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Motion and acceleration of electrons in high-intensity laser standing waves

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Chinese Physics B 2012年第1期21卷 171-176页

作者： Zhang qiu-ju Yu wei Luan Shi-xia Ma Guang-Jin College of Physics and Electronics Shandong Normal UniversityJinan 250014China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China

The motion and the energy of electrons driven by the ponderomotive force in linearly polarized high-intensity laser standing wave fields are considered. The results show that there exists a threshold laser intensity, above which the motion of electrons incident parallel to the electric field of the laser standing waves undergoes a transition from regulation to chaos. We propose that the huge energy exchange between the electrons and the strong laser standing waves is triggered by inelastic scattering, which is related to the chaos patterns. It is shown that an electron＇s energy gain of tens of MeV can be realized for a laser intensity of 10^20 W/cm^2.

关键词： electron motion inelastic scattering laser standing wave energy exchange

Innate and adaptive immune escape mechanisms of hepatitis B virus

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World Journal of Gastroenterology 2022年第9期28卷 881-896页

作者： Hua-jun Zhao Yi-Fei Hu qiu-ju Han Jian Zhang Institute of Immunopharmaceutical Sciences School of Pharmaceutical SciencesShandong UniversityJinan 250012Shandong ProvinceChina

Chronic hepatitis B virus(HBV)infection is an international health problem with extremely high mortality and morbidity *** current clinical chronic hepatitis B(CHB)treatment strategies can partly inhibit and eliminate HBV,viral breakthrough may result due to non-adherence to treatment,the emergence of viral resistance,and a long treatment *** CHB infection arises as a consequence of complex interactions between the virus and the host innate and adaptive immune ***,understanding the immune escape mechanisms involved in persistent HBV infection is important for designing novel CHB treatment strategies to clear HBV and achieve long-lasting immune *** review details the immunological and biological characteristics and escape mechanisms of HBV and the novel immune-based therapies that are currently used for treating HBV.

关键词： Hepatitis B virus Innate immunity Adaptive immunity Immune tolerance Therapeutic strategy

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“双一流”视域下实验教学中心持续建设探究

教育教学论坛 2024年第23期 89-92页

作者：张国娜罗书强周秋菊西南大学实验室建设与设备管理处重庆400715

实验教学示范中心的持续性建设对实验教学改革和创新人才培养有着巨大的支撑和推动作用,西南大学国家级实验教学示范中心结合新时代对实验实践能力提升的新要求,主动对接一流专业和一流课程建设,在建立先进的管理体制和运行机制、优化... 详细信息

实验教学示范中心的持续性建设对实验教学改革和创新人才培养有着巨大的支撑和推动作用,西南大学国家级实验教学示范中心结合新时代对实验实践能力提升的新要求,主动对接一流专业和一流课程建设,在建立先进的管理体制和运行机制、优化实验教学条件、构建科教融合实验项目、强化实验技术队伍建设等方面进行积极探索。通过探索和实践,开发了一批创新性强的实验项目,更新了实验教学内容,优化了实验教学体系,培育了职业化、专业化的实验技术队伍,切实提高了实验教学质量和水平。

关键词： “双一流”建设示范中心实验教学人才培养

Numerical study on erosion behavior of sliding sleeve ball seat for hydraulic fracturing based on experimental data

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Petroleum Science 2023年第1期20卷 515-525页

作者： Xuan-Li Zhou Yan-Bao Guo qiu-ju Xie De-Guo Wang Hyun C.Yoon College of Mechanical and Transportation Engineering China University of PetroleumBeijing102249China Harold Vance Department of Petroleum Engineering Texas A&M UniversityCollege StationTX77843United States Korea Institute of Geoscience and Mineral Resources Daejeon34132South Korea

The sleeve sealing ball seat is one of the important components in the multistage fracturing process of horizontal *** erosion and wear of the surface will decrease the sealing performance of the fracturing ball and the ball *** leads to pressure leakage during the fracturing process and fracturing *** this paper,combined with the actual ball seat materials and working conditions during the fracturing process,the erosion tests of ductile iron and tungsten carbide materials under different erosion speeds,angles,and mortar concentrations are carried *** the erosion test results were analyzed by mathematical fitting,and a set of erosion models suitable for sliding sleeve setting ball seat materials were innovatively *** the first time,this paper combines the erosion model obtained from the experiment and the computational fluid dynamics(CFD)with Fluent software to simulate the erosion of the ball *** on the simulation results,the morphology of the sliding sleeve seat ball after erosion is *** analysis of the test and simulation results,it is showed that the erosion rate of tungsten carbide material is lower and the wear resistance is better under the condition of small angle *** research can offer a strong basis for fracturing site selection,surface treatment methods,and prediction of failure time of ball seats.

关键词： Multistage fracturing Sliding sleeve ball seat Erosion wear Erosion model Fluent simulation

ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice

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Cellular & Molecular Immunology 2020年第2期17卷 163-177页

作者： Tian Deng Caixia Suo Jiali Chang Rui Yang Jingyu Li Ting Cai ju qiu CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Jiao Tong University School of Medicine(SJTUSM)&Shanghai Institutes for Biological Sciences(SIBS)Chinese Academy of Sciences(CAS)Shanghai 200031China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

OX40L is one of the co-stimulatory molecules that can be expressed by splenic lymphoid tissue inducer(Lti)cells,a subset of group 3 innate lymphoid cells(ILC3s).OX40L expression in subsets of intestinal ILC3s and the molecular regulation of OX40L expression in ILC3s are ***,we showed intestinal ILC3s marked as an OX40L high population among all the intestinal leukocytes and were the dominant source of OX40L in Rag1–/–*** ILC3 subsets expressed OX40L,and NCR–ILC3s were the most abundant source of *** expression of OX40L in ILC3s could be upregulated during *** addition to tumor necrosis factor(TNF)-like cytokine 1A(TL1A),which has been known as a trigger for OX40L,we found that Poly(I:C)representing viral stimulus promoted OX40L expression in ILC3s via a cell-autonomous ***,we demonstrated that IL-7-STAT5 signaling sustained OX40L expression by *** regulatory T cells(Tregs),most of which expressed OX40,had defective expansion in chimeric mice,in which ILC3s were specifically deficient for OX40L ***,co-localization of Tregs and ILC3s was found in the cryptopatches of the intestine,which suggests the close interaction between ILC3s and *** study has unveiled the crosstalk between Tregs and ILC3s in mucosal tissues through OX40–OX40L signaling,which is crucial for the homeostasis of intestinal Tregs.

关键词： Group 3 innate lymphoid cells OX40L Regulatory T cells Intestinal immunity

2022年泰州市某区PM_(2.5)中金属元素含量测定及健康风险评价

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江苏预防医学 2024年第2期35卷 219-222页

作者：王莉于芹生黄久红乔秋菊泰州市疾病预防控制中心江苏泰州225300

目的分析2022年泰州市某区大气PM_(2.5)中金属元素的变化特征,评估其对人群的健康风险。方法2022年每月10—16日在监测点进行PM_(2.5)采样,采用电感耦合等离子体质谱法测定12种金属元素含量,利用富集因子(enrich factor,EF)法识别金属... 详细信息

目的分析2022年泰州市某区大气PM_(2.5)中金属元素的变化特征,评估其对人群的健康风险。方法2022年每月10—16日在监测点进行PM_(2.5)采样,采用电感耦合等离子体质谱法测定12种金属元素含量,利用富集因子(enrich factor,EF)法识别金属元素的来源,并进行人群健康风险评价。结果2022年泰州市某区大气PM_(2.5)中金属元素平均浓度由高到低为Mn>Pb>As>Se>Cr>Ni>Sb>Cd>Hg>Be>Tl,其中Al、Cd、Hg、Ni、Se、Tl浓度变化均有季节性差异(H值分别为13.932、11.817、15.836、8.423、7.876、14.316,P值圴10。当人群暴露外环境时间达到3 h/d,Cr对成年男性、成年女性和儿童可能存在致癌风险;当暴露外环境中时间达到5 h/d,As对成年男性、成年女性可能存在致癌风险。结论该地区PM_(2.5)中金属元素主要来自于人为污染,季节性差异较为明显,Cr和As对人群的潜在健康风险较高,需引起重视。

关键词： PM_(2.5) 金属元素 Cr As 健康风险评价

人工智能驱动的自动化新工科专业建设探索与实践

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控制工程 2024年第9期31卷 1675-1684页

作者：陈东岳刘建昌潘峰杨涛常玉清王洪峰谭树彬邱菊东北大学信息科学与工程学院辽宁沈阳100819

在新工科专业改革的大背景下,围绕人工智能与自动化交叉融合的主题,针对相关专业背景和知识体系特点,介绍和讨论了自动化新工科专业的建设思路与改革举措。然后,结合东北大学信息科学与工程学院的自动化新工科专业建设工作,对上述建设... 详细信息

在新工科专业改革的大背景下,围绕人工智能与自动化交叉融合的主题,针对相关专业背景和知识体系特点,介绍和讨论了自动化新工科专业的建设思路与改革举措。然后,结合东北大学信息科学与工程学院的自动化新工科专业建设工作,对上述建设方案进行了系统性的探索与实践,在课程体系设计、教学资源建设和教学质量保障等方面进行了大量有益的尝试,并对相应的建设成果与问题进行了总结与分析,为人工智能驱动的自动化新工科专业建设探索了可供参考的实践方案。

关键词：新工科专业自动化人工智能课程体系教学改革

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吉贝咳喘胶囊联合肺康复治疗支气管扩张症痰热壅肺证临床研究

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中西医结合研究 2024年第5期16卷 294-298页

作者：李改改邱菊周洵刘明慧林昌洋贵州中医药大学第二附属医院呼吸与危重症医学科贵阳550003 贵州中医药大学研究生院贵阳550000

目的观察吉贝咳喘胶囊联合肺康复治疗支气管扩张症急性加重期(痰热壅肺证)的临床疗效。方法将50例支气管扩张症急性加重期痰热壅肺证患者随机分为治疗组和对照组,每组25例。对照组予以抗感染、化痰等常规西医治疗,治疗组在对照组基础上... 详细信息

目的观察吉贝咳喘胶囊联合肺康复治疗支气管扩张症急性加重期(痰热壅肺证)的临床疗效。方法将50例支气管扩张症急性加重期痰热壅肺证患者随机分为治疗组和对照组,每组25例。对照组予以抗感染、化痰等常规西医治疗,治疗组在对照组基础上加用吉贝咳喘胶囊联合肺康复治疗,2组疗程均为14 d。比较2组临床总有效率、痰液黏稠度、中医证候积分、血清炎症指标[白细胞计数(white blood cell count,WBC)、中性粒细胞百分比(neutrophils percentage,Neu%)、白细胞介素-6(interleukin-6,IL-6)、降钙素原(procalcitonin,PCT)、C-反应蛋白(C-reactive protein,CRP)]及不良反应发生率。结果治疗后,治疗组临床总有效率明显高于对照组(P0.05)。结论吉贝咳喘胶囊联合肺康复能显著改善支气管扩张症痰热壅肺证患者的临床症状和体征,降低炎症指标,并改善痰液黏稠度,且安全性良好。

关键词：支气管扩张症急性加重期吉贝咳喘胶囊肺康复痰热壅肺证

基于MaxEnt模型的细尤犀金龟在中国的适生分布区预测

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西南农业学报 2024年第7期37卷 1601-1610页

作者：张鸿辉舒旭余新林朱恩骄和秋菊赵敏易传辉西南林业大学林学院昆明650224 云南高黎贡山国家级自然保护区保山管护局腾冲分局云南腾冲679100 云南林业职业技术学院昆明650224 中国林业科学研究院高原林业研究所昆明650224 西南林业大学云南生物多样性研究院昆明650224

[目的]对濒危物种细尤犀金龟适生区进行预测,为其保护提供理论依据。[方法]基于地理分布记录和环境变量数据,采用MaxEnt模型,利用27个有效分布点和19个环境因子,借助ArcGIS软件模拟细尤犀金龟在中国当前气候条件和未来(2050s,2070s)RCP... 详细信息

[目的]对濒危物种细尤犀金龟适生区进行预测,为其保护提供理论依据。[方法]基于地理分布记录和环境变量数据,采用MaxEnt模型,利用27个有效分布点和19个环境因子,借助ArcGIS软件模拟细尤犀金龟在中国当前气候条件和未来(2050s,2070s)RCP2.6与RCP8.5此2种气候条件下的适生分布区,并筛选出影响分布的主导环境因子。[结果]对19个环境因子采用MaxEnt模型进行10次重复运算,计算出AUC值为0.986,表明MaxEnt模型精度高,同时去除掉贡献率和置换重要值较低的环境因子。采用MaxEnt模型中的“刀切法”筛选得到6个环境因子并进行分析,最终根据贡献率得出影响细尤犀金龟潜在地理分布的主导环境因子前4位依次为温度季节性(BIO4,53.7%)、最热季度的降水(BIO18,13.5%)、年降水量(BIO12,12.2%)和等温性(BIO3,11.8%)。在当前气候条件下,细尤犀金龟高适生区主要位于云南南部、西藏南部区域以及台湾地区中部零星区域。在2050年RCP2.6与2070年RCP8.5排放情景下,高适生区面积在台湾地区、云南和西藏部分地区虽有小幅度增加,但其它排放情景下的面积均有所减少。[结论]温度季节性、最热季度的降水、年降水量、等温性、最冷月份的最低温度和年温差是影响细尤犀金龟在中国潜在分布的主导环境因子。细尤犀金龟适生区的预测结果与其当前在中国的实际分布情况基本一致,但由于栖息地丧失、破碎化、退化以及生境的严重破坏,其未来的实际适生分布区存在进一步缩小和破碎化的趋势,濒危物种细尤犀金龟生存环境不容乐观。

关键词：细尤犀金龟潜在适生区濒危 MaxEnt ArcGIS