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Social distancing and testing as optimal strategies against the spread of COVID-19 in the Rio Grande Valley of Texas

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Infectious Disease Modelling 2021年第1期6卷 729-742页

作者： Kristina P.Vatcheva josef Sifuentes Tamer Oraby jose camp. maldonado Timothy Huber María Cristina Villalobos School of Mathematical&Statistical Sciences University of Texas Rio Grande ValleyBrownsvilleTX78520USA School of Mathematical&Statistical Sciences University of Texas Rio Grande ValleyEdinburgTX78539USA School of Medicine The University of Texas Rio Grande ValleyEdinburgTX78539USA

At the beginning of August 2020,the Rio Grande Valley(RGV)of Texas experienced a rapid increase of coronavirus disease 2019(abbreviated as COVID-19)cases and *** study aims to determine the optimal levels of effective social distancing and testing to slow the virus spread at the outset of the *** use an age-stratified eight compartment epidemiological model to depict COVID-19 transmission in the community and within *** a simulated 120-day outbreak period data we obtain a post 180-days period optimal control strategy *** results show that easing social distancing between adults by the end of the 180-day period requires very strict testing a month later and then daily testing rates of 5%followed by isolation of positive *** social distancing rates in adults from 50%to 25%requires both children and seniors to maintain social distancing rates of 50%for nearly the entire period while maintaining maximum testing rates of children and seniors for 150 of the 180 days considered in this *** have higher contact rates which leads to transmission based on our model,emphasizing the need for caution when considering school reopenings.

关键词： COVID-19 Mathematical modeling Optimal control Rio Grande Valley(RGV) Testing and social distancing School reopening

Cardiopulmonary Stability on a Patient with Hip Fracture and Severe Pulmonary Hypertension, Anesthetized with Lumbar-Sacral Plexus Block and Non-Invasive Ventilation: Case Report

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Open Journal of Anesthesiology 2022年第10期12卷 301-314页

作者： Uribe camp. Giselle Andrea Perales Caldera Eduardo Prol Carreiro Adolfo Velazco González jose Gamaliel Díaz Borjón Efraín Morales maldonado Rubén Alejandro Department of Anesthesiology Hospital ángeles Lomas México City Mexico Department of Intensive Care Hospital ángeles Lomas México City Mexico Department of Orthopaedics Hospital ángeles Lomas México City Mexico

Background: Pulmonary hypertension is defined as a mean arterial pressure in the pulmonary artery exceeding 20 mm Hg at rest, measured by means of right heart catheterization. Patients with pulmonary hypertension undergoing surgical procedures such as hemiarthroplasty present a high risk of fatal complications. Nonetheless, there are no widely accepted protocols explaining their perioperative care in great detail. Case presentation: We present a case with an 89-years-old patient, with comorbidities such as GOLD 4D chronic obstructive pulmonary disease (COPD) and, as a consequence of this, severe pulmonary hypertension with signs of right ventricular dysfunction, thus requiring of pulmonary vasodilator, that has suffered a subcapital hip fracture requiring urgent surgery. Surgery is carried out successfully, under regional lumbar-sacral plexus block and sedation assisted by non-invasive ventilation. Conclusion: Multidisciplinary specialized treatment, preoperative optimization, as well as the careful selection of both the surgical and anesthetic techniques to be used, are among the strategies that improve the perioperative outcome in patients with pulmonary hypertension with right ventricle systolic dysfunction. Regional lumbar-sacral plexus block plus sedation is a technique that maintains hemodynamic stability;however, these patients require advance measures and postoperative monitoring under intensive care.

关键词： Hip Fracture Pulmonary Hypertension Lumbar-Sacral Plexus Block Non-Invasive Ventilation Right Ventricular Failure

Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

Simulated Experiments for Teaching CAD Techniques Using Analytic and Finite Element Solutions of Electromagnetic Two-Dimensional Problems with Longitudinal Symmetry

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Journal of Electromagnetic Analysis and Applications 2019年第6期11卷 79-99页

作者： Antonio Flavio Licariao Nogueira Rodolfo Lauro Weinert Leonardo jose Amador Salas maldonado Santa Catarina State University JoinvilleBrazil

The paper describes an approach to teaching low-frequency electromagnetic CAD techniques to undergraduate students pursuing a degree course in electrical engineering. The simulated experiments make use of a two-dimensional open-access software based on the finite-element method. At the laboratory meetings, the problems are initially solved analytically. Upon this, students learn how to create the numeric model and how to define the sequence of field problems that lead to the required solution. Simulation tasks based on a force-producing electromagnet are used to introduce numeric techniques to determine magnetic field distribution, evaluation of energy storage and generation of magnetic forces. The nature of the magnetic force generated in the air gaps of the C-core electromagnet is explained in detail. Magnetic forces are calculated by the classical and weighted versions of the method of Maxwell stress tensor. The paper provides all the basic elements required for further exploration of devices with longitudinal symmetry.

关键词： Actuators Electromagnetic Engineering Education Energy Storage Finite Element Method Magnetic Forces

Towards Bio-impedance Based Labs： A Review

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Journal of Electrical Engineering 2016年第3期4卷 116-127页

作者： Pablo Perez Andres maldonado Alberto Yufera Gloria Huertas Adoracion Rueda jose Luis Huertas Instituto de Microelectr6nica de Sevilla Universidad de Sevilla CSIC Sevilla 41092 Spain Dpt. Electronic Technology ETSIL Universidad de Sevilla Sevilla 41012 Spain Dpt. Electronic and Electromagnetism F. Physics Universidad de Sevilla Sevilla 41012 Spain

Electron Paramagnetic Resonance of Gd3＋ in Cs 2Na Y0.75 H o0.25CI6

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材料科学与工程（中英文B版） 2011年第3期1卷 352-357页

作者： josefina maldonado Jorge Barreto jose Luis Boldu Hector del Castillo Eduardo Mufioz Picone Instituto de Fisica Universidad Nacional Autonoma de Mexico Circuito de la Investigacion Cientifica Ciudad Universitaria D.F. 04510 Mexico

Extraction and Separation Factor for Lanthanum(III) and Cerium(III) Complexes from Aqueous Medium Using Ionic Liquid and Kerosene

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Advances in Chemical Engineering and Science 2020年第4期10卷 343-357页

作者： Angelica Quintriqueo Julio Romero Esteban Quijada-maldonado E. Bringas Felipe Olea jose Hernández Laboratory of Membrane Separation Processes (LabProSeM) Department of Chemical Engineering University of Santiago de Chile Estación Central Chile Department of Chemical and Biomolecular Engineering ETSIIT University of Cantabria Santander Spain Advanced Materials Department Chilean Nuclear Energy Commission Santiago Chile

In this work, an experimental study was carried out to find the best-operating conditions for the study of the extraction percentage (%E) and the separation factor (SF) of La(III) and Ce(III) complexes. To carry out this study, a variation of β-diketone concentrations was used, keeping the concentration of tri-octyl phosphine oxide (TOPO) continuous at 0.05 M. The ratio of organic phase to the aqueous phase (O/A) was also studied. The %E and SF were analyzed and compared in the 1,1,1-trifluoro-2, 4-pentanedione (TFA) with TOPO, and 1,1,1,5,5,5-Hexafluoro-2,4-pentanedione (HFAc) with TOPO in Ionic Liquid (IL) and Kerosene. The one-stage extraction efficiency in IL of La(III) and Ce(III) complexes was 42.13% and 77.48% for the TFA-TOPO system and La(III) and Ce(III) complexes were 94.33% and 97.67% for the HFAc-TOPO system. While the SF between Ce(III) and La(III) complexes was 4.91 for TFA-TOPO and 2.64 for HFAc-TOPO. On the other hand, the one-stage extraction efficiency in Kerosene of La(III) and Ce(III) complexes was 27.57% and 63.70% in the TFA-TOPO system. The one-stage extraction efficiency of La(III) and Ce(III) complexes were 99.87% and 99.73% for the HFAc-TOPO system in Kerosene while the SF between Ce(III) and La(III) complexes was 4.62 for TFA-TOPO and 0.49 for HFAc-TOPO. The main conclusion was that using two extractants (β-diketone and TOPO) produced a synergistic effect improving the extraction capacity and SF of La(III) and Ce(III) complexes for both systems in IL and Kerosene.

关键词： Synergistic Extraction β-Diketone Tri-Octyl Phosphine Oxide Lanthanide Complex

Adapting Business of Energy Corporations to Macro-Policies Aiming at a Sustainable Economy. The Case for New Powering of Automobiles

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Energy and Power Engineering 2013年第1期5卷 92-108页

作者： jose M. “Chema” Martinez-Val Piera Alfonso maldonado-Zamora Ramon Rodríguez Pons-Esparver ETSI Minas Universidad Politécnica de Madrid Madrid Spain

A portfolio of new energy technologies has emerged in the first decade of the 21st Century, and many of them could be used for re-structuring the energy sector towards Sustainable Development. A key subject in this quest is the future of automobile, with possibilities on powering ranging from biofuels to Hydrogen Cars (HC), to Electric Vehicles (EV). In turn, the latter is closely connected with the need to deploy Renewable Energies (RE) for electricity generation. Within such new situation, countries and governments are aware that there are new tools for fighting Global Warming (GW), and new policies could be established for winning this battle against CO2. All these initiatives will affect the future of energy corporations, notably hydrocarbon companies;and it should be noted that it will be difficult for the companies to define long-term strategies if energy policies convey upheavals, sudden changes in promoting alternatives and interruptions on activities. Hence, it is very important to adopt energy policies allowing a smooth evolution of the companies’ activities to the new energy model. After analyzing the alternatives with a forecasting-backcasting methodology, an “eclectic approach” is proposed, with the Plug-in Hybrid car with Flexible Fuel (PiHFF) as the central paradigm in the coming promoting policies.

关键词： Sustainable Energy Policies Electric Vehicles Corporation Adaptation

The health care economic-industrial complex: Concepts and general characteristics

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Health 2013年第10期5卷 1607-1621页

作者： Carlos Augusto Grabois Gadelha Lais Silveira Costa jose Manuel Santos de Varge maldonado Pedro Ribeiro Barbosa Marco Antonio Vargas Science Technology and Strategic InputsMinistry of HealthBrasiliaBrazil Research Group Innovation in Health Care Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroBrazil Professional Master’s Degree Course in Politics and Management of Science Technology and Innovation in Health CareSergio Arouca School of Public HealthOswaldo Cruz FoundationRio de JaneiroBrazil Management and Institutional Development Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroBrazil Department of Economics Faculty of EconomicsUniversidade Federal FluminenseNiteroiBrazil

The strategic role of health care within the Brazilian development agenda has been increasingly recognized and institutionalized. Aside from its importance as a structural element of the Welfare State, health care plays a leading role in generating innovation. Despite this, the productive base of Brazil’s health care system is extremely fragile, jeopardizing both the universal provision of health care services and the country’s competitive insertion in the globalized environment. This suggests the need for a more systematic analysis of the complex relationships that exist between the technological and the social interests involved in the productive base of health care provision in Brazil. Therefore, the purpose of this article is to enhance our understanding of the productive base of health care, especially given its potential to contribute to a socially inclusive development model, which is the ultimate goal in Brazil.

关键词： Technological Development Policies Health Care Sector Economics Health Sciences Technology and Innovation Management Policies and Cooperation in Science Technology and Innovation