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The molecular interaction of ADAMTS-1 and fibulin-1 and its potential contribution to breast cancer biology

Journal of Cancer Metastasis and Treatment 2019年第5期4卷 1-15页

作者： Yamina Mohamedi Tania Fontanil Teresa cobo Jose A.Vega juan L.cobo Olivia García-Suárez juan cobo Santiago Cal Alvaro J.Obaya Departamento de Bioquímica y Biología Molecular Universidad de OviedoOviedo 33006AsturiasSpain Instituto Universitario de Oncología IUOPAUniversidad de OviedoOviedo 33006AsturiasSpain Departamento de Investigación Clínica OrdonezOviedo 33012AsturiasSpain Instituto Asturiano de Odontología Universidad de OviedoOviedo 33006AsturiasSpain Departamento de Cirugía y Especialidades Médico-Quirúrgicas Universidad de OviedoOviedo 33006AsturiasSpain Departamento de Morfología y Biología Celular Facultad de MedicinaUniversidad de OviedoOviedo 33006AsturiasSpain Facultad de Ciencias de la Salud Universidad Autónoma de ChileProvidenciaSantiago 7500912Chile Servicio de Cirugía Maxilofacial Hospital Universitario Central de Asturias(HUCA)Oviedo 33011AsturiasSpain Departamento de Biología Funcional Area de FisiologíaUniversidad de OviedoOviedo 33006AsturiasSpain

Aim: Fibulins and ADAMTSs are two families of extracellular matrix proteins implicated in key functional and pathological processes. The fact that the fibulin-1 and ADAMTS-1 proteins interact raises new questions about the roles of these extracellular matrix proteins in modulating tumor progression. Herein, we described the functional implications of the interaction between fibulin-1 and ADAMTS-1 on the behavior of breast cancer cell lines. Methods: Fibulin-1 and ADAMTS-1 were exogenously expressed in MCF-7 and MDA-MB-231 cell lines to assay the effect of their interaction in cellular properties. Results: ADAMTS-1 expression exacerbates tumor effects in terms of proliferation, invasion and mammosphere formation. In contrast, the simultaneous expression of ADAMTS-1 and fibulin-1 impairs these effects. The analysis of the expression of both proteins in human breast cancer tissue arrays provides new insights into the complex roles of fibulin-1 and ADAMTS-1 in this type of tumor. ;Conclusion: Our results suggests that the interaction between ADAMTS-1 and fibulin-1 induces a pronounced anti-tumoral effect.

关键词： ADAMTS-1 fibulin-1 cell migration cell proliferation breast cancer MCF-7 MDA-MB-231

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Relevant Aspects of Expert Interest in the Perception of the Facial Aesthetic Damage

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Forensic Medicine and Anatomy Research 2020年第1期8卷 1-10页

作者： Luiz Eugênio Nigro Mazzilli Nelson Massanobu Sakaguti Mário Marques Fernandes juan Antonio cobo Plana Fernanda Capurucho Horta Bouchardet Rogério Nogueira de Oliveira Forensic Dentistry Department of Social Dentistry University of São Paulo São Paulo Brazil Institute of Legal Medicine Zaragoza Spain

Forensic aesthetic facial damage—AFD expert’s valuation is a concerning matter in court as expressively vary in between experts. In fact, differences can be quite significant suggesting examiners age, sex and professional qualification may influence this valuation. Aiming to offer a systematic and more objective evaluation, some methods for assessing AFD had been proposed lately. Known as Aesthetic Impairment Impact Perception (AIPE), cobo-Plana’s revised methodology (2010) was idealized to minimize the examiner’s subjectivity by means of answering an ordered sequence of questions related to the specific damage perception. This research aims to access AFD perception differences (simulated cases) in between Lawyers, Heath professionals (Physicians and Dental surgeons) and general professionals (laypeople) under AIPE methodology in order to allow a better comprehension of AFD when dealing with forensic expertise cases. Within Groups perceptions varied (p < 0.05) when evaluating lesions below “important” severity grade. Raters over 35 Years age scored higher AFD lesions, and rater’s sex (as an independent variable) did not express any significant difference in AFD scoring. The tendency of under-rating AFD lesions below very important severity grade was observed being a matter of major concern considered their prevalence and the effective consequences involved to the victim. These results recommend extra caution when performing AFD evaluation and consequently expertise reports, claiming a more judicious analysis based on consolidated standards and suggest, examiners to be more perceptive to physical damage evaluation in order to include social perceptions and reactions, mainly, victims feelings and constrains over their aesthetic loss.

关键词： Aesthetic Facial Damage Aesthetic Facial Damage Society

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Variation in SARS-CoV-2 seroprevalence in children in the region of Asturias,Northern Spain

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World Journal of Pediatrics 2022年第12期18卷 835-844页

作者： Elisa García-García Mercedes Rodríguez-Pérez David Pérez-Solís Carlos Pérez-Méndez Cristina Molinos-Norniella Ángeles cobo-Ruisánchez Eva María Fernández Fernández Noelia García González Laura Calle-Miguel Pediatrics Department Centro de Salud LaviadaCalle Juanín de Mieres833207GijónSpain Microbiology Department Hospital Universitario Central de AsturiasOviedoSpain Pediatrics Department Hospital Universitario San AgustínAvilésSpain Pediatrics Department Hospital Universitario de CabueñesGijónSpain Pediatrics Department Hospital Carmen y Severo Ochoa.Cangas del NarceaSpain Pediatrics Department Centro de Salud TeatinosOviedoSpain Pediatrics Department Hospital Universitario Central de AsturiasOviedoSpain

Background Updated seroprevalence estimates are important to describe the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)landscape and to guide public health *** aims are to describe longitudinal changes in seroprevalence in children in a region in Northern Spain and to analyze factors associated with SARS-CoV-2 *** Prospective multicenter longitudinal study with subjects recruited from July to September ***(up to 14 years old)were included and followed up until September *** blood samples were collected every six months during three testing rounds and were analyzed for SARS-CoV-2 *** data regarding epidemiological features,contact tracing,symptoms,and virological tests were *** evolution of SARS-CoV-2 seroprevalence during the study and the differences between children with positive and negative SARS-CoV-2 antibody tests were *** Two hundred children were recruited(50.5%girls,median age 9.7 years).The overall seroprevalence increased from round 1[1.5%,95%confidence interval(CI)0.3%–4.3%]to round 2(9.1%,95%CI 4.6%–12.7%)and round 3(16.6%,95%CI 9.5%–19.6%)(P<0.001).Main changes occurred in children aged zero to four years(P=0.001)who lived in urban areas(P<0.001).None of the children who were previously positive became *** multivariable analysis,three variables independently associated with SARS-CoV-2 seropositivity were identified:close contact with coronavirus disease 2019(COVID-19)confirmed or suspected cases[odds ratio(OR)=3.9,95%CI 1.2–12.5],previous positive virological test(OR=17.1,95%CI 3.7–78.3)and fatigue(OR=18.1,95%CI 1.7–193.4).Conclusions SARS-CoV-2 seroprevalence in children has remarkably increased during the time of our *** was the only COVID-19-compatible symptom that was more frequent in seropositive than in seronegative children.

关键词： Antibodies Child COVID-19 Seroepidemiologic studies

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