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comparative efficacy of sodium glucose cotransporter-2 inhibitors in the management of type 2 diabetes mellitus:A real-world experience

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World Journal of Diabetes 2024年第3期15卷 463-474页

作者： Lubna Islam Dhanya jose Mohammed Alkhalifah Dania Blaibel Vishnu chandrabalan joseph M Pappachan Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Department of community Medicine Goa Medical CollegeGoa 403202India Department of Family Medicine King Faisal Specialist HospitalRiyadh 11564Saudi Arabia Department of Data Science Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityAll Saints BuildingManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

BAcKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT-2i)are a class of drugs with modest antidiabetic efficacy,weight loss effect,and cardiovascular benefits as proven by multiple randomised controlled trials(RcTs).However,real-world data on the comparative efficacy and safety of individual SGLT-2i medications is *** To study the comparative efficacy and safety of SGLT-2i using real-world clinical *** We evaluated the comparative efficacy data of 3 SGLT-2i drugs(dapagliflozin,canagliflozin,and empagliflozin)used for treating patients with type 2 diabetes *** on the reduction of glycated hemoglobin(HbA1c),body weight,blood pressure(BP),urine albumin creatinine ratio(AcR),and adverse effects were recorded *** Data from 467 patients with a median age of 64(14.8)years,294(62.96%)males and 375(80.5%)caucasians were *** diabetes duration was 16.0(9.0)years,and the duration of SGLT-2i use was 3.6(2.1)***-2i molecules used were dapagliflozin 10 mg(n=227;48.6%),canagliflozin 300 mg(n=160;34.3%),and empagliflozin 25 mg(n=80;17.1).Baseline median(interquartile range)HbA1c in mmol/mol were:dapagliflozin-78.0(25.3),canagliflozin-80.0(25.5),and empagliflozin-75.0(23.5)*** respective median HbA1c reduction at 12 months and the latest review(just prior to the study)were:66.5(22.8)&69.0(24.0),67.0(16.3)&66.0(28.0),and 67.0(22.5)&66.5(25.8)respectively(Pcomparisons from baseline).Significant improvements in body weight(in kilograms)from baseline to study end were noticed with dapagliflozin-101(29.5)to 92.2(25.6),and canagliflozin 100(28.3)to 95.3(27.5)*** reductions in median systolic and diastolic BP,from 144(21)mmHg to 139(23)mmHg;(P=0.015),and from 82(16)mmHg to 78(19)mmHg;(Pctively were also observed.A significant reduction of microalbuminuria was observed with canagliflozin only[AcR 14.6(42.6)at baseline to 8.9(23.7)at the study end;P=0.043].Adverse effects

关键词： Sodium glucose cotransporter-2 inhibitors Empagliflozin canagliflozin Dapagliflozin Type 2 diabetes mellitus cardiovascular disease Albumin creatinine ratio Diabesity

Stay in touch with the endoplasmic reticulum

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Science china(Life Sciences) 2024年第2期67卷 230-257页

作者： Sha Sun Gan Zhao Mingkang Jia Qing Jiang Shulin Li Haibin Wang Wenjing Li Yunyun Wang Xin Bian Yan G.Zhao Xun Huang Ge Yang Huaqing cai jose c.Pastor-Pareja Liang Ge chuanmao Zhang Junjie Hu National Laboratory of Biomacromolecules Institute of BiophysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China The Ministry of Education Key Laboratory of cell Proliferation and Differentiation College of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Laboratory of computational Biology&Machine Intelligence School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medicinal chemical Biology College of Life SciencesNankai UniversityTianjin 300071China Brain Research center Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Neurosciences Consejo Superior de Investigaciones Científicas-Universidad Miguel HernándezSan Juan de Alicante 03550Spain

The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic *** a result,it engages a variety of organelles by establishing membrane contact sites(McSs).These contacts regulate organelle positioning and remodeling,including fusion and fission,facilitate precise lipid exchange,and couple vital signaling ***,we systematically review recent advances and converging themes on ER-involved organellar *** molecular basis,cellular influence,and potential physiological functions for ER/nuclear envelope contacts with mitochondria,Golgi,endosomes,lysosomes,lipid droplets,autophagosomes,and plasma membrane are summarized.

关键词： endoplasmic reticulum nuclear envelope mitochondria Golgi apparatus endosome lysosome lipid droplets autophagosome plasma membrane membrane contact site

contribution of extracellular vesicles to steatosis-related liver disease and their therapeutic potential

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World Journal of Hepatology 2024年第9期16卷 1211-1228页

作者： Margarita Montoya-Buelna Inocencia G Ramirez-Lopez cesar A San Juan-Garcia jose J Garcia-Regalado Mariana S Millan-Sanchez Ulises de la cruz-Mosso Jesse Haramati Ana L Pereira-Suarez jose Macias-Barragan Laboratorio de Inmunología Departamento de FisiologíaUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Departamento de ciencias de la Salud Centro Universitario de los VallesUniversidad de GuadalajaraAmeca 46600JaliscoMexico Doctorado en ciencias Biomédicas Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Laboratorio de Inmunología Departamento de FisiologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Red de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Laboratorio de Inmunobiología Departamento de Biología Celular y MolecularCentro Universitario de Ciencias Biológicas y AgropecuariasUniversidad de GuadalajaraZapopan 45200JaliscoMexico Instituto de Investigación en ciencias Biomédicas Departamento de Microbiología y PatologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Extracellular vesicles(EVs)are small particles released by many cell types in different tissues,including the liver,and transfer specific cargo molecules from originating cells to receptor *** process generally culminates in activation of distant cells and inflammation and progression of certain *** global chronic liver disease(cLD)epidemic is estimated at 1.5 billion patients *** and liver cancer are the most common risk factors for ***,hepatitis c and B virus infection and obesity are also highly associated with ***,the etiology of many cLD pathophysiological,cellular,and molecular events are *** in hepatic lipid metabolism can lead to lipotoxicity events that induce EV ***,we aimed to present an overview of EV features,from definition to types and biogenesis,with particular focus on the molecules related to steatosis-related liver disease,diagnosis,and therapy.

关键词： Extracellular vesicles Exosomes chronic liver disease Hepatocellular carcinoma Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis

Frontier of the Paleo-Tethys Ocean in the western Mediterranean:Isotopic(Sm-Nd)constraints on sources of Devonian units from Menorca Island

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Geoscience Frontiers 2024年第5期15卷 323-338页

作者： Ricardo Arenas jose M.Fuenlabrada cristian Timoner Rubén Díez Fernández Esther Rojo-Pérez Departamento de Mineralogía y Petrología and Instituto de Geociencias(UcM CSIC)Universidad ComplutenseMadridSpain Unidad de Geocronología(cAI de ciencias de la Tierra y Arqueometría) Universidad ComplutenseMadridSpain Bayerisches Geoinstitut University of BayreuthBayreuthGermany Instituto Geológico y Minero de España–cSIc SalamancaSpain

The c.1000-m-thick pre-orogenic Devonian mainly metapelitic sequence of North Menorca Island shows a fairly complete stratigraphic *** rocks of this sequence indicate gradually increasing deeper marine conditions of sedimentation towards its uppermost ***,the obtained sedimentary characteristics resemble those related to a deep and narrow basin-associated *** sills of Ti-augite-bearing alkaline gabbros occur within the Devonian *** intensity of Variscan deformation increases downwards through the *** to the characteristics of the Devonian sequence and its location within the Variscan Orogen,a correlation with similar units located in the southern sectors of the central Iberian Zone(Iberian Massif)is *** Devonian metapelitic rocks have geochemical characteristics suggesting that they represent moderately recycled mature siliciclastic sediments,generated from erosion of distant source areas belonging to an upper continental *** relatively narrow range of variation observed in initial^(143)Nd/^(144)Nd ratios supports a similar source for the Menorcan slates(0.51165–0.51182).However,a marked trend is observed in these isotope ratios,from lower values at the base of the stratigraphic column(minimum value of 0.511941)to higher values at the top(maximum value of 0.512131).The^(147)Sm/^(144)Nd ratios vary between 0.1074 and 0.1238,within the range defined for siliciclastic rocks with felsic crustal *** Nd model ages define a narrow range between 1496 Ma and 1754 Ma(Late Paleoproterozoic–Early Mesoproterozoic),and they are consistently younger *** data rule out a provenance from the erosion of the West Africa craton,as they are more compatible with a provenance from regions located in the Trans-Saharan Belt or Sahara *** characteristics of the Menorcan Devonian sequence are compatible with its deposition in a narrow and deep peri-Gondwanan transtensional basin,gener

关键词： Western Paleo-Tethys frontiers Menorca Island Sm-Nd isotopic constraints Devonian sequence provenance in Gondwana

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碳基固体氧化物燃料电池研究进展

洁净煤技术 2024年第1期30卷 239-264页

作者：张伟魏嘉璐 jose Antonio Alonso 孙春文中国矿业大学(北京)化学与环境工程学院北京100083 Instituto de ciencia de los Materiales de Madrid CSICCantoblanco-Madrid 28049Spain

随着人们对绿色能源和环境友好型社会需求的日益增长,先进能量转换装置或系统的研发亟待加速,而燃料电池系统被认为是最有希望的未来发电装置。在不同种类的燃料电池中,固体氧化物燃料电池(SOFcs)是一种清洁环保的发电装置,因其独特的... 详细信息

随着人们对绿色能源和环境友好型社会需求的日益增长,先进能量转换装置或系统的研发亟待加速,而燃料电池系统被认为是最有希望的未来发电装置。在不同种类的燃料电池中,固体氧化物燃料电池(SOFcs)是一种清洁环保的发电装置,因其独特的多燃料运行能力及能量转化效率高等优点而前景广阔。然而,传统使用镍-金属陶瓷阳极的SOFcs,在碳氢化合物燃料下运行时,由于燃料的不完全氧化会使阳极产生积碳,从而导致电池性能下降。讨论了碳基SOFc中碳沉积机理和解决阳极积碳的策略,重点介绍了目前广泛研究的具有混合离子-电子导体的双金属-金属陶瓷材料的种类以及研究进展,并总结了双金属-金属陶瓷材料的抗积碳机理,主要表现为降低阳极表面的碳沉积速率以及加速积碳的去除。还介绍了在还原性气氛中,钙钛矿材料中纳米粒子原位偏析的原理,并讨论了原位偏析所形成的纳米颗粒以及其与钙钛矿主体所形成的金属氧化物异质结构在抗积碳阳极中的应用。此外,还探究了多层阳极和单原子催化剂阳极在中温SOFcs中的应用。在燃料电池技术巨大进步的推动下,人们对可用于固定式发电的集成煤气化的燃料电池发电系统(IGFcs)产生了新的兴趣,该系统对于实现煤炭的清洁高效利用具有重要意义,该技术的关键依托于SOFcs的成熟度。最后,总结并指出了碳基SOFcs未来的一些研究方向。

关键词：固体氧化物燃料电池阳极材料碳氢燃料碳沉积整体煤气化燃料电池

Hydrogeochemical and isotopic assessment of the origin of NO_(3)^(−)and N-NH_(3)contents in the aquifer located in a closed lacustrine volcano-sedimentary basin in the metropolitan area of Mexico city

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Acta Geochimica 2024年第4期43卷 719-736页

作者： jose Ivan Morales-Arredondo Maria Aurora Armienta Hernandez Joel Edmundo Ortega-Gutierrez Elisa cuellar Ramirez Natural Resources Department Institute of GeophysicsNational Autonomous University of MexicoCiudad Universitaria No.3000Col.Copilco UniversidadCoyoacán Delegation04360 MexicoCDMXMexico Instituto Politecnico Nacional ***án 55La Laguna Ticoman07340 MexicoCDMXMexico Benemérita Universidad Autónoma de Puebla ciudad Universitaria Col.San ManuelPueblaPueMexico

To explain the presence and spatial distribution of NO_(3)^(−)and N-NH_(3)in the Aquifer of the Metropolitan Area of Mexico city(AMAMc),a hydrogeochemical and isotopic analysis using^(13)c DIc(as well as the stable isotopes^(18)O and^(2)H)in groundwater was *** aquifer is located in an old closed lacustrine volcano-sedimentary basin;some wells hosted in the semi-confined zone contain high N-NH_(3)concentrations,while others present NO_(3)^(−)contents in the recharge zones(hosted in an oxidizing environment).In this study,a change in the isotopic signature(primarily in^(18)O and^(2)H)was observed from the recharge zones to the basin center in some of the wells with high NO_(3)^(−)concentrations,this behavior can be attributed to evaporation during the incorporation of recently infiltrated *** addition,the results for^(13)c(along with ^(2) H)in wells with the highest N-NH_(3)concentrations exhibited an atypically broad range of *** indicated the occurrence of hydrogeochemical and/or biochemical processes in the aquifer(in an oxidizing or reducing environment),such as organic degradation,bacterial decomposition(primarily in the ancient Lake Texcoco and which acts as a natural sink for carbon,nitrogen,sulfur,and phosphorus),besides rock weathering and dissolution,which may be responsible for a very marked isotopic modification of the^(13)c(and,to a lesser extent,2 H).Methanotrophic bacterial activity and methanogenic activity may be related to N-NH_(3)removal processes by oxidation and residual water incorporation respectively,whereas the increase in the NO_(3)^(−)content in some wells is due to the recent contribution of poor-quality water due to contamination.

关键词： 18 O and^(13)c isotopes Iron Hydrogeochemical processes Nitrate Nitrogen species

Auxin signaling gets oxidative to promote root hair growth

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Molecular Plant 2024年第5期17卷 696-698页

作者： Victoria Berdion Gabarain Miguel A.Ibeas Hernan Salinas-Grenet jose M.Estevez Fundación Instituto Leloir&IIBBA-cONIcET Av.Patricias Argentinas 435Buenos Aires C1405BWEArgentina centro de Biotecnología Vegetal Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile ANID Millennium Science Initiative ProgramMillennium Nucleus for the Development of Super Adaptable Plants(MN-SAP)SantiagoChile ANID Millennium Science Initiative ProgramMillennium Institute for Integrative Biology(iBio)SantiagoChile

Root hairs(RHs)emerge as cylindrical cell protrusions from the root epidermis in a polar manner,and these outgrows increase the rhizosphere space to acquire water and nutrients,anchor the plant,and interact with various soil *** is one of the key hormones to promote RH growth,and high levels of auxin are directly promoted by low levels of macronutrients in the soil,such as phosphate(Bhosale et al.,2018)and nitrates(Jia et al.,2023).The nutritional signals for roots,which rapidly change in both time and place within the soil,are tightly linked to signaling pathways that execute swifts on cellular processes to adjust to a challenging *** rapid alkalinization factors(RALFs)are peptides that are released outside the cell and act as peptide-hormone *** attach to the extracellular domains of members of the catharanthus roseus REcEPTOR-LIKE KINASE 1-LIKE family,specifically FERONIA(FER)in conjunction with its co-receptor LORELEI-LIKE-GPIANcHORED PROTEIN 1.

关键词： soil outside alkali

Electrifying Ba_(0.5)Sr_(0.5)co_(0.8)Fe_(0.2)O_(3-δ) for focalized heating in oxygen transport membranes

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Journal of Energy chemistry 2024年第4期91卷 99-110页

作者： Marwan Laqdiem Julio García-Fayos Laura Almar Alfonso J.carrillo Álvaro Represa JoséM.López Nieto Sonia Escolástico David catalán-Martinez jose M.Serra Instituto de Tecnología Química(Universitat Politècnica de València–consejo Superior de Investigaciones científicas) Av.Los Naranjos s/nE-46022 ValenciaSpain

Industry decarbonization requires the development of highly efficient and flexible technologies relying on renewable energy resources,especially biomass and solar/wind *** the case of pure oxygen production,oxygen transport membranes(OTMs)appear as an alternative technology for the cryogenic distillation of air,the industrially-established process of producing ***,OTMs could provide oxygen from different sources(air,water,cO_(2),etc.),and they are more flexible in adapting to current processes,producing oxygen at 700^(-1)000℃.Furthermore,OTMs can be integrated into catalytic membrane reactors,providing new pathways for different *** first part of this study was focused on electrification on a traditional OTM material(Ba_(0.5)Sr_(0.5)co_(0.8)Fe_(0.2)O_(3-δ)),imposing different electric currents/voltages along a capillary *** to the emerging Joule effect,the membrane-surface temperature and the associated O_(2) permeation flux could be ***,the OTM is electrically and locally heated and reaches 900℃on the surface,whereas the surrounding of the membrane was maintained at 650℃.The O_(2)permeation flux reached for the electrified membranes was~3.7 NmL min^(-1)cm^(-2),corresponding to the flux obtained with an OTM non-electrified at 900℃.The influence of depositing a porous ce_(0.8)Tb_(0.2)O_(2-δ) catalytic/protective layer on the outer membrane surface revealed that lower surface temperatures(830℃)were detected at the same imposed electric ***,the electrification concept was demonstrated in a catalytic membrane reactor(cMR)where the oxidative dehydrogenation of ethane(ODHE)was carried *** reaction is very sensitive to temperature,and here,we demonstrate an improvement of the ethylene yield by reaching moderate temperatures in the reaction chamber while the O_(2) injection into the reaction can be easily fine-tuned.

关键词： Oxygen permeation Oxidative dehydrogenation of ethane Oxygen transport membranes Joule effect Mixed ionic-electronic conductors catalytic membrane reactors

changes in cinnamic Acid Derivatives Associated with the Habituation of Maize cells to Dichlobenil

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Molecular Plant 2011年第5期4卷 869-878页

作者： Hugo Melida Jesus alvarez jose Luis Acebes Antonio Encina Stephen c. Fry Area de Fisiologia Vegetal Facultad de CC Biologicas y Ambientales Universidad de Leon E-24071 Leon Spain Edinburgh cell Wall Group Institute of Molecular Plant Sciences School of Biological Sciences University of Edinburgh Daniel Rutherford Building The King＇s Buildings Edinburgh EH9 3JH UK

The habituation of cell cultures to cellulose biosynthesis inhibitors such as dichlobenil （DcB） represents a valu- able tool to improve our knowledge of the mechanisms involved in plant cell wall structural plasticity. Maize cell lines habituated to lethal concentrations of DcB were able to grow through the acquisition of a modified cell wall in which cellulose was partially replaced by a more extensive network of arabinoxylans. The aim of this work was to investigate the phenolic metabolism of non-habituated and DcB-habituated maize cell cultures. Maize cell cultures were fed [14c]cinnamate and the fate of the radioactivity in different intra-protoplasmic and wall-localized fractions throughout the culture cycle was analyzed by autoradiography and scintillation counting. Non-habituated and habituated cultures did not markedly differ in their ability to uptake exogenous [14c]cinnamic acid. However, interesting differences were found in the radiolabeling of low- and high-Mr metabolites. Habituated cultures displayed a higher number and amount of radiola-beled low-Mr compounds, which could act as reserves later used for polysaccharide feruloylation. DcB-habituated cultures were highly enriched in esterified [14c]dehydrodiferulates and larger coupling products. In conclusion, an extensive and early cross-linking of hydroxycinnamates was observed in DcB-habituated cultures, probably strengthening their cellulose-deficient walls.

关键词： cell wall Zea mays maize dichlobenil DcB dehydrodiferulate ferulate cinnamic acid.