disruption was evident, and an urgent splenectomy was performed. After an uneventful postoperative period, she was discharged home. Splenic injury following colonoscopy is considered infrequent. Direct trauma and excessive traction of the splenocolic ligament can explain the occurrence of this complication. Many times the diagnosis is delayed because the symptoms are due to colonic insuffl ation, so the most frequent treatment is an urgent splenectomy. A high index of suspicion needs an early diagnosis and adequate therapy.

关键词：结肠镜检查脾脏损伤脾脏破裂脾切除术

End-of-life care in a cardiology department： have we improved？

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Journal of Geriatric Cardiology 2016年第7期13卷 587-592页

作者： juan Rulz-Garcia Pablo Dlez-Villanueva Ana Ayesta Vanessa Brufia Lourdes M Figueiras-Graillet Laura Gallego-Parra francisco Fernandez-Aviles Manuel Martinez-Selles Department of Cardiology Hospital General Universitario Gregorio Maranon Calle Doctor Esquerdo Madrid Spain Department of Cardiology Hospital Universitario de Torrejon Calle Mateo Inurria Torrejon de Ardoz Madrid Spain Universidad francisco de Vitoria Carretera Pozuelo a Majadahonda Pozuelo de Alareon Madrid Spain Department of Cardiology Hospital Universitario de la Princesa Calle de Diego de Leon Madrid Spain Departmet of Cardiology Hospital Universitario del Sureste Ronda del Sur Arganda del Rey Madrid Spain Universidad Complutense de Madrid Av. Seneca Madrid Spain Universidad Europea de Madrid Urbanizacion E1Bosque Calle Tajo Villaviciosa de Odon Madrid Spain

BackgroundEnd-of-life 照顾不通常是在心病学部门的优先级。我们寻求了在 do-not-resuscitate (DNR ) 的介绍以后在 end-of-life 照顾评估变化顺序 *** &；在在二经期的一个心病学部门的所有死亡的 ResultsRetrospective 分析... 详细信息

BackgroundEnd-of-life 照顾不通常是在心病学部门的优先级。我们寻求了在 do-not-resuscitate (DNR ) 的介绍以后在 end-of-life 照顾评估变化顺序 *** &；在在二经期的一个心病学部门的所有死亡的 ResultsRetrospective 分析，在协议的介绍前后。人口统计的特征， DNR 订单的使用，和 end-of-life 照顾的比较在两个时期之间发出，根据在表(组 A ) ，一份常规 DNR 订单(组 B ) 或任何 DNR 的缺席订的新 DNR 的第二经期(组 C ) 的存在。死亡的数字在两个时期是类似的(n = 198 对 n = 197 ) 。与一份 DNR 订单死的病人的率显著地增加了(57.1% 对 68.5% ；P = 0.02 ) 。仅仅在两个时期的 4% 病人知道关于心肺的复活作的决定。在组 A 的病人更早收到了 DNR 顺序一天，并且 24.5% 在录取的开始的 24 h 以内收到了它(对 2.6% 在第一个时期；P <；0.001 ) 。在有一个可植入的 cardioverter 使用高压脉冲来消减心脏(ICD ) 的组 A 的所有病人把电震疗法撤销(对 25.0% 在第一个时期；P = 0.02 ) 一个 DNR 顺序协议的 .ConclusionsThe 介绍可以由增加使用并且弄短在心脏病患者改进 end-of-life 照顾 DNR 订单的登记的时间。它可以也在地方与这些订单在病人贡献增加 ICD 释放。然而，在疾病的迟了的阶段的表的介绍没能改进耐心的参予。

关键词：心脏病患者护理生命 DNR 死亡人数统计特征心肺复苏 ICD

Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 330-339页

作者： Ana Mora-Boza francisco J.Aparicio Maria Alcaire Carmen López-Santos juan P.Espinós Daniel Torres-Lagares Ana Borrás Angel Barranco Consejo Superior de Investigaciones Cientificas. Instituto de Ciencia de Materiales de Sevilla (CSIC-Universidad de Sevilla) c/Americo Vespucio 49 41092 SevillaSpain Facultad de Odontologia Universidad de Sevilla (USE) c/Avicena41009 SevillaSpain

Novel antibacterial materials for implants and medical instruments are essential to develop practical strategies to stop the spread of healthcare associated infections. This study presents the synthesis of multifunctional antibacterial nanocoatings on polydimethylsiloxane (PDMS) by remote plasma assisted deposition of sublimated chlorhexidine powders at low pressure and room temperature. The obtained materials present effective antibacterial activity against Escherichia coli K12, either by contact killing and antibacterial adhesion or by biocide agents release depending on the synthetic parameters. In addition, these multifunctional coatings allow the endure hydrophilization of the hydrophobic PDMS surface, thereby improving their biocompatibility. Importantly, cell-viability tests conducted on these materials also prove their non-cytotoxicity, opening a way for the integration of this type of functional plasma films in biomedical devices.

关键词： plasma polymers conformal plasma deposition chlorhexidine bactericide PDMS biocompatibility

META-R:A software to analyze data from multi-environment plant breeding trials

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The Crop Journal 2020年第5期8卷 745-756页

作者： Gregorio Alvarado francisco M.Rodríguez Angela Pacheco juan Burgueño JoséCrossa Mateo Vargas Paulino Pérez-Rodríguez Marco A.Lopez-Cruz Biometrics and Statistics Unit International Maize and Wheat Improvement Center(CIMMYT)MexicoDF 6-64106600Mexico Centro de Investigación en Matemáticas(CIMAT)A.C. Jalisco S/NCol.ValencianaGuanajuatoGto 40236023Mexico Universidad Autónoma Chapingo Carretera Federal México-Texcoco km 38.5TexcocoMéxico 6356230Mexico Colegio de Postgraduados Carretera México-Texcoco Km.36.5MontecilloTexcoco 6356231Mexico Department of Plant Soil and Microbial SciencesMichigan State University1066 Bogue StEast LansingMI 48824USA

META-R(multi-environment trial analysis in R)is a suite of R scripts linked by a graphical user interface(GUI)designed in Java *** objective of META-R is to accurately analyze multi-environment plant breeding trials(METs)by fitting mixed and fixed linear models from experimental designs such as the randomized complete block design(RCBD)and the alpha-lattice/lattice ***-R simultaneously estimates the best linear and unbiased estimators(BLUEs)and the best linear and unbiased predictors(BLUPs).Additionally,it computes the variance-covariance parameters,as well as some statistical and genetic parameters such as the least significant difference(LSD)at 5%significance,the coefficient of variation in percentage(CV),the genetic variance,and the broad-sense *** parameters are very important in the selection of top performing genotypes in plant ***-R also computes the phenotypic and genetic correlations among environments and between traits,as well as their statistical *** genetic correlations between environments or traits can be visualized in a biplot graph or a tree diagram(dendrogram).Genetic correlations are very important for identifying environments with similar behavior or making indirect selection and identifying the most highly associated ***-R performs multi-environment analyses by using the residual maximum likelihood(REML)method;these analyses can be done by environment,across environments by grouping factors(stress conditions,nitrogen content,etc.)and across environments;the analyses across environments can be done with a pre-defined degree of heritability.

关键词： environments breeding variance

Integrating time progression in ecoimmunology studies: beyond immune response intensity

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Current Zoology 2019年第2期65卷 205-212页

作者： francisco Javier ZAMORA-CAMACHO Department of Biological Sciences Dartmouth College Hanover New Hampshire USA Department of Biogeography and Global Change Museo Nacional de Ciencias Naturales (MNCN) Spanish National Research Council (CSIC) Madrid Spain

Habitat alterations in agroecosystems may damage amphibian immune capacity. As agroecosystem extension is increasing worldwide, broader-context knowledge on the effects of agroecosystem stressful conditions on amphibian immune capacity is crucial for understanding and management of amphibian global declines. However, most studies on ecoimmunology assume synchronal amonggroup immune-response peaks, and focus on immune response after standardized time lapses, neglecting its progress!on. Herein, I compared inflamatory response short-term progression of agro ecosystem and n atural-habitat female and male n atterjack toads Epi da lea calamita, by measuri ng swelling response, once per hour, 6 h following an artificial immune challenge with innocuous antigen phytohemagglutinin. I also compared maximum magnitude of swelling response, irrespective of the moment when it was reached. Habitat differences arose only 3 h after challenge, when naturalhabitat toads showed greater swelling response. Maximum magnitude of swelling response was similar in toads from both habitats. However, agroecosystem toads showed a delayed swelling response as compared with natural-habitat conspecifics, probably as a consequenee of agroecosystem stressful conditions. Such a delay suggests a weaker immune capacity, and consequently impaired anti-pathogen performance. Regarding sex, swelling response magnitude did not differ between males and females. Female swelling response peaked earlier, but that of males was more sustai ned in time, which con tradicts general across-taxa fin dings that males show impaired immune response. Interestingly, results suggest that measuring swelling response only after some standardized period following stimulation may be a simplistic approach and produce unrealistic results. Consequently, studies on ecoimmunology should implement swelling response progression in order to produce unbiased science.

关键词： agroecosystem amphibian immunocompetence natural habitat immune response progressi on

Ecophysiology of egg rejection in hosts of avian brood parasites:new insights and perspectives

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Current Zoology 2021年第6期67卷 631-638页

作者： francisco RUIZ-RAYA Centro de Investigación Marina Universidade de VigoGEAVigo 36310Spain

Egg rejection is the most effective and widespread defense used by host species to counteract the extreme fitness costs frequently imposed by obligate avian brood ***,the proximate mechanisms underlying between-and within-individual variation in host responses remain poorly *** evidence suggests that egg rejection is dependent on individual physiological states,and draws attention to the role of hormones as mediators of flexible antiparasitic *** this perspective article,I outline recent advances in our understanding of the proximate factors that mediate egg rejection.I also point out some areas where knowledge remains still lacking,especially those related to the development and maintenance of effective cognitive functions,the potential role of oxidative stress,immunological state,and developmental stressors.I propose new hypotheses that stimulate future research on behavioral host responses toward brood parasitism.

关键词： cognitive performance condition-dependence corticosterone flexible responses prolactin

Different strategies of treatment for uterine cervical carcinoma stage ⅠB2-ⅡB

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World Journal of Clinical Oncology 2014年第2期5卷 86-92页

作者： Lucas Minig María Guadalupe Patrono Nuria Romero juan francisco Rodríguez Moreno Jesús Garcia-Donas Gynecologic Oncology Program Clara Campal Comprehensive Cancer CenterHM Hospitales28050 Madrid Spain Gynecologic Oncology Program Medical Oncology Department Clara Campal Comprehensive Cancer Center HM Hospitales28050 Madrid Spain

Uterine cervical cancer is the second most common gynecological malignancy. It is estimated that over 35% of tumors are diagnosed at locally advanced disease, stage ⅠB2-ⅡB with an estimated 5-year overall survival of 60%. During the last decades, the initial treatment for these women has been debated and largely varies through different countries. Thus, radical concurrent chemoradiation is the standard of care in United Sated and Canada, and neoadjuvant chemotherapy followed by radical surgery is the first line of treatment in some institutions of Europe, Asia and Latin America. Until today, there is no evidence of which strategy is better over the other. This article describe the evidence as well as the advantages and disadvantages of the main strategies of treatment for women affected by uterine cervical cancer stage ⅠB2-ⅡB.

关键词： Locally advanced cervical cancer Federation of Gynecology and Obstetrics stage ⅠB2-ⅡB Radiotherapy Neoajuvant chemotherapy Radical hysterectomy