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Extrahepatic cholestasis associated with paracoccidioidomycosis:Challenges in the differential diagnosis of biliopancreatic neoplasia

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2531-2540页

作者： jose Sebastiao dos Santos Vitor de Moura Arrais William jose Rosseto Ferreira Ricardo Ribeiro Correa Filho Mariangela Ottoboni Brunaldi Rafael Kemp Ajith Kumar Sankanrakutty Jorge Elias Junior Fernando Bellissimo-Rodrigues Roberto Martinez Edson Zangiacomi Martinez jose celso ardengh Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP) Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de PatologiaRibeirao Preto 14048900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Imagens MédicasHematologia e Oncologia ClínicaRibeirao Preto 14048900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Medicina SocialRibeirao Preto 14015-010Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Clínica MédicaRibeirao Preto 14015-010Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil and Hospital MoriahServico de Endoscopia DigestivaSao Paulo 04084-002Sao PauloBrazil

BACKGROUND Paracoccidioidomycosis(PCM)may involve the hepatic pedicle and peripan creatic lymph nodes,cause damage to the bile duct and manifest,exceptionally,in combination with extrahepatic cholestasis(EHC),making investigation and treatment *** To investigate the management of patients with visceral PCM admitted with *** All patients diagnosed with PCM treated in a public,tertiary teaching hospital between 1982 and 2020 were retrospectively *** also identified with EHC were allocated to two groups according to the treatment approach for the purpose of comparing clinical,laboratory,and imaging findings,resources used for etiological diagnosis,treatment results,and *** analyses were performed using the linear mixed-effects model(random and fixed effects),which was adjusted using the PROC MIXED procedure of the SAS®9.0 software,and Fisher’s exact *** Of 1645 patients diagnosed with PCM,40(2.4%)had *** these,20(50.0%)lived in the rural area and 29(72.5%)were men,with a mean age of 27.1 years(3-65 years).Jaundice as first symptom and weight loss of at least 10 kg were observed in 16 patients(40.0%),and a mass in the head of the pancreas was observed in 8(20.0%).The etiological diagnosis was made by tissue collection during surgery in 4 cases(10.0%)and by endoscopic methods in 3 cases(7.5%).Twenty-seven patients(67.5%)received drug treatment alone(Group 1),whereas 13(32.5%)underwent endoscopic and/or surgical procedures in combination with drug treatment(Group 2).EHC was significantly reduced in both groups(40.7% in Group 1,with a mean time of 3 months;and 38.4% in Group 2,with a mean time of 7.5 months),with no statistically significant difference between *** recurrence rates,associated mainly with treatment nonadherence,were similar in both groups:37% in Group 1 and 15.4% in Group *** mortality rate was 18.5% in Group 1 and 23% in Group 2,with survival estimates of 71.3% and 72.5%,respectively,with

关键词： Cholestasis Jaundice Obstructive Blastomycosis Paracoccidioides Diagnosis Treatment

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Endoscopic papillectomy: The limits of the indication, technique and results

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World Journal of Gastrointestinal Endoscopy 2015年第10期7卷 987-994页

作者： jose celso ardengh Rafael Kemp Eder Rios Lima-Filho jose Sebastiao dos Santos Division of Digestive and Endoscopic Surgery Department of Surgery and Anatomy Ribeirao Preto School of Medicine University of Sao Paulo Department of Surgery Hospital Federal dos Servidores do Estado Rua Sacadura Cabral Rio de Janeiro 20221-903 Brazil

In the majority of cases, duodenal papillary tumors are adenomas or adenocarcinomas, but the endoscopy biopsy shows low accuracy to make the correct differentiation. Endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography are important tools for the diagnosis, staging and management of ampullary lesions. Although the endoscopic papillectomy(EP) represent higher risk endoscopic interventions, it has successfully replaced surgical treatment for benign or malignant papillary tumors. The authors review the epidemiology and discuss the current evidence for the use of endoscopic procedures for resection, the selection of the patient and the preventive maneuvers that can minimize the probability of persistent or recurrent lesions and to avoid complications after the procedure. The accurate staging of ampullary tumors is important for selecting patients to EP or surgical treatment. Compared to surgery, EP is associated with lower morbidity and mortality, and seems to be a preferable modality of treatment for small benign ampullary tumors with no intraductal extension. The EP procedure, when performed by an experienced endoscopist, leads to successful eradication in up to 85% of patients with ampullary adenomas. EP is a safe and effective therapy and should be established as the first-line therapy for ampullary adenomas.

关键词： Epidemiology Ampullary tumors Endo-scopic resection Endoscopic ultrasound Staging Endoscopic papillectomy Surgical ampullectomy

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Different options of endosonography-guided biliary drainage after endoscopic retrograde cholangiopancreatography failure

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World Journal of Gastrointestinal Endoscopy 2018年第5期10卷 99-108页

作者： Josécelso ardengh César Vivian Lopes Rafael Kemp jose Sebastiao dos Santos Division of Surgery and Anatomy Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Gastroenterology and Digestive Endoscopy Santa Casa HospitalPorto Alegre 91410-000Brazil

AIM To investigate the success rates of endosonography(EUS)-guided biliary drainage(EUS-BD) techniques after endoscopic retrograde cholangiopancreatography(ERCP) failure for management of biliary *** From Feb/2010 to Dec/2016, ERCP was performed in 3538 patients, 24 of whom(0.68%) suffered failure to cannulate the biliary tree. All of these patients were initially submitted to EUS-guided rendez-vous(EUS-RV) by means of a transhepatic approach. In case of failure, the next approach was an EUS-guided anterograde stent insertion(EUS-ASI) or an EUS-guided hepaticogastrostomy(EUS-HG). If a transhepatic approach was not possible or a guidewire could not be passed through the papilla, EUS-guided choledochoduodenostomy(EUS-CD) was *** Patients were submitted to EUS-RV(7), EUS-ASI(5), EUS-HG(6), and EUS-CD(6). Success rates did not differ among the various EUS-BD techniques. Overall,technical and clinical success rates were 83.3% and 75%, respectively. Technical success for each technique was, 71.4%, 100%, 83.3%, and 83.3%, respectively(P = 0.81). Complications occurred in 3(12.5%) patients. All of these cases were managed conservatively, but one patient died after rescue percutaneous transhepatic biliary drainage(PTBD).CONCLUSION The choice of a particular EUS-BD technique should be based on patient's anatomy and on whether the guidewire could be passed through the duodenal papilla.

关键词： Cholestasis Drainage Endosonography Interventional procedures Jaundice Neoplasms

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Soil properties characterization for land-use planning and soil management in watersheds under family farming

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International Soil and Water Conservation Research 2022年第1期10卷 119-128页

作者： jose Miguel Reichert Paulo Ivonir Gubiani Danilo Rheinheimer dos Santos Dalvan jose Reinert celso Aita Sandro jose Giacomini Soils Department Universidade Federal de Santa Maria(UFSM)Santa MariaRSBrazil

Environmental monitoring of small,rural watersheds was one of the components of the Natural Re-sources Management and Rural Poverty Alleviation Program(RS-Rural)in southern *** purpose of the monitoring was to assess the impact of promoting soil conservation and environment manage-ment practices adopted by farmers and funded by the *** four small monitored watersheds,in a total of 95 plots representing distinct land use and soil management,surface soil was collected to characterize ground-zero of the Program by determining several soil physical,chemical and microbio-logical *** component analysis(PCA)shows soil physical,chemical and biological properties were decisive in defining the agricultural soils in the rural watersheds with family *** sensitivity to chemical properties provides an opportunity to improve soil quality if soil management focuses on altering those *** management practiced by tobacco farmers leads to rapid,intense degradation of some natural soil properties,especially those related to the dynamics of soil organic matter,compared with more conservationist uses(forest,regrowth,and grassland).Thus,soil management must be reoriented to avoid the progress of degradation and recover soil physical and biological *** crops and by land-abandonment to allow natural vegetation are important management strategies for the degraded soils used for tobacco production,increasing soil organic matter,nutrients and microbial activity and thus allowing further crop *** conclusion,wa-tersheds with tobacco cropping have soils with lower quality than when under no-tillage grain pro-duction,requiring changes in land use and soil management.

关键词： Natural resources management Environmental monitoring Soil conservation Soil quality Alleviating poverty

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Tourism Marketing Consciousness： The New Posture of the Tourism Consumer Citizen

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Journal of Tourism and Hospitality Management 2014年第2期2卷 67-76页

作者： celso jose de Campos Federal University of Rio de Janeiro (UNIRIO) Rio de Janeiro Brazil

We know that increased population and unrestrained consumption are generating problems, which becomes critical for our planet. This impending context is part of a whole system, triggered by a logic operation which needs to be reconsidered urgently. The consumer consciousness of tourism knows to what extent their different actions will help change something. To achieve this awareness of sustainable consumption requires a restructuring and reform of the cultural, social, and political aspects of the site and the citizen. With this vision and the proposal for a case study of tourism marketing consciousness, the objective of this study is to raise consumers＇ awareness of tourist destinations to develop their abilities to use the right information to make the right choices and to be ecologically responsible. Through this differentia/, every action carried out in the tourist spot is of singular importance to create sustainable added value for the citizen. In this case, tour operators, non-governmental organizations （NGOs）, and local governments should also invest in educational programs that guide these consumers to enjoy as citizens the tourist areas consciously and effectively. Thus, we believe that training in tourism will lead the stakeholders of consciousness tourist destination to feel protagonist in the broad economic context, social, political, and cultural society of the destination of their choices.

关键词： tourist marketing consciousness consumer sustainability

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Discovery of unique African Helicobacter pylori CagAmultimerization motif in the Dominican Republic

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World Journal of Gastroenterology 2020年第45期26卷 7118-7130页

作者： Takaaki Ono Modesto Cruz Hiroyuki Nagashima Phawinee Subsomwong Junko Akada Takashi Matsumoto Tomohisa Uchida Rumiko Suzuki celso Hosking jose A Jimenez Abreu Yoshio Yamaoka Department of Environmental and Preventive Medicine Oita University Faculty of MedicineYufu 879-5593Japan Criminal Investigation Laboratory Oita Prefectural Police HeadquartersOita 870-1117Japan Institute of Microbiology and Parasitology IMPAFaculty of ScienceAutonomous University of Santo DomingoSanto Domingo 10103Dominican Republic Department of Biomedical Research National Institute of Medicine and Diagnostic ImagingSanto Domingo 10107Dominican Republic Department of Gastroenterology Hokkaido Cancer CenterSapporo 003-0804Japan Department of Molecular Pathology Oita University Faculty of MedicineYufu 879-5593Japan Dominican-Japanese Digestive Disease Center Dr Luis E.Aybar Health and Hygiene CitySanto Domingo 10302Dominican Republic Department of Medicine Gastroenterology and Hepatology SectionBaylor College of MedicineHoustonTX 77030United States

BACKGROUND Helicobacter pylori(***)colonizes the human stomach and is a major cause of peptic ulcer disease and gastric ***,although the prevalence of *** is high in Africa,the incidence of gastric cancer is low,and this phenomenon is called to be African *** CagA protein produced by *** is the most studied virulence *** carcinogenic potential of CagA is associated with the Glu-Pro-Ile-Tyr-Ala(EPIYA)patterns and CagAmultimerization(CM)*** To better understand the EPIYA patterns and CM motifs of the cagA *** Gastric mucosal biopsy specimens were obtained from 258 patients with dyspepsia living in the Dominican Republic,from which 120 *** strains were *** the bacterial DNA extraction,the EPIYA pattern and CM motif genotypes were determined using a polymerase chain reaction-based *** population structure of the Dominican Republic strains was analyzed using multilocus sequence typing(MLST).Peptic ulcer disease and gastric cancer were identified via endoscopy,and gastric cancer was confirmed by *** scores of the gastric mucosa were evaluated using the updated Sydney *** All CagA-positive strains carried the Western-type CagA according to the identified EPIYA ***-seven kinds of CM motifs were *** the typical Western CM motif(FPLKRHDKVDDLSKVG)was observed most frequently,the typical East Asian CM motif(FPLRRSAAVNDLSKVG)was not ***,“FPLRRSAKVEDLSKVG”,similar to the typical East Asian CM motif,was found in 21 *** this type was significantly more frequent in strains classified as hpAfrica1 using MLST analysis(P=0.034),we termed it Africa1-CM(Af1-CM).A few hpEurope strains carried the Af1-CM motif,but they had a significantly higher ancestral Africa1 component than that of those without the Af1-CM motif(P=0.030).In 30 cagA-positive strains,the"GKDKGPE"motif was observed immediately upstream of the EPIYA motif in

关键词： Helicobacter pylori CagA CagA 3'region CagA-multimerization motif Glu-Pro-Ile-Tyr-Ala motif Dominican Republic

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Non-wetting Additive as a Solution to Minimize the Corrosion of Refractory Castables Against Molten Aluminum

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China's Refractories 2016年第1期25卷 20-25页

作者： Fernando VERNILLI Adriel Claro de FARIA Mateus Gomes VERNILLI Augusto celso AMOEDO Eduardo jose Togni CARDILLO Taner Augusto MAIA Matheus MARTINI Engineering School of Lorena University of Sao Paulo Lorena 12600-970 Brazil Togni S/A Materiais Refratarios Pocos de Caldas 37704-356 Brazil

The ternary compound barium aluminosilicate BaAl2Si2O8, known as celsian, a non-wetting additive that increases the corrosion resistance of refractor） materials against molten aluminum, was incorporated into the matrix of a high-alumina low cement castable after its synthesis using barite and a low cost source of alumina and silica. This paper presents the influence of this phase on the wetting angle formed between liquid aluminum alloy and solid refractory castable surface.

关键词： refractories con'osion non-wetting additive aluminmn alloy

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Evaluation of Antinociceptive and Anti-Inflammatory Effects of Synthetic O-Prenylated Phenolic Derivatives

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Pharmacology & Pharmacy 2012年第3期3卷 348-357页

作者： Niraldo Paulino Amarilis Scremin Paulino Priscila Vautier Laura Pisco Carolina Passarelli jose Matheus de Freitas Costa Dirk Michalik Paulo celso Pardi jose Agustín Quincoces Suarez Grupo de Pesquisa e Desenvolvimento de Biomedicamentos(BIOMED) Programa de Mestrado Profissional em FarmaciaUniversidade Bandeirante de Sao PauloSao PauloBrasil Programa de Pos-Graduacao em Farmacia Universidade Federal de Santa CatarinaFlorianopolisBrasil Laboratorio de Síntese Organica Universidade Bandeirante de Sao PauloSao PauloBrasil Leibniz-Institut für Katalyse an der Universitat Rostock RostockGermany

This work describes the synthesis, antinociceptive and anti-inflammatory effect of O-prenyl derivatives: O-prenyl derivatives 2-(3-methylbut-2-enyloxy)acetophenone (L1) and 3-methoxy-4-(3-methylbut-2-enyloxy)benzaldehyde (V1). Treatment with L1- or V1-produced antinociceptive effect on classical pain models: acetic acid abdominal contortions and formalin test (first and second phases), and in hot plate or tale flick models in mice without changing the locomotors performance, and anti-oedematogenic or anti-inflammatory effect in vivo: carrageenan-induced paw oedema and peritonitis in mice. In addition, L1 and V1 derivatives reduced nitric oxide production on RAW 264.7 cells stimulated with lipopolysaccharide without changing the cell viability. Taken together, our results show for the first time that L1 and V1 can produce antinociception and modulate inflammatory response when administered in mice.

关键词： Anti-Inflammatory Antinociception Synthesis O-Prenyl Compounds

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Kinetics and thermodynamic studies of Methyl Orange removal by polyvinylidene fluoride-PEDOT mats

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Journal of Environmental Sciences 2021年第2期33卷 62-73页

作者： Romario J.da Silva Lizeth Carolina Mojica-Sanchez Filipe D.S.Gorza Graciela C.Pedro Bruna G.Maciel Gabriela P.Ratkovski Herica D.daRocha Kamila T.O.do Nascimento Juan CMedina-Llamas Alicia E.Chavez-Guajardo jose J.Alcaraz-Espinoza celso P.de Melo Program a de Pos-Graduagao em Ciencia de Materials U niversidade Federal de Pernambuco50670-901 RecifePEBrazil Departamento de Ffsica Uniuersidade Federal de Pemambiico50670-901 Reci/ePEBrazil Centro de Estudios Cientificosy Tecnologicos No.18 Instituto Politecnico Nacional98160 ZacatecasZacMexico Unidad Academica de Ciencias de la Tierra Uniuersidad Aut6noma de Zacatecas98058 ZacatecasZacMexico Departamento de Quimica Universidad Autonoma Metropolitana09340Ciudad de MexicoMexico

We report the preparation of poly(3,4-ethylene dioxythiophene)(PEDOT)-modified polyvinylidene fluoride electrospun fibers and their use as a novel adsorbent material for the removal of the anionic dye Methyl Orange(MO)from aqueous *** novel adsorbent material can be used to selectively remove MO on a wide p H range(3.0-10.0),with a maximum capacity of 143.8 mg/g at p H *** used in a recirculating filtration system,the maximum absorption capacity was reached in a shorter time(20 min)than that observed for batch mode experiments(360 min).Based on the analyses of the kinetics and adsorption isotherm data,one can conclude that the predominant mechanism of interaction between the membrane and the dissolved dye molecules is ***,considering the estimated values for the Gibbs energy,and entropy and enthalpy changes,it was established that the adsorption process is spontaneous and occurs in an endothermic *** good mechanical and environmental stability of these membranes allowed their use in at least 20 consecutive adsorption/desorption cycles,without significant loss of their *** suggest that the physical-chemical characteristics of PEDOT make these hybrid mats a promising adsorbent material for use in water remediation protocols and effluent treatment systems.

关键词： Electrospinning Composite mats Pedot Pvdf mats Dye removal Water remediation

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Analysis of Percolation of the Stabilized Suspensions of TiO2 and SiO2 Nanoparticles in Soil Columns Simulating Landfill Layers

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Journal of Mechanics Engineering and Automation 2016年第1期6卷 47-52页

作者： Elizabeth Mendes de Oliveira Daniele Aparecida Nogueira Luis CarlosRolim Lopes jose Flavio Silveira Feiteira jose Adilson de Castro Escola de Engenharia de Alimentos Centro Federal de Educaao Tecnologica Celso Suckow da Fonseca Valenca 27600-000Rio de Janeiro Brasil Escola de Engenharia Industrial Metalurgica Universidade Federal Fluminense Volta Redonda 27255-125 Rio de Janeiro Brasil

It studied the behavior of transport and stability of TiO2 and SiO2 nanoparticles suspensions percolating through soil columns aiming at simulating municipal waste landfills covering soil layers performance. Experimental columns were constructed with landfill soils and water suspensions with nanoparticles percolation runs were carried out. The experimental columns were constructed with 100 mm and 200 mm of diameter and height, respectively. Outlet concentrations were measured along the percolation time using ICP-OES and nanoparticles tracking analyzer. It was observed that SiO2 nanoparticles acts as a stabilizer of TiO2 nanoparticles suspensions and promotes its transport through the soil columns, which simulates the conditions of the controlled landfills layers. The interaction of the suspensions of SiO2 nanoparticles with nanoparticles of TiO2, promote a high stability of the emulsions, which confers the high zeta potential present in SiO2 suspensions, promoting greater mobility and transport through the soil columns. The experimental results demonstrated that TiO2 nanoparticles were kept suspended, even after 10 days, which indicates good stability. It was observed that both TiO2 and SiO2 were kept in suspensions with negligible nanoparticles clustering and decantation. It was confirmed that the TiO2 and SiO2 of the outflow of soil columns are strongly affected by the soil pH, organic carbon and clay content of the soils. It was observed that the soil columns behave as a retention barrier for both TiO2 and SiO2 nanoparticles.

关键词： Stabilization column experiment and nanofluids.

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