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The association between radiological spreading pattern and clinical outcomes in necrotizing external otitis

journal of Otology 2022年第3期17卷 156-163页

作者： W.Leentje van der Meer Ahmed B.Bayoumy josje j.otten jerome j.Waterval Henricus P.M.Kunst Alida A.Postma Department of Radiology&Nuclear Medicine Maastricht University Medical Centerthe Netherlands Department of Otorhinolaryngology and Head and Neck Surgery Maastricht University Medical Centerthe Netherlands Department of Otorhinolaryngology and Head and Neck Surgery Radboud Institute for Health SciencesRadboud University Medical Centerthe Netherlands School for Mental Health&Neuroscience Maastricht UniversityMaastrichtthe Netherlands Dutch Academic Alliance Skull Base Pathology Maastricht University Medical Center+Radboud University Medical CenterMaastricht/Nijmegenthe Netherlands

Objectives: Necrotizing external otitis(NEO) is a rare infectious disease of the skull base. The purpose of this study was to determine whether clinical outcomes of NEO can be correlated to different infectious spread ***: Retrospective chart review from 2010 to 2019 with NEO patients, who were divided into two cohorts: single spreading patterns(group A) or complex spreading patterns(group B) as diagnosed by *** symptoms, diagnostic and treatment delay, course of disease, complications, and duration of antibiotic exposure were retrospectively collected from patient ***: 41 NEO patients were included, of which 27 patients belonged to group A(66%). The diseaserelated mortality rate was 12.2% among the entire cohort, no differences were found between group A and B. Higher rates of ***(42.9% vs 14.8% P = 0.047) and N. IX palsies were found in group B compared to group A(28.6% vs 3.7%, P = 0.039). The median duration of antibiotic use was significantly different for a complex spreading pattern, clinical recovery and hospitalizations. Complications were associated with higher diagnostic delay and with a complex spread pattern. The median duration of follow-up was 12.0(IQR 6.0-19.5) ***: NEO is a severe disease, with significant mortality and morbidity(cranial nerve palsies). The radiological spread pattern may assist in predicting clinical outcome. Furthermore, complex spread patterns are associated with higher rates of clinical nerve palsies(N. VII and ***), complications, surgery rates and longer duration of antibiotic use. Diagnostic delay was associated with mortality, complications and facial palsies.

关键词： Necrotizing external otitis Malignant external otitis Skull base osteomyelitis Clinical manifestation Spreading routes Antibiotic exposure Facial nerve palsy

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A mimic of soft tissue infection: intra-arterial injection drug use producing hand swelling and digital ischemia

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World journal of Emergency Medicine 2015年第3期6卷 233-236页

作者： Sean D.Foster Michael S.Lyons Christopher M.Runyan Edward j.otten Department of Emergency Medicine University of Cincinnati Department of Plastic Reconstructive & Hand Surgery University of Cincinnati

BACKGROUND: Inadvertent intra-arterial injection of illicit substances is a known complication of injection drug use and can lead to severe complications, including infection, ischemia and compartment syndrome. Identifying complications of intra-arterial injection can be difficult, as clinical manifestations overlap with other more common conditions such as cellulitis and soft tissue infection, and a history of injection drug use is frequently not ***: A 37-year-old male patient presented with 24 hours of right hand pain, erythema and swelling. Despite classic "track marks", he denied a history of injection drug use, and vascular insults were not initially considered. After failing to respond to three days of aggressive treatment for suspected deep-space infection, an arteriogram demonstrated findings consistent with digital ischemia of embolic ***: As a result of the delay in diagnosis, the lesion was not amenable to reperfusion and the patient required amputation of the distal ***: Practitioners should be alert to the possibility of intra-arterial injection and resulting complications when evaluating unusual extremity infections or unexplained ischemic symptoms, even in the absence of a definite history of injection drug use.

关键词： Intra-arterial injection Opioid abuse Injection drug use Digital ischemia

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An INDEHISCENT-Controlled Auxin Response Specifies the Separation Layer in Early Arabidopsis Fruit

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Molecular Plant 2016年第6期9卷 857-869页

作者： Kasper van Gelderen Martin van Rongen An'an Liu Anne otten Remko Offringa Molecular and DeveLopmental Genetics Institute of Biology Leiden Leiden University Sylviusweg 72 2333 BE Leiden the Netherlands These authors contributed equally to this article. Present address: Plant Ecophysjology Institute of Environmental Biology Utrecht University 3584 CH Utrecht the Netherlands Present address: Sainsbury Laboratory 47 Sateman Street Cambridge CB2 1LR UK

Seed dispersal is an important moment in the life cycle of a plant species. In Arabidopsis thaliana, it is dependent on transcription factor INDEHISCENT （IND）-mediated specification of a separation layer in the dehiscence zone found in the margin between the valves （carpel walls） and the central replum of the developing fruit. It was proposed that IND specifies the separation layer by inducing a local auxin minimum at late stages of fruit development. Here we show that morphological differences between the ind mutant and wild-type fruit already arise at early stages of fruit development, coinciding with strong IND expression in the valve margin. We show that IND-reduced PIN-FORMED3 （PIN3） auxin efflux carrier abundance leads to an increased auxin response in the valve margin during early fruit develop- ment, and that the concomitant cell divisions that form the dehiscence zone are lacking in ind mutant fruit. Moreover, IND promoter-driven ectopic expression of the AGC kinases PINOID （PID） and WAG2 induced indehiscence by expelling auxin from the valve margin at stages 14-16 of fruit development through increased PIN3 abundance. Our results show that IND, besides its role at late stages of Arabi- dopsis fruit development, functions at early stages to facilitate the auxin-triggered cell divisions that form the dehiscence zone.

关键词： seed dispersal polar auxin transport PINOID INDEHISCENT separation layer Arabidopsis

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Manual mid-stromal dissection as a low risk procedure to stabilize mild to moderate progressive keratoconus

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Eye and Vision 2018年第1期5卷 233-239页

作者： Rénuka S Birbal Korine van Dijk jack S Parker Henny otten Maha Belmoukadim Lisanne Ham Lamis Baydoun Isabel Dapena Gerrit R j Melles Netherlands Institute for Innovative Ocular Surgery(NIIOS)Rotterdam Laan op Zuid 883071AA RotterdamThe Netherlands Melles Cornea Clinic Rotterdam RotterdamThe Netherlands Amnitrans EyeBank Rotterdam RotterdamThe Netherlands. NIIOS-USA San DiegoUSA Parker Cornea BirminghamALUSA Visser Contact Lens Practice Nijmegen/Rotterdam RotterdamThe Netherlands

Background:To evaluate the efficacy of manual mid-stromal dissection in stabilizing progressive ***:Surgeries were performed in 16 eyes of 14 patients with progressive *** eyes were examined before and at 1 day,1 week,1,3,6 and 12 months after surgery,and every 6 months ***(simK,Kmax and pachymetry),best corrected visual acuity(BCVA)and subjective refraction were recorded up to the latest follow-up visit(mean follow-up time 6.6±2.4 years).Results:All surgeries were uneventful,and no postoperative complications *** values(n=15)stabilized in 6/11 eyes(55%)with a preoperative Kmax60 D showed continued *** 11/15 eyes(73%)pachymetry was *** with spectacles remained stable in 7/12 eyes(58%)and improved≥2 Snellen lines in 5/12 eyes(42%).BCVA with a contact lens remained stable in 4/9 eyes(44%),improved≥2 Snellen lines in 3/9 eyes(33%)and deteriorated in 2/9 eyes(22%).Conclusions:Manual mid-stromal dissection was effective in 50%of keratoconic corneas with Kmax values<60 D and may be considered in cases ineligible for other interventions such as UV-crosslinking,stromal ring implantation or Bowman layer *** advantage of the procedure may be that the tissue is unaltered and that no synthetic or biological implant is required.

关键词： Keratoconus Manual cornea dissection Progressive ectasia Surgical technique

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MightySat Ⅱ.1超光谱成像器的工程样机

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红外 2000年第10期21卷 20-27页

作者： L.j.otten III 顾聚兴美国Kestrel公司

MightySat Ⅱ.1卫星的主要有效载荷中有一台傅里叶变换超光谱成像器,这是将要在空间飞行的这类传感器中的首台仪器。在过去的一年中,该传感器已通过初步设计阶段,传感器的一个工程样机已经制成。该样机已开始受到鉴定。到目前为止,传感... 详细信息

MightySat Ⅱ.1卫星的主要有效载荷中有一台傅里叶变换超光谱成像器,这是将要在空间飞行的这类传感器中的首台仪器。在过去的一年中,该传感器已通过初步设计阶段,传感器的一个工程样机已经制成。该样机已开始受到鉴定。到目前为止,传感器已达到其重量、体积和电源的设计目标。一种异乎寻常的高水平随机振动鉴定迫使人们重新设计两块反射镜的安装技术。一种定制的、适用于空间的VME电子摄像机接口和用以处理20M位组/秒图象数据的控制卡已经设计和制成,而且已同一组(4个)C-40处理器耦合以提供160 MIPS的星上处理能力。现正在研究任务的运行,利用卫星的在轨三轴操纵能力,仪器将演示 30 m的地面采样距离。根据预定计划,有效载荷应于1999年初交付以便在总线上的装配。

关键词：超光谱成像器 MIGHTYSATII.1 卫星传感器

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百欧仕EGSB厌氧处理PTA废水工程实例分析

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广西轻工业 2010年第4期26卷 78-79页

作者：王进 Michael otten 徐正雄威立雅水处理技术上海有限公司上海200001 威立雅水处理技术新加坡有限公司新加坡508706

Biothane(荷兰百欧仕)公司是一家国际性污水处理公司,其在全世界已拥有500多项污水处理业绩。本工程实例是采用百欧仕的EGSB厌氧技术处理对苯二甲酸(PTA)污水,经过一年的实际运行,容积负荷率逐步提升到约10-15kgCOD/m3.d,SCOD的去除率... 详细信息

Biothane(荷兰百欧仕)公司是一家国际性污水处理公司,其在全世界已拥有500多项污水处理业绩。本工程实例是采用百欧仕的EGSB厌氧技术处理对苯二甲酸(PTA)污水,经过一年的实际运行,容积负荷率逐步提升到约10-15kgCOD/m3.d,SCOD的去除率保持在45-65%,苯甲酸去除率达约90%。经2个月时间的启动驯化期后,当进水PTA浓度低于800mg/L时,去除率可稳定在90%以上。偏苯三酸则需1年的滞后期后去除率稳定在80-90%。

关键词： Biothane(百欧仕) EGSB(膨胀颗粒污泥床) PTA(对苯二甲酸) 偏苯三酸

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Pediatric sinonasal and skull base lesions

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World journal of Otorhinolaryngology-Head and Neck Surgery 2020年第2期6卷 118-124页

作者： Charles A.Riley Christian P.Soneru jonathan B.Overdevest Marc L.otten David A.Gudis Department of Otolaryngology Head and Neck SurgeryNew York Presbyterian Hospital-Columbia University Medical CenterNew YorkNYUSA Department of Neurological Surgery New York Presbyterian Hospital-Columbia University Medical CenterNew YorkNYUSA

Pediatric skull base lesions are complex and challenging *** and comprehensive management of this diverse group of disorders requires the expertise of an experienced multidisciplinary skull base *** endoscopic skull base surgery has evolved due to technologic and surgical advancements,multidisciplinary team approaches,and continued *** principles continue to advance the care delivered to the pediatric *** approach and management of these lesions varies considerably based on tumor anatomy,pathology,and surgical *** understanding of the nuances of skull base reconstruction unique to the pediatric population is critical for successful outcomes.

关键词： Pediatrics Endoscopic sinus surgery Endoscopic skull base surgery juvenile nasopharyngeal angiofibroma Meningoencephalocele Pituitary adenoma Craniopharyngioma Clival chordoma Chondrosarcoma

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1989－1994年中国脊髓灰质炎病毒的分子流行病学

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病毒学报 1995年第4期11卷 289-297页

作者：郑渡平张礼璧侯晓辉朱宏 Mac otten David R Kilpatnck Mark Pallansch Olen M Kew 江西省卫生防疫站中国预防医学科学院病毒学研究所国家脊灰实验室世界卫生组织(WHO)驻中国消灭脊灰官员美国疾病控制中心

１９８９～１９９４年中国发生的脊髓灰质炎流行，疫情开始集中于华东、中南地区，后期趋于南部沿海一带。对近百份来自１８个省、市、自治区脊灰病毒流行期间标本的分子生物学特征分析，发现流行主要由脊灰病毒Ⅰ型野毒株引起，未发现... 详细信息

１９８９～１９９４年中国发生的脊髓灰质炎流行，疫情开始集中于华东、中南地区，后期趋于南部沿海一带。对近百份来自１８个省、市、自治区脊灰病毒流行期间标本的分子生物学特征分析，发现流行主要由脊灰病毒Ⅰ型野毒株引起，未发现Ⅱ型野毒株，但１９９３年在新疆分离到１株Ⅲ型野毒株。Ⅰ型野毒株中共存在４个基因型病毒，其中ＣＨＮＰ１－Ｒ９１型病毒为这几年流行中新产生的重组病毒，在ＶＰ１／２Ａ区含有一段疫苗株序列，另一段野毒株序列很可能来自ＣＨＮＰ１－ＪＸ８９型病毒。这两个基因型病毒分布在全国大部份地区。病毒核酸的亲缘关系研究还证明，９２～９４年流行在南方沿海一带的脊髓灰质炎，主要由９１年产生的重组病毒引起。此研究揭示了各地区、各基因型病毒与疫情之间的流行病学关系及传播模式。

关键词：脊髓灰质炎病毒分子流行病学

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无异柠檬酸脱氢酶1基因R132H突变的弥漫性脑胶质瘤的BOLD血管调节异常更严重

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国际医学放射学杂志 2018年第4期 483-484页

作者： Z.K.Englander C.I.Horenstein S.G.Bowden D.S.Chow M.L.otten 朱桐 Department of Radiology Columbia University Medical Center

目的探讨弥漫性脑胶质瘤R132H基因突变状态对血管调节异常程度的影响,以及对外科切除术后残余脑组织的血氧水平依赖(BOLD)异常的影响。材料与方法该研究经机构伦理委员会批准,回顾性分析2010年—2017年的病人数据库。最终共纳入39例弥... 详细信息

目的探讨弥漫性脑胶质瘤R132H基因突变状态对血管调节异常程度的影响,以及对外科切除术后残余脑组织的血氧水平依赖(BOLD)异常的影响。材料与方法该研究经机构伦理委员会批准,回顾性分析2010年—2017年的病人数据库。最终共纳入39例弥漫性神经胶质瘤病人。所有病人术前行头颅MRI检查,包括平面回波成像、BOLD功能MR成像。识别BOLD时间序列上与肿瘤及正常脑组织不同的体素获得BOLD血管异常调节图。采用Dice系数评价肿瘤与血管调节异常的重叠区域。另外,肿瘤边缘外的BOLD异常信号区被定义为BOLD异常分数(BOF)。利用线性回归模型评估R132H突变状态对Dice系数、BOF以及肿瘤术后残留异常BOLD信号的影响。结果与野生型R132H胶质瘤(R132H-)相比,R132H突变型胶质瘤(R132H+)BOLD异常信号和肿瘤区域之间具有更大的空间重叠范围(平均Dice系数:R132H+,0.659±0.020;R132H-,0.327±0.04;P<0.001)、肿瘤外区域异常的BOLD信号较少(平均BOF:R132H+,0.255±0.03;R132H-,0.728±0.04;P<0.001)以及术后异常BOLD信号较少(残余分数:R132H+,0.046±0.0047;R132H-,0.397±0.045;P<0.001)。受试者操作特征曲线分析表明Dice系数和BOF在R132H+和R132H-肿瘤的鉴别诊断中具有高敏感性和高特异性(曲线下面积分别为0.967和0.977)。结论R132H基因突变的状态是影响肿瘤相关血管调节异常程度的重要因素,同时是胶质瘤术后持续血管调节异常的重要影响因素。

关键词：脑胶质瘤 R132H 弥漫性

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脑性瘫痪早产儿伸展运动中姿势控制的运动学特征

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 61-61页

作者： Van Der Heide j.C. Fock j.M. otten B. M. Hadders-Algra 虎小毅 Universit y Hospital Groningen Developmental Neurology Hanzeplein 1 9713 GZ Groningen Netherlands Dr.

The relationships between kinematic characteristics of sitting posture during reaching movements of the dominant arm and 1)the kinematics of the reaching move ment itself and 2) functional performance during daily life activities (PEDI) we re assessed in 51 sitting preterm children with cerebral palsy (CP). The childre n were 2-11 y, 33 had spastic hemiplegia (SH) and 18 bilateral CP (Bi-CP). The data were compared with those of 26 typically developing children (TD). Sitting posture before the onset of reaching of children with CP differed from that of TD children: they sat with a more reclined pelvis and a more collapsed trunk. Th e more reclined pelvic position was associated with a better quality of reaching movements. The different sitting postures of pelvis and trunk were not related to functional performance during daily life activities. Displacement of the head , trunk, and pelvis of the children with CP did not differ from that of the TD c hildren. Nevertheless, in the children with CP a more stable head, a more mobile trunk, and a more stable pelvis were related to better functional performance a nd/or a better quality of reaching. This suggests that physiotherapeutic guidanc e of children with CP should focus rather on the latter postural parameters than on the different sitting posture of pelvis and trunk.

关键词：脑性瘫痪伸展运动运动学特征痉挛性偏瘫臂运动数据资料双侧性

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