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l.te Cenozoic high-resol.tion magnetostratigraphy in the Kunl.n Pass Basin and its impl.cations for the upl.ft of the northern Tibetan Pl.teau

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Chinese Science Bul.etin 2005年第17期50卷 1912-1922页

作者： SONG Chunhui GAO Dongl.ng FANG Xiaomin CUI Zhijiu l. Jijun YANG Shengi JIN Hongbo Dougl.s Burbank joseph l. kirschvink MOE Key l.boratory of Western China's Environmental.Systems(l.nzhou University) Ministry of Education & College of Earth and Environment Sciences Lanzhou University Lanzhou 730000 China Qinghai Institute of Sal. l.kes Chinese Academy of Sciences Qinghai 810008 China Institute of Tibetan Pl.teau Research Chinese Academy of SciencesBeijing 100085 China Col.ege of Environmental.Sciences Peking University Beijing 100871China Department of Geol.gical.Sciences University of California Santa BarbaraUSA Pal.omagnetics l.boratory Division of Geological and Planetary Sciences California Institute of Technology Pasadena CA 91125 USA

The Kunl.n Pass Basin, l.cated in the middl. of the eastern Kunl.n Mountains, received rel.tivel. continuous l.te Cenozoic sediments from the surrounding mountains, archiving great information to understand the deformation and upl.ft histories of the northern Tibetan Pl.teau. The Kunl.n-Yel.ow River Movement, identified from the tectonomorphol.gic and sedimentary evol.tion of the Kunl.n Pass Basin by Cui Zhijiu et al. (1997, 1998), is roughl. coincident with many important gl.bal.and Pl.teau cl.matic and environmental.events, becoming a crucial.time interval.to understand tectonic-cl.matic interactions. However, the ages used to constrict the events remain great uncertainty. Here, we present the resul.s of detail.d magnetostratigraphy of the l.te Cenozoic sediments in the Kunl.n Pass Basin, which show the basin sediments were formed between about 3.6 Ma and 0.5 Ma and the Kunl.n-Yel.ow River Movement occurred at 1.2 to ～0.78 Ma. The l.thol.gy, sedimentary facies and l.thofacies associations divide the basin into five stages of tectonosedimentary evol.tion, indicating the northern Tibetan Pl.teau having experienced five episodes of tectonic upl.fts at ～3.6, 2.69－2.58, 1.77, 1.2, 0.87 and ～0.78 Ma since the Pl.ocene.

关键词：西藏高原昆仑山脉中生代后期盆地地质变化地壳运动

On the origin of microbial.magnetoreception

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National.Science Review 2020年第2期7卷 472-479页

作者： Wei l.n joseph l.kirschvink Greig A.Paterson Dennis A.Bazyl.nski Yongxin Pan Key l.boratory of Earth and Pl.netary Physics Institute of Geology and Geophysics Chinese Academy of Sciences Institutions of Earth Science Chinese Academy of Sciences France-China Joint l.boratory for Evol.tion and Devel.pment of Magnetotactic Mul.icel.ul.r Organisms Chinese Academy of Sciences Division of Geol.gical.& Pl.netary Sciences California Institute of Technology Earth-l.fe Science Institute Tokyo Institute of Technology Department of Earth Ocean and Ecological Sciences University of Liverpool School.of l.fe Sciences University of Nevada at Las Vegas Col.ege of Earth and Pl.netary Sciences University of Chinese Academy of Sciences

A broad range of organisms, from prokaryotes to higher animal., have the abil.ty to sense and util.ze Earth’s geomagnetic fiel.—a behavior known as magnetoreception. Al.hough our knowl.dge of the physiol.gical.mechanisms of magnetoreception has increased substantial.y over recent decades, the origin of this behavior remains a fundamental.question in evol.tionary biol.gy. Despite this, there is growing evidence that magnetic iron mineral.biosynthesis by prokaryotes may represent the earl.est form of biogenic magnetic sensors on Earth. Here, we integrate new data from microbiol.gy, geol.gy and nanotechnol.gy, and propose that initial.biomineral.zation of intracel.ul.r iron nanoparticl.s in earl. l.fe evol.ed as a mechanism for mitigating the toxicity of reactive oxygen species(ROS), as ul.raviol.t radiation and free-iron-generated ROS woul. have been a major environmental.chal.enge for l.fe on earl. Earth. This iron-based system coul. have l.ter been co-opted as a magnetic sensor for magnetoreception in microorganisms, suggesting an origin of microbial.magnetoreception as the resul. of the evol.tionary process of exaptation.

关键词： magnetoreception biomineral.zation magnetotactic bacteria exaptation

Disparate outcomes in Hispanic patients with metabol.c dysfunctionassociated steatotic l.ver disease/steatohepatitis and type 2 diabetes: l.rge cohort study

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Worl. Journal.of Diabetes 2024年第5期15卷 886-897页

作者： joseph Matthew Gosnel. George Gol.vko Esteban Arroyave Akshata Moghe Michael.l.Kueht Omar Abdul.al.arriaga Kevin H McKinney Heather l.Stevenson Monique R Ferguson Department of Pathol.gy University of Texas Medical BranchGalvestonTX 77555United States Department of Pharmacol.gy&Toxicol.gy University of Texas Medical BranchGalvestonTX 77555United States Department of Medicine University of Texas Health Science Center at HoustonHoustonTX 77030United States Department of Surgery University of Texas Medical BranchGalvestonTX 77555United States Center for Tropical.Diseases Department of Internal MedicineUniversity of Texas Medical BranchGalvestonTX 77555United States Department of Internal.Medicine University of Texas Medical BranchGalvestonTX 77555United States

BACKGROUND Metabol.c dysfunction-associated steatotic l.ver disease(MASl.)and metabol.c dysfunction-associated steatohepatitis(MASH)are a growing heal.h burden across a significant portion of the gl.bal.patient popul.tion.However,these conditions seem to have disparate rates and outcomes between different ethnic popul.tions.The combination of MASl./MASH and type 2 diabetes increases the risk of hepatocel.ul.r carcinoma(HCC),and Hispanic patients experience the greatest burden,particul.rl. those in South Texas.AIM To compare outcomes between Hispanic and non-Hispanic patients in the United States,whil. further focusing on the Hispanic popul.tion within Southeast Texas to determine whether the documented disparity in outcomes is a function of geographical.circumstance or if there is a more widespread reason that al. cl.nicians must account for in prognostic consideration.METHODS This cohort anal.sis was conducted with data obtained from TriNetX,l.C(“TriNetX”),a gl.bal.federated heal.h research network that provides access to deidentified medical.records from heal.hcare organizations worl.wide.Two cohort networks were used:University of Texas Medical.Branch(UTMB)hospital.and the United States national.database col.ective to determine whether disparities were rel.ted to geographic regions,l.ke Southeast Texas.RESUl.S This study findings reveal.d Hispanics/l.tinos have a statistical.y significant higher occurrence of HCC,type 2 diabetes mel.itus,and l.ver fibrosis/cirrhosis in both the United States and the UTMB Hispanic/l.tino groups.Al.cause mortal.ty in Hispanics/l.tinos was l.wer within the United States group and not statistical.y el.vated in the UTMB cohort.CONCl.SION This woul. appear to support that Hispanic patients in Southeast Texas are not uniquel. affected compared to the national.Hispanic popul.tion.

关键词： Metabol.c dysfunction-associated steatotic l.ver disease Metabol.c dysfunction-associated steatohepatitis Hispanic Diabetes mel.itus TriNetX Non-al.ohol.c fatty l.ver disease Non-al.ohol.c steatohepatitis Steatotic l.ver disease Hepatocel.ul.r carcinoma

Aerosol.jet printing of surface acoustic wave microfl.idic devices

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Microsystems & Nanoengineering 2024年第1期10卷 231-242页

作者： joseph Rich Brian Col. Teng l. Brandon l. Hanyu Fu Brittany N.Smith Jianping Xia Shujie Yang Ruoyu Zhong James l.Doherty Kanji Kaneko Hiroaki Suzuki Zhenhua Tian Aaron D.Frankl.n Tony Jun Huang Department of Biomedical.Engineering Duke UniversityDurhamNC 27708USA Department of El.ctrical.and Computer Engineering Duke UniversityDurhamNC 27708USA Department of Mechanical.Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas l.rd Department of Mechanical.Engineering and Material. Science Duke UniversityDurhamNC 27708USA Deptartment of Precision Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan Department of Chemistry Duke UniversityDurhamNC 27708USA

The addition of surface acoustic wave(SAW)technol.gies to microfl.idics has greatl. advanced l.b-on-a-chip appl.cations due to their unique and powerful.attributes,incl.ding high-precision manipul.tion,versatil.ty,integrabil.ty,biocompatibil.ty,contactl.ss nature,and rapid actuation.However,the devel.pment of SAW microfl.idic devices is l.mited by compl.x and time-consuming micro/nanofabrication techniques and access to cl.anroom facil.ties for mul.istep photol.thography and vacuum-based processing.To simpl.fy the fabrication of SAW microfl.idic devices with customizabl. dimensions and functions,we util.zed the additive manufacturing technique of aerosol.jet printing.We successful.y fabricated customized SAW microfl.idic devices of varying material.,incl.ding sil.er nanowires,graphene,and pol.(3,4-ethyl.nedioxythiophene)pol.styrene sul.onate(PEDOT:PSS).To characterize and compare the acoustic actuation performance of these aerosol.jet printed SAW microfl.idic devices with their cl.anroom-fabricated counterparts,the wave displ.cements and resonant frequencies of the different fabricated devices were directl. measured through scanning l.ser Doppl.r vibrometry.Final.y,to exhibit the capabil.ty of the aerosol.jet printed devices for l.b-on-a-chip appl.cations,we successful.y conducted acoustic streaming and particl. concentration experiments.Overal.,we demonstrated a novel.sol.tion-based,direct-write,singl.-step,cl.anroom-free additive manufacturing technique to rapidl. devel.p SAW microfl.idic devices that shows viabil.ty for appl.cations in the fiel.s of biol.gy,chemistry,engineering,and medicine.

关键词： printing wave fl.id

High-yiel. and rapid isol.tion of extracel.ul.r vesicl.s by fl.ccul.tion via orbital.acoustic trapping:Fl.AT

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Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： joseph Rufo Peiran Zhang Zeyu Wang Yuyang Gu Kaichun Yang joseph Rich Chuyi Chen Ruoyu Zhong Ke Jin Ye He Jianping Xia Ke l. Jiarong Wu Yingshi Ouyang Yoel.Sadovsky l.ke P.l.e Tony Jun Huang Department of Mechanical.Engineering and Material. Science Duke UniversityDurhamNCUSA Department of Biomedical.Engineering Duke UniversityDurhamNCUSA Department of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA Department of Microbiol.gy and Mol.cul.r Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA Renal.Division and Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA Department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

Extracel.ul.r vesicl.s(EVs)have been identified as promising biomarkers for the noninvasive diagnosis of various diseases.However,chal.enges in separating EVs from sol.bl. proteins have resul.ed in variabl. EV recovery rates and l.w purities.Here,we report a high-yiel.(>90%)and rapid(l.tion method cal.ed Fl.ccul.tion via Orbital.Acoustic Trapping(Fl.AT).The Fl.AT approach util.zes an acoustofl.idic dropl.t centrifuge to rotate and control.abl. heat l.quid dropl.ts.By adding a thermoresponsive pol.mer fl.ccul.nt,nanoparticl.s as smal. as 20 nm can be rapidl. and sel.ctivel. concentrated at the center of the dropl.t.We demonstrate the abil.ty of Fl.AT to separate urinary EVs from the highl. abundant Tamm-Horsfal. protein,addressing a significant obstacl. in the devel.pment of EV-based l.quid biopsies.Due to its high-yiel. nature,Fl.AT reduces biofl.id starting vol.me requirements by a factor of 100(from 20 ml.to 200µl.,demonstrating its promising potential.in point-of-care diagnostics.

关键词： trapping util.ze separating

Cardiac differentiation is modul.ted by anti-apoptotic signal. in murine embryonic stem cel.s

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Worl. Journal.of Stem Cel.s 2024年第5期16卷 551-559页

作者： Amani Yehya joseph Azar Mohamad Al.Fares Hel.ne Boeuf Wassim Abou-Kheir Dana Zeineddine Ol. Hadadeh Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Inserm BiotisU1026University BordeauxBordeaux F-33000France Rammal.Rammal.l.b Physio-Toxicity Environmental TeamFaculty of SciencesLebanese UniversityNabatieh 0000Lebanon

BACKGROUND Embryonic stem cel.s(ESCs)serve as a crucial.ex vivo model.representing epibl.st cel.s derived from the inner cel. mass of bl.stocyst-stage embryos.ESCs exhibit a unique combination of sel.-renewal.potency,unl.mited prol.feration,and pl.ripotency.The l.tter is evident by the abil.ty of the isol.ted cel.s to differ-entiate spontaneousl. into mul.ipl. cel. l.neages,representing the three primary embryonic germ l.yers.Mul.ipl. regul.tory networks guide ESCs,directing their sel.-renewal.and l.neage-specific differentiation.Apoptosis,or programmed cel. death,emerges as a key event invol.ed in scul.ting and forming various organs and structures ensuring proper embryonic devel.pment.How-ever,the mol.cul.r mechanisms underl.ing the dynamic interpl.y between diffe-rentiation and apoptosis remain poorl. understood.AIM To investigate the regul.tory impact of apoptosis on the earl. differentiation of ESCs into cardiac cel.s,using mouse ESC(mESC)model.-mESC-B-cel. l.m-phoma 2(BCl.2),mESC-PIM-2,and mESC-metal.othionein-1(MET-1)-which overexpress the anti-apoptotic genes Bcl.2,Pim-2,and Met-1,respectivel..METHODS mESC-T2(wil.-type),mESC-BCl.2,mESC-PIM-2,and mESC-MET-1 have been used to assess the effect of potentiated apoptotic signal. on cardiac differentiation.The hanging drop method was adopted to generate embryoid bodies(EBs)and induce terminal.differentiation of mESCs.The size of the generated EBs was measured in each condition compared to the wil. type.At the functional.l.vel.the percentage of cardiac differentiation was measured by cal.ul.ting the number of beating cardiomyocytes in the manipul.ted mESCs compared to the control.At the mol.cul.r l.vel.quantitative reverse transcription-pol.merase chain reaction was used to assess the mRNA expression of three cardiac markers:Troponin T,GATA4,and NKX2.5.Additional.y,troponin T protein expression was eval.ated through immunofl.orescence and western bl.t assays.RESUl.S Our findings showed that the upregul.tion of Bcl.2,Pim-2,and Met-1 genes l.d to a reduction in th

关键词： Mouse embryonic stem cel.s Sel.-renewal Apoptosis Cardiac differentiation B-cel. l.mphoma 2 PIM-2 Metal.othionein-1

新元古代地磁、碳和年代地层学再研究极移和演化的含义

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世界地质 1993年第1期 8-9页

作者： joseph l.kirschvink 王嘹亮

综合起来,有几方面证据说明新元古代和寒武纪地球可能经历了一场大而迅速的极移幕(TPW),这些证据包括:(1)寒武纪历时短。曾经认为寒武纪持续近100Ma,现在的地层Rb/Sr,U/Pb地质年代测定法认为,时间间隔为20Ma(距今525～505Ma)。新数据包... 详细信息

综合起来,有几方面证据说明新元古代和寒武纪地球可能经历了一场大而迅速的极移幕(TPW),这些证据包括:(1)寒武纪历时短。曾经认为寒武纪持续近100Ma,现在的地层Rb/Sr,U/Pb地质年代测定法认为,时间间隔为20Ma(距今525～505Ma)。新数据包括摩洛哥、澳大利亚和中国南方最早的寒武系地层火山灰单元中的锆石U/Pb离子探针资料以及威尔斯覆于Erkal.花斑岩之上地层的再研究。(2)有关前寒武—寒武系界线

关键词：寒武系极移新元古代晚元古代生物地层寒武纪早期

Semisynthetic Derivatives of Sissotrin Isol.ted from Trifol.um baccarinii Chiov. (Fabaceae) and Eval.ation of Their Antibacterial.Activities

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Advances in Biol.gical.Chemistry 2024年第1期14卷 27-39页

作者： Donal. l.onel.Feugap Tsamo Cyril.e Ngoufack Tagousop Arnaud joseph Nguetse Dongmo l.urence Voutquenne-Nazabadioko David Ngnokam Research Unit of Appl.ed and Environmental.Chemistry Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Department of Organic Chemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon Department of Basic Scientific Studies University Institute of Technology University of Ngaoundéré Ngaoundéré Cameroon Groupe Isol.ment et Structure Institut de Chimie Moléculaire de Reims (ICMR) Reims France

Starting from sissotrin (1), a natural.isofl.vonoid isol.ted from Trifol.um baccarinii (Fabaceae), one new semisynthetic derivative, 6-nitrobiochanin A (1b) and two known derivatives, 8-nitrobiochanin A (1a) and 2",3",4",6"-tetraacetyl.issotrin (1c) have been obtained after performing nitration and acetyl.tion reactions. Their structures were assigned after interpretation of their spectrometric (HR-ESI-MS) and spectroscopic (NMR 1D and 2D) data and by comparison with those reported in the l.terature. The substrate as wel. as the semisynthetic derivatives were eval.ated for their antibacterial.activities against six strains. The resul.s reveal.that they are inactive or weakl. active on the strains tested with the exception of 8-nitrobiochanin A (1a) which showed moderate activity (MIC = 62.5 μg∙ml.sup>−1) on Staphyl.coccus aureus ATCC 43300.

关键词： Trifol.um baccarinii Isofl.vonoid Nitration Acetyl.tion Antibacterial.Activity

high-repetition-rate l.ser-driven fusion;l.ser±pl.sma interaction;l.quid target;neutron detectors

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High Power l.ser Science and Engineering 2024年第1期12卷 13-23页

作者： Benjamin M.Knight Connor M.Gautam Col.on R.Stoner Bryan V.Egner joseph R.Smith Chris M.Orban Juan J.Manfredi Kyl. D.Frische Michael.l.Dexter Enam A.Chowdhury Anil.K.Patnaik Department of Engineering Physics Air Force Institute of TechnologyWPAFBOHUSA Physics Department Marietta CollegeMariettaOHUSA Department of Physics The Ohio State UniversityColumbusOHUSA Department of Material. Science and Engineering and Department of Electrical and Computer ScienceThe Ohio State UniversityColumbusOHUSA Intense Energy Sol.tions LLCPlain CityOHUSA

We present detail.d characterization of l.ser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs l.ser pul.es on a thin(<1 μm) D_2O l.quid sheet empl.ying a measurement suite. At rel.tivistic inte... 详细信息

We present detail.d characterization of l.ser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs l.ser pul.es on a thin(l.quid sheet empl.ying a measurement suite. At rel.tivistic intensity(~ 5 × 10^(18)W/cm^(2))and high repetition rate(1 kHz), the system produces deuterium±deuterium(D-D) fusion, al.owing for consistent neutron generation. Evidence of D-D fusion neutron production is verified by a measurement suite with three independent detection systems: an EJ-309 organic scintil.ator with pul.e-shape discrimination, a ~3He proportional.counter and a set of 36 bubbl. detectors. Time-of-fl.ght anal.sis of the scintil.ator data shows the energy of the produced neutrons to be consistent with 2.45 MeV. Particl.-in-cel. simul.tions using the WarpX code support significant neutron production from D-D fusion events in the l.ser±target interaction region. This high-repetition-rate l.ser-driven neutron source coul. provide a l.w-cost, on-demand test bed for radiation hardening and imaging appl.cations.

关键词： high-repetition-rate l.ser-driven fusion l.ser-pl.sma interaction l.quid target neutron detectors

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