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Effects of Semi-Ablative Fractional Radiofrequency Associated with Growth Factors in Stretch Marks: A Randomized Controlled Trial

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Open Journal of Applied Sciences 2021年第4期10卷 379-394页

作者： Patricia F. Meyer Rodrigo Marcel V. Da Silva Liliane S. Vasconcelos Louhanne Christine B. Bezerra Maria Paula M. Oliveira Eneida M. Carreiro Ciro D. Soares Fabio S. Borges Monica Etrusco joyce rodrigues Silene B. Ribeiro Hernan Andrés B. Ortiz Federal University of Rio Grande do Norte (UFRN) Natal Brazil Physiotherapy Course at UNIRN Natal Brazil Mauricio de Nassau Natal Natal Brazil Physiotherapy Course at Potiguar University (UnP) Natal Brazil Potiguar University (UnP) Natal Brazil Graduate Program in Stomatopathology State University of Campinas S&#227 o Paulo Brazil Postgraduate Program in Dermatofunctional Physiotherapy Estácio de Sá University Rio de Janeiro Brazil Minas Gerais Faculty of Medical Sciences Minas Gerais Brazil Sã o Judas Tadeu University Butant&#227 Brazil FSG Centro Universitário Caxias do Sul Brazil Physiotherapy Course Escuela de Kinesiología Facultad de Ciencias de la Rehabilitación Universidad Andrés Bello Santiago Chile

Background: To investigate the effects of the association of semi-ablative fractional radiofrequency (RFF) with growth factors in stretch marks. Methods: This is a randomized controlled trial. The sample consisted of 28 female patients with complaints of gluteus or abdomen striae and divided into 2 equitable groups, named G1 (semi-ablative RFF without active principle association) and G2 (semi-ablative RFF with active principle association), being subdivided into G-1A and G-2A (abdominal applications) and G-1B and G-2B (gluteus applications). A photographic and histological analysis was performed using questionnaires about inflammation, presence of adverse effects and satisfaction of volunteers. Photographic analysis showed a reduction in the amount of striae alba in all groups. Results: The histological analysis showed an increase in fibroblast activity, collagen type I, and blood vessels, especially in the groups that associated the RFF with the active principle. In the inflammation analysis, the groups that performed intervention with active ingredients showed lower inflammatory signal. All groups had a reasonable level of satisfaction after the interventions;however, the group that used active ingredients reported greater results. Conclusion: The association of semi ablative RFF with growth factors showed a reduction in clinical inflammatory signs, mainly in the first 15 days, as well as higher collagen production, verified in 30 days, with satisfactory clinical results in all groups.

关键词： Striae Distensae Collagen Wound Healing

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The potential development of drug resistance in rheumatoid arthritis patients identified with p53 mutations

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Genes & Diseases 2023年第6期10卷 2252-2255页

作者： Congling Qiu joyce Tsz Wai Chan David Wei Zhang Io Nam Wong Yaling Zeng Betty Yuen Kwan Law Simon Wing Fai Mok Ivo Ricardo De Seabra rodrigues Dias Wenfeng Liu Liang Liu Vincent Kam Wai Wong Dr.Neher's Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao SAR 999078China Department of Public Health and Preventive Medicine School of MedicineJinan UniversityGuangzhouGuangdong 510000China Faculty of Medicine Macao University of Science and TechnologyMacao SAR 999078China School of Biotechnology and Health Sciences Wuyi UniversityJiangmenGuangdong 529000China

Rheumatoid arthritis(RA)is a chronic inflammatory disease characterized by cartilage and bone damage with the presence of pannus formation which causes uncontrollable proliferation and invasion of fibroblast-like synoviocytes(FLS).Since rheumatoid arthritis is a chronic disorder,the patients normally need to undergo prolonged antirheumatic treatment with the use of disease-modifying antirheumatic drugs(DMARDs),steroids,and nonsteroidal anti-inflammatory drugs(NSAIDs).The efficacy of such long-term pharmaceutical intervention can be significantly affected by the development of drug *** pathological relationship between rheumatoid arthritis and cancer hinted that some chemotherapeutic drugs,such as methotrexate(MTX),could be used for RA *** idea was reinforced by the analysis of mutations in p53 tumor suppressor *** 50%of p53 somatic mutations observed from various cancers are also identified in the synovium of RA patients1(Fig.1A).Of note,the hyperplastic synovium in RA with overexpressed p53 mutants contributed to the destruction of joints in patients with erosive RA.

关键词： patients drugs rheumatoid

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Concordance of the point-of-care circulating cathodic antigen test for the diagnosis of intestinal schistosomiasis in a low endemicity area

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Infectious Diseases of Poverty 2019年第3期8卷 99-100页

作者： Sergei Rodrigo Magalhaes de Sousa Isabelle Helena Lima Dias Alvaro Luan Santana Fonseca Bianca rodrigues Contente joyce Favacho Cardoso Nogueira Tatyellen Natasha da Costa Oliveira Stefan Michael Geiger Martin Johannes Enk Programa de Pos-Graduacao Strictu Sensu em Biologia Parasitaria na Amazonia da Universidade do Estado do Para Tv.Perebebui2623-MarcoBelemPA 66087Brazil Laboratorio de Parasitoses Intestinais Esquistossomose e Malacologia(LPIEM)Secgao de ParasitologiaInstituto Evandro Chagas/SVS/MSAnanindeuaParaBrazil

Background:The Kato-Katz technique is recommended worldwide for the diagnosis of intestinal schistosomiasis,detecting parasite eggs in feces of infected ***,new tests have been developed in order to facilitate diagnosis,*** detection of specific antigens secreted by schistosomes,such as the circulating cathodic antigen(CCA).The aim of this study was to evaluate the performance of the point-of-care circulating cathodic antigen test(POC-CCA)compared to the Kato-Katz technique in a low prevalence area in the Amazon Region,located in the municipality of Primavera,State of Para,***:Positivity rates of the POC-CCA test and the Kato-Katz technique were *** sensitivity,specificity,accuracy and kappa coefficient were determined by comparing both *** reference standard was established using 16 Kato-Katz slides,12 of the first fecal sample,two of the second and two of the third *** study also included the concordance between POC-CCA results and different numbers and combinations of Kato-Katz ***:The prevalence of schistosomiasis according to the reference standard or POC-CCA test reached a rate of 9.4%or 23.9%,respectively,among a total of 372 *** positivity rates by the Kato-Katz technique increased from 2.4 to 9.4%,according to the increase in the number of slides examined and fecal samples colleaed.A sensitivity of 55.6%,specificity 76.9%,accuracy 76%and k coefficient of 0.06 was observed by comparing one slide of the first sample and *** 6 slides from three different samples,two slides of each,with POC-CCA resulted in a sensitivity of 583%,specificity 78.4%,accuracy 77%and k coefficient of ***,the comparison of 16 slides from three different samples with POC-CCA revealed a sensitivity of 65.7%,specificity 80.4%,accuracy 79%,and k coefficient of ***:The immunochromatographic test has the potential to be an important tool to combat schistosomiasis because of its practi

关键词： Schistosoma mansoni Kato-Katz POC-CCA Accuracy Diagnosis Low prevalence area

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Prevalence of Decreased Susceptibility of Cryptococcus spp. Isolates to Fluconazole in Urban Sources of Presidente Prudente

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Journal of Pharmacy and Pharmacology 2017年第12期5卷 891-897页

作者： Camila Marcon Caroline Lucio Moreira Daniela Adelia Femandes Inocencio Larissa rodrigues de Oliveira Mariana Polidorio Kato joyce Marinho de Souza Marcus Vinicius Pimenta rodrigues Daniela Vanessa Moris The Department of lmmunology and Microbiology University of Western Sao Paulo Sao Paulo 19050-920 Brazil

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Evaluation of Antimicrobial Susceptibility by <i>Staphylococcus aureus</i>Isolated from the Nutrition Service of a Teaching Hospital

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Advances in Microbiology 2018年第4期8卷 270-285页

作者： Marilda Moreira da Silva Giovana Nicolete Barbara Dayene Lopes Carolina Hiromi Morita joyce Marinho de Souza Lizziane Kretli Winkelstroter Marcus Vinícius Pimenta rodrigues Nutrition Course Faculty of Health Sciences S&atilde o Paulo Western University-UNOESTE Presidente Prudente Brazil Master in Environment and Regional Development S&atilde o Paulo Western University-UNOESTE Presidente Prudente Brazil Biomedical Sciences Course Faculty of Health Sciences S&atilde o Paulo Western University-UNOESTE Presidente Prudente Brazil Master in Health Sciences S&atilde o Paulo Western University-UNOESTE Presidente Prudente Brazil

The bacteria Staphylococcus aureus is found in the nasal passages, mouth and skin of the human population and stands out among foodborne diseases. Some causes of foodborne illness are related with food, handlers, and utensils contamination in a hospital’s nutrition service. The aim of this study was to investigate the presence of S. aureus in food handlers, equipment, counter-tops and utensils of the nutrition service of a teaching hospital. Samples of the environment, hands and nasal mucosa of employees of a nutrition service were collected with two sterile swabs, in 2016, March and June. A total of 134 samples were obtained, which were submitted to characterization tests Biochemistry and morphotinorial (gram staining, catalase and coagulase tests in tube), phenotypic evaluation by drug diffusion technique and D-test approach, and the biofilm phenotype characterization by culture on Congo Red Agar. Results showed high rates of S. aureus colonization, mainly in the kitchen, high frequency of antimicrobial resistance, especially erythromycin and the presence of multi-resistant microorganisms. Large number of positive samples was also found for biofilm production, with totality for the samples of handlers. We highlight the relevance of the data in virtue of the serious consequences and risks that can be triggered in the hospital environment.

关键词： Staphylococcus aureus Multiresistance Contamination Manipulators

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Genotyping and Antifungal Susceptibility Profile of Sequential Candida albicans Isolated from the Oral Cavity of HIV-Infected Individuals

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Journal of Pharmacy and Pharmacology 2018年第4期6卷 350-361页

作者： Daniela Vanessa Moris joyce Marinho de Souza Marcia Souza Carvalho Melhem Marilena dos Anjos Martins Caroline Lucio Moreira Lenice Rosario de Souza Gioconda San-Blas Maria Walderez Szeszs Lidia Raquel Carvalho Marcus Vinicius Pimenta-rodrigues Rinaldo Poncio Mendes Tropical Diseases Area--Faculdade de Medicina de Botucatu Universidade Estadual Paulista "Julio de Mesquita Filho "--UNESP Sao Paulo Botucatu 18600-000 Brazil Masters in Health Seience--Universidade do Oeste Paulista--UNOESTE Sao Paulo Presidente Prudente 19067-175 Brazil Department of Biomedical Sciences--Universidade do Oeste Paulista--UNOESTE Presidente Prudente 19050-920 Brazil Instituto Adolfo Lutz Sao Paulo 01246-000 Brazil Venezuelan Institute for Scientific Research Center for Microbiology and Cell Biology Caracas 11 01204 Venezuela Biostatistics Department Instituto de Biociencias Universidade Estadual Paulista "Julio de Mesquita Filho "--UNESP Sao Paulo Botueatu 18600-000 Brazil

Objective: The study aimed to evaluate the genotypic profiles of C. albicans (Candida albicans) sequentially isolated throughout the course of HIV infections, and to determine its MIC (minimal inhibitory concentrations) to AMB (amphotericin B), FLC (fluconazole), KTC (ketoconazole), and ITC (itraconazole). Design: samples were collected from the oral cavity of HIV-positive individuals during 4 years, with a sterilized swab. MIC was performed by using the microdilution method AFST/EUCAST. The genetic similarities within and between sequential clones of C. albicans were assessed by DNA fingerprinting using the random amplification of polymorphic DNA technique. Results: A total of 142 oral samples were isolated from 59 HIV-infected individuals who attempted up to five visits each, with or without symptoms of oropharyngeal candidiasis. Profile analysis revealed that yeasts isolated over sequential visits from symptomatic or asymptomatic individuals showed 78% or 87% relatedness, respectively. The degree of similarity among C. albicans was higher for isolates from colonization than for those from infection. Genetically identical C. albicans samples also formed connected subclusters in sequential visits. In regard to susceptibility profile, all isolates were susceptible to AMB, FLC, KTC, and ITC and maintained this pattern all along, no differences in MICs of any given antifungal compound were observed for sequential C. albicans isolates. Conclusions: These data suggest that genotype and susceptibility to antifungal drugs were maintained over time in sequentially isolates of C. albicans colonization and a diverse evolutionary genetic trend in C. albicans sequentially isolated from the oral candidiasis of HIV infected individuals.

关键词： Candida HIV 危险性抗真菌孤立感染侧面 MIC

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