检索结果-南通市图书馆

平均听阈正常的听神经瘤患者临床及听力学特征分析

在线全文

学校读者我要写书评

暂无评论

中国听力语言康复科学杂志 2024年第3期22卷 259-263,274页

作者：郑秋晨张秋静范佳琳吴谢东张阳兰兰王国建王秋菊韩东一解放军总医院第六医学中心耳鼻咽喉头颈外科医学部国家耳鼻咽喉疾病临床医学研究中心北京100853

目的分析平均听阈正常(PTA≤25 dB HL)的单侧听神经瘤患者的临床特征及听力学特征,为听神经瘤早期筛查及诊断提供参考。方法选取平均听阈正常的单侧听神经瘤患者32例(32耳)作为试验组,选取与年龄、性别相匹配的平均听阈正常的耳鸣患... 详细信息

目的分析平均听阈正常(PTA≤25 dB HL)的单侧听神经瘤患者的临床特征及听力学特征,为听神经瘤早期筛查及诊断提供参考。方法选取平均听阈正常的单侧听神经瘤患者32例(32耳)作为试验组,选取与年龄、性别相匹配的平均听阈正常的耳鸣患者20例(32耳)作为对照组,试验组和对照组均在符合国家标准的隔声室行纯音测听、声导抗、听性脑干反应、畸变产物耳声发射检查,回顾性分析两组临床及听力学特征。结果单纯耳鸣、耳鸣伴反复发作且可治愈的突发性听力下降为平均听阈正常听神经瘤患者常见的首发症状,占50.00%,多见于30~40岁人群。试验组听性脑干反应异常率为75.00%(24/32),畸变产物耳声反射异常率为78.12%(25/32),患耳的同侧镫骨肌声反射和健耳的交叉声反射异常率分别为28.13%、56.25%,健耳的同侧镫骨肌声反射和患耳的交叉声反射异常率分别为6.25%、62.50%。通过对比分析试验组和对照组听力学特征,两组听性脑干反应的波Ⅲ、波Ⅴ潜伏期、波Ⅰ-波Ⅲ波间期、波Ⅰ-波Ⅴ波间期,患耳的交叉声反射和健耳的交叉声反射(0.5、1、2、4 kHz)、患耳的同侧声反射(2 kHz),均存在统计学差异(P0.05)。结论听性脑干反应及镫骨肌声反射检测有助于听神经瘤早期诊断,DPOAE是敏感性高但特异性差的检测指标。对门诊平均听阈正常的单侧耳鸣,或伴有反复发作的、可治愈的突发性听力下降患者,建议联合应用听性脑干反应、镫骨肌声反射、畸变产物耳声发射综合评估,为听神经瘤的早期诊断提供依据。

关键词：听神经瘤纯音听阈正常听性脑干反应镫骨肌声反射

Reasonable suppression of polysulfides/polyselenides shuttle based on MXene in Na-SeS_(2)batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2023年第5期42卷 1594-1602页

作者： qiu-ju Yang Jing Zhao Wei Gao Wei Zhong Yu-Ruo Qi Jin Han Shu-juan Bao Mao-Wen Xu School of Materials and Energy Southwest UniversityChongqing400715China Helmholtz Institute Ulm Ulm89081Germany Karlsruhe Institute of Technology Karlsruhe76021Germany

Metal-sulfur/selenium batteries have become the focus of new-generation energy storage systems due to the advantages of low-cost and high energy ***,it still suffers from the notorious shuttle of polysulfides/polyselenides,poor electronic conductivity and tremendous volume ***,a dual defense system for polysulfides/polyselenides was proposed and constructed based on *** nitrogen-doped porous carbon(NPC)decorated by Ti_(3)C_(2)T_(x)MXene(M@NPC)was employed as the SeS_(2)host(SeS_(2)@M@NPC).Particularly,Ti_(3)C_(2)T_(x)sheets wrapped on NPC guarantee the rapid ion diffusion and serve as the first barrier for SeS_(2)and dissolved sodium polysulfides/***,the few-layered Ti_(3)C_(2)T_(x)sheets coated on glass fiber separators act as the second barrier for alleviating the shuttle of polysulfides/polyselenides through physical interception and chemical *** this elaborate design,the integrated Na-SeS_(2)battery achieves a high specific capacity of 1243 mAh·g^(-1)at 1.0C,revealing a distinct superiority over its counterparts(SeS_(2)@M@NPC,1083mAh·g^(-1)at 0.5C;and SeS_(2)@NPC,823 mAh·g^(-1)at 0.5C).The findings gained in this work provide a creative idea for the construction of durable room-temperature Na-SeS_(2)batteries based on MXenes and their derivative materials.

关键词： MXene Integrated strategy Shuttle effect Room temperature(RT)Na-SeS_(2)batteries

基于简单加权分析的花椒果皮DNA快速提取方法比较研究

在线全文

学校读者我要写书评

暂无评论

食品安全质量检测学报 2024年第6期15卷 101-108页

作者：易秋菊邢冉冉王琳葛毅强陈颖中国检验检疫科学研究院北京100176 中国农业大学食品科学与营养工程学院北京100083 中国农村技术开发中心北京100045

目的开发和探究适用于花椒基因组DNA的快速提取方法。方法选取8种不同品种的花椒,分别利用3种不同的DNA提取方法,包括一管式植物DNA抽提试剂盒、基于载体的纤维素滤纸提取法和无菌拭子浸入法,进行花椒果皮基因组DNA快速提取,比较不同DN... 详细信息

目的开发和探究适用于花椒基因组DNA的快速提取方法。方法选取8种不同品种的花椒,分别利用3种不同的DNA提取方法,包括一管式植物DNA抽提试剂盒、基于载体的纤维素滤纸提取法和无菌拭子浸入法,进行花椒果皮基因组DNA快速提取,比较不同DNA提取方法在花椒果皮基因组提取中的效果。其中纤维素滤纸提取法和无菌拭子浸入法均通过载体转移进行DNA的快速提取,基于十六烷基三甲基溴化铵(hexadecyl trimethyl ammonium bromide,CTAB)和十二烷基硫酸钠(sodium dodecyl sulfate,SDS)两种不同的裂解液,在3 min以内即可提取DNA并得到聚合酶链式反应(polymerase chain reaction,PCR)扩增体系。通过简单加权(simple additive weighting,SAW)分析,基于PCR扩增能力、提取时间、提取成本、试剂安全性、程序简单性等方面进行综合评分。结果所选的快速提取试剂盒不适用于花椒果皮这类含次生代谢物较多的实验材料,而无菌拭子、纤维素滤纸两种载体提取得到的花椒果皮DNA均可以进行后续的PCR操作,最终CTAB纤维素滤纸法以其低成本、短时间、高扩增效率等优势排名第一。结论本研究探究了适用于花椒果皮基因组DNA的快速提取方法,并且通过SAW分析得出CTAB纤维素滤纸法是最优选择,表明载体转移法可以作为花椒基因组DNA快速提取方法之一,为花椒基因组DNA快速提取提供了参考方案,并为类似动植物基因组DNA的快速提取研究提供了参考。

关键词：花椒果皮 DNA提取简单加权快速提取

Fine mapping and genetic analysis of resistance genes,Rsc18,against soybean mosaic virus

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2022年第3期21卷 644-653页

作者： LIU Sang-lin CHENG Yan-bo MA Qi-bin LI Mu JIANG Ze XIA qiu-ju NIAN Hai The State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources South China Agricultural UniversityGuangzhou 510642P.R.China The Key Laboratory of Plant Molecular Breeding of Guangdong Province College of AgricultureSouth China Agricultural UniversityGuangzhou 510642P.R.China Maize Research Institute Jilin Academy of Agricultural SciencesGongzhuling 130033P.R.China Beijing Genomics Institute(BGI)-Shenzhen Shenzhen 518086P.R.China

Soybean mosaic virus(SMV) affects seed quality and production of soybean(Glycine max(L.) Merr.) ***18 is one of the dominant SMV strains in South China,and accession Zhonghuang 24 displayed resistance to *** F_(1),F_(2) and 168 F_(11) recombinant inbred lines(RILs) population derived from a hybridization between Zhonghuang 24(resistant,R) and Huaxia 3(susceptible,S) were used in this *** to the segregation ratios of the F_(2) generation(3 R:1 S) and the recombinant inbred lines(RILs) population(1 R:1 S),one dominant locus may regulate the resistance to SC18 in Zhonghuang *** using composite interval mapping(CIM),Rsc18 was mapped to a 415.357-kb region on chromosome *** candidate genes,including one NBS-LRR type gene and two serine/threonine protein type genes,were identified according to the genetic annotations,which may be related to the resistance to *** q RT-PCR demonstrated that these genes were up-regulated in the R genotype compared to the *** conclusion,the findings of this research enhanced the understanding about the R genes at the Rsc18 ***,our results will provide insights for designing molecular markers to improve marker-assisted selection and developing new varieties with resistance to SC18.

关键词： soybean mosaic virus(SMV) fine mapping recombinant inbred lines(RILs) resistance gene

Clinical outcomes of using three gonadatropins and medroxyprogestrone acetate(MPA) during ovarian stimulation in normal ovulatory women undergoing IVF/ICSI treatments

在线全文

学校读者我要写书评

暂无评论

Journal of Reproduction and Contraception 2015年第1期26卷 22-30页

作者： Xiu-xian ZHU qiu-ju CHEN Yan-ping KUANG Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine

Objective To compare the clinical characteristics in a gonadotropin （Gn） and medroxyprogestrone acetate （MPA） protocol using three types of Gn in normal ovulatory women undergoing IVF/ICSI treatments. Methods A total of 258 normal ovulatory IVF/ICSI patients undergoing ovarian stimulation in a Gn and MPA protocol were analyzed in this retrospective study and allocated into three groups according to the Gn used： group A, hMG-A （brand name： Fengyuan, n=105）; group B, hMG-B （brand name： Lebaode, n=90）; group C： u-FSH （brand name： Lishenbao, n=63）. The hormone profile, embryological characteristics, and the pregnant results after frozen-thawed embryo transfer （FET） were compared among the three groups. Results There was no significant difference in the number of oocytes retrieved among the three groups （12.1± 6.9 vs 12.1±5.6 vs 13.1 ±8.8, P〉0.05）. Other indicators such as the number of mature oocyte, fertilization, cleavage and viable embryo were similar （P〉0.05）. No premature LH surges were detected, with a range of 0.04-7.38 IU/L. No differences were found in the clinical pregnancy rate per transfer （43.48% vs 37.93% vs 40. 74%, P〉0.05） and the implantation rate （34.88% vs 22.22% vs 26.42%, P〉O.05）. Conclusion MPA is an effective oral alternative for the prevention of premature LH surges. Progestin-primed ovarian stimulation （PPOS） is a novel regimen of ovarian stimulation in combination with embryo cryopreservation, in which the two types of hMG are as effective as u-FSH.

关键词： human menopausal gonadtropin(h MG) urinary follicle stimulation hormone(u-FSH) medroxyprogestrone acetate(MPA) luteinizing hormone(LH) surge frozen-thawed embryo transfer(FET)

Undifferentiated embryonal sarcoma of the liver:Clinical characteristics and outcomes

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第20期8卷 4763-4772页

作者： Chong Zhang Chang-jun Jia Can Xu qiu-ju Sheng Xiao-Guang Dou Yang Ding Department of Infectious Diseases Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of General Surgery Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of Pathology Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina

BACKGROUND Undifferentiated embryonal sarcoma of the liver(UESL)is a rare liver malignancy originating from primary mesenchymal *** clinical manifestations,laboratory tests,and imaging examinations of the disease lack specificity and the preoperative misdiagnosis rate is *** overall prognosis is poor and survival rate is *** To investigate the diagnosis,treatment,and prognosis of *** We performed a retrospective,single-center cohort study in Shengjing Hospital of China Medical University,which is a central hospital in northeast *** 2005 to 2017,we recruited 14 patients with pathologically confirmed *** analyzed the clinical manifestations,laboratory tests,imaging examinations,pathological examinations,therapy,and prognosis of these *** There were nine males and five females aged 2-60 years old included in the *** major initial symptoms were abdominal pain(71.43%)and fever(57.14%).Preoperative laboratory tests revealed that seven patients had increased leukocyte levels,four showed a decrease in hemoglobin levels,seven patients had increased glutamyl transpeptidase levels,nine had increased lactate dehydrogenase levels,and three showed an increase in carbohydrate antigen *** was no difference in the rate of misdiagnosis in preoperative imaging examinations of UESL between adults and children(6/6 vs 5/8,P=0.091).The survival rate after complete resection was 6/10,while that after incomplete resection was 0/4(P=0.040),suggesting that complete resection is important to improve survival *** total,five out of the eight children achieved *** the follow-up,the maximum survival time was shown to be 11 years and minimum survival time was 6 *** adult patients relapsed late after surgery and all of them *** Preoperative imaging examination for UESL has a high misdiagnosis *** collaboration can improve the diagnostic accuracy of *** surgical resection is the fi

关键词： Undifferentiated embryonal sarcoma of the liver Retrospective study Clinical characteristics Diagnosis Treatment Prognosis

Mesenchymal stem cells rescue acute hepatic failure by polarizing M2 macrophages

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第45期23卷 7978-7988页

作者： yan-wei li chong zhang qiu-ju sheng han bai yang ding xiao-guang dou department of infectious diseases shengjing hospital of china medical university

AIM To investigate whether M1 or M2 polarization contributes to the therapeutic effects of mesenchymal stem cells(MSCs) in acute hepatic failure(AHF).METHODS MSCs were transfused into rats with AHF induced by D-galactosamine(DGal N). The therapeutic effects of MSCs were evaluated based on survival rate and hepatocyte proliferation and apoptosis. Hepatocyte regeneration capacity was evaluated by the expression of the hepatic progenitor surface marker epithelial cell adhesion molecule(Ep CAM). Macrophage polarization was analyzed by M1 markers [CD68,tumor necrosis factor alpha(TNF-α),interferon-γ(IFN-γ),inducible nitric oxide synthase(INOS)] and M2 markers [CD163,interleukin(IL)-4,IL-10,arginase-1(Arg-1)] in the survival and death groups after MSC *** The survival rate in the MSC-treated group was increased compared with the DPBS-treated control group(37.5% vs 10%). MSC treatment protected rats with AHF by reducing apoptotic hepatocytes and promoting hepatocyte regeneration. Immunohistochemical analysis showed that MSC treatment significantly increased the expression of Ep CAM compared with the control groups(P < 0.001). Expression of Ep CAM in the survival group was significantly up-regulated compared with the death group after MSC transplantation(P = 0.003). Transplantation of MSCs significantly improved the expression of CD163 and increased the gene expression of IL-10 and Arg-1 in the survival group. IL-4 concentrations were significantly increased compared to the death group after MSC transplantation(88.51 ± 24.51 pg/m L vs 34.61 ± 6.6 pg/m L,P < 0.001). In contrast,macrophages showed strong expression of CD68,TNF-α,and INOS in the death group. The concentration of IFN-γ was significantly increased compared to the survival group after MSC transplantation(542.11 ± 51.59 pg/m L vs 104.07 ± 42.80 pg/m L,P < 0.001).CONCLUSION M2 polarization contributes to the therapeutic effects of MSCs in AHF by altering levels of anti-inflammatory and pro-infla

关键词： Acute hepatic failure Mesenchymal stem cells Macrophages Polarization Inflammation

能谱CT物质分离技术对膝关节骨性关节炎髌下脂肪垫物质的相关性研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国CT和MRI杂志 2024年第1期22卷 162-163页

作者：张敏谭辉樊秋菊于楠党珊马春玲陕西中医药大学附属医院医学影像科陕西咸阳712000 陕西中医药大学陕西咸阳712046 咸阳市秦都区中医医院陕西咸阳712025

目的利用能谱CT水脂分离技术对膝关节骨性关节炎患者进行髌下脂肪垫水脂定量分析的相关性研究,探讨髌骨下脂肪垫在骨性关节炎中的病理变化。方法对临床已进行WOMA疼痛评分的176膝患者进行分组,研究组A组为疼痛评分>40分的骨性关节炎患... 详细信息

目的利用能谱CT水脂分离技术对膝关节骨性关节炎患者进行髌下脂肪垫水脂定量分析的相关性研究,探讨髌骨下脂肪垫在骨性关节炎中的病理变化。方法对临床已进行WOMA疼痛评分的176膝患者进行分组,研究组A组为疼痛评分>40分的骨性关节炎患者98膝,对照组B组为疼痛评分0.05,58.62±8.13 vs 56.56±7.99岁。组内脂基值及水基值数据均呈明显的负相关,P<0.05,A组r=-0.93,B组r=-0.90;组间脂基值及水基值P<0.05,有统计学差异。结论膝关节骨性关节炎的患者其髌骨下脂肪垫的水含量(炎性水肿)增高,相对脂肪含量降低。

关键词：能谱CT 物质分离技术骨性关节炎髌下脂肪垫

Pharmacokinetics Applications of Traditional Chinese Medicines

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2016年第1期2卷 42-47页

作者： qiu-ju Li Ai-Hua Zhang Hui Sun Xi-jun Wang National TCM Key Lab of Serum Pharmacochemistry Key Laboratory of Metabolomics and Chinmedomics Department of Pharmaceutical AnalysisHeilongjiang University of Chinese Medicine

Traditional Chinese medicine(TCM) has been widely used in many oriental countries for thousands of years and played an indispensable role in the prevention and treatment of diseases, especially the complicated and chronic ones. It is a very complex mixture containing hundreds or thousands of different components. Pharmacokinetic study on active constituents in TCM preparations is a good way for us to explain and predict a variety of events related to the efficacy and toxicity of TCM. In the drug discovery phases, pharmacokinetics is a key to guide medicinal chemists in the optimization process of a chemical series and to assist pharmacologists to design in vivo *** explore the potentially bioactive components in TCM, it is necessary to further study the in vivo pharmacokinetic characteristics of multiple absorbed components and find out the optical time-course behavior to providing more substantial research for new leads in drug discovery. Pharmacokinetics screening method could provide a reliable means of prospecting natural products in the search for new leads in drug discovery. This review summarizes the research progress of PK on TCM in the search for suitable lead compounds in recent years.

关键词： Traditional Chinese medicine Pharmacokinetics Drug discovery Active constituents