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Infectious diseases of Poverty 2015年第1期4卷 83-87页

作者： joshua d jones division of Virology Department of PathologyUniversity of CambridgeTennis Court RoadCambridge CB21QPUK

Background:Monoclonal antibody therapy has an important role to play as a post-exposure prophylactic and therapeutic for the treatment of viral infections,including emerging *** example,several patients of the present Ebola virus outbreak in West Africa were treated with ZMapp,a cocktail of three monoclonal antibodies which are expressed in Nicotiana ***:The majority of monoclonal antibodies in clinical use are expressed in mammalian cell lines which offer native folding and glycosylation of the expressed *** antibody expression in vegetal systems offers advantages over expression in mammalian cell lines,including improved potential for scale up and reduced *** this paper,I highlight the advantages of an upcoming protozoal system for the expression of recombinant antibody *** tarentolae offers a robust,economical expression of proteins with mammalian glycosylation patterns expressed in stable cell lines and grown in suspension *** advantages of this system make it particularly suited for use in developing ***:Given the potential importance of monoclonal antibody therapy in the containment of emerging viral infections,novel and alternative strategies to improve production must be explored.

关键词： Antibody Ebola Emerging Expression Infection Leishmania Monoclonal Therapy

Phrenic nerve block: the key to managing acute biliary pain?

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World Journal of Emergency Medicine 2024年第1期15卷 62-63页

作者： Michael Shalaby joshua Luftig department of Emergency Medicine and Critical Care Herbert Wertheim College of Medicine at Florida International UniversityMiami 33199USA Advanced Emergency Ultrasound Mount Sinai Medical CenterMiami Beach 33140USA department of Emergency Medicine Highland HospitalAlameda Health SystemOakland 94602USA

Over the past two decades,the USA has witnessed a steep rise in the incidence of acute cholecystitis(AC),[1]even among children,[2]with over 200,000 cases annually.[3]Patients with AC often present to the emergency department(Ed)experiencing severe distress,with most describing their pain level as“intolerable.”[4]Furthermore,there is usually a considerable delay before surgery,with a median time from diagnosis of AC to surgery of 28.5 h,[5]and a substantial percentage of patients wait as long as 10 d.[6]Prolonged delays before surgery lead to increased opioid use,which is associated with extended hospital stays and higher rates of readmission after cholecystectomy.[7]Furthermore,opioids can lead to vomiting,respiratory depression,delirium,and ultimately addiction.[8]We propose a novel regional anesthesia technique for managing AC:right phrenic nerve *** method could offer improved pain control and a more favorable risk profile in selected patients when compared to current Ed practices.

关键词： pain anesthesia diagnosis

Relating estimates of wood properties of birch to stem form, age and species

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Journal of Forestry Research 2024年第3期35卷 1-11页

作者： Grace jones Maria Ulan Mateusz Liziniewicz Johan Lindeberg Stergios Adamopoulos Teagasc Forestry development department Ashtown Research CentreDublin 15 D15DY05Ireland Research Institutes of Sweden(RISE) GoteborgSweden The Forest Research Institute of Sweden(Skogforsk) Ekebo 225026890SvalovSweden department of Forestry and Wood Technology Linnaeus University35195VaxjoSweden department of Forest Biomaterials and Technology Swedish University of Agricultural SciencesBox 700875007 UppsalaSweden

Birch has long suffered from a lack of active forest management,leading many researchers to use mate-rial without a detailed management *** collected from three birch(Betula pendula Roth,*** Ehrh.)sites in southern Sweden were analyzed using regression analysis to detect any trends or differences in wood proper-ties that could be explained by stand history,tree age and stem *** sites were genetics trials established in the same *** of acoustic velocity(AV)from non-destructive testing(NdT)and predicted AV had a higher correlation if data was pooled across sites and other stem form factors were considered.A subsample of stems had radial profiles of X-ray wood density and ring width by year created,and wood density was related to ring number from the pith and ring *** seemed likely that wood density was negatively related to ring width for both birch *** models had slight improvements if site and species were included,but only the youngest site with trees at age 15 had both birch *** paper indicated that NdT values need to be considered separately,and any predictive models will likely be improved if they are specific to the site and birch species measured.

关键词： Acoustic velocity Non-destructive testing Predictive models Regression analysis Wood density

Obstructive sleep apnea:Overlooked comorbidity in patients with diabetes

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World Journal of diabetes 2024年第7期15卷 1448-1460页

作者： Eric d Tenda joshua Henrina Jin H Cha Muhammad R Triono Ersananda A Putri dahliana J Aristy dicky L Tahapary division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia Head of Research Group Artificial Intelligence and digital Health Indonesian Medical Education and Research InstituteFaculty of Medicine University of IndonesiaDKI JakartaJakarta Pusat 10430Indonesia division of Endocrinology Metabolism and DiabetesDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia

In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2dM),highlighting a significant yet often overlooked *** delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose *** research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related *** the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2dM and *** review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

关键词： Obstructive sleep apnea Type 2 diabetes mellitus Macrovascular Microvascular Weight loss Positive airway pressure

Post-operative protein supplementation following orthopaedic surgery: A systematic review

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Sports Medicine and Health Science 2024年第1期6卷 16-24页

作者： Andrew George Brendan M.Holderread Bradley S.Lambert joshua d.Harris Patrick C.McCulloch Houston Methodist Orthopedics and Sports Medicine 6445 Main Street Suite 2300HoustonTX77030USA Houston Methodist Orthopedic Biomechanics Research Laboratory 6670 Bertner AveHoustonTX77030USA

decreased mechanical loading after orthopaedic surgery predisposes patients to develop muscle *** purpose of this review was to assess whether the evidence supports oral protein supplementation can help decrease postoperative muscle atrophy and/or improve patient outcomes following orthopaedic surgery.A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and MetaAnalysis(PRISMA).PubMed(MEdLINE),Embase,Scopus,and Web of Science were searched for randomized controlled trials that assessed protein or amino acid supplementation in patients undergoing orthopaedic *** investigators independently conducted the search using relevant Boolean *** outcomes included functional or physiologic measures of muscle atrophy or *** studies including 611 patients(224 males,387 females)were *** studies evaluated protein supplementation after ACL reconstruction(ACLR),3 after total hip arthroplasty(THA),5 after total knee arthroplasty(TKA),and 3 after surgical treatment of hip *** supplementation showed beneficial effects across all types of *** primary benefit was a decrease in muscle atrophy compared to placebo as measured by muscle cross sectional *** authors also demonstrated improved functional measures and quicker achievement of rehabilitation *** supplementation has beneficial effects on mitigating muscle atrophy in the postoperative period following ACLR,THA,TKA,and surgical treatment of hip *** effects often correlate with improved functional measures and quicker achievement of rehabilitation *** research is needed to evaluate long-term effects of protein supplementation and to establish standardized population-specific regimens that maximize treatment efficacy in the postoperative period.

关键词： Orthopaedic surgery Protein supplementation Systematic review Muscle atrophy

3d laparoscopy and fluorescence imaging can improve surgical precision for hepatectomy

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 544-547页

作者： joshua Sheng Hao Lim Vishal G.Shelat department of General Surgery Tan Tock Seng HospitalSingaporeSingapore

Laparoscopic hepatectomy for the treatment of hepatocellular carcinoma(HCC)has been shown to have superior short-term and comparable long-term outcomes compared with open hepatectomy in experienced centres(1).Short-term advantages include small incisions,reduced post-operative pain,faster recovery,reduced blood loss and lower risk of complications(2).However,the loss of tactile sensation makes it challenging to accurately locate lesions and define tumour margins.

关键词： 3d laparoscopy hepatocellular carcinoma(HCC) indocyanine green dye(ICG dye) liver resection

Mechanically driven assembly of biomimetic 2d-material microtextures with bioinspired multifunctionality

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Nano Research 2024年第2期17卷 663-678页

作者： Yang Li Lin Jing joshua M.Little Haochen Yang Tsai-Chun Chung Po-Yen Chen department of Chemical and Biomolecular Engineering University of MarylandCollege ParkMD 20740USA Maryland Robotics Center University of MarylandCollege ParkMD 20742USA School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Nature provides a wealth of bio-inspiration for advanced material *** various nanomaterials into biomimetic microtextures with bioinspired functionalities has spurred increasing research interests and facilitated technological advances in various *** recent years,two-dimensional materials(2dMs)have emerged as important building block units in the biomimicry field due to their distinct chemical,physical,electrical,electrochemical,and catalytic *** this review article,various mechanically driven assembly approaches are summarized to fabricate various genealogies of biomimetic 2dM microtextures with bio-inspired ***,sequential deformation strategies are discussed to programmably construct higher dimensional 2dM microtextures,ranging from wrinkles/crumples(one-time deformation)to multiscale hierarchies(multiple deformations).Next,the current progress using higher dimensional 2dM microtextures to imitate different biological structures and/or induce bio-inspired multifunctionality is systematically *** showcases of bio-inspiration and biomimicry using different 2dM nanosheets are highlighted:(1)wrinkle patterns of an earthworm that spur the design of strain sensors with programmable working ranges and sensitivities,(2)wrinkle appearance of a Shar-Pei dog that motivates the fabrication of stretchable energy storage devices,(3)hierarchical scale textures of a desert lizard that inspire cation-induced gelation platforms for 2dM aerogels,and(4)wrinkle skin of an elephant that influences the development of 2dM protective skin for soft ***,challenges and future opportunities of adopting 2dM nanosheets to assemble biomimetic microstructures with synergistic functionalities are discussed.

关键词： two-dimensional(2d)materials mechanically driven assembly biomimetic microtextures functional nanocomposite bio-inspired multifunctionality

A phase Ⅰ study of Hemay022, an irreversible dual EGFR/HER2 tyrosine kinase inhibitor in Chinese patients with HER2-positive advanced breast cancer

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Chinese Journal of Cancer Research 2024年第1期36卷 46-54页

作者： Pin Zhang Lin Wang Yueying Zhen Zhihong Wang Hesheng Zhang Richard jones Binghe Xu department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tianjin Hemay Pharmaceutical Co. LTDTianjin 300308China

Objective: Hemay022 is a novel small-molecule and an irreversible tyrosine kinase inhibitor with the target of epidermal growth factor receptor(EGFR)/human epidermal growth factor receptor 2(HER2), which demonstrated anti-tumor activity in preclinical studies. This first-in-human study evaluated the safety, pharmacokinetics,tolerability and preliminary anti-tumor activity of Hemay022 in HER2-positive advanced breast cancer ***: Heavily pretreated patients with HER2-positive advanced breast cancer were assigned to eight dose cohorts in a 3+3 dose-escalation pattern at doses of 50-600 mg Qd and 300 mg BId. Eligible patients were given a single dose of Hemay022 on d 1 in week 0, followed by once daily continuous doses for four weeks in 28-day *** samples were obtained on d 1 and d 28. Clinical responses were assessed every eight ***: Twenty-eight patients with advanced breast cancer were treated with Hemay022. The most frequently reported drug-related adverse events were diarrhoea(85.7%), vomiting(28.6%), nausea(25.0%) and decreased appetite(17.9%). No grade 4 drug-related adverse events were reported. At 50-600 mg doses, steady state areas under the concentration-time curve and peak concentrations increased with doses. One patient achieved complete response(CR), and three achieved partial response(PR). The objective response rate(ORR) and disease control rate(dCR) were 14.3% and 46.4% in 28 patients, respectively. The median progression-free survival(PFS) was3.98 ***: Hemay022 at the dose of 500 mg once daily was well tolerated. The pharmacokinetic properties and encouraging anti-tumor activities of Hemay022 in advanced breast cancer patients warranted further evaluation of Hemay022 for treating breast cancer patients in the current phase Ⅲ trial(No. NCT05122494).

关键词： Advanced breast cancer HER2-positive Hemay022 first-in-human trial

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霜冻时的热泵

科技纵览 2024年第5期 16-17页

作者： Willie d.jones 不详

有批评意见认为,空气源热泵为房屋供暖的能力会在温度降到4℃以下时下降。不过,8家领先的热泵制造商表示,他们已经开发出了能够在室外严寒中保持室内温暖舒适的热泵。通过参加由美国能源部与加拿大自然资源部合作主办的住宅寒冷气候热... 详细信息

有批评意见认为,空气源热泵为房屋供暖的能力会在温度降到4℃以下时下降。不过,8家领先的热泵制造商表示,他们已经开发出了能够在室外严寒中保持室内温暖舒适的热泵。通过参加由美国能源部与加拿大自然资源部合作主办的住宅寒冷气候热泵挑战赛(Residential ColdClimate Heat Pump Challenge),他们正在证明这一点。参赛公司之一的特灵科技公司在美国得克萨斯州泰勒的冷藏室测试了其热泵。在实验室测试中,有些原型机能够经受住低至-30℃的温度,之后这些原型机在美国北部十个州和加拿大两个省的些家庭中经受着严寒环境的考验。

关键词：空气源热泵美国能源部批评意见实验室测试寒冷气候自然资源部

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机械巨星

科技纵览 2024年第4期 14-15页

作者： WILLIE d.jones 不详

2023年末,位于美国亚特兰大的乔治亚理工大学的研究人员发布了一个机器人表演雕塑作品,他们将其命名为美杜莎.它以神话中的蛇发女怪美杜莎为原型,美杜莎将所有看着她的人都变成了石头.该机器人有着蛇形机械臂,可以同时演奏打击乐和弦乐... 详细信息

2023年末,位于美国亚特兰大的乔治亚理工大学的研究人员发布了一个机器人表演雕塑作品,他们将其命名为美杜莎.它以神话中的蛇发女怪美杜莎为原型,美杜莎将所有看着她的人都变成了石头.该机器人有着蛇形机械臂,可以同时演奏打击乐和弦乐,并可与观众互动"跳舞".乔治亚理工大学音乐技术中心教授吉尔·温伯格(Gil Weinberg)是美杜莎团队的负责人,他解释道:"这件作品一方面揭示了由人工智能驱动的机器蛇跟踪和威胁人类的怪异概念,另一方面激发了人类突破创造力和表达极限的潜力;这两者在作品中达到了完美的平衡."

关键词：美国亚特兰大人工智能雕塑作品温伯格观众互动美杜莎机械臂理工大学