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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit dey Arvind K.Singh Chandel Rupa Sanyal Amarnath mishra devendra Kumar Pandey Valentina de Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat dewanjee Jayalakshmi Vallamkondu jose m.perez de la lastra department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

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Insights into the origin of precipitation moisture for tropical cyclones during rapid intensification process

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Tropical Cyclone Research and Review 2024年第2期13卷 72-87页

作者： Albenis perez-Alarcon jose C.Fernandez-Alvarez Ricardo m.Trigo Raquel Nieto Luis Gimeno Centro de Investigacion mari~na Universidade de VigoEnvironmental Physics Laboratory(EPhysLab)Campus As Lagoas s/nOurenseSpain departamento de meteorología Instituto Superior de Tecnologías y Ciencias AplicadasUniversidad de La HabanaLa HabanaCuba Instituto Dom Luiz(IDL) Facultade de Ci^enciasUniversidade de LisboaLisboaPortugal departamento de meteorologia Universidade Federal do Rio de JaneiroRio de JaneiroBrazil

In this study,we identiﬁed the moisture sources for the precipitation associated with tropical cyclones(TCs)during the rapid intensiﬁcation(RI)process from 1980 to 2018 by applying a lagrangian moisture source diagnostic *** detected sixteen regions on a global scale for RI events distributed as follows:four in the North Atlantic(NATL),two in the Central and East Paciﬁc Ocean(NEPAC),the North Indian Ocean(NIO)and South Indian Ocean(SIO),and three in the South Paciﬁc Ocean(SPO)and the Western North Paciﬁc Ocean(WNP).The moisture uptake(mU)mostly was from the regions where TCs underwent *** Western NATL,tropical NATL,Caribbean Sea,the Gulf of mexico and the Central America and mexico landmass supported~85.4%of the precipitating moisture in the NATL,while the latter source and the eastern North Paciﬁc Ocean provided the higher amount of moisture in NEPAC(~84.3%).The Arabian Sea,the Bay of Bengal and the Indian Peninsula were the major moisture sources in NIO,contributing approximately 81.3%.The eastern and western parts of the Indian Ocean supplied most of the atmospheric humidity in SIO(~83.8%).The combined contributions(~87.9%)from the western and central SPO and the Coral Sea were notably higher in ***,TCs in the WNP basin mostly received moisture from the western North Paciﬁc Ocean,the Philippine Sea and the China Sea,accounting for 80.1%.The remaining moisture support in each basin came from the summed contributions of the remote ***,RI TCs gained more moisture up to 2500 km from the cyclone centre than those slow intensiﬁcation(SI)and the total mU was approximately three times higher during RI than ***,the patterns of the mU differences respond to the typical pathways of moisture transport in each basin.

关键词： Tropical cyclones Rapid intensiﬁcation moisture sources Precipitation lagrangian moisture tracking

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Low prevalence of germline hmSH6 mutations in colorectal cancer families from Spain

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World Journal of Gastroenterology 2005年第37期11卷 5770-5776页

作者： Ana Sánchez de Abajo miguel de la Hoya Alicia Tosar Javier Godino Juan manuel Fernández jose Lopez Asenjo Beatriz perez Villamil Pedro perez Segura Eduardo Diaz-Rubio Trinidad Caldes laboratorio de Oncología molecular Hospital Clinico San Carlos Madrid Spain Servicio de Anatomía Patológica Hospital Clinico San Carlos Madrid Spain Servicio de Oncología médica Hospital Clinico San Carlos Madrid Spain

AIm: To investigate the prevalence and penetrance of hmSH6 mutations in Spanish HNPCC families that was negative for mutation in hmLH1 or ***: We used PCR-based DGGE assay and direct Sequencing to screen for hmSH6 gene in 91 HNPCC ***: we have identified 10 families with germ-line mutations in the DNA sequence. These mutations included two intronic variation, three missense mutation, one nonsense mutation, and four silent mutations. Among the 10 germ-line mutations identified in the Spanish cohort,8 were novel, perhaps, suggesting different mutational spectra in the Spanish population. detailed pedigrees were constructed for the three families with a possible pathogenic hmSH6 mutation. The two silent mutations H388H and L758L, detected in a person affected of colorectal cancer at age 29, produce loss of the wild-type allele in the tumor sample. Immunohistochemical analysis showed that expression of mSH6 protein was lost only in the tumors from the carriers of V878A and Q263X ***: Altogether, our results indicate that disease-causing germ-line mutations of hmSH6 are very less frequent in Spanish HNPCC families.

关键词： HNPCC mmR hmSH6 mSI IHC SPANISH

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Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in murine model

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Chinese Journal of Integrative medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago Eva maria Galan-moya jose Ramon munoz-Rodriguez miguel Angel de la Cruz-morcillo Francisco Javier Redondo-Calvo Ignacio Gracia-Fernandez Peter m.Elias jose manuel perez-Ortiz mao-Qiang man dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRNA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HmGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,Pmoreover,topical applications of TASE upregulated the expression levels of epidermal mRNA for ELOVL4,HmGCoA,SPT,filaggrin,loricrin and involucrin(Pmparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),Pmulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

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mid and late Holocene forest fires and deforestation in the subalpine belt of the Iberian range,northern Spain

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Journal of mountain Science 2016年第10期13卷 1760-1772页

作者： jose m.GARCIA-RUIZ Yasmina SANJUAN Graciela GIL-ROmERA Penelope GONZALEZ-SAmPERIZ Santiago BEGUERIA jose ARNAEZ Paz COBA-perez Amelia GOmEZ-VILlaR Javier ALVAREZ-mARTINEZ Noemi laNA-RENAULT Estela perez-CARDIEL Carlos LOPEZ de CALLE Instituto Pirenaico de Ecologfa Consejo Superior de Investigaciones Cientificas(IPE-CSIC)Campus de Aula DeiP.O.Box 13.03450.080-ZaragozaSpain Estacion Experimental de Aula dei Consejo Superior de Investigaciones Cientificas(EEAD-CSIC)Campus de Aula DeiP.O.Box 13.03450.080-ZaragozaSpain Area of Physical Geography University ofLa Rioja26.004-LogronoSpain Centro de Investigaciones en Geografia Ambiental Universidad Nacional Autonoma de MexicoUnidad MoreliaAntigua Carretera a Patzcuaro 870158190-MoreliaMichoacanMexico departamento de Geografia y Geologia Faeultad de Filosofia y LetrasUniversidad de LeonCampus de Vegazana24.071-LeonSpain departamento de Ingenieria Agricola y Forestal Universidad de ValladolidCampus La Yutera34.071-PalenciaSpain department of Geography and land management University of Zaragoza50.009-ZaragozaSpain Freelance archaeologist Auda.Colon426003-LogronoSpain

The conversion of subalpine forests into grasslands for pastoral use is a well-knownphenomenon, although for most mountain areas the timing of deforestation has not been determined. The presence of charcoal fragments in soil profiles affected by shallow landsliding enabled us to date the occurrence of fires and the periods of conversion ofsubalpine forest into grasslands in the Urbión mountains, Iberian Range, Spain. We found that the treeline in the highest parts of the northwestern massifs of the Iberian Range(the Urbión, demanda, Neila, and Cebollera massifs) is currently between 1500 and 1600 m a.s.l., probably because of pastoral use of the subalpine belt, whereas in the past it would have reached almost the highest divides(at approximately 2100–2200 m a.s.l.). The radiocarbon dates obtained indicate that the transformation of the subalpine belt occurred during the late Neolithic, Chalcolithic, Bronze Age, Iron Age, and middle Ages. Forest clearing was probably moderate during fires prior to the middle Ages, as the small size of the sheep herds and the local character of the markets only required small clearings, and therefore more limited fires. Thus, it is likely that the forest recovered burnt areas in a few decades; this suggests the management of the forest and grasslands following a slash-andburn system. During the middle and modern Ages deforestation and grassland expansion affected most of the subalpine belt and coincided with the increasing prevalence of transhumance, as occurred in other mountains in the Iberian Peninsula(particularly the Pyrenees). Although the occurrence of shallow landslides following deforestation between the Neolithic and the Roman Period cannot be ruled out, the most extensive shallow landsliding processes would have occurred from the middle Ages until recent times.

关键词： Forest fires Holocene Subalpinegrasslands Shallow landslides landscape changes Iberian Range

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XAANTAL2 （AGL14） Is an Important Component of the Complex Gene Regulatory Network that Underlies Arabidopsis Shoot Apical meristem Transitions

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molecular Plant 2015年第5期8卷 796-813页

作者： Rigoberto V. perez-R.u.iz Berenice Garcia-Ponce Nayelli marsch-martinez Yamel Ugartechea-Chirino mitzi Villajuana-Bonequi Stefan de Folter Eugenio Azpeitia jose Davila-Velderrain David Cruz-Sanchez Adriana Garay-Arroyo maria de la Paz Sanchez Juan m. Estevez-Palmas Elena R. Alvarez-Buylla Instituto de Ecologia Universidad Nacionat Autonoma de Moxico 3er Circuito Exterior s/no Junto al Jardin Bot~nico and Centro de Ciencias de la ComplejidadCiudad Universitaria Coyoacan 04510 Mexico D.F. Mexico laboratorio Nacional de Genemica para la Biodiversidad (langebio) Centro de Investigaci6n y de Estudios Avanzados del Instituto Polit~cnico Nacional(CINVESTAV-IPN) Km. 9.6 Carretera Irapuato - Leen AP 629 36821 Irapuato Guanajuato Mexico University of California 431 Koshland Hall Berkeley CA 94720 USA These authors contributed equally to this article. present address: departamento de Biotecnologia y Biquimica Centro de )nvestigaci6n y de Estudios Avanzados del Instituto Polit6cnico Nacional(CINVESTAV-IPN) Km. 9.6 Libramiento Norte Carr. Irapuato-Leen 36821 Irapuato Guanajuato Mexico present address: max Planck Institute for Plant Breeding Research D-50829 Cologne Germany Present address: INRIA Project-Team Virtual Plants/CIRAD/INRA UMR AGAP Campus St Priest - BAT 5 CC 05018 860 rue de St Priest 34095 Montpellier Cedex5 France

In Arabidopsis thaliana, multiple genes involved in shoot apical meristem （SAm） transitions have been char- acterized, but the mechanisms required for the dynamic attainment of vegetative, inflorescence, and floral meristem （Vm, Im, Fm） cell fates during SAm transitions are not well understood. Here we show that a mADS-box gene, XAANTAL2 （XAL2/AGL14）, is necessary and sufficient to induce flowering, and its regula- tion is important in Fm maintenance and determinacy, xal2 mutants are late flowering, particularly under short-day （SD） condition, while XAL2 overexpressing plants are early flowering, but their flowers have vege- tative traits. Interestingly, inflorescences of the latter plants have higher expression levels of LFY, AP1, and TFL1 than wild-type plants. In addition we found that XAL2 is able to bind the TFL1 regulatory regions. On the other hand, the basipetal carpels of the 35S：：XAL2 lines lose determinacy and maintain high levels of WUS expression under SD condition. To provide a mechanistic explanation for the complex roles of XAL2 in SAm transitions and the apparently paradoxical phenotypes of XAL2 and other mADS-box （SOCl, AGL24） over- expressors, we conducted dynamic gene regulatory network （GRN） and epigenetic landscape modeling. We uncovered a GRN module that underlies Vm, Im, and Fm gene configurations and transition patterns in wild- type plants as well as loss and gain of function lines characterized here and previously. Our approach thus provides a novel mechanistic framework for understanding the complex basis of SAm development.

关键词： XAL2/AGL14 mADS-box TFL1 SAm transitions floral reversion gene regulatory networks,epigenetic landscape modeling

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Impact of potato psyllid （Hemiptera： Triozidae） feeding on free amino acid composition in potato

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Insect Science 2011年第6期18卷 663-670页

作者： Xiang-Bing Yang Nasir S. A. malik jose L. perez Tong-Xian Liu Key laboratory of Applied Entomology Northwest A＆F University Yangling Shaanxi China Vegetable IPm laboratory Texas AgriLife Research Texas A＆M System Kika de la Garza Subtropical Agricultural Research Center USDA-ARS Weslaco Texas USA

The impacts of potato psyllid （Bactericera cockerelli） feeding on potato foliage on the free amino acids （FAAs） composition in potato leaf and tubers were determined under greenhouse conditions. The free amino acids in plant extracts were separated by high-performance liquid chromatography, and in both leaf and tuber samples, at least 17 FAAs were detected. Psyllid feeding significantly changed the levels of several FAAs in both leaf and tuber samples. The concentration of leucine increased 1.5-fold, whereas that of serine and proline increased 2- and 3-fold, respectively. In contrast, the concentrations ofglutamic acid, aspartic acid and lyscine were significantly reduced by 42.0%, 52.1% and 27.5%, respectively. There were also significant changes in the levels of FAAs in the Zebra chip （ZC） infected tubers compared with the healthy tubers, and the levels of six of the FAAs increased, and the levels of nine of the FAAs decreased. The results from this study indicate that potato psyllid causes major changes in free amino acid composition of plant tissues, and this change in plant metabolism may contribute to the plant stress as indicated by increased levels of proline in the leaves and hence promoting the development of plant diseases such as ZC disease.

关键词： Bactericera cockerelli free amino acids HPLC potato stress Zebra chip

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Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study

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Journal of Geriatric Cardiology 2022年第5期19卷 354-366页

作者： jose m de la Torre Hernandez Ramon Lopez Palop Jesus m Jimenez mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-Carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés martínez Cáceres jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo Juan CRama merchán Catia Costa Juan Sanchis Renato Fernandes Alberto Rodrigues jose m Vegas Valle Hélder Pereira Armando perez de Prado Cardiology department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain Cardiology department Hospital Universitario San JuanAlicanteSpain Cardiology department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Cardiology department Hospital Universitario Puerta del MarCadizSpain Cardiology department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain Cardiology department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain Cardiology department Hospital Universitario de CrucesBilbaoSpain Cardiology department Hospital Regional Universitario de MálagaMalagaSpain Cardiology department Hospital Universitario Puerta de HierroMadridSpain Cardiology department Hospital Alvaro CunqueiroVigoSpain Cardiology department Hospital Juan Ramon JimenezHuelvaSpain Cardiology department Hospital Universitario de BadajozBadajozSpain Cardiology department Hospital Universitario Lucus AugustiLugoSpain Cardiology department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain Cardiology department Hospital Santa CruzLisboaPortugal Cardiology department Hospital Clínico Universitario Lozano BlesaZaragozaSpain Cardiology department Hospital Universitario Miguel ServetZaragozaSpain Cardiology department Hospital Germans Trias i PujolBadalonaSpain Cardiology department Hospital de MeridaMeridaSpain Cardiology department Hospital São BernardoSetúbalPortugal Cardiology department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain Cardiology department Hospital do Espirito SantoEvoraPortugal Cardiology department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal Cardiology department Hospital de CabueñesGijonSpain Cardiology department Hospital Garcia de OrtaAlmadaPortugal Cardiology department Complejo Asistencial Universitario de LeónLeonSpain

OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).mETHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT ***-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as *** Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex ***-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored *** stent thrombosis reported in the subgroup with 1-3 months DAPT *** compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic

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molecular isolation and identification of mycobacterium avium *** in Didelphis virginiana from Hidalgo,mexico

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Asian Pacific Journal of Tropical medicine 2020年第3期13卷 131-136页

作者： Nallely Rivero-perez Juan Ocampo-López Benjamín Valladares-Carranza Fabián R.Gómez de Anda Francisco J.Pena Jiménez Victor m.martínez Juárez Armando Peláez Acero jose I.Olave Leyva deyanira Ojeda-Ramírez Adrian Zaragoza-Bastida Area Académica de medicina Veterinaria y Zootecnia Instituto de Ciencias AgropecuariaUniversidad Autónoma del Estado de HidalgoAv.Universidad Km 1Ex-Hda.de AquetzalpaC.P.43600 TulancingoHidalgoMéxico Centro de Investigación y Estudios Avanzados en Salud Animal Facultad de Medicina Veterinaria y ZootecniaUniversidad Autónoma del Estado de MéxicoKm 15.5 Carretera Panamericana Toluca-AtlacomulcoC.P.50200 TolucaEstado de MéxicoMéxico Centro Universitario del Sur/División de Ciencias de la Salud/departamento de Ciencias Clínicas/Hospital Veterinario CUSUR Universidad de Guadalajara Av.Enrique Arreola Silva No.883colonia centro C.P.49000Ciudad GuzmánJaliscoMéxico

Objective:To isolate and identify the exact species of the genus mycobacterium from Didelphis(D.)virginiana,and the direct implications of this bacterium to public health and veterinary ***:Thirty-one *** were captured and necropsied in Hidalgo,*** samples were collected to culture mycobacteria present and examine individual specimens’*** identification was obtained through the application of amplification and sequencing of 16S rDNA ***:Three strains were isolated and identified as mycobacterium(m.)avium *** by utilizing *** complexspecific *** lesions were observed in the subpleural zone(granuloma gradeⅡ)and bronchial(granuloma gradeⅠ)of the lungs of *** with positive ***:Three strains of *** ***,from lung tissue samples of *** were *** subspecies of *** has important implications in public health and veterinary medicine.

关键词： Didelphis virginiana mycobacterium avium complex mycobacterium avium subsp.hominissuis Public health

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Preoperative calculation of angles of vision and working area in laparoscopic surgery to treat a giant hiatal hernia

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1638-1650页

作者： Francisco Javier perez lara Rogelio Zubizarreta Jimenez Francisco Javier moya Donoso jose manuel Hernández Gonzalez Tatiana Prieto-Puga Arjona Arturo del Rey moreno maria Pitarch martinez Surgery Service Antequera HospitalRincón de la Victoria 29730MálagaSpain DOXA microfluidics Rincon de la Victoria 29738MálagaSpain

BACKGROUND Giant hiatal hernias still pose a major challenge to digestive surgeons,and their repair is sometimes a highly complex *** is usually performed by laparoscopy,while the role of the thoracoscopic approach has yet to be clearly *** To preoperatively detect patients with a giant hiatal hernia in whom it would not be safe to perform laparoscopic surgery and who,therefore,would be candidates for a thoracoscopic *** In the present study,using imaging test we preoperatively simulate the field of vision of the camera and the working area(instrumental access)that can be obtained in each patient when the laparoscopic approach is *** From data obtained,we can calculate the access angles that will be obtained in a preoperative computerised axial tomography coronal section,according to the location of the *** also provide the formula for performing the angle calculations If the trocars are placed in loss common situations,thus enabling us to determine the visibility and manoeuvrability for any position of the *** The working area determines the cases in which we can operate safely and those in which certain areas of the hernia cannot be accessed,which is when the thoracoscopic approach would be safer.

关键词： Hiatal hernia Angles Approach laparoscopy Thoracoscopy

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