检索结果-南通市图书馆

Current perspectives and the future of disease-modifying therapies in type 1 diabetes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2025年第1期16卷 12-21页

作者： Sunetra mondal joseph m Pappachan Department of Endocrinology NRS Medical College and HospitalKolkata 700014West BengalIndia Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Department of Endocrinology Kasturba Medical CollegeManipal 576104India

Use of immunomodulating agents to prevent the progression of autoimmuneβ-cell damage leading to type 1 diabetes mellitus(T1Dm)is an interesting area for *** include non-specific anti-inflammatory agents,immunologic vaccination and anti-inflammatory agents targeting specific immune cells or *** is an anti-CD3-molecule that binds to and leads to the disappearance of the CD3/TCR complex and rendering the T cell anergic to its target *** and clinical trials have demonstrated its efficacy in reducing the decline in serum C-peptide levels and the need for insulin therapy if used early in the disease process of *** benefits have been apparent as early as six months to as long as seven years after *** has recently been approved by the Food and Drug Administration to delay the onset of clinical(stage 3)type 1 diabetes in children above 8 years of *** their recent metaanalysis published in the World Journal of Diabetes,ma et al found that those in the teplizumab treatment group have a greater likelihood of reduction in insulin use,change in C-peptide response,and better glycemic control compared to the control group with a good safety ***,all the included randomized control trials have been conducted in high-income *** cost of therapy and unknown utility of the molecule in stage 3 disease limit its widespread use.

关键词： Teplizumab Type 1 diabetes mellitus Disease modifying therapy β-cell function C-peptide Immunotherapy

Small dissymmetry, yet large effects on the transport propertiesof electrolytes based on imide salts: Consequences on performancein Li-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2022年第2期31卷 352-366页

作者： joseph Chidiac Laure Timperman mérièm Anouti Laboratoire PCm2E Universitéde ToursParc de Grandmont37200 ToursFrance

To gain better insight into the influence of the anion size and symmetry on the transport properties and thermal stability of an electrolyte based on lithium(fluorosulfonyl)(trifluoromethanesulfonyl)-imide(FTFSI)salt,we performed the physical and electrochemical characterization of an electrolyte based on FTFSI incorporated in standard binary(3 EC/7 EmC)and ternary(EC/PC/3 DmC)alkylcarbonate *** applying the Jones-Dole-Kaminsky(JDK),Eyring and Arrhenius empirical models to the electrolyte viscosity we show that the activation enthalpy and entropy energy barriers(ΔH≠,ΔS≠)for viscous flow are between 12 and 15 kJ·mol^(-1).They are strongly dependent on the solvent nature and are significantly lower than their symmetric anions LiFSI and LiTFSI(19-20 kJ·mol^(-1))in the binary ***,the hydrodynamic radius,rs,calculated by JDK,and the ionicity behavior illustrated by the Walden role,showed that the FTFSI anion is outside the solvation sphere(rs>0.6 nm)which is smaller in the case of an EC/EmC solvent *** the 3 EC/7 EmC solvent mixture,LiFTFSI is less conductive than in the ternary mixture i.e.,σ_(max)=8.9 mS cm^(-1) at C_(max)=1.1 mol L^(-1) for 3 EC/7 EmC and,σ_(max)=10.5 mS cm^(-1) at max=0.7 mol L^(-1) for EC/PC/3 DmC,due to a strong solvation and a greater association of FTFSI ions in the binary solvent *** thermal stability of FTFSI based electrolytes was determined by the shift of the evaporation temperature of the volatile solvents(DmC,EmC)in the presence of salt,towards the higher *** feature is visible on the thermograms obtained by DSC both with the liquid electrolyte and with charged LmO cathodes in presence of *** consequences of these properties on the electrochemical behavior of a graphite(Gr)half-cell,a lithium metal(Li)anode and a manganese lithium oxide(LmO)cathode demonstrated on the one hand the formation of a thick solid electrolyte interphase(SEI)on graphite that consumed a significant amou

关键词： LiFTFSI Electrolyte Viscosity Interface Li-ion battery

Chemical exposures and suspected impacton Gulf War Veterans

在线全文

学校读者我要写书评

暂无评论

military medical Research 2023年第5期10卷 577-586页

作者： Rami Elhaj joseph m.Reynolds Center for Cancer Biology Immunology and InfectionChicago Medical SchoolRosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA

Gulf War Illness(GWI) encompass a spectrum of maladies specific to troops deployed during the Persian Gulf War(1990–1991). There are several hypothesized factors believed to contribute to GWI, including(but not limited to)exposures to chemical agents and a foreign environment(e.g., dust, pollens, insects, and microbes). moreover, the inherent stress associated with deployment and combat has been associated with GWI. While the etiology of GWI remains uncertain, several studies have provided strong evidence that chemical exposures, especially neurotoxicants,may be underlying factors for the development of GWI. This mini style perspective article will focus on some of the major evidence linking chemical exposures to GWI development and persistence decades after exposure.

关键词： Gulf War Illness(GWI) Sarin Neuroinfammation Organophosphate(OP)

The role of undifferentiated adipose-derived stem cells in peripheral nerve repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第5期13卷 757-763页

作者： Rui Zhang joseph m.Rosen Dartmouth Geisel School of medicine Dartmouth-Hitchcock Medical Center

Peripheral nerve injuries impose significant health and economic consequences, yet no surgical repair can deliver a complete recovery of sensory or motor function. Traditional methods of repair are less than ideal： direct coaptation can only be performed when tension-free repair is possible, and transplantation of nerve autograft can cause donor-site morbidity and neuroma formation. Cell-based therapy delivered via nerve conduits has thus been explored as an alternative method of nerve repair in recent years. Stem cells are promising sources of the regenerative core material in a nerve conduit because stem cells are multipotent in function, abundant in supply, and more accessible than the myelinating Schwann cells. Among different types of stem cells, undifferentiated adipose-derived stem cell（uASC）, which can be processed from adipose tissue in less than two hours, is a promising yet underexplored cell type. Studies of uASC have emerged in the past decade and have shown that autologous uASCs are non-immunogenic, easy to access, abundant in supply, and efficacious at promoting nerve regeneration. Two theories have been proposed as the primary regenerative mechanisms of uASC： in situ trans-differentiation towards Schwann cells, and secretion of trophic and anti-inflammatory factors. Future studies need to fully elucidate the mechanisms, side effects, and efficacy of uASC-based nerve regeneration so that uASCs can be utilized in clinical settings.

关键词： peripheral nerve injury adipose-derived stem cells Schwann cells cell therapy nerve conduits axonal regeneration stem cell differentiation neurotrophic factors anti-apoptosis immunosuppression

Does acid pickling of mg-Ca alloy enhance biomineralization?

在线全文

学校读者我要写书评

暂无评论

Journal of magnesium and Alloys 2021年第3期9卷 1028-1038页

作者： Shebeer A Rahim VP muhammad Rabeeh m A joseph T Hanas Department of mechanical Engineering National Institute of Technology CalicutKerala 673601India Nanomaterials Research Laboratory School of Materials Science and EngineeringNational Institute of Technology CalicutKerala 673601India

The mechanical and physical properties of biodegradable magnesium(mg)alloys make them suitable for temporary orthopaedic *** success of these alloys depends on their performance in the physiological *** the present work,surface modification of mg-Ca binary alloy by acid pickling for better biomineralization and controlled biodegradation is *** corrosion rates of nitric and phosphoric acid treated samples were analysed by conducting electrochemical corrosion *** vitro degradation behaviour was studied using immersion test in simulated body fluid(SBF).The sample surfaces were characterized using scanning electron microscope(SEm),energy dispersive X-ray spectroscopy(EDS),Fourier transform infrared spectroscopy(FTIR)and X-ray photoelectron spectroscopy(XPS).It is seen that acid pickling leads to significant improvement in biomineralization and develop in situ calcium phosphate(Ca P)coating on the sample *** addition,the treated samples recorded a reduced degradation rate in the SBF compared to untreated ***,acid pickling is suggested as an effective surface treatment method to tailor the biomineralization and degradation behaviour of the mg-Ca alloy in the physiological environment.

关键词： Inorganic acid pickling magnesium alloy Surface pretreatment Surface characterization Biomineralization Degradation rate

Strategies to enhance monoclonal antibody uptake and distribution in solid tumors

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & medicine 2021年第3期18卷 649-664页

作者： Brandon m.Bordeau joseph P.Balthasar Department of Pharmaceutical Science University at BuffaloBuffaloNY 14214USA

Despite the significant resources dedicated to the development of monoclonal antibody(m Ab)therapies for solid tumors,the clinical success,thus far,has been *** efficacy of m Ab in solid tumors likely relates to unique aspects of tumor *** tumors have an aberrant vasculature and a dense extracellular matrix that slow both the convective and diffusive transport of m Abs into and within *** m Abs that are directed against cellular antigens,high antigen expression and rapid antigen turnover can result in perivascular cells binding to and eliminating a significant amount of extravasated m Ab,limiting m Ab distribution to portions of the tumor that are distant from functional *** preclinical investigations have reported strategies to improve m Ab uptake and distribution;however,to our knowledge,none have translated into the ***,we provide an overview of several barriers in solid tumors that limit m Ab uptake and distribution and discuss approaches that have been utilized to overcome these barriers in preclinical studies.

关键词： Solid tumors antibody uptake and distribution monoclonal antibody antibody-drug conjugate

Preserving fertility in the hypogonadal patient： an update

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2015年第2期17卷 197-200,I0006,I0007页

作者： Ranjith Ramasamy joseph m Armstrong Larry I Lipshultz Department of Urology Baylor Collegesssss of Medicine Houston TX USA.

An increasing number of young and middle-aged men are seeking treatment for symptoms related to deficient levels of androgens （hypogonadism） including depression, loss of libido, erectile dysfunction, and fatigue. The increase in prevalence of testosterone supplementation in general and anabolic steroid-induced hypogonadism specifically among younger athletes is creating a population of young men who are uniquely impacted by the testicular end-organ negative consequences of exogenous steroid use. Exogenous testosterone therapy can alter the natural regulation of the hypothalamic-pituitary-gonadal axis leading to impaired spermatoganesis with azoospermia being a serious possible result, thus rendering the individual infertile. For men of reproductive age who suffer from hypogonadal symptoms, preservation of fertility is an important aspect of their treatment paradigm. Treatment with human chorionic gonadotropin （hCG） has shown the ability not only to reverse azoospermia brought on by testosterone supplementation therapy but also to help maintain elevated intratesticular testosterone levels. In addition, selective estrogen receptor modulators, often used with hCG have been shown both to elevate total testosterone levels and to maintain spermatogenesis in hypogonadal men.

关键词： human chorionic gonadotropin selective estrogen receptor modulators spermatogenesis testosterone supplementation therapy

cGmP signaling:a potential therapeutic target for neurodegeneration in glaucoma?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第6期18卷 1267-1268页

作者： joseph m.Holden Lauren K.Wareham Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

Neurodegeneration of the central nervous system(CNS)underscores many of humanity’s most debilitating diseases,including Alzheimer’s disease,Parkinson’s disease,and multiple ***,the nitric oxide-guanylate cyclase-cyclic guanosine monophosphate(NOGC-cGmP)signaling pathway has gained traction as a neuroprotective pathway in the *** an extension of the CNS,the retina is also susceptible to neurodegeneration with *** most prevalent optic neuropathy is glaucoma,the world’s leading cause of irreversible blindness,predicted to affect more than 112 million people worldwide by 2040(Calkins,2021).In glaucoma,vision loss occurs due to the progressive degeneration of retinal ganglion cells(RGCs),the output neurons of the retina,along with their axons which form the optic nerve(Wareham et al.,2022).Degeneration of RGCs leads to a characteristic pattern of scotopic visual field deficiencies that spread from one retinotopic sector to the next(Elze et al.,2015).Visual deficits are linked to increasing age and the sensitivity of RGCs to intraocular pressure(Calkins,2021).

关键词： glaucoma degeneration protective

monogenic diabetes in children:An underdiagnosed and poorly managed clinical dilemma

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第6期15卷 1051-1059页

作者： Saptarshi Bhattacharya joseph m Pappachan Department of Endocrinology Indraprastha Apollo HospitalsDelhi 110076India Department of Endocrinology and metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

monogenic diabetes,constituting 1%-2%of global diabetes cases,arises from single gene defects with distinctive inheritance *** over 50 associated genetic disorders,accurate diagnoses and management of monogenic diabetes remain inadequate,underscoring insufficient clinician *** disease spectrum encompasses maturity-onset diabetes of the young(mODY),characterized by distinct genetic mutations affecting insulin secretion,and neonatal diabetes mellitus(NDm)-a heterogeneous group of severe hyperglycemic disorders in *** diabetes,autoimmune monogenic diabetes,genetic insulin resistance and lipodystrophy syndromes further diversify the monogenic diabetes landscape.A tailored approach based on phenotypic and biochemical factors to identify candidates for genetic screening is recommended for suspected cases of *** diagnosis warrants immediate molecular genetic testing for infants under six *** these genetic defects presents a unique opportunity for precision *** research aimed to develop cost-effective genetic testing methods and gene-based therapy can facilitate appropriate identification and optimize clinical *** and study of new genes offer a valuable opportunity to gain deeper insights into pancreatic cell biology and the pathogenic mechanisms underlying common forms of *** clinical review published in the recent issue of World Journal of Diabetes is such an attempt to fill-in our knowledge gap about this enigmatic disease.

关键词： monogenic diabetes maturity-onset diabetes of the young Neonatal diabetes mitochondrial diabetes Insulin resistance syndromes Genetic testing Next generation sequencing