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Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer＇s Disease

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Chinese Medical Journal 2017年第24期130卷 2978-2990页

作者： Xi-Lin Wu juan pina-Crespo Yun-Wu Zhang Xiao-Chun Chen Hua-Xi Xu Neuroscience Initiative Neuroscience and Aging Research Center Sanford Burnham Prebys Medical Discovery Institute La Jolla CA 92037 USA Department of Neurology Fujian Institute of Geriatrics Fujian Medical University Union Hospital Fujian Key Laboratory of Molecular Neurology Fujian Medical University Fuzhou Fujian 350001 China Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of Neuroscience College of Medicine Xiamen University XiamenFujian 361102 China

Objective：To review recent research advances on tau,a major player in Alzheimer＇s disease （AD） pathogenesis,a biomarker for AD onset,and potential target for AD *** Sources：This review was based on a comprehensive search using online literature databases,including PubMed,Web of Science,and Google *** Selection：Literature search was based on the following keywords：Alzheimer＇s disease,tau protein,biomarker,cerebrospinal fluid （CSF）,therapeutics,plasma,imaging,propagation,spreading,seeding,prion,conformational templating,and posttranslational *** articles were carefully reviewed,with no exclusions applied to study design and publication ***：Amyloid plaques enriched with extracellular amyloid beta （Aβ） and intracellular neurofibrillary tangles comprised of hyperphosphorylated tau proteins are the two main pathological hallmarks *** the Aβ hypothesis has dominated AD research for many years,clinical Aβ-targeting strategies have consistently failed to effectively treat AD or prevent AD *** research focus in AD has recently shifted to the role oftau in *** addition to phosphorylation,tau is acetylated and proteolytically cleaved,which also contribute to its physiological and pathological *** evidence characterizing pathological tau propagation and spreading provides new avenues for research into the molecular and cellular mechanisms underlying AD *** to detect tau at minute levels in CSF and blood have been developed,and improved tracers have facilitated tau imaging in the *** advances have potential to accurately determine tau levels at early diagnostic stages in *** that tau is a potential therapeutic target,anti-tau immunotherapy may potentially be a viable treatment strategy in AD ***：Detecting changes in tau and targeting tau pathology represent a promising lead in the diagnosis and treatment of AD.

关键词： Alzheimer's Disease Biomarker lmmunotherapy Tau Imaging Tau Protein Transcellular Propagation

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Impact of Organic and Mineral Fertilization in Pecan Nut on Production,Quality and Antioxidant Capacity

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Agricultural Sciences 2019年第2期10卷 227-240页

作者： Linda Citlalli Noperi-Mosqueda juan Manuel Soto-Parra Esteban Sánchez Francisco Javier pina-Ramírez Ramona Pérez-Leal María Antonia Flores-Córdova Nora Aideé Salas-Salazar Facultad de Ciencias Agrotecnológicas Universidad Autónoma de ChihuahuaChihuahuaMéxico Centro de Investigación en Alimentación y Desarrollo A.C.Delicias ChihuahuaMéxico

The pecan nut is considered one of the most important dried fruits in the world by its classification as healthy food. The nutritional balance in the harvest is crucial for its impact on the production, quality and content of bioactive compounds. This research was carried out in the city of Aldama, Chihuahua (Mexico), where doses of mineral and organic fertilization were tested in L25 Taguchi structure with 6 factors and 5 levels by factor: nitrogen (N) 0 - 240 kg·ha-1, phosphate (P2O5) 0 - 120 kg·ha-1, potassium (K2O) 0 - 100 kg·ha-1, calcium (CaO) 0 - 400 kg·ha-1, liquid humus 0 - 3600 L·ha-1 and solid humus 0 - 8000 kg·ha-1. An average yield of 2.2 t·ha-1 was obtained;145 nuts per kilogram, 60% of the edible part of the nut. The total phenolic content was 225.9 mg gallic acid g-1 and the antioxidant capacity was 180.9 mg Trolox g-1. It is concluded that the factor with the greatest impact on yield, quality and antioxidant capacity in pecan nut was nitrogen. It was also found that the combination of mineral and organic fertilization helps to maintain the production and quality ranges of the nut. In turn, these factors contribute to the increase in the phenolic strength and antioxidant capacity. The optimal fertilization dosis to obtain the maximum levels in production of 3.2 t·ha-1;decrease the number of nuts per kilogram to 135, increase the percentage of the edible part of the nut to 61.8%, the increase in the total phenolic content to 318.6 mg of gallic acid g-1 and in the antioxidant capacity with 187.2 mg of Trolox g-1, was 184 kg·ha-1 of N, 107.4 kg·ha-1 of P2O5, 50 kg·ha-1 of K2O y 2777 L·ha-1 of liquid humus. Finally, the mineral fertilization complemented with organic fertilization is considered a good fertilization strategy for pecan trees and its possible benefits to health and the environment.

关键词： Carya illinoinensis(Wangen K.Koch) Pecan Nut Nutrition Organic Fertilization Antioxidants

Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population

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Neuroscience Bulletin 2018年第5期34卷 867-869页

作者： Hong Pan Jun-Yi Shen juan-juan Du Shi-Shuang Cui Jin Liu Yi-Qi Lin Yi-Xi He Yang Fu Chao Gao Gen Li Sheng-Di Chen Jian-Fang Ma Laboratory of Neurodegenerative Diseases Institute of Health Sciences Shanghai Institutes for Biological SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Department of Neurology and Collaborative Innovation Center for Brain Science Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Recently, several single nucleotide polymorphisms （SNPs; rs34094401 on RAD51B, rs41309351 on CPXM1, rs143555311 on MPHOSPHIO, rs141620200 on SER- pina1, and rs2424913 on DNMT3B） have been associated with Parkinson＇s disease （PD） in Caucasians [1-3]. Con- sidering the genetic variance among different ethnic populations, it is essential to know whether these candidate SNPs are also associated with PD in other ethnic cohorts. Therefore, we investigated these newly-reported risk SNPs in 249 PD patients and 239 controls to test their association with PD.

关键词： As

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西班牙阿尔卡萨尔德圣胡安旅游办公室

现代装饰 2015年第11期 62-67页

作者： David Pérez Rocio pina Carmelo Rodriguez Enrique Espinosa Javier de Paz Garcia 姜敏华 PKMN Architectures

传统的旅游办公厅往往张贴着一些具有当地特色的景点海报,或是摆放极具特色的纪念品,而本案则是一间外表看似如同店铺的旅游办公室。项目位于西班牙阿尔卡萨尔德圣胡安,由PKMN建筑事务所设计。乍一看,这似乎是一个除了几把＂座椅＂,连... 详细信息

传统的旅游办公厅往往张贴着一些具有当地特色的景点海报,或是摆放极具特色的纪念品,而本案则是一间外表看似如同店铺的旅游办公室。项目位于西班牙阿尔卡萨尔德圣胡安,由PKMN建筑事务所设计。乍一看,这似乎是一个除了几把＂座椅＂,连个像样的家具都没有的空间,身处其中,却能深切地感受到轻松惬意的氛围。

关键词：圣胡安卡萨阿尔建筑事务所雕刻艺术品动态效果几何造型陶壶工作区堂吉诃德

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软质小麦品质的辅助选择

麦类作物学报 2007年第3期27卷 445-450页

作者：周淼平吴宏亚余桂红任丽娟马鸿翔江苏省农业科学院农业生物技术研究所江苏南京210014 江苏里下河地区农业科学研究所江苏扬州225007

为建立软质小麦品质的筛选和评价体系,对黄淮麦区和长江下游麦区20个不同硬度小麦品种的Puroindoline基因型以及全麦粉和面粉的部分相关品质性状进行了检测。结果表明,20个品种中,2个品种为pina-D1b硬质突变型,6个品种为Pinb-D1b硬质突... 详细信息

为建立软质小麦品质的筛选和评价体系,对黄淮麦区和长江下游麦区20个不同硬度小麦品种的Puroindoline基因型以及全麦粉和面粉的部分相关品质性状进行了检测。结果表明,20个品种中,2个品种为pina-D1b硬质突变型,6个品种为Pinb-D1b硬质突变型,其余12个品种为软质小麦;硬、软质小麦的全麦粉硬度和SDS沉淀值的差异均达到极显著水平,但碱水保持力差异不显著;硬、软质小麦面粉的碱水保持力和溶剂保持力均达到极显著差异。性状间的相关分析表明,全麦粉硬度与SDS沉淀值、面粉的碱水保持力、水溶剂保持力、碳酸钠溶剂保持力、蔗糖溶剂保持力均呈极显著相关,相关系数分别为0.64、0.94、0.94、0.91和0.81,SDS沉淀值与乳酸溶剂保持力相关也极显著,相关系数0.80。这些结果说明Puroindoline基因型检测、全麦粉硬度和SDS沉淀值检测可以作为软质小麦的早代筛选方法。

关键词：小麦硬度 Puroindoline基因品质

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