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Gastrointestinal tuberculosis is not associated with proton pump inhibitors:A retrospective cohort study

World Journal of Gastroenterology 2013年第2期19卷 258-264页

作者： Kyoung Sup Hong Seung Joo Kang Jong Kyoung Choi ju han kim Heewon Seo Suehyun Lee Jae-Woo jung Hye-Ryun Kang Sang-Heon Cho Joo Sung kim Department of Internal Medicine Drug Safety Monitoring CenterSeoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Department of Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Division of Biomedical Informatics Systems Biomedical Informatics Research CenterSeoul National University College of MedicineSeoul 110799South Korea

AIM:To evaluate the effect of proton pump inhibitors(PPIs) on the development of gastrointestinal ***:All patients who were more than 20 years old and who had received a prescription for PPIs among those who visited Seoul National University Hospital from January 1,2005 to December 31,2009 were *** to the low sensitivity of the microbiologic test and the nonspecific pathologic findings,the diagnosis of gastrointestinal tuberculosis was confirmed through the presence of active ulcerations and the responses to anti-tuberculosis *** patients were divided into two groups according to treatment duration(group 1:≤ 3 mo;group 2:> 3 mo) and were followed up from the time they took the first prescription of PPIs until their last *** regression analysis was used to calculate the relative risks(RR) and 95%CI,adjusting for ***:Among the 61 834 patients exposed to PPIs(50 534 in group 1;11 300 in group 2),21 patients were diagnosed with PPI-associated gastrointestinal tuberculosis during 124 274 person-years of *** 21 patients,the 12 who revealed only scar changes in the colonoscopy were excluded from the statistical *** those who remained,2 were excluded because they underwent gastrointestinal endoscopy within 4 wk of the first prescription for *** exposure to PPI was associated with a higher mean age(55.0 ± 14.5 in group 1 vs 58.2 ± 13.3 in group 2,P han-three-month PPI treatment period in group 1,the over-three-month PPI therapy period in group 2 was not associated with increased risk of acquiring gastrointestinal tuberculosis,after adjusting for age and co-morbidities,whereas the Charlson co-morbidity index was associated

关键词： Proton pump inhibitor Acid suppression Tuberculosis Gastrointestinal tuberculosis Tuberculous colitis

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Catalytic Performance of Carbon Smoke over Ag-LSCF Composite Catalysts

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 30-34页

作者： GUO Guanlun han Ming LU Shaomin YU Jing ju Hongling 无 Hubei Key Laboratory of Advanced Technology for Automotive Components&Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China College of Mechanical and Transportation Southwest Forestry UniversityKunming 650000China

To improve the catalytic performance of La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3)(LSCF)towards carbon soot,we utilized the impregnation method to incorporate Ag into the prepared LSCF *** conducted a series of characterization tests and evaluated the soot catalytic activity of the composite catalyst by comparing it with the LaCoO_(3) group,LaFeO_(3) group,and catalyst-free *** results indicate that the Ag-LSCF composite catalyst exhibits the highest soot catalytic activity,with the characteristic temperature values of 376.3,431.1,and 473.9℃at 10%,50%,and 90%carbon soot conversion,*** values are 24.8,20.2,and 23.1℃lower than those of the LSCF *** also shows that LSCF can improve the catalytic activity of soot after compounding with Ag,and reflects the necessity of using catalysts in soot combustion *** characterization and BET test show that Ag-LSCF has more abundant surface-adsorbed oxygen species,larger specific surface area and pore volume than LSCF,which also proves that Ag-LSCF has higher soot catalytic activity.

关键词： metallic composites carbon smoke oxidation perovskite catalyst soot

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-ju kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young kim Yury I.Miller Won-Kyu ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Effect of Radiant Spectral Characteristics on Performance of a Near-Infra-Red Heating Module

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Journal of Thermal Science 2011年第6期20卷 510-515页

作者： ju-Hyun kim Won-Taek Choi Minsub han School of Mechanical System Engineering University of Incheon Araytech IncheonKorea

We simulated the heat transfer phenomena of the heating module that is primarily based on the radiant energy in the near-infra-red(NIR) *** the module,the power emitted by the lamp filament is distributed to the lamp glass,reflector,and the target medium,which are cooled by an air *** radiant heat transfer is simulated by using the ray-tracing scheme,in which the spectral characteristics of the emission and the materials are *** heat transport from the lamp glass to the cooling air is analyzed by using the finite volume *** the lamp-filament temperature rises in the range of 3000-3400K,the NIR radiant power on the target medium ***,the lamp-glass temperature also rises,and the proportion of the NIR power to the entire radiation has a peak in the temperature *** spectral distributions of the absorbed energies in all the components in the module are highly non-uniform,and a monochromatic model of the radiant heat transfer may result in a significant discrepancy.

关键词： Computational Fluid Dynamics(CFD) Curing Drying Coating process

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All-fiber acousto-optic modulator based on a cladding-etched optical fiber for active mode-locking

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Photonics Research 2017年第5期5卷 391-395页

作者： JIHWAN kim JOONHOI KOO ju han LEE School of Electrical and Computer Engineering University of Seoul

An all-fiber acousto-optic modulator(AOM), which features a compact structure and a low-driving voltage, is experimentally demonstrated for the active mode-locking of a fiber laser. The proposed AOM is based on the short length of the cladding-etched fiber, the ends of which are fixed on a slide glass. On top of the cladding-etched fiber, a piezoelectric transducer was overlaid. A chemical wet-etching technique, which is based on a mixed solution of NH_4F and (NH_4)2SO_4, is used to reduce the fiber diameter down to ～25 μm, and the length of the etched section is only 0.5 cm. The fabricated device exhibited a modulation depth of 73.10% at an acoustic frequency of 918.9 kHz and a peak-to-peak electrical voltage of 10 V, while a laser beam was coupled at 1560 *** using the prepared AOM within an erbium-doped-fiber ring cavity, the mode-locked pulses with a temporalwidth of 2.66 ps were readily obtained at a repetition rate of 1.838 MHz.

关键词： All-fiber acousto-optic modulator based on a cladding-etched optical fiber for active mode-locking

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Correlation between macular ganglion cell-inner plexiform layer thickness and visual acuity after resolution of the macular edema secondary to central retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 256-261页

作者： Hyun ju kim han Gyul Yoon Seong Taeck kim Department of Ophthalmology Chosun University School of Medicine

AIM： To examine the thickness of the ganglion cell-inner plexiform layer（GCIPL） in eyes with resolved macular edema（ME） in non-ischemic central retinal vein occlusion（CRVO）, applying spectral-domain optical coherence tomography（SD-OCT）, and its relationship with visual ***： The retrospective observational case-control study included 30 eyes of non-ischemic CRVO patients with resolved ME（ME eyes） after treatment, and 30 eyes of non-ischemic CRVO patients without ME（non-ME eyes）. The macular GCIPL thickness, peripapillary retinal nerve fiber layer（p RNFL） thickness and central macular thickness（CMT） were measured on a SD-OCT scan. Linear regression analyses were performed to determine the correlation between the thickness of each and the visual acuity（VA）.RESULTS： No significant difference in average GCIPL thickness, mean pR NFL thickness and CMT were observed between ME group and non-ME group（P=0.296, 0.183, 0.846）. But, minimum GCIPL thickness was reduced in ME eyes compared with non-ME eyes（P=0.022）. Final VA significantly correlated with the minimum GCIPL thickness in ME eyes（r=-0.482, P=0.007）, whereas no correlation was found with average GCIPL thickness, average pR NFL thickness and mean ***： Minimum GCIPL thickness is reduced in ME eyes compared with non-ME eyes, and correlated with the VA in non-ischemic CRVO. These results propose that inner retinal damage occurring in patients with ME secondary to non-ischemic CRVO may lead to permanent visual defect after treatment.

关键词： central retinal vein occlusion ganglion cellinner plexiform layer optical coherence tomography

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Tumor response assessment by the single-lesion measurement per organ in small cell lung cancer

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Chinese Journal of Cancer Research 2016年第2期28卷 161-167页

作者： Soong Goo jung jung han kim Hyeong Su kim Kyoung ju kim Ik Yang Department of Internal Medicine Kangnam Sacred-Heart HospitalHallym University Medical CenterHallym University College of MedicineSeoulRepublic of Korea Department of Radiation Oncology Kangnam Sacred-Heart HospitalHallym University Medical CenterHallym University College of MedicineSeoulRepublic of Korea Department of Radiology Kangnam Sacred-Heart HospitalHallym University Medical CenterHallym University College of MedicineSeoulRepublic of Korea

Background： The criterion of two target lesions per organ in the Response Evaluation Criteria in Solid Tumors （RECIST） version I. 1 is an arbitrary one, being supported by no objective evidence. The optimal number of target lesions per organ still needs to be investigated. We compared tumor responses using the RECIST 1.1 （measuring two target lesions per organ） and modified RECIST I. 1 （measuring the single largest lesion in each organ） in patients with small cell lung cancer （SCLC）. Methods： We reviewed medical records of patients with SCLC who received first-line treatment between January 2004 and December 2014 and compared tumor responses according to the two criteria using computed tomography. Results： There were a total of 34 patients who had at least two target lesions in any organ according to the RECIST 1.1 during the study period. The differences in the percentage changes of the sum of tumor measurements between RECIST 1.1 and modified RECIST 1.1 were all within 13%. Seven patients showed complete response and fourteen showed partial response according to the RECIST I.I. The overall response rate was 61.8%. When assessing with the modified RECIST 1.1 instead of the RECIST 1.1, tumor responses showed perfect concordance between the two criteria （k= 1.0）. Conclusions： The modified RECIST 1.I showed perfect agreement with the original RECIST 1.I in the assessment of tumor response of SCLC. Our result suggests that it may be enough to measure the single largest target lesion per organ for evaluating tumor response.

关键词： Target lesion Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1) modified Response Evaluation Criteria in Solid Tumors tumor response I.I (modified RECIST 1.1) small cell lung cancer (SCLC)

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Experimental assessment of two-phase bubble pump for solar water heating

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Journal of Central South University 2012年第6期19卷 1590-1599页

作者： CHUNG han-shik WOO ju-sik SHIN Yong-han kim jun-hyo JEONG Hyo-min Institute of Marine Industry Department of Mechanical and Precision EngineeringGyeongsang National University445 Inpyeong DongTongyeongGyeongsangnamdo650-160Korea Department of Mechanical and Precision Engineering Gyeongsang National University445 Inpyeong DongTongyeongGyeongsangnamdo650-160Korea Division of Marine Engineering Mokpo National Maritime UniversityHaeyangdaehang-Ro 91Mokpo-siJeollanam-do530-729Korea

The research goal is to develop a new solar water heater system(SWHS) that uses a solar bubble pump instead of an electric *** pump is powered by the steam produced from an evacuated tube ***,heat could be transferred downward from the collector to a hot water storage *** designed system consists of two sets of heat-pipe evacuated tube collectors,a solar bubble pump installed at an upper level and a water storage tank with a heat exchanger at a lower *** heads of 1 and 5 m were *** bubble pump could operate at the collector temperature of about 90-100 ℃ and vapor gage pressure of 80-90 *** is found that water circulation within the SWHS depends on the incident solar intensity and system discharge *** investigations are conducted to obtain the system thermal efficiencies from the hourly,daily and long-term performance *** thermal performance of the proposed system is compared with conventional solar water *** results show that the proposed system achieves system characteristic efficiency of 10% higher than that of the conventional systems using electric pump if taking the consumption of electric power into *** the former is a zero carbon system.

关键词： two-phase bubble pump solar water heater system (SWHS) zero carbon

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Radial Pulse and Electrocardiography Modulation by Mild Thermal Stresses Applied to Feet: An Exploratory Study with Randomized, Crossover Design

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Chinese Journal of Integrative Medicine 2020年第4期26卷 299-306页

作者： Jang-han Bae Boncho Ku Young ju Jeon Hyunho kim Jihye kim Haebeom Lee Jong Yeol kim Jaeuk U.kim Korea n Medici ne Fun dame ntal Research Divisi on Korea Institute of Oriental MedicineDaejeon(34054)Republic of Korea Department of Biofunctional Medicine and Diagnostics College of Korea n MedicineKyung Hee UniversitySeoul(02453)Republic of Korea Department of Human Informatics of Korean Medicine Interdisciplinary ProgramsKyung Hee UniversitySeoul(02453)Republic of Korea

Objective:To investigate the changes in radial pulse induced by thermal stresses(TSs).Methods:Sixty subjects were *** an open-label,2x2 crossover randomization design,both feet of each subject were immersed in 15%:water for cold stress(CS)and in 40 X:water for heat stress(HS)for 5 min *** pulse,respiration and electrocardiogram(ECG)signals were recorded before,during and immediately after the ***:The an alysis of heart rate variability revealed that CS in creased the low-freque ncy(LF)and high-frequency(HF)components(P<0.05)and that HS reduced the LF and HF components(P<0.01).Both TSs reduced the normalized LF,increased the normalized HF,and reduced the LF/HF *** differences in the ECG signals were more dominant during the TS sessions,but those in the radial pulse signals became more domi nant immediately after the TS sessi *** decreased the pulse depth(P<0.01)and in creased the radial augme ntation in dex(P<0.1),and HS in creased the pulse pressure(P<0.1)and sube ndocardial viability ratio(P<0.01).There were no significant differences in pulse rate during the three time sequences of each *** respiration rate was increased(P<0.1),and the pulse rate per respiration(P/R ratio)was significantly decreased(P<0.05)with *** HF region(10-30 Hz)of the pulse spectral density was suppressed during both ***:CS induced vasoconstriction and sympathetic reactions,and HS induced vasodilation and parasympathetic reacti *** on defi nitions used in pulse diag no sis,we made the novel discoveries that the pulse became slower(decreased P/R ratio),more floating and tenser under CS and that the HF region of the spectral power decreased significantly under both TSs.

关键词： radial pulse pulse diag no sis thermal stress electrocardiography heart rate variability

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