检索结果-南通市图书馆

Associations of lifestyle and diet with the risk of nasopharyngeal carcinoma in Singapore:a case–control study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2017年第2期36卷 63-70页

作者： Sook Kwin Yong Tam Cam Ha Ming Chert Richard Yeo Valerie Gaborieau James D.McKay joseph wee Division of Clinical Trials and Epidemiological Sciences National Cancer Centre Singapore11 Hospital DriveSingapore 169610Singapore Medical Education Research&Evaluation Department(MERE)Duke-NUS Medical School8 College RoadSingapore 169857Singapore Division of Radiation Oncology National Cancer Centre Singapore11 Hospital DriveSinga-pore 169610Singapore Genetic Cancer Susceptibility Group International Agency for Research on CancerWorld Health Organization150 Cours Albert Thomas69372 Lyon Cedex 08France

Background: Nasopharyngeal carcinoma(NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of this study was to examine associations between modifiable lifestyle factors and the risk of NPC in the Singaporean ***: We conducted a case–control study in Singapore with 300 patients and 310 controls who were recruited between 2008 and 2012. Each control was selected and individually matched to each patient based on sex, ethnicity, and age(±5 years). A total of 290 pairs of cases and controls were matched successfully. We examined lifestyle factors such as tobacco smoking, alcohol drinking, various salted and preserved food consumption, and weaning ***: After adjusting for covariates, multivariate analysis showed that those participants who were current smokers and had ever smoked tobacco had a higher risk of NPC than participants who had never smoked, with odds ratios(ORs) of 4.50(95% confidence interval [CI] 2.58–7.86; P week also showed a significantly increased risk of NPC than those who never or rarely consumed salted vegetables, with an OR of 4.18(95% CI 1.69–10.38; P = 0.002).Conclusion: Smoking(currently and ever-smoked) and consuming salted vegetables once a week or more were lifestyle risk factors for NPC, and changes of these factors for the better may reduce the risk of NPC.

关键词： Nasopharyngeal carcinoma Diet Smoking Alcohol drinking Case–control study Preserved food

High incidence of nasopharyngeal cancer: similarity for 60% of mitochondrial DNA signatures between the Bidayuhs of Borneo and the Bai-yue of Southern China

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2012年第9期31卷 455-456页

作者： joseph wee Tam Cam Ha Susan Loong Chao-Nan Qian Department of Radiation Oncology National Cancer Centre Singapore Division of Clinical Trials&Epidemiological Sciences National Cancer Centre Singapore Duke-NUS Graduate Medical School State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center Van Andel Research Institute

Populations in Southern China (Bai-yue) and Borneo (Bidayuh) with high incidence of nasopharyngeal cancer (NPC) share similar mitochondrial DNA signatures, supporting the hypothesis that these two populations may share the same genetic predisposition for NPC, which may have first appeared in a common ancestral reference population before the sea levels rose after the last ice age.

关键词：线粒体DNA 中国南方相似性婆罗洲发病率鼻咽癌签名遗传易感性

Is nasopharyngeal cancer really a “Cantonese cancer”?

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2010年第5期29卷 517-526页

作者： joseph Tien Seng wee Tam Cam Ha Susan Li Er Loong Chao-Nan Qian Division of Clinical Trials & Epidemiological Sciences National Cancer Centre Singapore 169610 Singapore Department of Radiation Oncology National Cancer Centre Singapore 169610 Singapore NCCS-VARI Translational Cancer Research Laboratory Humphrey-Oei Institute of Cancer Research National Cancer Centre Singapore 169610 Singapore State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 P.R. China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P.R. China

Nasopharyngeal cancer(NPC) is endemic in Southern China,with Guandong province and Hong Kong reporting some of the highest incidences in the *** journal Science has called it a "Cantonese cancer".We propose that in fact NPC is a cancer that originated in the Bai-Yue("proto-Tai-Kadai" or "proto-Austronesian" or "proto-Zhuang") peoples and was transmitted to the Han Chinese in southern China through ***,the work by John Ho raised the profile of NPC,and because of the high incidence of NPC in Hong Kong and Guangzhou,NPC became known as a Cantonese *** searched historical articles,articles cited in PubMed,Google,monographs,books and Internet articles relating to genetics of the peoples with high populations of *** migration history of these various peoples was extensively researched,and where possible,their genetic fingerprint identified to corroborate with historical *** and anthropological evidence suggest there are a lot of similarities between the Bai-Yue and the aboriginal peoples of Borneo and Northeast India;between Inuit of Greenland,Austronesian Mayalo-Polynesians of Southeast Asia and Polynesians of Oceania,suggesting some common *** studies also suggest the present Cantonese,Minnans and Hakkas are probably an admixture of northern Han and southern *** these populations have a high incidence of *** early contact between southern Chinese and peoples of East Africa and Arabia can also account for the intermediate incidence of NPC in these regions.

关键词：鼻咽癌广东省全国人民代表大会中国南部发病率个人资料指纹识别格陵兰岛

Retreatment in locally recurrent nasopharyngeal carcinoma:Current status and perspectives

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2021年第5期41卷 361-370页

作者： Sharon Shuxian Poh Yoke Lim Soong Kiattisa Sommat Chwee Ming Lim Kam Weng Fong Terence WK Tan Melvin LK Chua Fu Qiang Wang Jing Hu joseph TS wee Division of Radiation Oncology National Cancer Centre SingaporeSingapore 169610 Oncology Academic Clinical Programme Duke-NUS Graduate Medical SchoolSingapore 169857 Department of Otorhinolaryngology-Head and Neck Surgery Singapore General HospitalSingapore 169608 Surgery Academic Clinical Programme Duke-NUS Graduate Medical SchoolSingapore 169857

1 Background Nasopharyngeal carcinoma(NPC)arises from the epithelial cells that cover and line the *** it is considered a rare cancer globally,it is commonly observed in South China and a few other ethnically distinct racial *** to its propensity to spread early through the submucosal tissue and the highly infiltrative nature of this disease,NPC spreads easily through areas of lesser resistance within the pharyngobasilar fascia with a tendency for neural infiltration[1-3].

关键词： Nasopharyngeal Carcinoma Radiation Oncology Head and Neck Tumor

新加坡的生活方式和饮食习惯与鼻咽癌风险的关系:一项病例对照研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

癌症 2018年第11期37卷 502-510页

作者： Sook Kwin Yong Tam Cam Ha Ming Chert Richard Yeo Valerie Gaborieau James D.McKay joseph wee Division of Clinical Trials and Epidemiological Sciences National Cancer Centre Singapore Medical Education Research & Evaluation Department (MERE) Duke-NUS Medical School Division of Radiation Oncology National Cancer Centre Singapore Genetic Cancer Susceptibility Group International Agency for Research on Cancer World Health Organization

背景与目的鼻咽癌(nasopharyngeal carcinoma,NPC)是东南亚地区一种常见的癌症。许多研究已经对NPC的风险因素进行了研究,但一些风险因素的作用仍无定论。本研究旨在探讨新加坡人可改变的生活方式因素与NPC风险之间的关系。方法我们在... 详细信息

背景与目的鼻咽癌(nasopharyngeal carcinoma,NPC)是东南亚地区一种常见的癌症。许多研究已经对NPC的风险因素进行了研究,但一些风险因素的作用仍无定论。本研究旨在探讨新加坡人可改变的生活方式因素与NPC风险之间的关系。方法我们在新加坡进行了一项病例对照研究,在2008年至2012年期间招募了300例患者和310例对照。根据性别、种族和年龄(±5岁)对各例对照进行选择并分别与每一例患者匹配。共有290对病例和对照成功匹配。我们对多个生活方式因素,如吸烟、饮酒、各种腌制和罐头食品消费以及断奶习惯进行了研究。结果调整协变量后多因素分析显示,现行吸烟者和有既往吸烟史的参与者比从未吸烟的参与者患NPC的风险更高,优势比(odds ratios,ORs)分别为4.50 [95%置信区间(confidence interval,CI):2.58–7.86;P <0.001]和2.52(95%CI:1.54–4.12;P <0.001)。每周至少吃1次腌制蔬菜的人也比那些从不或很少食用腌制蔬菜的人表现出NPC风险显著增加,OR值为4.18(95%CI:1.69–10.38;P=0.002)。结论吸烟(现行和经常吸食)和每周1次或多次食用腌制蔬菜是NPC的生活方式风险因素,戒除这些不良因素可以降低NPC的风险。

关键词：鼻咽癌饮食吸烟饮酒病例对照研究罐头食品

The most important questions in cancer research and clinical oncology

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2017年第2期36卷 1-7页

作者： joseph T. S. wee Sharon Shuxian Poh Division of Radiation Oncology National Cancer Centre Duke-NUSMedicalSchool

Specific research foci:(1) Mouse models of gamma-herpes virus-68(γHV-68) and polyomavirus(Py V) infections during neonatal versus adult life.(2) For human papilloma virus(HPV)-positive oropharyngeal carcinoma(OPC)—(a) Asking the question: Is oral sex a powerful carcinogen?(b) Examining the evidence for the vertical transmission of HPV infection.(c) Examining the relationship between HPV and Epstein–Barr virus(EBV) infections and nasopharyngeal cancer(NPC) in West European, East European, and East Asian countries.(d) Examining the association between HPVpositive OPC and human leukocyte antigen(HLA).(3) For non-smoking East Asian female lung adenocarcinoma—(a) Examining the incidence trends of HPV-positive OPC and female lung adenocarcinoma according to birth cohorts.(b) Examining the association between female lung adenocarcinoma and HPV.(c) Examining the associations of lung adenocarcinoma with immune modulating factors.(4) For triple-negative breast carcinoma(TNBC) in East Asians—(a) Examining the association between TNBC and HPV.(b) Examining the unique epidemiological characteristics of patients with TNBC. A summary "epidemiological" model tying some of these findings together.

关键词： HPV The most important questions in cancer research and clinical oncology

同方期刊数据库

Carcinogenesis of nasopharyngeal carcinoma:an alternate hypothetical mechanism

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2016年第1期35卷 26-34页

作者： Sharon Shuxian Poh Melvin Lee Kiang Chua joseph T.S.wee Division of Radiation Oncology National Cancer Centre11 Hospital Drive Duke-NUS Graduate Medical School

Current proposed mechanisms implicate both early and latent Epstein-Barr virus(EBV)infection in the carcinogenic cascade,whereas epidemiological studies have always associated nasopharyngeal carcinoma(NPC)with early childhood EBV infection and with chronic ear,nose,and sinus ***,most patients with NPC present with IgA antibody titers to EBV capsid antigen(VCA-lgA),which can precede actual tumor presentation by several *** early childhood EBV infection indeed constitutes a key event in NPC carcinogenesis,one would have to explain the inability to detect the virus in normal nasopharyngeal epithelium of patients at a high risk for EBV *** is perhaps possible that EBV resides within the salivary glands,instead of the epithelium,during *** claim is indirectly supported by observations that the East Asian phenotype shares the characteristics of an increased susceptibility to NPC and immature salivary gland morphogenesis,the latter of which is influenced by the association of salivary gland morphogenesis with an evolutionary variant of the human ectodysplasin receptor gene(EDAR),*** the immature salivary gland represents a more favorable nidus for EBV is uncertain,but in patients with infectious mononucleosis,EBV has been isolated in this anatomical *** presence of EBV-induced lymphoepitheliomas in the salivary glands and lungs further addresses the possibility of submucosal spread of the *** to the fact that the fossa of Rosen Muller contains a transformative zone active only in the first decade of life,one might be tempted to speculate the possibility of an alternative carcinogenic cascade for NPC that is perhaps not dissimilar to the model of human papillomavirus and cervical cancer.

关键词： Nasopharyngeal carcinoma, Carcinogenesis, Epstein-Barr virus, Transformation zone, Toll-like receptor 8(TLR8), EDAR gene, HLA

西双版纳曼旦村人工橡胶林“退胶还林”经济补偿标准研究

在线全文

学校读者我要写书评

暂无评论

资源科学 2015年第12期37卷 2461-2470页

作者：张佳琦 Sun joseph Chang Alison wee 薛达元中央民族大学生命与环境科学学院北京100081 中国科学院西双版纳热带植物园综合保护中心勐仑666303 Louisiana State University School of Renewable Natural Resources Baton Rouge 70803

热带雨林是地球的生物多样性宝库,近年人类活动导致全球热带雨林面积不断减少,使得保护雨林、保护环境,促进可持续发展成为当今世界各个国家和人民的共同愿望。从20世纪50年代至今,西双版纳森林覆盖面积减少了近30%,大部分转变为人工橡... 详细信息

热带雨林是地球的生物多样性宝库,近年人类活动导致全球热带雨林面积不断减少,使得保护雨林、保护环境,促进可持续发展成为当今世界各个国家和人民的共同愿望。从20世纪50年代至今,西双版纳森林覆盖面积减少了近30%,大部分转变为人工橡胶林。面对经济发展与不良生态效应之间的矛盾关系,以政府为主导的有偿"退胶"是在一定程度上拯救雨林的直接途径。本研究采用土地期望值理论和复利计算法,估算出西双版纳曼旦村橡胶林的土地期望值和森林价值,进而制定出"退胶还林"经济补偿标准,并采用了以20年为年限分期付款、征收/租赁的补偿方式。这一研究结果在理论和实践两方面为"退胶还林"面临的实际问题提供了科学的解决方案和参考依据。为促进"退胶还林"的实施,本文还建议在大规模"退胶还林"计划实施之前,要采取政策和措施,尽可能缓解大面积橡胶林对西双版纳当地生态环境的负面影响。

关键词：西双版纳退胶还林土地期望值经济补偿补偿标准勐腊县曼旦村

Prevalence of metabolic syndrome in type 2 diabetic patients: A comparative study using WHO, NCEP ATP III, IDF and Harmonized definitions

在线全文

学校读者我要写书评

暂无评论

Health 2013年第10期5卷 1689-1696页

作者： Mun Chieng Tan Ooi Chuan Ng Teck wee Wong Anthony joseph Yoke Mun Chan Abdul Rahman Hejar Department of Community Health Faculty of Medicine and Health Sciences Universiti Putra Malaysia Selangor Malaysia Department of Medicine Faculty of Medicine and Health Sciences Universiti Putra Malaysia Selangor Malaysia Department of Medicine Faculty of Medicine and Health Sciences Universiti Putra Malaysia Selangor Malaysia Department of Nutrition and Dietetics Faculty of Medicine and Health Sciences Universiti Putra Malaysia Selangor Malaysia Heart and Lung Centre iHEAL Medical Centre Kuala Lumpur Federal Territory of Kuala Lumpur Kuala Lumpur Malaysia Institute of Gerontology Universiti Putra Malaysia Selangor Malaysia

To determine the prevalence of metabolic syndrome (MetS) in Malaysian type 2 diabetic patients using WHO, NCEP ATP III, IDF and the new Harmonized definitions, and the concordance between these definitions. This study involved 313 patients diagnosed with type 2 diabetes mellitus (T2DM) at two Malaysian tertiary hospitals. Socio-demographic data were assessed using a pre-tested interviewer-administered structured questionnaire. Anthropometric measurements were carried out according to standard protocols. Clinical and laboratory characteristics were examined. Kappa (k) statistics were used for the agreement between the four MetS definitions. The overall prevalence rates of MetS (95% CI) were 95.8% (93.6-98.1), 96.1% (94.0-98.3), 84.8% (80.8-88.9) and 97.7% (96.1-99.4) according to the WHO, NCEP ATP III, IDF and the Harmonized definitions, respectively. The Kappa statistics demonstrated a slight to substantial agreement between the definitions (k = 0.179-0.875, p k = 0.875, p hest specificity (100%) in identifying MetS. In conclusion, the new Harmonized criteria established the highest prevalence of MetS among the four definitions applied. There was a very good concordance between the WHO and NCEP ATP III criteria. The extremely high prevalence of MetS observed in type 2 diabetic patients indicates an impending pandemic of CVD risk in Malaysia. Aggressive treatment of MetS components is required to reduce cardiovascular risk in T2DM.

关键词： Metabolic Syndrome Type 2 Diabetes Mellitus (T2DM) World Health Organization (WHO) Third Report of the National Cholesterol Education Expert Panel on Detection Evaluation Treatment of High Blood Cholesterol in Adults (NCEP ATP III) International Diabetes Federation (IDF) Harmonized Definition