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TLR4 Knockout Attenuates BDL-induced Liver Cholestatic Injury through Amino Acid and Choline Metabolic Pathways

Current Medical Science 2021年第3期41卷 572-580页

作者： Shou-hua ZHANG Meng-jie YU Jin-long YAN ju-hua xiao Yu xiao Jia-le YANG jun LEI Xin YU Wei-long CHEN Yong CHAI Department of General Surgery Jiangxi Provincial Children's HospitalNanchang 330006China Key Laboratory of Drug Metabolism and Pharmacokinetics China Pharmaceutical UniversityNanjing 210009China Department of General Surgery Second Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Ultrasound Jiangxi Provincial Maternal and Child Health HospitalNanchang 330006China department of Ophthalmology Jiangxi Provincial Children's HospitalNanchang 330006China

The exact mechanism by which knockout of Toll-like receptor 4(TLR4)attenuates the liver injury remains *** present study aimed to examine the role of TLR4 in the pathogenesis of bile duct ligation(BDL)-induced liver cholestatic injury and the underlying *** type(WT)mice and TLR4 knockout(TLR4-KO)mice were used for the establishment of the BDL *** were applied to analyze the changes of small molecular metabolites in the serum and liver of the two *** serum biochemical indexes and the HE staining results of liver tissue showed that liver damage was significantly reduced in TLR4-KO mice after BDL when compared with that in WT *** metabolite analysis results showed that TLR4 KO could maintain the metabolisms of amino acids-and choline-related *** BDL,the amino acids-and choline-related metabolites,especially choline and 3-hydroxybutyrate,were significantly increased in WT mice(both in serum and liver),but these metabolites in the liver of TLR4-KO mice after BLD were not significant different from those before *** conclusion,TLR4 KO could attenuate BDL-induced liver cholestatic injury through regulating amino acid and choline metabolic pathways.

关键词： Toll-like receptor 4 biliary obstruction metabolomics liver bile duct ligation

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A Mean-Field Game for a Forward-Backward Stochastic System With Partial Observation and Common Noise

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 746-759页

作者： Pengyan huang Guangchen Wang Shujun Wang hua xiao the School of Control Science and Engineering Shandong University the School of Statistics and Mathematics Shandong University of Finance and Economics IEEE the School of Management Shandong University the School of Mathematics and Statistics Shandong University

This paper considers a linear-quadratic(LQ) meanfield game governed by a forward-backward stochastic system with partial observation and common noise,where a coupling structure enters state equations,cost functionals and observation ***,to reduce the complexity of solving the meanfield game,a limiting control problem is *** virtue of the decomposition approach,an admissible control set is *** a filter technique and dimensional-expansion technique,a decentralized control strategy and a consistency condition system are derived,and the related solvability is also ***,we discuss an approximate Nash equilibrium property of the decentralized control ***,we work out a financial problem with some numerical simulations.

关键词： Decentralized control strategy ϵ-Nash equilibrium forward-backward stochastic system mean-field game partial observation

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Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions

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World Journal of Gastroenterology 2024年第14期30卷 1968-1981页

作者： Hong-ju Sun Bo Jiao Yan Wang Yue-hua Zhang Ge Chen Zi-Xuan Wang Hong Zhao Qing Xie xiao-hua Song Department of General Medicine Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Gastroenterology Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Medical Administration Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Qingdao Medical College Qingdao UniversityQingdao 266042Shandong ProvinceChina Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver ***,the disease is underappreciated as a remarkable chronic disorder as there are rare managing *** studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic ***,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular *** the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the *** study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic ***,further studies are necessary.

关键词： Nonalcoholic fatty liver disease Apoptosis Necroptosis Cell death Diagnosis Treatment

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Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure

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Chinese Journal of Integrative Medicine 2024年第5期30卷 458-467页

作者： HU Yu-xuan QIU Sheng-lei SHANG ju-ju WANG Zi LAI xiao-lei Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China

Although there have been significant advances in the treatment of heart failure in recent years,chronic heart failure remains a leading cause of cardiovascular disease-related *** studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart ***,most of the drugs that increase cardiac energy are still in the theoretical or testing *** research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate *** this review,we summarized the mechanisms by which botanical drugs(the active ingredients/formulas/Chinese patent medicines)improve substrate utilization and promote myocardial energy metabolism by activating AMP-activated protein kinase(AMPK),peroxisome proliferator-activated receptors(PPARs)and other related *** the same time,some potential protective effects of botanical drugs on myocardium,such as alleviating oxidative stress and dysbiosis signaling,caused by metabolic disorders,were briefly discussed.

关键词： botanical drugs chronic heart failure myocardial metabolism pharmacological effects review

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Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 186-194页

作者： Meng-xiao Feng hua Zou Yuan-Qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and ***,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide poisoning in *** study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide ***:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning from june 2022 to july *** entire course of the incidents was described in *** 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass ***-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic ***:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective *** typical course of 2-amino-5-chloro-N,3-dimethylbenzamide poisoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical *** and fever may be the important premonitory symptoms for further organ *** chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and *** patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive *** patient survived by liver *** postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual ***:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide Poisoning Clinical characteristics Liver injury

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Maximum Principle for Stochastic Control System with Elephant Memory and jump Diffusion

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Journal of Systems Science & Complexity 2024年第4期37卷 1392-1412页

作者： FENG Siqi GAO Lei WANG Guangchen xiao hua School of Control Science and Engineering Shandong UniversityJinan 250061China School of Economics Shandong UniversityJinan 250100China School of Mathematics and Statistics Shandong UniversityWeihai 264209China

Motivated by a duopoly game problem,the authors study an optimal control problem where the system is driven by Brownian motion and Poisson point process and has elephant memory for the control variable and the state ***,the authors establish the unique solvability of an anticipated backward stochastic differential equation,derive a stochastic maximum principle,and prove a verification theorem for the aforementioned optimal control ***,the authors generalize these results to nonzero-sum stochastic differential game ***,the authors apply the theoretical results to the duopoly game problem and obtain the corresponding Nash equilibrium solution.

关键词： Anticipated backward stochastic differential equation elephant memory Fréchet derivative maximum principle stochastic delayed differential equation

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Cretaceous magmatic arc in Hainan and the peri-South China Sea asevidenced by geochemical fingerprinting of granitoids in the region

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Geoscience Frontiers 2024年第5期15卷 355-371页

作者： xiao-Yan Jiang Yildirim Dilek Xian-hua Li State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Department of Geology and Environmental Earth Science Miami UniversityOxfordOH 45056USA

Mesozoic magmatic rocks occur widely in the South China Block and are generally interpreted as the manifestations of the subduction of the Paleo-Pacific oceanic lithosphere beneath *** magmatism in southeast(SE)China continued from the Late Permian through the Late Cretaceous with an inferred lull between 125 Ma and 115 Ma that is known in the literature as the Cretaceous"magmatic quiescence".We report in-situ zircon U-Pb ages,Hf-O and whole-rock Sr-Nd isotopes,and whole-rock geochemistry of Cretaceous granitoids on Hainan Island and discuss their magmatic evolution within the framework of the Late Mesozoic geodynamics of SE *** recognize two main stages of the emplacement of Cretaceous granitoids on Hainan,first around 120 Ma and then around 100-95 Ma,displaying high-K calc-alkaline,I-type geochemical *** in both age groups are enriched in LILE and LREE,but depleted in Nb,Ta,Ba,Sr,and *** 120 Ma granites have zircon ε_(Hf)(t)values of-2.6 to 2.3 corresponding to Hf crustal model ages,ranging from 0.79 Ga to 1.03 Ga,and δ^(18)O values ranging from 6.9‰to 7.7‰.Zircons from 100-95 Ma granites have ε_(Hf)(t)values of-4.2 to 1.1 corresponding to Hf crustal model ages of 1.08 Ga to 1.42 Ga,and δ^(18)O values ranging from 6.7‰to 8.4‰.Increasing ε_(Hf)(t)values of the Cretaceous Hainan granites with younger crystallization ages indicate addition of more juvenile components and reworking of crustal material into their melt *** ε_(Nd)(t)values of the 120 Ma and 100-95 Ma granitoids range between-4.1 to-0.4 and-7.7 to-4.0,*** calculated two-stage model age of the 100-95 Ma granitoids clusters between 1.25 Ga and 1.53 *** isotopic data suggest that magmas of the Cretaceous granitoids were produced by partial melting of Mesoproterozoic metabasaltic rocks,which make up much of the crystalline basement of the southern Cathaysia *** geochemical and isotopic characteristics of the Cretaceous granitoids on H

关键词： I-type granites Cretaceous Hainan Island Southeast China Magmatic arc peri-South China Sea region

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Advances of biomarkers in nasopharyngeal carcinoma’s early detection

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Science Bulletin 2024年第2期69卷 141-145页

作者： xiao-Hui Zheng Allan Hildesheim Wei-hua Jia State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Costa Rican Agency for Biomedical Investigation INCIENSA FoundationSan Jose 10108Costa Rica

Nasopharyngeal carcinoma(NPC),a highly invasive and metastatic cancer,is widely prevalent in South China,Southeast Asia,and North *** patients with stages I and II are often ***,NPC patients are usually diagnosed with advanced-stage(stages III and IV)at their first *** of NPC at early stage is the key to improve the survival of ***-Barr virus(EBV)plays an essential role in NPC occurrence in endemic ***-based biomarkers,including EBV antibody in serum and EBV DNA in plasma,have been specifically proposed for NPC early ***,we summarize recent advances in biomarkers for the early detection of NPC.

关键词： patients nasopharyngeal Nasopharyngeal

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Optimal scheduling of flexible grid-side resources and auxiliary service cost allocation model considering renewable-energy penetration

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Clean Energy 2024年第4期8卷 90-102页

作者： Bin Bai Yanli xiao Rui Zhao Xin ju Shangke Liu State Grid Ningxia Electric Power Co. Ltd.Economic Technology Research InstituteYinchuan 750011China

Renewable energy has penetrated power grid enterprises on a large *** to the intermittency and volatility of renewable energy generation,it is necessary to build new flexible grid-side resources to ensure the safe and stable operation of the power grid,which will cause great pressure on cost allocation for power grid *** article considers four types of flexible grid-side resources and constructs a dual-level configuration optimization model for flexible grid-side resources under the penetration of renewable en*** on the configuration results,the cost scale of flexible grid-side resources is estimated and an improved ancillary service cost allocation model based on the Shapley value method is proposed to smooth the allocation of ancillary service costs in the cost of flexible grid-side resources between the two main bodies of renewable energy and *** calculation results show that,when the penetration rate of renewable-energy power is 30%and 35%,respectively,the cost of flexible grid-side resources is 9.606 billion yuan and 21.518 billion yuan,*** proportion of ancillary service costs allocated to load is relatively high-about five times that of the ancillary service costs allocated to renewable energy-and the higher the penetration rate of renewable energy,the higher the proportion of ancillary service costs allocated to renewable energy.

关键词： renewable-energy penetration flexible grid-side resources ancillary service costs Shapley allocation model

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Creep-Resistant Covalent Adaptable Networks with Excellent SelfHealing and Reprocessing Performance via Phase-Locked Dynamic Covalent Benzopyrazole-Urea Bonds

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Chinese Journal of Polymer Science 2024年第10期42卷 1545-1556,I0013页

作者： Miao Xie xiao-Rong Wang Zhan-hua Wang He-Sheng Xia State Key Laboratory of Polymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu610065China School of Petrochemical Engineering Liaoning Petrochemical UniversityFushun113001China

Covalent adaptive networks(CANs)are capable of undergoing segment rearrangement after being heated,which endows the materials with excellent self-healing and reprocessing performance,providing an efficient solution to the environment pollution caused by the plastic *** main challenge remains in developing CANs with both excellent reprocessing performance and creep-resistance *** this study,a series of CANs containing dynamic covalent benzopyrazole-urea bonds were developed based on the addition reaction between benzopyrazole and isocyanate *** calculation confirmed that relatively low dissociation energy is obtained through undergoing a five-member ring transition state,confirming excellent dynamic property of the benzopyrazole-urea *** verified by the FTIR results,this nice dynamic property can be well maintained after incorporating the benzopyrazole-urea bonds into polymer *** self-healing and reprocessing performance is observed by the 3-ABP/PDMS elastomers owing to the dynamic benzopyrazole-urea *** separation induced by the aggregation of the hard segments locked the benzopyrazole-urea bonds,which also makes the elastomers display excellent creep-resistance *** hard phase locking strategy provides an efficient approach to design CANs materials with both excellent reprocessing and creep-resistance performance.

关键词： Covalent adaptive networks Self-healing polymer Dynamic covalent bond

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