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World Journal of Gastrointestinal Surgery 2012年第11期4卷 246-250页

作者： Belinda Sánchez-Pérez José Manuel Aranda-Narváez Miguel Angel Suárez-Muoz Moises elAdel-delFresno José luis Fernández-Aguilar jose Antonio Pérez-Daga Ysabel Pulido-Roa Julio Santoyo-Santoyo Department of General Digestive and Transplantation SurgeryUniversity Regional Hospital Carlos Haya29010 MálagaSpain

AIM:To analyze our results after the introduction of a fast-track(FT) program after laparoscopic liver surgery in our Hepatobiliarypancreatic ***:All patients(43) undergoing laparoscopic liver surgery between March 2004 and March 2010 were included and divided into two consecutive groups:Control group(CG) from March 2004 until December 2006 with traditional perioperative cares(17 patients) and fast-track group(FTG) from January 2007 until March 2010 with FT program cares(26 patients).Primary endpoint was the influence of the program on the postoperative stay,the amount of re-admissions,morbidity and *** we considered duration of surgery,use of drains,conversion to open surgery,intensive cares needs and ***:Both groups were homogeneous in age and *** differences in technique,time of surgery or conversion to open surgery were found,but more malignant diseases were operated in the FTG,and then transfusions were higher in *** and morbidity were similar in both groups,without *** stay was similar,with a median of 3 for CG vs 2.5 for ***,the 80.8% of patients from FTG left the hospital within the first 3 d after surgery(58.8% for CG).CONCLUSION:The introduction of a FT program after laparoscopic liver surgery improves the recovery of patients without increasing complications or re-admissions,which leads to a reduction of the stay and costs.

关键词： Liver surgery Laparoscopy Fast-track

The Usefulness of Magnetic Resonance Imaging in the Preoperative Study and Postoperative Control in the Laparoscopic Treatment of the Incisional Hernia

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Surgical Science 2015年第8期6卷 376-382页

作者： J.C.Martín del Olmo luis García-Vallejo jose Nunez Gestal Pablo Concheiro Coello Francisco Blanco Antona Miguel Toledano Trincado Javier Sanchez Gonzalez M.Luz Martín Esteban L.Colao Carlos Vaquero Puerta Miguel Carbajo Surgery Department Medina del Campo HospitalValladolidSpain Surgery Department CHUSCalle Rua de Ramon BaltarSantiago de CompostelaSpain Radiology Department CHUSCalle Rua de Ramon BaltarSantiago de CompostelaSpain Department of General and Digestive Surgery Medina del Campo HospitalValladolidSpain Surgery Department University of ValladolidValladolidSpain CEOAD ValladolidSpain

Background and Objectives: The aim of this study is to evaluate the usefulness of Magnetic Resonance Imaging (MRI) for planning surgery and postoperative control of complex cases of abdominal wall hernia. Methods: Included in a prospective data base with more than 350 patients treated in two centers, a prospective study over ten patients with complex incisional hernias was designed. In all cases, preoperative diagnosis study and postoperative imaging control by MR Imaging were established. In the early and late follow-up controls, local and general complications were specifically noted and studied by MRI in each case. Results: The preoperative MRI was effective method for an adequate understanding of the defects and hernia sack content. In the postoperative control, the MRI was useful in the follow-up of the mesh integration, detection of complications and diagnosis of the relapsing. Conclusion: In our experience the MRI test is specially recommended in the preoperative workup of complex cases of incisional hernia.

关键词： Incisional Hernia MR Imaging Laparoscopic Eventroplasty

Renal function assessment in atrial fibrillation:Usefulness of chronic kidney disease epidemiology collaboration vs reexpressed 4 variable modification of diet in renal disease

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World Journal of Cardiology 2015年第10期7卷 685-694页

作者： Rami Riziq-Yousef Abumuaileq Emad Abu-Assi Andrea López-López Sergio Raposeiras-Roubin Moisés Rodríguez-Manero luis Martínez-Sande Francisco Javier García-Seara Xesus Alberte Fernandez-López jose Ramón González-Juanatey Cardiology Department University Clinical Hospital of Santiago de Compostela

AIM: To compare the performance of the re-expressed Modification of Diet in Renal Disease equation vs the new Chronic Kidney Disease Epidemiology Collaboration equation in patients with non-valvular atrial ***: We studied 911 consecutive patients with non-valvular atrial fibrillation on vitamin-K antagonist. The performance of the re-expressed Modification of Diet in Renal Disease equation vs the new Chronic Kidney Disease Epidemiology Collaboration equation in patients with non-valvular atrial fibrillation with respect to either a composite endpoint of major bleeding, thromboembolic events and all-cause mortality or each individual component of the composite endpoint was assessed using continuous and categorical ≥ 60, 59-30, and < 30 m L/min per 1.73 m2 estimated glomerular filtration ***: During 10 ± 3 mo, the composite endpoint occurred in 98(10.8%) patients: 30 patients developed major bleeding, 18 had thromboembolic events, and 60 died. The new equation provided lower prevalence of renal dysfunction < 60 m L/min per 1.73 m2(32.9%),compared with the re-expressed equation(34.1%). Estimated glomerular filtration rate from both equations was independent predictor of composite endpoint(HR = 0.98 and 0.97 for the re-expressed and the new equation, respectively; P < 0.0001) and all-cause mortality(HR = 0.98 for both equations, P < 0.01). Strong association with thromboembolic events was observed only when estimated glomerular filtration rate was < 30 m L/min per 1.73 m2: HR is 5.1 for the re-expressed equation, and HR = 5.0 for the new equation. No significant association with major bleeding was observed for both ***: The new equation reduced the prevalence of renal dysfunction. Both equations performed similarly in predicting major adverse outcomes.

关键词： Atrial fibrillation Anticoagulants Follow-up studies Kidney Prognosis

PKR and PP1C Polymorphisms in Alzheimer’s Disease Risk

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Neuroscience & Medicine 2011年第3期2卷 226-231页

作者： Ernest Palomer Gerard ILL-Raga Marta Tajes Eva Ramos-Fernández Mònica Bosch-Morató Biuse Guivernau jose J.Galan Jordi Clarimon Carmen Antunez Merce Boada luis M.Real César Fandos Francisco J.Munoz Laboratory of Molecular Physiology and Channelopathies Department of Experimental and Health SciencesPompeu Fabra University(UPF)BarcelonaSpain NeoCodex SevillaSpain Alzheimer Laboratory Neurology DepartmentSanta Creu and Sant Pau HospitalBiomedical Research Center on Neurodegenerative Diseases(CIBERNED)BarcelonaSpain Fundacion Alzheimur Dementia UnitVirgen de la Arrixaca HospitalMurciaSpain Memory Clinic of ACE Foundation Catalan Institute of Applied NeurosciencesBarcelonaSpain Neurology Department Vall d’Hebron Universitary HospitalBarcelonaSpain

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofibrillary tangles. Senile plaques are deposits of amyloid ?-peptide (A?) produced by the cleavage of a transmembrane protein termed Amyloid Precursor Protein (APP). The amyloidogenic cleavage of APP is performed by γ-secretase complex and ?-site APP cleaving enzyme 1 (BACE1), a key enzyme in AD that can be activated by different noxious stimuli. Interestingly, some viruses could activate double-stranded RNA-activated protein kinase (PKR), which phosphorylates Eukaryotic Initiation Factor 2 alpha (eIF2α). This phosphorylation stops global translation to avoid any synthesis of viral infective proteins, but paradoxically up-regulates BACE1 translation. One of the viral mechanisms to circumvent eIF2α phosphorylation is the recruitment of protein phosphatase 1 (PP1), to fully dephosphorylate eIF2α and allow viral protein synthesis. Due to the functional relationship between BACE1, PKR, PP1 and AD we have performed a large (1122 cases and 1191 control individuals) case-control genetic analysis using two biallelic polymorphisms rs2254958 and rs7480390, located within the genes coding for PKR and the catalytic unit A of PP1, respectively. Although a trend to association of the rs2254958 TT genotype with AD risk was found, our results show that neither rs7480390 nor rs2254958 are associated with AD susceptibility.

关键词： Alzheimer’s Disease BACE1 PKR PP1 eIF2α

Theoretical and Experimental Exploration of Organic Synthesis Routes to Obtain Natural Rubber Analogues

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材料科学与工程（中英文A版） 2014年第9期4卷 290-296页

作者： David Ramirez-Sanchez Danilo Gonzalez Pablo Ramos luis-Carlos garcia Centro de Bioinform6tica y Simulacion Molecular Universidad de Talca Talca 346-0000 Chile Departamento de Quimica Universidad Nacional de Colombia Bogota 11001 Colombia Theoretical Chemistry Rutgers University Newark 10032 United States of America Proyecto Curricular Licenciatura en Quimica Universidad Distrital Francisco Jose de Caldas Bogota 11001 Colombia

In the present work, synthesis routes and the reactions involved in the polymerization of two organic compounds similar to natural rubber were studied. To these routes and reactions, modifications related with the previously reported in the literature were performed in order to study them through theoretical tools and determine their prediction capability for the design of those analogs. The semi-empirical method Austin Model 1 (AM1) was used for the study of electronic configurations and it was shown that the synthesis of the polystyrene polymer (PS) and the poly copolymer (styrene-butadiene) (SBR) is possible through the use of free radicals from styrene and 1,3-butadiene monomers using benzoyl peroxide as the catalyst in both cases; going through the intermediates 1-phenyl-2-[(phenylcarbonyl)oxy]ethyl and (2E)-4(oxy (phenylcarbonyl))2-buten-1-yl. The results show that the higher electronic densities are found over the active atom in the radical compared to the electronic densities over the ions and the interest atoms in a possible condensation. Additionally, the study of the reaction mechanisms for the designed organic synthesis routes was performed by applying the frontier orbitals theory developed by R. B. Woodward, and R. Hoffmann and the respective correlation diagrams that showed thermal viability were built demonstrating the consistency between the characteristics of the orbital symmetry in the concerted reactions of the reactants and products; therefore it is seen that the free radical synthesis do not show symmetry restrictions, and it is possible to make it by a thermal route with low activation energy thresholds. The experimental yields of polymerizations were 90% and 75% for polystyrene (PS) and poly (styrene-butadiene) (SBR) respectively. Additionally mechanical tests were performed to the synthesized polymers and it was proved that the properties of the synthesized compounds are consistent with those reported in the literature. In the future it is ex

关键词：有机合成路线天然橡胶类似物实验苯乙烯聚合物有机化合物轨道对称性聚合反应

西班牙伊比利亚户外养殖系统中,诺维氏梭状芽胞杆菌感染致使猪群中母猪猝死

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国外畜牧学（猪与禽） 2011年第4期31卷 35-37页

作者：倪晓丹 Alfredo Garc í a Dolores Ayuso jose Manuel Ben í tez Waldo luis Garc í a Remigio Mart í nez Sergio S a nchez

诺维氏梭状芽胞杆菌(Clostridium novyi)是致使两例成年伊比利亚妊娠母猪死亡的可疑致病因,其中一例伴随着充气性肝坏死,快速腐烂,尸体鼓胀,并缺乏其他任何可检测到的死因。厌氧培养能够产生大量梭状芽胞杆菌样微生物,而B型诺维氏梭状... 详细信息

诺维氏梭状芽胞杆菌(Clostridium novyi)是致使两例成年伊比利亚妊娠母猪死亡的可疑致病因,其中一例伴随着充气性肝坏死,快速腐烂,尸体鼓胀,并缺乏其他任何可检测到的死因。厌氧培养能够产生大量梭状芽胞杆菌样微生物,而B型诺维氏梭状芽胞杆菌可以通过多重PCR分析鉴定得到。在妊娠母猪意外死亡的病例中,兽医需要注意到导致死亡的最普遍因素,包括诺维氏梭状芽胞杆菌的感染。为了达到正确的诊断,尸体检查是必要的,并在死后尽快收集样本。此外,运用PCR的方法能够对诺维氏梭状芽胞杆菌及其相关种型进行快速鉴定。

关键词：猪诺维氏梭状芽胞杆菌伊比利亚种猪猝死

Happiness, Hope, and Affection as Predictors of Quality of Life and Functionality of Individuals With Heart Failure at Three-Month Follow-up

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Psychology Research 2012年第9期2卷 532-539页

作者： Elisabete Diogo Proenga jose luis Pais-Ribeiro Mario Joao Martins-Oliveira Nave-LealLisbon Polytechnic Institute Lisbon Portugal Porto University Porto Portugal Lisbon's Central Hospital Center Lisbon Portugal

The scientific evidence supporting the management of the chronically ill in a positive psychological perspective in opposition to traditional pathological approach is scarce. This study examines issues associated with recovery of health status in heart failure, in particular hope, affection, and happiness. We use a longitudinal study of 128 symptomatic patients who after medical intervention reported improved quality of life and function at 3-month follow-up. We evaluated the contribution of happiness, hope and affection, individually and as a whole, in the quality of life and functionality of individuals with heart failure. Happiness (Subjective Happiness Scale), Hope (HOPE Scale), and affection (PANAS (positive and negative affect schedule)) were determined before medical intervention. Individually, we found that happiness is correlated with the quality of life and functionality, hope to self-efficacy dimension of the quality of life scale, positive affect to functionality and negative affect with symptoms dimension, quality of life dimension, and overall sum of the quality of life scale. Overall, we found that happiness has a unique contribution to the quality of life, except in self-efficacy dimension where hope takes this contribution and positive affect has a unique contribution to the functionality in this short-term follow-up. The results highlight the importance of positive variables to health outcomes for people with heart failure and should be considered in intervention programs for this syndrome.

关键词：生活质量衰竭心脏预测随访情感健康状况科学证据

Raman Spectroscopy Mapping of Plasma Thermally Sprayed Silicon Sheet for Solar Cell Substrate

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材料科学与工程（中英文版） 2011年第5期5卷 561-569页

作者： Igor Alessandro Silva Carvalho Ricardo luis Ribeiro Andre luis Pimenta Farial Eduardo Perini Muniz jose Roberto Tavares Branco Technological Center Foundation of Minas Gerais Brazil Material Engineering Thematic Web Brazil University of the State of Minas Gerais Brazil Federal Technological Education Center Brazil Federal University of Espirito Santo Brazil

High purity semiconductor films commit 50% of crystalline photovoltaic cell cost and current efforts focus on photovoltaic alternative devices, known as wafer equivalents, based on reduction of substrate and active light absorbing layer thickness and use of foreign substrates instead of traditional silicon wafers. In this way, knowing the substrate crystalline fraction, roughness and grain size distribution is relevant for thin film epitaxial growth. This work presents a semi-quantitative crystalline fraction analysis measured by Raman mapping microscopy of pc-Si sheets prepared by Atmospheric Thermal Plasma Spray (ATPS) as initial reference for solar cell substrates. Results showed a structural mixed silicon sheet with different values of crystalline fraction, specific regions of amorphous structure contribution, transition regions and a range of crystallite size. The results suggests the need for better ATPS substrate temperature control for higher and homogeneous crystalline fraction values to attend to requirements of a thin film solar cell substrate.

关键词：薄膜太阳能电池基板温度等离子热喷涂硅钢片拉曼光谱映射薄膜外延生长半导体薄膜

P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析

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中华医学杂志 2016年第33期96卷 2611-2615页

作者：冯斯婷严妍范婧尧王晓郑文聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii luis C Correia Masa-aki Kawashiri Sasko Kedev 首都医科大学附属北京安贞医院急诊危重症中心 100029 University Hospital Alvaro Cunqueiro Vigo Spain Academic Medical Center Amsterdam the Netherlands Dipartimento di Scienze Mediche Divisione di Cardiologia Citta della Salute e della Scienza Turin Italy North Shore University Hospital Chicago USA University Clinical Hospital of Santiago de Compostela Santiago de compostela Spain Libin Cardiovascular Institute of Alberta Calgary Canada San Carlos Hospital Madrid Spain Bellvitge University Hospital Barcelona Spain University Patras Hospital Athens Greece Kerckhoff Heart and Thorax Center Frankfurt Germany Graduate School of Medicine Kyoto University Kyoto Japan University Clinical Hospital Warsaw Poland Hospital Sao Rafael Salvador Brazil Kanazawa University Graduate School of Medicine Kanazawa Japan University Clinic of Cardiology Skopje Macedonia

目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂（PPI）治疗对经皮冠状动脉介入（PCI）术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究，纳入2003至2014年因急性冠脉综合征人院行PCI术的患者，分... 详细信息

目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂（PPI）治疗对经皮冠状动脉介入（PCI）术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究，纳入2003至2014年因急性冠脉综合征人院行PCI术的患者，分为PPI组及非PPI组并随访1年，主要临床终点为全因死亡／再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类，将入组患者分为氯吡格雷组及替格瑞洛组，并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者，PPI组占54．8％，具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡／再发心肌梗死复合事件的发生差异无统计学意义（HR1．00，95％CI 0．86—1．18）。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组，不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异，联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险，尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。

关键词：急性冠脉综合征氯吡格雷质子泵抑制剂患者结局评价替格瑞洛