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Tumor invasion front in oral squamous cell carcinoma

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World Journal of Clinical Cases 2022年第28期10卷 10387-10390页

作者： juan Carlos Cuevas-González Maria Veronica Cuevas-González Leon francisco Espinosa-Cristobal Alejandro Donohue Cornejo Institute of Biomedical Sciences Universidad Autonoma de Ciudad JuarezJuarez 32320ChihuahuaMexico Faculty of Health Sciences Valle de las Palmas Universidad Autonoma de Baja CaliforniaTijuana 21480Baja CaliforniaMexico

Oral squamous cell carcinoma is a neoplasm that originates from the epithelial *** is usually more frequent between the fifth and sixth decades of life,and more than 90% of carcinomas of the oral cavity are squamous cell *** is an invasive neoplasia with a significant recurrence rate;40% of patients present with metastases in the cervical lymph nodes at the time of *** tumor invasion front is a characteristic of tumor growth,which can be infiltrative or *** histopathological parameters examined include the number of mitoses,depth of the tumor,invasion pattern,degree of keratinization,and nuclear *** the pathologist,these parameters are routinely evaluated but are not reported to the treating physician in all cases,which we consider to be useful information when determining the therapeutic route.

关键词： Oral squamous cell carcinoma Invasive neoplasia Therapeutic route Life Tumor growth Pleomorphism

High prevalence of hepatic steatosis and vascular thrombosis in COVID-19:A systematic review and meta-analysis of autopsy data

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World Journal of Gastroenterology 2020年第48期26卷 7693-7706页

作者： Luis Antonio Díaz francisco Idalsoaga Macarena Cannistra Roberto Candia Daniel Cabrera francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise juan Pablo Arab Department of Gastroenterology Escuela de MedicinaPontificia Universidad Católica de ChileSantiago 8320000Chile Department of Internal Medicine Pontificia Universidad Católica de ChileSantiago 8320000Chile School of Medicine Pontificia Universidad Católica de ChileSantiago 8320000Chile Facultad de Ciencias Médicas Universidad Bernardo O'HigginsSantiago 8320000Chile Department of Laboratory Medicine and Pathology Mayo Clinic RochesterMinnesotaMN 55902United States Católica de Chile Santiago 8320000Chile Division of Gastroenterology and Hepatology Mayo Clinic RochesterMinnesotaMN 55905United States

BACKGROUND Coronavirus disease 2019(COVID-19)disease can frequently affect the *** on hepatic histopathological findings in COVID-19 is *** To characterize hepatic pathological findings in patients with *** We conducted a systematic review with meta-analysis registered on PROSPERO(CRD42020192813),following PRISMA *** trials were those including patients of any age and COVID-19 diagnosis based on a molecular *** reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were *** including less than ten patients were *** were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,*** We identified 18 studies from 7 countries;all were case reports and case series from *** the patients were over 15 years old,and 67.2%were *** performed a meta-analysis of 5 studies,including 116 *** prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and *** We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver *** frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or *** studies are needed to establish the mechanisms and implications of these findings.

关键词： Pathology SARS-CoV-2 COVID-19 Autopsies Liver Liver biopsies

Effect of the interfacial electric field on the HER on Pt(111)modified with iron adatoms in alkaline media

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Chinese Journal of Catalysis 2022年第11期43卷 2826-2836页

作者： francisco J.Sarabia Víctor Climent juan M.Feliu Instituto Universitario de Electroquímica Universidad de AlicanteCarretera San Vicente del Raspeig s/nE-03690 San Vicente del RaspeigAlicanteSpain

The study of the hydrogen evolution reaction(HER)aimed to reach a deeper understanding of the parameters that control the rate of this reaction is of great importance given the technical relevance of hydrogen production as an energy vector in the so-called hydrogen *** previous works,laser-induced temperature jump(LITJ)experiments on Pt(111)modified with Ni(OH)_(2)in alkaline media have revealed the importance of the interfacial electric field in the rate of the *** was hypothesised that small amounts of Ni(OH)_(2)cause a decrease of the electric field because of a negative shift of the pzfc toward the onset of the hydrogen *** this work,to test the validity of this hypothesis,the study has been extended to Pt(111)surfaces modified with Fe(OH)_(2).The modified surfaces have been studied voltammetrically,and the voltammetric charges have been *** voltammograms show a peak in the hydrogen evolution region that suggest the transformation in the adlayer from Fe(II)to Fe(0).In agreement with the coulometric analysis,the voltammetric features in the OH adsorption region would be related with the oxidation to the+3 valence *** results obtained with LITJ method reflect the existence of a strong interaction of the Fe oxophilic species with the water molecules,shifting the potential of maximum entropy away from the onset of the ***,the most catalytic surface is the one with the lowest Fe coverage.

关键词： Hydrogen evolution reaction Iron adatoms Platinum single crystal Pt(111) Laser induced temperature jump Interfacial electric field Potential of zero charge

National assessment of the fragmentation,accessibility and anthropogenic pressure on the forests in Mexico

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Journal of Forestry Research 2012年第4期23卷 529-541页

作者： Rafael Moreno-Sanchez juan Manuel Torres-Rojo francisco Moreno-Sanchez Sue Hawkins Justin Little Susan McPartland University of Colorado Denver Department of Geography and Environmental SciencesCampus Box 172 P.O.Box 173364DenverCO 80217-3364USA. Centro de Investigación y Docencia Económicas(CIDE) Carretera México-Toluca 3655Col.Lomas de Santa FeMéxicoD.F.01210México. Instituto Nacional de Investigaciones Forestales y Agropecuarias(INIFAP) Av Progreso #5CoyoacánMéxico D.F.04100México Department of Geography and Environmental Sciences University of Colorado DenverCampus Box 172 P.O.Box 173364 DenverCO 80217-3364USA

Forest managers and policy makers increasingly demand to have access to estimates of forest fragmentation, human accessibility to forest areas and levels of anthropogenic pressure on the remaining forests to integrate them into monitoring systems, management and conservation plans. Forest fragmentation is defined as the breaking up of a forest unit, where the number of patches and the amount of expose edge increase while the amount of core area decreases. Forest fragmentation studies in Mexico have been limited to local or regional levels and have concen- trated only on specific forest types. This paper presents an assessment of the fragmentation of all forest types at the national level, their effective proximity to anthropogenic influences, and the development of an indica- tor of anthropogenic pressure on the forests areas. Broadleaf forests, tropical evergreen forests and tropical dry deciduous forests show the greatest fragmentation. Almost half （47%） of the tropical forests are in close effective proximity to anthropogenic influences and only 12% of their area can be considered isolated from anthropogenic influences. The values for the temperate forests are 23% and 29% respectively. Anthro- pogenic pressure in the immediate vicinity of anthropogenic activities is much higher in the tropical forests （75 in a scale 0-100） than in the tem- perate forests （30）. When considering these results jointly, the tropical forests, and more specifically, the tropical evergreen forests and tropical dry deciduous forests are under the greatest pressure and risks of degra- dation.

关键词： forest fragmentation effective proximity anthropogenicpressure Mexico forests GIS.

Leaching kinetics in cyanide media of Ag contained in the industrial mining-metallurgical wastes in the state of Hidalgo, Mexico

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International Journal of Mining Science and Technology 2014年第5期24卷 689-694页

作者： juan Hernandez francisco Patino Isauro Rivera Iván Alejandro Reyes Misrael Uriel Flores Julio Cesar Juarez Martín Reyes Research Centre in Materials and Metallurgy Autonomous University of Hidalgo Pachuca 42184 Mexico

The leaching kinetics in cyanide media of the silver contained in the Dos Carlos waste tailings at the City of Pachuca de Soto, Hidalgo State, Mexico were carried out. The used material contained the following chemical composition: 56 10-6of Ag, 0.6 10 6of Au and 70.43%(by weight) of SiO2; 7.032%(by weight) of Al2O3; 2.69%(by weight) of Fe; 0.46%(by weight) of Mn; 3.98%(by weight) of K2O; 3.34%(by weight) of CaO; 2.50%(by weight) of Na2O; 0.04%(by weight) of Zn; 0.026%(by weight) of Pb. The mineralogical phases present were the following: Silica, albite, argentite, berlinite, orthoclase, potassium jarosite, and natrojarosite. In the leaching kinetics in cyanide media, and under the studied conditions,the effect of the CN concentration on the reaction rate has no effect on the whole process of alkaline cyanidation, of which the reaction order is n 0. Temperature has an effect on the cyanidation rate of the reaction, with an activation energy of 47.9 KJ/mol. At the same time, when the particle size decreases there is an increase in the reaction rate, which is inversely proportional to the particle diameter; when increasing the NaOH concentration there is an increase in the reaction rate Kexp, with a reaction order(n) of 0.215 under the studied ranges.

关键词： Silver Waste tailings Cyanidation Leaching

Early pancreatic cancer in Ig G4-related pancreatic mass:A case report

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World Journal of Gastrointestinal Surgery 2019年第12期11卷 443-448页

作者： juan Glinka francisco Calderón Martín de Santibanes Sung Ho Hyon Adrián Gadano Eduardo Mullen Melina Pol juan Spina Eduardo de Santibanes Department of General Surgery Hepato-bilio-pancreatic UnitHospital Italiano de Buenos AiresBuenos Aires C1181ACHArgentina Department of General Surgery Image Guided Minimally Invasive Surgery UnitHospital Italiano de Buenos AiresBuenos Aires C1181ACHArgentina Hepatology Section Hospital Italiano Buenos AiresBuenos Aires C1181ACHArgentina Department of Surgical Pathology Hospital Italiano de Buenos AiresBuenos Aires C1181ACHArgentina Department of Radiology Hospital Italiano de Buenos AiresBuenos Aires C1181ACHArgentina

BACKGROUND IgG4-related disease can manifest diversely,including autoimmune pancreatitis and IgG4-related *** are reporting a very unusual cause of pancreatic cancer triggered in a previously unknown IgG4-related *** SUMMARY A 75-year-old man was diagnosed with a 43 mm×33 mm pancreatic head tumor after consulting for abdominal pain and jaundice.A pancreaticoduodenectomy was carried out uneventfully,and the histopathology report showed an early stage of acinar-cell pancreatic *** patient reconsulted on the 30th postoperative day with fever,jaundice and *** resonance cholangiopancreatography evidenced an extense bile duct stricture.A percutaneous biliary drainage proved to be ineffective,even after exchanging it with larger bore *** the surgical specimen,features compatible with IgG4-related disease were ***,empiric treatment with steroids was initiated achieving excellent *** IgG4-related disease may cause chronic inflammation of the pancreas and can condition pancreatic malignancies.

关键词： Autoimmune pancreatitis Pancreatic adenocarcinoma Pancreatic cancer IgG4 IgG4-related disease Case report

Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado francisco J.Llorente-Cantarero juan francisco Pascual-Gázquez Kirsten K.Ness Vicente Martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

Integrating time progression in ecoimmunology studies: beyond immune response intensity

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Current Zoology 2019年第2期65卷 205-212页

作者： francisco Javier ZAMORA-CAMACHO Department of Biological Sciences Dartmouth College Hanover New Hampshire USA Department of Biogeography and Global Change Museo Nacional de Ciencias Naturales (MNCN) Spanish National Research Council (CSIC) Madrid Spain

Habitat alterations in agroecosystems may damage amphibian immune capacity. As agroecosystem extension is increasing worldwide, broader-context knowledge on the effects of agroecosystem stressful conditions on amphibian immune capacity is crucial for understanding and management of amphibian global declines. However, most studies on ecoimmunology assume synchronal amonggroup immune-response peaks, and focus on immune response after standardized time lapses, neglecting its progress!on. Herein, I compared inflamatory response short-term progression of agro ecosystem and n atural-habitat female and male n atterjack toads Epi da lea calamita, by measuri ng swelling response, once per hour, 6 h following an artificial immune challenge with innocuous antigen phytohemagglutinin. I also compared maximum magnitude of swelling response, irrespective of the moment when it was reached. Habitat differences arose only 3 h after challenge, when naturalhabitat toads showed greater swelling response. Maximum magnitude of swelling response was similar in toads from both habitats. However, agroecosystem toads showed a delayed swelling response as compared with natural-habitat conspecifics, probably as a consequenee of agroecosystem stressful conditions. Such a delay suggests a weaker immune capacity, and consequently impaired anti-pathogen performance. Regarding sex, swelling response magnitude did not differ between males and females. Female swelling response peaked earlier, but that of males was more sustai ned in time, which con tradicts general across-taxa fin dings that males show impaired immune response. Interestingly, results suggest that measuring swelling response only after some standardized period following stimulation may be a simplistic approach and produce unrealistic results. Consequently, studies on ecoimmunology should implement swelling response progression in order to produce unbiased science.

关键词： agroecosystem amphibian immunocompetence natural habitat immune response progressi on

A bibliometric review of cryptocurrencies:how have they grown?

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Financial Innovation 2022年第1期8卷 25-55页

作者： francisco Javier García-Corral JoséAntonio Cordero-García Jaime de Pablo-Valenciano juan Uribe-Toril Research Group:Almeria Group of Applied Economy(SEJ 147) University of AlmeriaCarretera Sacramento s/n04120La Cañada de San UrbanoAlmeríaSpain Department of Law Financial and Tax LawUniversity of AlmeriaCarretera Sacramento s/n04120La Cañada de San UrbanoAlmeríaSpain Department of Business and Economics Applied Economic AreaUniversity of AlmeríaCarretera Sacramento s/n04120La Cañada de San UrbanoAlmeríaSpain

With the development of new technologies,some concepts become relevant in the economic area,as is the case with cryptocurrencies,in general,or Bitcoin and Ethereum,in *** to the impact of these tools,a detailed bibliometric study that allows us to obtain all information about cryptocurrencies must be *** study will help scientific production by specifying the development and lines of related research that have been followed and are currently being *** have used Tableau,R(Bibliometrix R Package),and VOSviewer software to analyze the *** have been combined to create and review unified metadata from the Web of Science(WoS)and Scopus *** bibliometric analysis shows 771 articles on the WoS database and 648 articles on Scopus published between 2010 and early *** present the most relevant articles,research areas,countries,institu-tions,authors,journals,and trends during the last few *** conclusion,the number of publications has grown in the last 3 *** analysis shows the evolution of block-chain technology used in this type of *** review of this period marks a possible end to the historical part of cryptocurrencies,thereby opening the current topic to its multiple applications.

关键词： Cryptocurrency Bitcoin Ethereum Bibliometric analysis Business and economics