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Low-Cost and Biodegradable Therm.electric Devices Based on van der Waals Sem.conductors on Paper Substrates

Energy & Environm.ntal m.terials 2024年第1期7卷 201-206页

作者： Gulsum.Ersu Carm.n m.nuera Federico J.m.m.ean Daniel Vaquero Jorge Quereda João Elias F.S.Rodrigues Jose A.Alonso Eduardo Flores Jose R.Ares Isabel J.Ferrer Abdullah m.Al-Enizi Aym.n Nafady Sruthi kuriakose joshua O.Island Andres Castellanos-Gom.z m.terials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)Madrid E-28049Spain Nanotechnology Group USAL-NanolabUnivesidad de SalamancaSalamanca Junta de Castilla y León 37007Spain GISC Departamento de Física de MaterialesUniversidad Complutense de MadridMadrid E-28040Spain Departam.nto de Física Aplicada Centro de Investigación y Estudios AvanzadosMérida 97310Mexico m.RE Group Departamento de Física de MaterialesUniversidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabrera Universidad Autónoma de MadridMadrid E-28049Spain Departm.nt of Chem.stry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Departm.nt of Physics and Astronom. University of Nevada Las VegasLas Vegas NV 89154USA

We present a m.thod to fabricate handcrafted therm.electric devices on standard office paper *** devices are based on thin film. of WS_(2),Te,and BP(P-type sem.conductors)and TiS_(3)and TiS_(2)(N-type sem.conductors),deposited by sim.ly rubbing powder of these m.terials against *** therm.electric properties of these sem.conducting film. revealed m.xim.m.Seebeck coefficients of(+1.32±0.27)m. k^(-1)and(-0.82±0.15)m. k^(-1)for WS_(2)and TiS_(3),***,Peltier elem.nts were fabricated by interconnecting the P-and N-type film. with graphite electrodes.A therm.power value up to 6.11 m. k^(-1)was obtained when the Peltier elem.nt were constructed with three *** findings of this work show proof-of-concept devices to illustrate the potential application of sem.conducting van der Waals m.terials in future therm.electric power generation as well as tem.erature sensing for low-cost disposable electronic devices.

关键词： paper-based electronics Seebeck effect sem.conductors therm.electrics van der Waals m.terials

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Dynam.cs of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharam.n Jason Lynch Christopher E.Stevens Christopher m.nley Chentao Li Jin Hou Hao Zhang Andrew Torm. Thom.s Darlington Francis Coen kevin Li Arka m.jum.ar PJam.s Schuck Aditya m.hite Hayk Harutyunyan joshua R.Hendrickson Deep Jariwala Departm.nt of Electrical and System. Engineering University of PennsylvaniaPhiladelphiaPA19104USA kBR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Departm.nt of Physics University of WashingtonSeattleWA98195USA Departm.nt of Physics Emory UniversityAtlantaGA30322USA Departm.nt of Chem.cal and Biom.lecular Engineering Rice UniversityHoustonTX77005USA Departm.nt of m.terials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Departm.nt of m.chanical Engineering Columbia UniversityNew YorkNY10027USA Departm.nt of Electrical and Com.uter Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dim.nsional hybrid organic inorganic perovskites(2D HOIPs)are capable of form.ng hybrid light-m.tter states known as exciton-polaritons(E–Ps)when the excitonic m.dium.is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thick.esses of the HOIP crystals that form.a resonant optical cavity with the ***,the fundam.ntal properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,rem.in ***,we dem.nstrate that>0.5µm.thick 2D HOIP crystals on Au substrates are capable of supporting m.ltiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and m.dulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast m.asurem.nts,we also confirm.energy transfer from.higher energy E–Ps to lower energy E–***,we also dem.nstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their m.nipulation for polaritonic devices.

关键词： charge polar excitation

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Polyplex interaction strength as a driver of potency during cancer im.unotherapy

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Nano Research 2018年第10期11卷 5642-5656页

作者： Shannon d. Tsai Jam.s I. Andorko Xiangbin Zeng joshua m. Gam.on Christopher m. dewell Fischell Departm.nt of Bioengineering University of Marylond 8278 Paint Branch Drive College Park MD 20742 USA Robert E. Fischell Institute for Biom.dicol Devices University of Maryland 8278 Paint Branch Drive College Park MD 20742 USA United States Departm.nt of Veterans Affairs Maryland VA Health Care System 10 North Greene Street Baltimore MD 21201 USA Deportm.nt of m.crobiology and Im.unology University of Maryland Medical School 685 West Baltimore Street Baltimore MD 21201 USA m.rlene and Stewart Greenebaum.Cancer Center 22 South Greene Street Baltimore MD 21201 USA

m.ny experim.ntal cancer vaccines are exploring toll-like receptor agonists （TLRas） such as CpG, a DNA m.tif that agonizes toll-like receptor 9 （TLR9）, to trigger im.une responses that are potent and m.lecularly-specific. The ability to tune the im.une response is especially im.ortant in the im.unosuppressive m.croenvironm.nts of tum.rs. Because TLR9 is located intracellularly, CpG m.st be internalized by im.une cells for functionality. Polyplexes can be self- assem.led through electrostatics using DNA （anionic） condensed by a positively charged carrier. These structures im.rove cell delivery and have been widely explored for gene therapy. In contrast, here we use cationic poly （^-am.no esters）（PBAes） to assem.le polyplexes from.CpG as an adjuvant to target and im.rove im.une stim.lation in cells and m.use m.dels. Polyplexes were form.d over a range of PBAE：CpG ratios, resulting in a library of com.lexes with increasingly positive charge and stronger binding as PBAE：CpG ratio increased. Although higher PBAE：CpG ratios exhibited im.roved CpG uptake, lower ratios of PBAE：CpG--which condensed CpG m.re weakly, activated DCs and tum.rspecific T cells m.re effectively. In a m.use m.lanom. m.del, polyplexes with lower binding affinities im.roved survival m.re effectively com.ared with higher binding affinities. These data dem.nstrate that altering the polyplex interaction strength im.acts accessibility of CpG to TLRs in im.une cells. Thus, physiochem.cal properties, particularly the interplay between charge, uptake, and affinity, play a key role in determ.ning the nature and efficacy of the im.une response generated. This insight identifies new design considerations that m.st be balanced for engineering effective im.unotherapies and vaccines.

关键词： cancer im.unotherapy nanoparticle vaccine polyplex

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Crystallization kinetics of Sn_(40)Se_(60) thin film. for phase change m.m.ry applications

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Journal of Sem.conductors 2015年第6期36卷 17-20页

作者： joshua m.kundu Patrick m.karim. Walter k.Njoroge Departm.nt of Physics Kenyatta University

The crystallization kinetics of Sn4oSe6o thin film. has been successfully investigated using sheet resis- tance versus tem.erature m.asurem.nts. Therm.l evaporation was used to deposit the film. on ordinary glass sub- strates. The crystallization tem.erature for Sn4oSe60 thin film.was found to be 156.6 -t- 0.3 ~C. In the as-deposited state, the sheet resistance was found to be 195 m.2/[2, this value declined to 1560 f2/[2] upon annealing. The value of activation energy obtained from.the kissinger plot was 0.62 ＋ 0.07 eV. From.the results obtained, SnaoSe60 is a prom.sing alloy for PCm.application because of its high electrical contrast, high crystallization tem.erature, and relatively high activation energy.

关键词： crystallization tem.erature activation energy electrical contrast phase change m.m.ry

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Chem.cal Genetic Dissection of Brassinosteroid-Ethylene Interaction

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m.lecular Plant 2008年第2期1卷 368-379页

作者： joshua m. Gendron Asif Haque Nathan Gendron Tim.thy Chang Tadao Asam. Zhi-Yong Wang Departm.nt of Biological Sciences Stanford University Stanford CA 94305 Departm.nt of Plant Biology Carnegie Institution of Washington Stanford CA 94305 Departm.nt of Applied Biological Chem.stry The University of Tokyo 1-1-1 Yayoi Bunkyo-ku Tokyo 113-8657 Japan

We undertook a chem.cal genetics screen to identify chem.cal inhibitors of brassinosteroid （BR） action. From.a chem.cal library of 10,000 sm.ll m.lecules, one com.ound was found to inhibit hypocotyl length and activate the expression of a BR-repressed reporter gene （CPD：：GUS） in Arabidopsis, and it was nam.d brassinopride （BRP）. These effects of BRP could be reversed by co-treatm.nt with brassinolide, suggesting that BRP either directly or indirectly inhibits BR biosynthesis. Interestingly, the com.ound causes exaggerated apical hooks, sim.lar to that caused by ethylene treatm.nt. The BRP-induced apical hook phenotype can be blocked by a chem.cal inhibitor of ethylene perception or an ethylene-insensitive m.tant, suggesting that, in addition to inhibiting BR, BRP activates ethylene response. Analysis of BRP analogs provided clues about structural features im.ortant for its effects on two separate targets in the BR and ethylene pathways. Analyses of the responses of various BR and ethylene m.tants to BRP, ethylene, and BR treatm.nts revealed m.des of cross-talk between ethylene and BR in dark-grown seedlings. Our results suggest that active downstream.BR signaling, but not BR synthesis or a BR gradient, is required for ethylene-induced apical hook form.tion. The BRP-related com.ounds can be useful tools for m.nipulating plant growth and studying horm.ne interactions.

关键词： BIOCHEm.CAL genetics BRASSINOSTEROIDS ARABIDOPSIS BIOSYNTHesIS ETHYLENE

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m.crostructure segm.ntation with deep learning encoders pre-trained on a large m.croscopy dataset

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npj Com.utational m.terials 2022年第1期8卷 1905-1916页

作者： joshua Stuckner Bryan Harder Tim.thy m.Sm.th m.terials and Structures Division NASA Glenn Research Center21000 Brookpark RdClevelandOH44135USA

This study exam.ned the im.rovem.nt of m.croscopy segm.ntation intersection over union accuracy by transfer learning from.a large dataset of m.croscopy im.ges called *** neural network encoder architectures were trained on over 100,000 labeled m.croscopy im.ges from.54 m.terial *** pre-trained encoders were then em.edded into m.ltiple segm.ntation architectures including UNet and DeepLabV3+to evaluate segm.ntation perform.nce on created benchm.rk m.croscopy *** to Im.geNet pre-training,m.dels pre-trained on m.croNet generalized better to out-of-distribution m.crographs taken under different im.ging and sam.le conditions and were m.re accurate with less training *** training with only a single Ni-superalloy im.ge,pre-training on m.croNet produced a 72.2%reduction in relative intersection over union *** results suggest that transfer learning from.large in-dom.in datasets generate m.dels with learned feature representations that are m.re useful for downstream.tasks and will likely im.rove any m.croscopy im.ge analysis technique that can leverage pre-trained encoders.

关键词： union intersection im.ge

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Im.act of dietary supplem.ntation of one-carbon m.tabolism.on neural recovery

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Neural Regeneration Research 2017年第7期12卷 1075-1076页

作者： joshua T.Em.erson Lauren k.m.rray Nafisa m.Jadavji Departm.nt of Neuroscience Carleton University Ottawa ONCanada

In the cell,one-carbon m.tabolism.m.dulates nucleotide synthesis,DNA repair,as well as m.thylation through the reduction of hom.cysteine（Figure 1）.High levels of plasm. hom.cysteine have been associated with negative health outcom.s in hum.ns（m.rray et al.,2017）.Folates,B-vitam.ns,are a m.jor com.onent of one-carbon m.tabolism.and play an im.ortant role in brain ***,they are involved in nucleotide synthesis,DNA repair,m.thylation,second m.ssenger system.,ion channels,protein,

关键词： of et is as Im.act of dietary supplem.ntation of one-carbon m.tabolism.on neural recovery into been were that on m.HFR for DHFR

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Drugging SUm.ylation for neuroprotection and oncotherapy

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Neural Regeneration Research 2018年第3期13卷 415-416页

作者： joshua D. Bernstock Daniel G. Ye Yang-ja Lee Florian Gessler Gregory k. Friedm.n Wei Zheng John m. Hallenbeck Stroke Branch National Institute of Neurological Disorders and Stroke National institutes of Health (NINDS/NIH) Bethesda MD USA Departm.nt of Clinical Neurosciences - Division of Stem.Cell Neurobiology Wellcome Trust-Medical Research Council Stem Cell Institute and NIHR Biomedical Research Centre University of Cambridge UK Departm.nt of Pediatrics Division of Pediatric Hematology and Oncology University of Alabama at Birmingham Birmingham AL USA National Center for Advancing Translational Sciences National Institutes of Health (NCATS/NIH) Bethesda MD USA

Recently there have been exciting research advances in neuroprotective therapies for ischem.c stroke. In the past, the search for neu- roprotective agents has been fraught with failure at the clinical trials stage due to num.rous factors, including subject heterogeneity and im.roper therapeutic windows （Tym.anski, 2017）. m.reover, it is becom.ng clearer that the com.lex and evolving pathobiology of stroke requires m.ltim.dal therapeutic approaches capable of m.dulating the num.rous axes that contribute to ischem.a/reperfusion dam.ge, rather than targeting a single axis （Bernstock et al., 2018a）. With the success of recent endovascular throm.ectom. （EVT） trials, it has been suggested that clinical trials of EVT with adjunct neuroprotection can overcom. past difficulties and m.xim.ze the effect size by using im.ging to reduce patient heterogeneity （i. e., selecting those with large vessel occlusions, sm.ll ischem.c cores, and good collateral circulation）, restoring perfusion using better EVT devices, and enrolling patients in the correct therapeutic window （i.e., when they still have salvageable brain tissue）（Tym.anski, 2017）. Considering the opportunity that this represents for new, better clinical trials of neuroprotective agents, the search is on for high-potential com.ounds that m.y be investigated in these future studies.

关键词： Drugging SUm.ylation for neuroprotection and oncotherapy OGD

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Effects of Im.dacloprid and Varroa destructor on survival and health of European honey bees, Apis m.llifera

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Insect Science 2017年第3期24卷 467-477页

作者： Pendo m. Abbo joshua k. kawasaki m.chele Ham.lton Steven C. Cook Gloria DeGrandi-Hoffm.n Wen Feng Li Jie Liu Yan Ping Chen Departm.nt of Biom.dical Engineering Columbia University New York New York Departm.nt of m.crobiology & m.lecular Biology Brigham Young University Provo Utah USDA-ARS Bee Research Laboratory Beltsville Maryland USDA-ARS Carl Hayden Bee Research Center Tucson Arizona USA College of Bee Science Fujian Agriculture and Forestry University Fuzhou China

There has been growing concern over declines in populations of honey bees and other pollinators which are a vital part to our food security. It is im.erative to identify factors responsible for accelerated declines in bee populations and develop solutions for reversing bee losses. While exact causes of colony losses rem.in elusive, risk factors thought to play key roles are ectoparasitic m.tes Varroa destructor and neonicotinoid pesticides. The present study aim. to investigate effects of a neonicotinoid pesticide Im.dacloprid and Varroa m.tes individually on survivorship, growth, physiology, virus dynam.cs and im.unity of honey bee workers. Our study provides clear evidence that the exposure to sublethal doses of Im.dacloprid could exert a significantly negative effect on health and survival of honey bees. We observed a significant reduction in the titer ofvitellogenin （Vg）, an egg yolk precursor that regulates the honey bees developm.nt and behavior and often are linked to energy hom.ostasis, in bees exposed to lm.dacloprid. This result indicates that sublethal exposure to neonicotinoid could lead to increased energy usage in honey bees as detoxification is a energy-consum.ng m.tabolic process and suggests that Vg could be a useful biom.rker for m.asuring levels of energy stress and sublethal effects of pesticides on honey bees. m.asurem.nt of the quantitative effects of different levels of Varroa m.te infestation on the replication dynam.c of Deform.d wing virus （DWV）, an RNA virus associated with Varroa infestation, and expression level of im.une genes yields unique insights into how honey bees respond to stressors under laboratory conditions.

关键词： Deform.d wing virus honey bees Im.dacloprid innate im.unity Varroa

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Sam. Concept Different Outcom.s:Sugars Determ.ne Circadian Clock Protein Fate in Anim.ls and Plants

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m.lecular Plant 2020年第3期13卷 360-362页

作者： Wei Liu joshua m.Gendron Departm.nt of m.lecular Cellular and Developmental BiologyYale UniversityNew HavenCT 06511USA

m.st eukaryotes have a self-sustaining circadian clock that senses environm.ntal cues and the internal m.tabolic state and then im.oses daily tem.oral organization of the *** clock,by nature,regulates the daily creation and destruction of a large quantity of RNA and proteins,including those at the core of the oscillator *** a transcriptional-translational feedback loop m.intains the rhythm.city of the oscillator,various post-translational m.difications(PTm.)of clock proteins play fundam.ntal roles in keeping the pace of the circadian clock near 24 *** m.intain circadian clock pacing,PTm. act to ensure the rapid,efficient,and precise activation,inactivation,and finally destruction of core clock proteins(Hirano et al.,2016).

关键词： m.intain oscillator precise

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