检索结果-南通市图书馆

Pathogenesis of occult chronic hepatitis B virus infection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第12期17卷 1543-1548页

作者： Rocio Aller de la Fuente maría L Gutiérrez Javier Garcia-Samaniego Conrado Fernández-Rodriguez jose Luis Lledó Gregorio Castellano Gastroenterology Hospital Clinico Universitario Valladolid Institute of endocrinology and Nutrition Medical SchoolUniversity of Valladolid47003 ValladolidSpain Service of Gastroenterology Hospital Universitario Fundación AlcorcónAv Budapest-128922 AlcorcónMadridSpain Gastroenterology Department Hospital Carlos IIIc/Sinesio Delgado28029 MadridSpain Hospital Universitario 12 de Octubre Av de Andalucia 2804128039 MadridSpain

Occult hepatitis B infection(OBI) is characterized by hepatitis B virus(HBV) DNA in serum in the absence of hepatitis B surface antigen(HBsAg) presenting HBsAg-negative and anti-HBc positive serological *** HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays;but more frequently it is due to a strong suppression of viral replication and gene *** is an entity with world-wide *** failure to detect HBsAg,despite the persistence of the viral DNA,is due in most cases to the strong suppression of viral replication and gene expression that characterizes this"occult"HBV infection;although the mechanisms responsible for suppression of HBV are not well *** majority of OBI cases are secondary to overt HBV infection and represent a residual low viremia level suppressed by a strong immune response together with histological derangements which occurred during acute or chronic HBV *** evidence suggests that it can favour the progression of liver fibrosis and the development of hepatocellular carcinoma.

关键词： Occult hepatitis B virus infection Hepatitis B virus-DNA Anti-HBc alone Hepatitis B virus Hepadnaviral hepatitis Occult viral persistence Primary occult infection Secondary occult infection Virus reactivation

Dialogue Promotes Sustainable Development of Biosphere Reserves

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国新闻发布(英文版) 2024年第Z1期 48-48页

作者： jose Cassandra

Biosphere reserves can help promote innovation and global dialogue in sustainable development. As a member of the UNESCO Biosphere Reserve, the island of Principe in the Gulf of Guinea has a small population of just over 10,000 and enjoys very limited resources. However, people there have free access to the internet, a fact that makes it possible for people there to stay connected with the world at any time.

关键词：

Microphysiological systems for solid tumor immunotherapy:opportunities and challenges

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2023年第6期9卷 77-106页

作者： Sara Abizanda-Campo maría Virumbrales-Muñoz Mouhita Humayun Ines marmol David J.Beebe Ignacio Ochoa Sara Oliván jose M.Ayuso Department of Dermatology University of Wisconsin-MadisonMadisonWIUSA University of Wisconsin Carbone Cancer Center MadisonWIUSA Department of Biomedical Engineering University of WisconsinMadisonWIUSA Tissue Microenvironment Lab(TME lab) Aragón Institute of Engineering Research(I3A)University of ZaragozaZaragozaSpain Instituto de Investigación Sanitaria Aragón(IISA) ZaragozaSpain Centro Investigación Biomédica en Red.Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN)ZaragozaSpain Department of Obstetrics and Gynecology University of Wisconsin-MadisonMadisonWIUSA Department of Biological Engineering Massachusetts Institute of Technology CambridgeCambridgeMAUSA Department of Pathology&Laboratory Medicine University of WisconsinMadisonWIUSA

Immunotherapy remains more effective for hematologic tumors than for solid *** of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate,which limits the cytotoxic capabilities of immune effector cells(e.g.,cytotoxic T and natural killer cells).This microenvironment is characterized by hypoxia,nutrient starvation,accumulated waste products,and acidic ***-hijacked cells,such as fibroblasts,macrophages,and T regulatory cells,also contribute to this inhospitable microenvironment for immune cells by secreting immunosuppressive cytokines that suppress the antitumor immune response and lead to immune ***,there is a strong interest in developing new drugs and cell formulations that modulate the tumor microenvironment and reduce tumor cell immune *** systems(MPSs)are versatile tools that may accelerate the development and evaluation of these therapies,although specific examples showcasing the potential of MPSs remain *** in microtechnologies have led to the development of sophisticated microfluidic devices used to recapitulate tumor *** resulting models,also known as microphysiological systems(MPSs),are versatile tools with which to decipher the molecular mechanisms driving immune cell antitumor cytotoxicity,immune cell exhaustion,and immune cell exclusion and to evaluate new targeted ***,we review existing microphysiological platforms to study immuno-oncological applications and discuss challenges and opportunities in the field.

关键词： immunotherapy versatile solid

Overlap of reflux and eosinophilic esophagitis in two patients requiring different therapies:A review of the literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第9期14卷 1463-1466页

作者： Javier Molina-Infante Lucía Ferrando-Lamana jose maría Mateos-Rodríguez Belén Pérez-Gallardo Ana Beatriz Prieto-Bermejo Unit of Gastroenterology Hospital San Pedro de Alcantara Avda. Pablo Naranjo s/n 10003 Caceres Spain Department of Pathology. Hospital San Pedro de Alcantara Avda. Pablo Naranjo s/n 10003 Caceres Spain

Eosinophilic esophagitis (EE) and gastroesophageal reflux disease (GERD) have overlapping clinical, manometric, endoscopic and histopathologic features. The diagnosis of EE is nowadays based upon the presence of 15 or more eosinophils per high power field (eo/HPF) in esophageal biopsies. We report the cases of two young males suffering from dysphagia and recurrent food impaction with reflux esophagitis and more than 20 eo/HPF in upper-mid esophagus biopsies, both of which became asymptomatic on proton pump inhibitor (PPI) therapy. The first patient also achieved a histologic response, while EE remained in the other patient after effective PPI treatment, as shown by 24-h esophageal pH monitoring. Topical steroid therapy combined with PPI led to complete remission in this latter patient. GERD and EE may be undistinguishable, even by histology, so diagnosis of EE should only be established after a careful correlation of clinical, endoscopic and pathologic data obtained under vigorous acid suppression. These diagnostic difficulties are maximal when both diseases overlap. Limited data are available about this topic, and the interaction between EE and GERD is a matter of debate. In this setting, upper-mid esophagus step biopsies and esophageal pH monitoring of patients on PPI therapy are pivotal to evaluate the role of each disease. A PPI trial is mandatory in patients with a histopathologic diagnosis of EE; in those unresponsive to PPI treatment, EE should be suggested. However, a clinical response to PPI may not rule out quiescent EE, as shown in this report.

关键词： Eosinophils Eosinophilic esophagitis Gastroesophageal reflux Proton pump inhibitors Overlap

Role of second look endoscopy in endoscopic submucosal dissection and peptic ulcer bleeding:Meta-analysis of randomized controlled trials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 214-226页

作者： Gowthami Sai Kogilathota Jagirdhar jose Andres Perez Akshat Banga Rakhtan K Qasba Ruman K Qasba Harsha Pattnaik Muhammad Hussain Yatinder Bains Salim Surani Department of Medicine Saint Francis Health Science CenterNewarkNJ 07107United States Department of Medicine Saint Francis Health SystemsTulsaOK 74133United States Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India Department of Medicine Green Life Medical College and HospitalDhaka 1205Bangladesh Department of Medicine Sher-i-kashmir Institute of Medical ScienceJammuSrinagar 190011India Department of Medicine Lady Hardinge Medical CollegeNew Delhi 110001India Department of Gastroenterology Saint Michaels Medical CenterNewarkNJ 07102United States Department of Medicine and Pharmacology Texas AM UniversityCollege StationTX 77843United States

BACKGROUND Second-look endoscopy(SLE)to prevent recurrent bleeding in patients with peptic ulcer disease(PUD)and those undergoing endoscopic submucosal dissection(ESD)is routinely being *** evidence exists regarding efficacy,risk,benefit,and *** To identify the role and effectiveness of SLE in ESD and PUD,associated rebleeding and PUD-related outcomes like mortality,hospital length of stay,need for endoscopic or surgical intervention and blood *** A systematic review of literature databases PubMed,Cochrane,and Embase was conducted from inception to January 5,*** controlled trials that compared patients with SLE to those who did not have SLE or evaluated the role of prophylactic hemostasis during SLE compared to other conservative interventions were *** study was conducted per PRISMA guidelines,and the protocol was registered in PROSPERO(ID CRD42023427555:).RevMan was used to perform meta-analysis,and Mantel-Haenszel Odds ratio(OR)were generated using random effect *** A total of twelve studies with 2687 patients were included in our systematic review and meta-analysis,of which 1074 patients underwent SLE after ESD and 1613 patients underwent SLE after PUD-related *** ESD,the rates of rebleeding were 7%in the SLE group compared to 4.4%in the non-SLE group with OR 1.65,95%confidence intervals(CI)of 0.96 to 2.85;P=0.07,whereas it was 11%in the SLE group compared to 13%in the non-SLE group with OR 0.895%CI:0.50 to 1.29;P=*** mean difference in the blood transfusion rates in the SLE and no SLE group in PUD was OR 0.01,95%CI:-0.22 to 0.25;P=*** SLE vs non-SLE groups with PUD,the OR for Endoscopic intervention was 0.29,95%CI:0.08 to 1.00;P=0.05 while it was OR 2.03,95%CI:0.95 to 4.33;P=0.07,for surgical *** mean difference in the hospital length of stay was-3.57 d between the SLE and no SLE groups in PUD with 95%CI:-7.84 to 0.69;P=0.10,denoting an average of

关键词： Endoscopy Endoscopic submucosal dissection Peptic ulcer Gastrointestinal bleeding

Habitat-dependent breeding biology of the Blue Tit(Cyanistes caeruleus)across a continuous and heterogeneous Mediterranean woodland

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Avian Research 2023年第3期14卷 499-510页

作者： Jorge Garrido-Bautista Carmen Hernandez-Ruiz jose Luis Ros-Santaella Eliana Pintus Nicola Bernardo mar Comas Gregorio Moreno-Rueda Department of Zoology Faculty of SciencesUniversity of Granada18071GranadaSpain Tecnologías y Servicios Agrarios S.A. S.M.E.M.P.(Tragsatec)06800BadajozSpain Department of Veterinary Sciences Faculty of AgrobiologyFood and Natural ResourcesCzech University of Life Sciences PragueKamýcka 12916500Prague 6-SuchdolCzech Republic Biological Station of Donana EBD-CSICAv.Americo Vespucio 2641092SevilleSpain Department of Biological Sciences Dartmouth College03755HanoverNHUSA

Mediterranean woodland environments are characterised by high spatial and temporal heterogeneity,which means the inhabiting species face a wide variety of selective *** may respond differently to habitat heterogeneity and so distinct eco-evolutionary scenarios may be responsible for the inter-habitat variability in reproductive strategies observed in certain *** inter-forest variability of some reproductive traits in passerines has been examined by comparing forest patches or separated ***,there is still little information regarding how such highly mobile animals adjust their breeding performance across continuous and heterogeneous *** we studied the reproductive performance of a population of Blue Tits(Cyanistes caeruleus) in an area of continuous Mediterranean woodland that included two mountain slopes and four different types of forest,ranging from deciduous oak forests to perennial non-oak *** studied the habitat heterogeneity and inter-forest phenotypic variation in terms of reproductive performance and adult and nestling biometry,besides also exploring the effects of ectoparasites on Blue Tit *** were laid earliest in deciduous Pyrenean Oak(Quercus pyrenaica) forests,while clutch size and the number of fledglings were highest in the humid Pyrenean Oak forest,which had the greatest tree coverage and most humid climate,and lowest in the coniferous Scots Pine(Pinus sylvestris) *** were no inter-forest differences in hatching(percentage of nests with at least one egg hatched) and fledging(percentage of nests in which at least one nestling fledged)***,there were no inter-forest differences in adult and nestling biometry,but adults that raised more fledglings had a lower body mass,while males whose females laid larger clutches had smaller *** ectoparasites did not affect Blue Tit reproduction,although Culicoides had a negative impact on nestling body *** results

关键词： Birds Breeding success Cavity-nesting birds Paridae Passerines Reproduction

Stem cells therapy for regenerative medicine:Principles of present and future practice

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2014年第2期7卷 49-57页

作者： jose A.Andrades jose Becerra Ramon Munoz-Chápuli Salvador martínez Angel Raya Javier García-Sancho jose M.moraleda Laboratory of Bioengineering and Tissue Regeneration(LABRET) Department of Cell BiologyGenetics and PhysiologyFaculty of SciencesIBIMAUniversity of MálagaMálagaSpain Networking Biomedical Research Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)MálagaSpain Andalusian Centre for Biotechnology and Nanomedicine(BIONAND) Parque Tecnológico de AndalucíaCampanillasMálagaSpain Department of Animal Biology Faculty of SciencesUniversity of MálagaMálagaSpain Institute of Neurosciences University of Miguel HernándezAlicanteSpain Control of Stem Cell Potency Group Institut for Bioengineering of Catalonia(IBEC)BarcelonaSpain Institucio Catalana de Recerca i Estudis Avancats(ICREA) P.Lluís CompanysBarcelonaSpain Institute of Molecular Biology and Genetics(IBGM) University of ValladolidValladolidSpain Unit of Transplant and Cell Therapy University of MurciaIMIBUniversity Clinic Hospital Virgen de la ArrixacaEl PalmarMurciaSpain

The characterization and isolation of various stem cell populations, from embryonic to tissue-derived stem cells and induced pluripotent stem cells (iPSCs), have led to a rapid growth in the field of stem cell research and its potentially clinical application in the field of regenerative medicine and tissue repair. Stem cell therapy has recently progressed from the preclinical to the early clinical trial arena for a variety of diseases states, although further knowledge on action mechanisms, long-term safety issues, and standardization and characterization of the therapeutic cell products remains to be thoroughly elucidated. In this paper we summarize the current state of the art of basic and clinical research that were highlighted at the 2012 meeting of the Spanish Cell Therapy Network. This includes the current research involving in genomic and transcriptomic characterization of selected stem cell populations, studies of the role of resident and transplanted stem cells during tissue regeneration and their mechanism of action, improved new strategies of tissue engineering, transplantation of mesenchymal stem cells (MSCs) in different animal models of disease, disease correction by iPSCs, and preliminary results of cell therapy in human clinical trials.

关键词： Spanish Cell Therapy Network Stem Cell Cell Therapy Tissue Engineering Regenerative Medicine

N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第18期14卷 2851-2857页

作者： Luis G Guijarro jose Mate Javier P Gisbert jose Luis Perez-Calle Ignacio marín-Jimenez Encarna Arriaza Tomás Olleros mario Delgado maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea Department of Biochemistry and Molecular Biology CIBERehd Alcalá University Alcalá de Henares Madrid Spain Gastroenterology Unit CIBERehd La Princesa University Hospital Autonomous University Madrid Spain Gastroenterology Unit Gregorio Maraón University Hospital Complutense University Madrid Spain Group Farmasierra SL. Ctra N-Ⅱ Km 26.200 San Sebastián de los Reyes Madrid Spain Laboratory of Immunogenetics Department of Pathology VU University Medical Center Amsterdam The Netherlands

AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects.

关键词： Ulcerative colitis Interleukin Mesalamine N-acetyl-L-cysteine

Social distancing and testing as optimal strategies against the spread of COVID-19 in the Rio Grande Valley of Texas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2021年第1期6卷 729-742页

作者： Kristina P.Vatcheva josef Sifuentes Tamer Oraby jose Campo Maldonado Timothy Huber maría Cristina Villalobos School of Mathematical&Statistical Sciences University of Texas Rio Grande ValleyBrownsvilleTX78520USA School of Mathematical&Statistical Sciences University of Texas Rio Grande ValleyEdinburgTX78539USA School of Medicine The University of Texas Rio Grande ValleyEdinburgTX78539USA

At the beginning of August 2020,the Rio Grande Valley(RGV)of Texas experienced a rapid increase of coronavirus disease 2019(abbreviated as COVID-19)cases and *** study aims to determine the optimal levels of effective social distancing and testing to slow the virus spread at the outset of the *** use an age-stratified eight compartment epidemiological model to depict COVID-19 transmission in the community and within *** a simulated 120-day outbreak period data we obtain a post 180-days period optimal control strategy *** results show that easing social distancing between adults by the end of the 180-day period requires very strict testing a month later and then daily testing rates of 5%followed by isolation of positive *** social distancing rates in adults from 50%to 25%requires both children and seniors to maintain social distancing rates of 50%for nearly the entire period while maintaining maximum testing rates of children and seniors for 150 of the 180 days considered in this *** have higher contact rates which leads to transmission based on our model,emphasizing the need for caution when considering school reopenings.

关键词： COVID-19 Mathematical modeling Optimal control Rio Grande Valley(RGV) Testing and social distancing School reopening