检索结果-南通市图书馆

Retinal nerve fiber layer defects and chronic kidney disease:the Kailuan Eye Study

International Journal of Ophthalmology(English edition) 2024年第9期17卷 1696-1706页

作者： Qian-Qian Wan Jin-Qiong Zhou Li-Jian Fang Ya-Xing Wang Ye-Nan Wang Qian Wang Yan-Ni Yan Xuan Yang Shou-Ling Wu Shuo-Hua Chen jost b jonas Wen-bin Wei beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Ophthalmology Beijing Liangxiang HospitalCapital Medical UniversityBeijing 102400China beijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual SciencesBeijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100730China Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Health Care Center Kailuan GroupTangshan 063000Hebei ProvinceChina Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University of HeidelbergHeidelberg 69117Germany

AIM:To investigate whether retinal nerve fiber layer defects(RNFLDs)is a potential risk factor for chronic kidney disease(CKD)in Chinese ***:The Kailuan Eye Study was a populationbased study that included 14440 *** participants underwent detailed assessments,RNFLDs were diagnosed using color fundus ***:Overall,12507 participants[8533 males(68.23%)]had complete systemic examination data and at least one evaluable fundus *** were found in 621 participants[5.0%;95%confidence interval(CI):4.6%-5.34%],and 70 cases of multiple RNFLDs were found(11.27%).After adjusting multiple factors,RNFLDs was significantly associated with CKD severity,the ORs of CKD stage 3,stage 4 and stage 5 were 1.698,4.167,and 9.512,*** RNFLDs were also associated with CKD severity after adjusting multiple factors,the ORs of CKD stage 3 and stage 5 were 4.465 and 11.833 ***,2294 participants had CKD(18.34%,95%CI:17.68%-18.99%).After adjusting for other factors,CKD presence was significantly correlated with the presence of ***:The strongest risk factors for RNFLDs are CKD and ***,RNFLDs can be an ocular feature in patients with *** can help detect systemic diseases,and assessment for RNFLDs should be considered in CKD patients.

关键词： chronic kidney disease retinal nerve fiber layer defects Kailuan Eye Study fundus examination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in myopia research anatomical findings in highly myopic eyes

引用

Eye and Vision 2020年第1期7卷 434-443页

作者： jost b.jonas Ya Xing Wang Li Dong Yin Guo Songhomitra Panda-jonas Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karis-UniversityUniversitäts-AugenklinikTheodor-Kutzer-Ufer 1-368167 MannheimGermany beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Institute of OphthalmologyBeijing Tongren HospitalCapital Medical UniversityBeijingChina beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key LabBeijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Tongren HospitalCapital Medical UniversityBeijingChina Tongren Eye Care Center Beijing Tongren HospitalCapital Medical UniversityBeijingChina

background:The goal of this review is to summarize structural and anatomical changes associated with high *** text:Axial elongation in myopic eyes is associated with retinal thinning and a reduced density of retinal pigment epithelium(RPE)cells in the equatorial *** of the retina and choriocapillaris and RPE cell density in the macula are independent of axial *** and scleral thickness decrease with longer axial length in the posterior hemisphere of the eye,most marked at the posterior *** any eye region,thickness of bruch’s membrane(bM)is independent of axial *** opening,as the inner layer of the optic nerve head layers,is shifted in temporal direction in moderately elongated eyes(axial lengthbM into the intrapapillary compartment at the nasal optic disc side,and to an absence of bM at the temporal disc *** lack of bM at the temporal disc side is the histological equivalent of parapapillary gamma *** zone is defined as the parapapillary region without *** highly myopic eyes(axial length>26.5 mm),bM opening enlarges with longer axial *** leads to a circular gamma *** a parallel manner,the peripapillary scleral flange and the lamina cribrosa get longer and thinner with longer axial length in highly myopic *** elongated peripapillary scleral flange forms the equivalent of parapapillary delta zone,and the elongated lamina cribrosa is the equivalent of the myopic secondary *** prevalence of bM defects in the macular region increases with longer axial length in highly myopic *** staphylomas are characterized by marked scleral thinning and spatially correlated bM defects,while thickness and density of the choriocapillaris,RPE and bM do not differ markedly between staphylomatous versus non-staphylomatous eyes in the respective ***:High axial myopia is associated with a thinning of the sclera and choroid posteriorly and thinnin

关键词： High myopia Myopia bruch’s membrane Optic nerve head Optic disc Parapapillary gamma zone Parapapillary delta zone Lamina cribrosa Anatomical changes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ophthalmology： potential future developments in China and worldwide

引用

Chinese Medical Journal 2014年第8期127卷 1401-1404页

作者： jost b. jonas Songhomitra Panda-jonas Wang Yaxing Wei Wenbin beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University beijing Ophthalmology & Visual Science Key Laboratory Beijing 100730 China Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg Germany

With a volume of about 6 ml and weight of approximately 6 g, the eye makes out only 1/10 000part of the body. Despite this minuscule proportion of the eye on the whole body, quality of life is profoundly influenced by the quality of vision. It shows the high importance of ophthalmology in the field of public health in general and in clinical medicine in particular.

关键词： ophthalmology " cataract " glaucoma " cornea " macular degeneration " retinal vein occlusion " optic nerve " retina

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progression of diabetic retinopathy： the beijing Eye Study

引用

Chinese Medical Journal 2011年第22期124卷 3635-3640页

作者： TU Ying XU Liang WEI Wen-bin WANG Shuang WANG Ya-xing jost b jonas beijing Tongren Hospital Capital Medical University beijing Ophthalmology ＆ Visual Sciences Key Lab Beijing 100730 China

background Diabetic retinopathy （DR） has emerged as a leading cause of visual impairment and blindness in the working-aged population worldwide. This study aimed to assess frequency and associated factors of progression of DR in subjects with known diabetes in a population-based setting. Methods The beijing Eye Study is a population based study performed in Greater beijing in 2001 and 2006. The present investigation included all subjects with known diabetes mellitus in 2001, who participated in the follow-up examination in 2006. Fundus photographs were assessed. Results The study included 170 subjects; 51 （30%） subjects showed signs of DR in 2001 and were re-examined in 2006, 36 （21.2%） subjects （18 subjects with DR present at baseline, 18 subjects with newly diagnosed DR in 2006） showed a progression of DR during follow-up. Progression of DR was associated with rural region （odds ratio （OR）： 5.43, P=0.001） and self-reported arterial hypertension （OR： 3.85, P=0.023）. In the non-progressive subgroup, presence of DR was associated with different levels of education （〈middle school, middle school, college or higher, OR： 0.30, P=-0.023）, treatment modes of diabetes mellitus （OR： 10.24, P=0.003） and cataract surgery （OR： 9.14, P=0.007）. Conclusions In a population-based setting in Greater beijing, progression of DR occurred in 35% of subjects with pre-existing DR and overall in 21% of subjects with known diabetes within a 5-year period. Progression of DR was significantly associated with rural region and self-reported arterial hypertension. In the stable subjects, presence of DR was significantly associated with poor educational level, insulin treatment of diabetes and cataract surgery.

关键词： progression diabetic retinopathy beijing Eye Study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune oppression array elucidating immune escape and survival mechanisms in uveal melanoma

引用

International Journal of Ophthalmology(English edition) 2016年第12期9卷 1701-1712页

作者： Fang Hou Qi-Ming Huang Dan-Ning Hu jost b.jonas Wen-bin Wei beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Science Key Lab Departments of Ophthalmology and Pathology New York Eye and Ear Infirmary of Mount Sinai Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University

AIM： To examine the genetic profile of primary uveal melanoma （UM） as compared to UM in immune ***： Dendritic cells （DC） loaded with lysates of UM cells of high metastatic potential were used to stimulate CTLs（CTLs）. When CTLs co-cultured with the UM cells, most UM cells could be eliminated. Survival UM cells grew slowly and were considered to be survival variants and examined by a microarray analysis. These differential genes were analyzed further with Venn Diagrams and functions related to immune escape. We additionally examined transcriptional changes of manually selected survival variants of UM cells and of clinical UM samples by quantitative real-time polymerase chain reaction （qRT-PCR）, and analyzed the correlation of these expressions and patients’ ***： Gene expression analyses revealed a marked up-regulation of SLAMF7 and CCL22 and a significant down-regulation of KRT10, FXYD3 and AbCC2. The expression of these genes in the relapsed UM was significantly greater than those in primary UM. UM patients with overexpression of these genes had a shorter survival period as compared with those of their ***： Gene expression, in particular of SLAMF7, CCL22, KRT10, FXYD3 and AbCC2, differed between primary UM cells and survival variants of UM cells.

关键词： uveal melanoma dendritic cells immuneescape gene expression profile b"~2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Retinal vessel oxygen saturation in healthy subjects and early branch retinal vein occlusion

引用

International Journal of Ophthalmology(English edition) 2017年第2期10卷 267-270页

作者： Jing-Yan Yang bing You Qian Wang Szy Yann Chan jost b.jonas Wen-bin Wei beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Science Key LabCapital Medical UniversityBeijing 100730China Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-UniversityMannheim 69047Germany beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing 100730China

AIM： To measure the retinal oxygen saturation in healthy subjects and early branch retinal vein occlusion（bRVO） in Chinese ***： The retinal vessel oxygen saturation of the healthy subjects and bRVO patients were measured by a noninvasive retinal oximeter（Oxymap ehf.,Reykjavik,Iceland）.RESULTS： The study included 22 patients with unilateral bRVO（mean age： 55.1±8.8y） in the study group and 91 healthy participants（mean age： 37.5±14.0y） in the control *** the healthy individuals,mean arterial and venous oxygen saturation were significantly（P〈0.001）higher in the superior nasal quadrant（98.5%±10.1%and 57.3%±8.7%,respectively） than in the inferior nasal quadrant（94.2%±9.0% and 54.1%±9.6%,respectively）,followed by the superior temporal quadrant（89.1%±10.1%and 51.9%±8.9%,respectively） and the inferior temporal quadrant（86.4%±9.4% and 46.6%±9.6%,respectively）.In patients with ischemic bRVO,arterial oxymetric values were significantly higher and venous measurements significantly lower for the affected vessel（107.5%±9.7% and46.4%±14.2%,respectively） than the unaffected vessel in the same eye（99.2%±12.2% and 55.5%±7.9%,respectively）and as compared to the vessel in the unaffected fellow eye（93.1%±6.9% and 55.7%±6.8%）（P=0.005 and P=0.02,respectively）.In the patients with non-ischemic bRVO,mean venous oxygen saturation was lower in the affected vein（39.8%±12.2%） than in the unaffected vessels of the same eye（50.8%±10.5%） and in the fellow eye（58.21%±5.7%）（P=0.03）.Mean arterial oxygen saturation did not differ significantly（P=0.42） between all three ***： In patients with bRVO,the venous oxygen saturation in the affected vessels is decreased potentially due to decreased blood velocity and ***,thearterial oxygen saturation in eyes with ischemic bRVO is increased in the affected arteries.

关键词： ischemia retinal oxygen saturation branchretinal vein occlusion retinal oximetry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of risk and protective factors associated with retinal nerve fiber layer defect in a Chinese adult population

引用

International Journal of Ophthalmology(English edition) 2023年第3期16卷 427-433页

作者： Ye-Nan Wang Ya-Xing Wang Jin-Qiong Zhou Qian-Qian Wan Li-Jian Fang Hai-Wei Wang Jing-Yan Yang Li Dong Jin-Yuan Wang Xuan Yang Yan-Ni Yan Qian Wang Shou-Ling Wu Shuo-Hua Chen Jing-Yuan Zhu Wen-bin Wei jost b.jonas beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230011Anhui ProvinceChina Department of Ophthalmology Beijing Liangxiang HospitalCapital Medical UniversityBeijing 102401China Department of Ophthalmology Fuxing HospitalCapital Medical UniversityBeijing 100045China Cardiology Department Kailuan General HospitalTangshan 063001Hebei ProvinceChina Health Care Center Kailuan GroupTangshan 063000Hebei ProvinceChina Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University of HeidelbergHeidelberg 68167Germany

AIM:To investigate the risk and protective factors associated with the retinal nerve fiber layer defect(RNFLD)in a Chinese adult ***:This study was a cross-sectional populationbased investigation including employees and retirees of a coal mining company in Kailuan City,Hebei *** the study participants underwent a comprehensive systemic and ophthalmic *** was diagnosed on fundus *** logistic regression was used to investigate the risk and protective factors associated with the ***:The community-based study included 14440 *** were 10473 participants in our study,including 7120 males(68.0%)and 3353 females(32.0%).The age range was 45-108y,averaging 59.56±*** 568 participants had RNFLD and the prevalence rate was 5.42%.A higher prevalence of RNFLD was associated with older age[Pbetes mellitus(P=0.019,OR:0.684;95%CI:0.499-0.939).The protective factors of RNFLD were visual acuity(P=0.038,OR:0.617;95%CI:0.391-0.975),and central anterior chamber depth(P=0.046,OR:0.595;95%CI:0.358-0.990).CONCLUSION:In our cross-sectional community-based study,with an age range of 45-108y,RNFLD is associated with older age,longer axial length,hypertension,and diabetes *** protective factors of RNFLD are visual acuity and central anterior chamber *** can help to predict and evaluate RNFLD related diseases and identify high-risk populations early.

关键词： retinal nerve fiber layer defect retinal nerve fiber layer age axial length hypertension diabetes mellitus visual acuity central anterior chamber depth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intravitreai medication:From triamcinolone to bevacizumab/ranibizumab to intravitreal cell-encoated drug therapy

Intravitreai medication:From triamcinolone to bevacizumab/ra...

引用

中华医学会第十二届全国眼科学术大会

作者： jost b．jonas Eye Hospital Mannheim University Gemany

In the last 5 years,ophthalmology has been revolutionized by the intravitreal application of drugs for treatment of intraocular edematous,proliferative and edematous diseases such as exudative age—related mac-

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

10-year fundus tessellation progression and retinal vein occlusion

引用

International Journal of Ophthalmology(English edition) 2018年第7期11卷 1192-1197页

作者： Yan-Ni Yan Ya-Xing Wang Yan Yang Liang Xu Jie Xu Qian Wang Jing-Yan Yang Wen-Jia Zhou Wen-bin Wei jost b.jonas beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology & Visual Sciences Key Lab Beijing Tongren Hospital Capital Medical University Beijing 100730 China beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical UniversityBeijing Ophthalmology & Visual Science Key Lab Beijing 100730 China beijing Aier-Intech Eye Hospital Beijing 100730 China Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University Seegartenklinik Heidelberg 68167 Germany

AIM： To access the 10-year fundus tessellation progression in patients with retinal vein occlusion. METHODS： The beijing Eye Study 2001/2011 is a populationbased longitudinal study. The study participants underwent a detailed physical and ophthalmic examination. Degree of fundus tessellation was graded by using fundus photographs of the macula and optic disc. Progression of fundus tessellation was calculated by fundus tessellation degree of 2011 minus degree of 2001. Fundus photographs were used for assessment of retinal vein occlusion. RESULTS： The beijing Eye Study included 4403 subjects in 2001, 3468 subjects was repeated in 2011. Assessment of retinal vein obstruction and fundus tessellation progression were available for 2462 subjects（71.0%）, with 66 subjects fulfilled the diagnosis of retinal vein occlusion. Of the 66 participants, 59 participants with unilateral branch retinal vein occlusion, 5 participants with unilateral central retinal vein occlusion, 1 participant with bilateral branch retinal vein occlusion, and 1 participant with branch retinal vein occlusion in one eye and central retinal vein occlusion in the other eye. Mean degree of peripapillary fundus tessellation progression were significantly higher in the whole retinal vein occlusion group（0.33±0.39, P〈0.001）, central retinal vein occlusion group（0.71±0.8, P=0.025） and branch retinal vein occlusion group（0.29±0.34, P=0.006） than the control group（0.20±0.26）. After adjustment for age, prevalence of tilted disc, change of best corrected visual acuity, axial length, progression of peripapillary fundus tessellation was associated with the presence of retinal vein occlusion（P=0.004; regression coefficient b, 0.094; 95%CI, 0.029, 0.158; standardized coefficient b, 0.056）. As a corollary, after adjusting for smoking duration, systolic blood pressure, anterior corneal curvature, prevalence of RVO was associated with more peripapillary fundus tessellation progression（P〈0.001; regression coefficient b： 1

关键词： fundus tessellation retinal vein occlusion beijing Eye Study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

葡萄膜黑色素瘤和视网膜组织相关性的病理学分析（英文）

引用

国际眼科杂志 2020年第2期20卷 197-202页

作者：张举魏文斌李彬顼晓琳 jost b jonas 首都医科大学附属北京同仁医院、北京同仁眼科中心眼科学与视觉科学北京市重点实验室、眼内肿瘤诊治研究北京市重点实验室中国北京市100730 首都医科大学附属北京同仁医院、北京同仁眼科中心、北京市眼科研究所、眼科学与视觉科学北京市重点实验室、眼内肿瘤诊治研究北京市重点实验室中国北京市100730 德国海德堡大学曼海姆临床医学院眼科德国曼海姆市69115

目的:分析葡萄膜黑色素瘤的形状对视网膜结构的影响。方法:回顾性分析葡萄膜黑色素瘤患者的病理切片和临床资料,分析肿瘤形状、大小、高度-基底比值、视网膜薄变和浸润的差异。结果:本研究包括102例患者(102眼),平均年龄45.6±12.4岁。... 详细信息

目的:分析葡萄膜黑色素瘤的形状对视网膜结构的影响。方法:回顾性分析葡萄膜黑色素瘤患者的病理切片和临床资料,分析肿瘤形状、大小、高度-基底比值、视网膜薄变和浸润的差异。结果:本研究包括102例患者(102眼),平均年龄45.6±12.4岁。其中葡萄膜黑色素瘤76眼(75%)为梭形细胞型,6眼(6%)为上皮样细胞型,16眼(16%)为混合细胞型,其它4眼(4%)。按肿瘤部位分:睫状体黑色素瘤3眼(2.9%),睫状体和脉络膜黑色素瘤28眼(27.5%),脉络膜黑色素瘤71眼(69.6%)。视网膜组织的分析中,43眼(43%)发现视网膜变薄,86眼(84%)发现视网膜浸润。肿瘤的高度在1.2~15.6(平均8.3±3.6) mm,肿瘤基底直径为4.8~31.2(平均17.3±6.5) mm。肿瘤峰高度-基底R值为0.53±0.32。视网膜薄变组(n=43)的平均R值显着高于无视网膜薄变组(n=59)(0.69±0.31与0.42±0.27;P<0.01)。视网膜肿瘤浸润组(n=86)的平均R值比无视网膜浸润组(n=16)略高(0.56±0.33比0.41±0.25;P=0.09),但无统计学意义。结论:高R值的肿瘤与其邻近视网膜薄变有关,与视网膜内肿瘤细胞浸润相关性不大。葡萄膜黑色素瘤的切面形状和邻近视网膜组织的受累情况关系紧密。

关键词：葡萄膜肿瘤病理学黑色素瘤

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：