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Mediation role of cardiorespiratory fitness on the association between fatness and cardiometabolic risk in European adolescents: The HELENA study

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Journal of Sport and Health Science 2021年第3期10卷 360-367页

作者： carlos Cristi-Montero Javier Courel-Ibanez Francisco B.Ortega jose Castro-Pinero Alba Santaliestra-Pasias Angela Polito Jeremy Vanhelst Ascension Marcos Luis M.Moreno Jonatan R.Ruiz IRyS Group Physical Education SchoolPontificia Universidad Catolicade ValparaisoValparaisso 2530388Chile Department of Physical Activity and Sport Faculty of Sport SciencesUniversity of MurciaMurcia 30071Spain PROmoting FITness and Health through Physical Activity Research Group(PROFITH) Department of Physical Education and SportsFaculty of Sport SciencesUniversity of GranadaGranada 18001Spain Department of Physical Education Faculty of Education SciencesUniversity of CadizPuerto Real 11003Spain Department of Health and Human Performance School of Health SciencesUniversity of ZaragozaZaragoza 50001Spain Growth ExerciseNutrition and Development(GENUD)Research GroupZaragoza 50001Spain National Institute for Food and Nutrition Research Rome 80070Italy Lille Inflammation Research International Center University of LilleLille 59000France Immunonutrition Research Group Department Metabolism and NutritionInstitute of Food Science and Technology and Nutrition(ICTAN)Spanish National Research Council(CSIC)Madrid E-28040 Spain

Purpose:This study was aimed to analyze the mediation role of cardiorespiratory fitness(CRF)on the association between fatness and cardiometabolic risk scores(CMRs)in European ***:A cross-sectional study was conducted in adolescents(n=525;46%boys;14.1±1.1 years old,mean ±SD)from 10 European cities involved in the Healthy Lifestyle in Europe by Nutrition in Adolescence *** was measured by means of the shuttle run test,while fatness measures included body mass index(BMI),waist to height ratio,and fat mass index estimated from skinfold thicknesses.A clustered CMRs was computed by summing the standardized values of homeostasis model assessment,systolic blood pressure,triglycerides,total cholesterol/highdensity lipoprotein cholesterol ratio,and ***:Linear regression models indicated that CRF acted as an important and partial mediator in the association between fatness and CMRs in 1217-year-old adolescents(for BMI:coefficients of the indirect role b=0.058(95%confidence interval(95%CI):0.023-0.101),Sobel test z=3.11(10.0%mediation);for waist to height ratio:b=4.279(95%CI:2.242-7.059),z=3.86(11.5%mediation);and for fat mass index:b=0.060(95%CI:0.020-0.106),z=2.85(9.4%mediation);all p<0.01).Conclusion:In adolescents,the association between fatness and CMRs could be partially decreased with improvements to fitness levels;therefore,CRF contribution both in the clinical field and public health could be important to consider and promote in adolescents independently of their fatness levels.

关键词： Cardiovascular disease Children Fat mass Fitness Health Physical activity

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The versatility of Fe(Ⅱ) in the synthesis of uniform citrate-stabilized plasmonic nanoparticles with tunable size at room temperature

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Nano Research 2020年第9期13卷 2351-2355页

作者： carlos Fernández-Lodeiro Javier Fernández-Lodeiro Enrique Carbó-Argibay carlos Lodeiro Jorge Pérez-Juste Isabel Pastoriza-Santos CINBIO Universidade de VigoCampus universitario LagoasMarcosende36310 VigoSpain Galicia Sur Health Research Institute(IIS Galicia Sur) SERGAS-UVIGO36312 VigoSpain BIOSCOPE Group LAQV@REQUIMTEChemistry DepartmentNOVA School of Science and TechnologyNOVA University LisbonCaparica Campus2829-516 CaparicaPortugal PROTEOMASS Scientific Society Rua dos InventoresMadam ParqueCaparica Campus2829-516 CaparicaPortugal International Iberian Nanotechnology Laboratory(INL) Av.Mestre Jose Veiga s/n4715-330 BragaPortugal

A highly versatile seed-mediated approach for the synthesis of citrate-stabilized gold,silver and palladium nanoparticles(NPs)with size control is *** use of iron(Ⅱ)as a reducing agent enables the fabrication of monodisperse NPs in a wide range of sizes(from 15 nm to at least 120 nm(90 nm for Pd))at room *** citrate as capping ligand on the NPs surface facilitates its further surface modification with proteins and thiolated molecules.

关键词： plasmonic nanoparticles gold silver palladium citrate-stabilized Fe(Ⅱ)

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即刻牙槽嵴修复技术

即刻牙槽嵴修复技术

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2015年

作者： jose carlos Martins da Rosa原闫峻主译

本书通过编者实施的大量成功的病例，从功能和美学层面，以完整的种植手术、软硬组织处理及义齿修复的全过程介绍了缺损的牙槽嵴即刻牙种植的经验，尤其是在自体上颌结节骨移植即刻种植及即刻负重上有独特的创意，提出了皮质－松质骨复... 详细信息

本书通过编者实施的大量成功的病例，从功能和美学层面，以完整的种植手术、软硬组织处理及义齿修复的全过程介绍了缺损的牙槽嵴即刻牙种植的经验，尤其是在自体上颌结节骨移植即刻种植及即刻负重上有独特的创意，提出了皮质－松质骨复合移植的“三层移植”方法。

关键词：种植牙-口腔外科学

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Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility

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Asian Journal of Andrology 2004年第1期6卷 59-65页

作者： Nicolás Garrido Marcos Meseguer carlos Simon Antonio Pellicer José Remohi Instituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Fundación Instituto Valenciano de Infertilidad Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Fundación Instituto Valenciano de Infertilidad Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 Spain Department of Pediatrics Obstetrics and Gynecology Valencia University School of Medicine Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 SpainDepartment of Pediatrics Obstetrics and Gynecology Valencia University School of Medicine Valencia SpainDepartment of Obstetrics and Gynecology Hospital Dr. Peset Valencia SpainInstituto Valenciano de Infertilidad Valencia Valencia 46015 SpainDepartment of Obstetrics and Gynecology Hospital Dr. Peset Valencia Spain

Oxidative stress is a common condition suffered by biological systems in aerobic conditions. Human semen also has its own molecular guard against the free radicals created by normal respiratory process or from immune reactions. The equilibrium of the creation and scavenging of free radicals is mandatory in the spermatozoa to fertilize and initiate a full-term pregnancy. The paper is a systematic review of publications that evaluate oxidative stress in semen. The Cochrane Library, Medline (1966-2003), Embase (1988-2003), SciSearch (1981-2003) and the conference papers were searched. When sperm samples from fertile and infertile males were analyzed, some of the mechanisms that determine the oxidative stress level were found to be impaired while others were unaltered. In conclusion, the literature as a whole provides contradictory findings and it is necessary to carry out more work to identify all the enzymatic and non-enzymatic systems involved in oxidative stress in the ejaculate, in order to develop new diagnostic systems and therapeutic strategies for combating detrimental free radical imbalance in the semen.

关键词： oxidative stress antioxidants semen spermatozoa male fertility

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Inflammatory effect on the gastrointestinal system associated with COVID-19

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World Journal of Gastroenterology 2021年第26期27卷 4160-4171页

作者： Paulina Delgado-Gonzalez carlos A Gonzalez-Villarreal Jorge A Roacho-Perez Adriana G Quiroz-Reyes jose Francisco Islas Juan Luis Delgado-Gallegos Daniel Arellanos-Soto Kame A Galan-Huerta Elsa N Garza-Treviño Departamento de Bioquimica y Medicina Molecular UANLMonterrey 64610Nuevo LeónMexico Universidad de Monterrey UDEM Vicerrectoria de Ciencias de la SaludMonterrey 66238Nuevo LeonMexico

The severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)that causes coronavirus disease-2019(COVID-19)has provoked a global pandemic,mainly affecting the respiratory tract;however,a percentage of infected individuals can develop gastrointestinal(GI)*** studies describe the development of GI symptoms and how they affect the progression of *** this review,we summarize the main mechanisms associated with gut damage during infection by SARS-CoV-2 as well as other organs such as the liver and *** only are host factors associated with severe COVID-19 but intestinal microbiota dysbiosis is also observed in patients with severe disease.

关键词： SARS-CoV-2 Gastrointestinal symptoms COVID-19 Gastrointestinal system

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Excretion of biliary compounds during intrauterine life

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世界胃肠病学杂志：英文版 2009年第7期15卷 817-828页

作者： Rocio IR Macias jose JG Marin Maria A Serrano Laboratory of Experimental Hepatology and Drug Targeting CIBERehdUniversity of Salamanca

In adults,the hepatobiliary system,together with the kidney,constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine,***,during intrauterine life the biliary route of excretion for cholephilic compounds,such as bile acids and biliary pigments,is very *** very early in pregnancy the fetal liver produces bile acids,bilirubin and biliverdin,these compounds cannot be efficiently eliminated by the fetal hepatobiliary system,owing to the immaturity of the excretory machinery in the fetal ***,the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the *** to the presence of detoxifying enzymes and specifi c transport systems at different locations of the placental barrier,such as the endothe-lial cells of chorionic vessels and trophoblast cells,this organ plays an important role in the hepatobiliary-like function during intrauterine *** relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the *** may result in oxidative stress and apoptosis,mainly in the placenta and fetal liver,which might affect normal fetal development and challenge the fate of the *** present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem.

关键词：胆道排泄化合物胆汁酸生活宫内血管内皮细胞胎儿肝脏胎盘屏障

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Nonlinear constrained optimization using the flexible tolerance method hybridized with different unconstrained methods

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Chinese Journal of Chemical Engineering 2017年第4期25卷 442-452页

作者： Alice Medeiros Lima Antonio jose Goncalves Cruz Wu Hong Kwong Chemical Engineering Graduate Program Federal University of Sdo CarlosRodovia Washington Luizkm 235-5P310Sao CarlosSP 13565-905Brazil Department of Chemical Engineering Federal University of Sao CarlosRodovia Washington Luizkm 235-SP 310Silo CarlosSP 13565-905Brazil

This paper proposes the use of the flexible tolerance method(FTM) modified with scaling of variables and hybridized with different unconstrained optimization methods to solve real constrained optimization *** benchmark problems used to analyze the performance of the methods were taken from G-Suite *** original method(FTM) and other four proposed methods:(i) FTM with scaling of variables(FTMS),(ii) FTMS hybridized with BFGS(FTMS-BFGS),(iii) FTMS hybridized with modified Powell's method(FTMS-Powell)and(iv) FTMS hybridized with PSO(FTMS-PSO), were implemented. The success rates of the methods were 80%,100%, 75%, 95% and 85%, for FTM, FTMS, FTMS-BFGS, FTMS-Powell and FTMS-PSO, respectively. Numerical experiments including real constrained problems indicated that FTMS gave the best performance, followed by FTMSPowell and FTMS-PSO. Despite the inferior performance compared to FTMS and FTMS-Powell, the FTMS-PSO method presented some advantages since good different initial points could be obtained, which allow exploring different routes through the solution space and to escape from local optima. The proposed methods proved to be an effective way of improving the performance of the original FTM.

关键词： Flexible tolerance method Modified Powell’s method BFGS PSO Scaling Hybridization

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On a Classical Theorem on the Diameter and Minimum Degree of a Graph

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Acta Mathematica Sinica,English Series 2017年第11期33卷 1477-1503页

作者： Veronica HERNANDEZ Domingo PESTANA jose M. RODRIGUEZ Universidad carlosⅢde Madrid Avenida de la Universidad3028911 LeganesSpain

In this work, we obtain good upper bounds for the diameter of any graph in terms of its minimum degree and its order, improving a classical theorem due to Erdos, Pach, Pollack and Tuza. We use these bounds in order to study hyperbolic graphs （in the Gromov sense）. To compute the hyperbolicity constant is an almost intractable problem, thus it is natural to try to bound it in terms of some parameters of the graph. Let H（n, δ0） be the set of graphs G with n vertices and minimum degree 50, and J（n, Δ） be the set of graphs G with n vertices and maximum degree A. We study the four following extremal problems on graphs： a（n,δ0） = min{δ（G）｜ G ∈H（n, δ0）}, b（n, δ0） =- max{δ（G）｜ e ∈H（n, δ0）}, α（n, Δ） = min{δ（G） [ G ∈ J（n, Δ）} and β（n,Δ） = max{δ（G） ] G∈Π（n,Δ）}. In particular, we obtain bounds for b（n, δ0） and we compute the precise value of a（n, δ0）, α（n, Δ） and w（n, Δ） for all values of n, r0 and A, respectively.

关键词： Extremal problems on graphs diameter minimum degree maximum degree Gromov hyperbolicity hyperbolicity constant finite graphs

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Acute hepatitis with autoimmune features after COVID-19 vaccine:coincidence or vaccine-induced phenomenon?

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Gastroenterology Report 2022年第1期10卷 628-631页

作者： jose M.Pinazo-Bandera Alicia Hernandez-Albujar Ana Isabel Garcia-Salguero Isabel Arranz-Salas Raul J.Andrade Mercedes Robles-Diaz Division of Gastroenterology and Hepatology Instituto de Investigacion Biomedica de Malaga-IBIMAHospital Universitario Virgen de la VictoriaUniversidad de MalagaMalagaSpain Division of Anatomical Pathology Hospital Universitario Virgen de la VictoriaMalagaSpain Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas(CIBERehd) MadridSpain

Introduction Autoimmune diseases result from a breach of immunological self-tolerance and tissue damage by autoreactive T *** acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection is characterized by an inflam... 详细信息

关键词： autoimmune vaccine acute

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Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2007年第31期13卷 4242-4248页

作者： Silvia Sookoian Gustavo Castao Carolina Gemma Tomas Fernández Gianotti carlos jose Pirola Instituto de Investigaciones Medicas A. Lanari. Universidad de Buenos Aires CONICET Combatiente de Malvinas 3150 1427-Ciudad Autonoma de Buenos Aires Argentina Consejo de Investigación GCBA Buenos Aires Argentina Consejo de Investigación GCBA Buenos Aires Argentina Instituto de Investigaciones Medicas A. Lanari. Universidad de Buenos Aires CONICET Combatiente de Malvinas 3150 1427-Ciudad Autonoma de Buenos Aires Argentina

AIM: To investigate the role of gene variants and derived haplotypes of the CLOCK transcription factor in nonalcoholic fatty liver disease (NAFLD) and their relation with the disease severity. METHODS: A total of 136 patients with NAFLD and 64 healthy individuals were studied. Liver biopsy was performed in 91 patients. Six tag SNPs showing a minor allele frequency > 10% (rs1554483 C/G; rs11932595 A/G; rs4580704 C/G; rs6843722 A/C; rs6850524 C/G and rs4864548 A/G) encompassing 117 kb of chromosome 4 and representing 115 polymorphic sites (r2 > 0.8) were genotyped. RESULTS: rs11932595 and rs6843722 showed signifi cant associations with NAFLD (empiric P = 0.0449 and 0.023, respectively). A significant association was also observed between clinical or histologic spectrum of NAFLD and rs1554483 (empiric P = 0.0399), rs6843722 (empiric P = 0.0229) and rs6850524 (empiric P = 0.00899) and between fibrosis score and rs1554483 (empiric P = 0.02697), rs6843722 (empiric P = 0.01898) and rs4864548 (empiric P = 0.02697). Test of haplotypic association showed that CLOCK gene variant haplotypes frequencies in NAFLD individuals significantly differed from those in controls (empiric P = 0.0097). CONCLUSION: Our study suggests a potential role of the CLOCK polymorphisms and their haplotypes insusceptibility to NAFLD and disease severity.

关键词：生理节奏蛋白质基因变异肝疾病

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