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Organochlorine pesticide and heavy metal residues in some edible biota collected from Quanzhou Bay and Xinghua Bay,Southeast China

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Journal of Environmental Sciences 2010年第2期22卷 314-320页

作者： Mangala Yatawara Odhiambo joshua Owago Julia E Burnet Key Laboratory of Biogeology and Environmental Geology of Ministry of Education

In order to assess the contamination of edible marine organisms in Quanzhou and Xinghua Bays, Fujian Province, China, concentrations of organochlorine pesticides （hexachlorocyclohexane isomers or HCHs and dichlorodiphenyltrichloroethane isomers/derivatives or DDTs） and heavy metals （Cu, Pb, Zn, As, Cr, Cd, Ni and Hg） in 13 species collected from different sites in the hays were analyzed by GC-ECD and ICP-MS. The concentration of the sum of DDTs exceeded that the sum of HCHs in the samples. Most of the organisms showed higher levels of DDTs than the first level criterion （10 ng/g） for marine biological quality in China （GB 18421-2001） but conformed to the first level criterion （20 ng/g） for HCHs. The estimated mean daily uptake of pesticides was below the level for minimal risk to the consumers. The levels of Cd, As and Pb in most organisms from both bays were markedly elevated and above the recommended legal limits for human consumption. Our results showed the need for routine monitoring of marine species contamination to ensure public and environmental health.

关键词： organochlorine pesticides residue levels technical HCH heavy metals Fujian Province

Keeping nephrotic syndrome on the emergency department edema differential: A case report

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World Journal of Emergency Medicine 2019年第2期10卷 116-118页

作者： joshua Goodwin Bijon Das Department of Emergency Medicine Dalhousie University Faculty of Medicine

Dear editor,Nephrotic syndrome is defined by the presence of peripheral edema,heavy proteinuria(greater than 3.5 g/24h),and hypoalbuminemia(less than 3 g/dL).^[1]Nephrotic syndrome is relatively rare,with an incidence of 3 new patients per 100,000 per year in adults.^[1]Despite being a known cause for new onset edema in patients at any age,nephrotic syndrome is often neglected in considering differential diagnoses for this presentation in primary care settings,and initial workups often focus on ruling out cardiac and hepatic causes of edema.^[1-3]In this case report,we describe a 25-year-old male patient who presented to the emergency department(ED)complaining of a 10-day history of *** was later diagnosed with nephrotic syndrome secondary to minimal change *** case served as a reminder to include the differential diagnosis of nephrotic syndrome early in the workup of an adult with peripheral edema presenting to the ED.

关键词： Dear editor Nephrotic syndrome peripheral edema

Euglycemia despite a sodium glucose co-transporter 2 inhibitor overdose

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World Journal of Emergency Medicine 2022年第2期13卷 147-148页

作者： Muhammad Akbar Baig joshua Nogar NorthShore University Health System ManhassetNY 11030USA

Dear editor,Sodium glucose co-transporter 2 inhibitors(SGLT2I)reduce the majority of reabsorption of glucose in the proximal tubules,which reduces blood glucose levels by allowing excretion of excess glucose in the urine.[1]By inhibiting glucose reabsorption,they increase the osmotic pressure of urine resulting in diuresis which can cause a reduction of blood pressure.[2]Fortunately,as these drugs are not directly implicated in altering glucose metabolism or causing insulin secretion,SGLT2I monotherapy does not result in severe hypoglycemia.

关键词： urine metabolism drugs

From Tongbo Village to Widow Villagc The Legacy of the Chinese Civil War

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Frontiers of History in China 2017年第1期12卷 75-92页

作者： joshua Fan Department of History University of Texas at E1 Paso E1 Paso 79968 USA

Located on Dongshan Island, off the coast of Fujian province, is a typical rural village called Tongbo. On May 10, 1950, 147 men were abducted by the KMT army on its way to Taiwan. Since a majority of the men were already married, overnight, their wives became ＂widows,＂ and most would remain so for the rest of their lives. Consequently, Tongbo village became more widely known as Widow Village. The first objective of this paper is to document the tragic experiences of men and women in Tongbo village, focusing on these forced separations in 1950, the possibility of reunion after 1987, and the struggle to cope with the difficulties in between. The second objective of this paper is to argue that while heartbreaking, the experiences of this village are not extraordinary in the context of the Chinese Civil War. What made the men and women in Tongbo extraordinary is not their collective suffering, but how these villagers suffered less, not more, than in many other places, because of the actions of three key figures.

关键词： Chinese Civil War Tongbo village Widow Village Gu Wenchang,Hao Jianxiu Huang Zhengguo

Are fat NKT cells born that way?

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Cellular & Molecular Immunology 2017年第8期14卷 658-661页

作者： joshua A Vieth Derek B Sant'Angel Child Health Institute of New Jersey Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA Graduate School of Biomedical Sciences Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA Department of Pediatrics Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901USA

The role of natural killer T(NKT)cells in adipose tissue is a topic of much interest,as reports have suggested a correlation between depletion of the adipose-resident NKT(arNKT)cell population and chronic obesity.1 Fu... 详细信息

关键词： NKT killer obesity

Probing Electrocatalytic CO_(2) Reduction at Individual Cu Nanostructures via Optically Targeted Electrochemical Cell Microscopy

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Journal of Analysis and Testing 2019年第2期3卷 140-149页

作者： joshua D.Walmsley joshua W.Hill Partha Saha Caleb M.Hill Department of Chemistry University of WyomingLaramieWY 82071USA

Optically targeted electrochemical cell microscopy(OTECCM)was applied to measure electrocatalytic rates at individual Cu nanoparticles(NPs)under electrolyte conditions relevant to CO_(2) *** electrocatalytic responses from individual NPs were found to exhibit a wide variation in behavior,with significant NP-to-NP variations in the magnitude of electrocata-lytic currents and necessary overpotentials being *** of these quantities with metrics of NP size suggest no significant variations in the inherent electrocatalytic activity of the NPs with *** element simulations of diffusion in this system demonstrate the observed diffusion-limited currents are significantly smaller than expected,attributable to the presence of a significant amount of residual ligand on the surface of the Cu NPs,which were prepared via an organic phase *** results presented here further demonstrate the promise of techniques which employ correlated optical and electrochemical measurements,such as OTECCM,for studying electrocatalysis at individual NPs.

关键词： Electrochemistry Electrochemical microscopy Nanoparticles CO_(2)reduction

Crohn’s disease:Innate immunodeficiency?

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World Journal of Gastroenterology 2006年第42期12卷 6751-6755页

作者： Jesus K Yamamoto-Furusho joshua R Korzenik Gastro-intestinal Unit and Center for the Study of Inflammatory Bowel Disease Massachusetts General Hospital and Harvard Medical School Boston MA 02114 United States

In the past, Crohn’s disease (CD) has been understood primarily as an immunologic disorder characterized by an abnormal T-cell response. Recent in vitro and in vivo data suggests that CD may instead be precipitated by innate immune dysfunction resulting from a combination of genetic and environmental factors. Some reports have demonstrated a defective immune response in a variety of other cellular components, including neutrophils, monocytes and dendritic cells. Recent studies of granulocyte-macrophage colony-stimulating factor (GM- CSF) in CD, aiming to stimulate the innate immune system with the conception that an innate immune defect underlies the development of the disease, have been demonstrated a clinical benefit and reinforce this evolving understanding of the disease.

关键词： Crohn's disease Innate immunity Immunodeficiency NOD2

Same Concept Different Outcomes:Sugars Determine Circadian Clock Protein Fate in Animals and Plants

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Molecular Plant 2020年第3期13卷 360-362页

作者： Wei Liu joshua M.Gendron Department of Molecular Cellular and Developmental BiologyYale UniversityNew HavenCT 06511USA

Most eukaryotes have a self-sustaining circadian clock that senses environmental cues and the internal metabolic state and then imposes daily temporal organization of the *** clock,by nature,regulates the daily creation and destruction of a large quantity of RNA and proteins,including those at the core of the oscillator *** a transcriptional-translational feedback loop maintains the rhythmicity of the oscillator,various post-translational modifications(PTMs)of clock proteins play fundamental roles in keeping the pace of the circadian clock near 24 *** maintain circadian clock pacing,PTMs act to ensure the rapid,efficient,and precise activation,inactivation,and finally destruction of core clock proteins(Hirano et al.,2016).

关键词： maintain oscillator precise

Resonant magnetoelastic microstructures for wireless actuation of liquid flow on 3D surfaces and use in glaucoma drainage implants

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Microsystems & Nanoengineering 2015年第1期1卷 26-34页

作者： Venkatram Pepakayala joshua Stein Yogesh Gianchandani Center for Wireless Integrated MicroSensing and Systems(WIMS2) Department of Electrical Engineering and Computer ScienceUniversity of MichiganAnn ArborMIUSA Department of Ophthalmology and Visual Sciences University of MichiganAnn ArborMIUSA

Magnetoelastic resonators made from metal alloy foils are widely used for miniature wireless anti-theft tags and have also been explored for use in various sensing *** annealing within three-dimensional(3D)molds,these foils can be formed into curved ***,magnetoelastic materials present an opportunity for the development of a new class of wireless,actuators that have small form factors and low surface profiles and that can conform to curved *** paper describes passive,wireless,resonant magnetoelastic actuators intended for the generation of fluid flow on the surfaces of implantable Ahmed glaucoma drainage *** actuators are remotely excited to resonance using a magnetic field generated by external *** fluid flow is intended to limit cellular adhesion to the surface of the implant,as this adhesion can ultimately lead to implant encapsulation and *** actuators are micromachined from planar 29-μm-thick foils of Metglas 2826MB(Fe_(40)Ni_(38)Mo_(4)B_(18)),an amorphous magnetoelastic alloy,using photochemical *** 10.3×5.6 mm^(2),the planar structures are annealed in 3D molds to conform to the surface of the drainage device,which has an aspherical *** actuator designs are described,with varying shapes and resonant mode *** resonant frequencies for the different designs vary from 520 Hz to 4.7 *** velocities of up to 266μm s^(−1) are recorded at a wireless activation range of 25–30 mm,with peak actuator vibration amplitudes of 1.5μ*** actuators such as those described here have the potential to greatly enhance the effectiveness of glaucoma drainage devices at lowering eye pressure and may also be useful in other areas of medicine.

关键词： actuator fibrosis glaucoma magnetostriction Metglas