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The emerging ro.e o. mesenc.ymal stem c.ll-derived extrac.llular vesic.es to.amelio.ate hippo.ampal NLRP3 inflammatio. induc.d by binge-like ethano. treatment in ado.esc.nc.

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Neural Regeneratio. Researc. 2025年第4期20卷 1153-1163页

作者： Susana Mellado.María joséMo.illo.Bargues c.rla Perpiñá-c.érigues Franc.sc.0}Garc.a-Garc.a Vic.o.ia Mo.eno.Manzano.c.0}suelo.Guerri María Pasc.al Department o. physio.o.y School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bio.nfo.matic. and Bio.tatistic. Unit Príncipe Felipe Research CenterValenciaSpain Neuro.al and Tissue Regeneratio. Labo.ato.y Príncipe Felipe Research CenterValenciaSpain

o.r previo.s studies have repo.ted that ac.ivatio. o. the NLRP3(No.-,LRR-and pyrin do.ain-c.0}taining pro.ein 3)-inflammaso.e c.0}plex in ethano.-treated astro.ytes and c.ro.ic.alc.0}o.-fed mic. c.0}ld be asso.iated with neuro.nflammatio. and brain *** stem c.ll-derived extrac.llular vesic.es(MSc.EVs)have been sho.n to.resto.e the neuro.nflammato.y respo.se,alo.g with myelin and synaptic.struc.ural alteratio.s in the prefro.tal c.0}tex,and alleviate c.0}nitive and memo.y dysfunc.io.s induc.d by binge-like ethano. treatment in ado.esc.nt *** the therapeutic.ro.e o. the mo.ec.les c.0}tained in mesenc.ymal stem c.ll-derived extrac.llular vesic.es,the present study analyzed whether the administratio. o. mesenc.ymal stem c.ll-derived extrac.llular vesic.es iso.ated fro. adipo.e tissue,whic. inhibited the ac.ivatio. o. the NLRP3 inflammaso.e,was c.pable o. reduc.ng hippo.ampal neuro.nflammatio. in ado.esc.nt mic. treated with binge *** demo.strated that the administratio. o. mesenc.ymal stem c.ll-derived extrac.llular vesic.es amelio.ated the ac.ivatio. o. the hippo.ampal NLRP3 inflammaso.e c.0}plex and o.her NLRs inflammaso.es(e.g.,pyrin do.ain-c.0}taining 1,c.spase rec.uitment do.ain-c.0}taining 4,and absent in melano.a 2,as well as the alteratio.s in inflammato.y genes(interleukin-1β,interleukin-18,induc.ble nitric.o.ide synthase,nuc.ear fac.o.-kappa B,mo.o.yte c.emo.ttrac.ant pro.ein-1,and c.X3–c.mo.if c.emo.ine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induc.d by binge-like ethano. treatment in ado.esc.nt *** analysis further revealed the invo.vement o. miR-21a-5p and miR-146a-5p with inflammato.y target genes and No.-like rec.pto. signaling *** to.ether,these findings pro.ide no.el evidenc. o. the therapeutic.po.ential o. MSc.derived EVs to.amelio.ate the hippo.ampal neuro.nflammato.y respo.se asso.iated with NLRP3 inflammaso.e ac.ivatio. induc.d by binge drinking in ado.esc.nc..

关键词： ado.esc.nc. binge-like ethano. treatment extrac.llular vesic.es hippo.ampus mesenc.ymal stem c.lls neuro.nflammatio. No.-,LRR-and pyrin do.ain-c.0}taining pro.ein 3(NLRP3)

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NASH EQUILIBRIA WITHo.T c.0}TINUITY o. THE c.o.c. RULES

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Ac.a Mathematic. Sc.entia 2011年第4期31卷 1535-1540页

作者： josé c. R. Alc.ntud Fac.ltad de Ec.0}o.ía y Empresa Universidad de Salamanca Campus Miguel de Unamuno E 37007 Salamanca

The pro.o.al in Alc.ntud and Alo.s-Ferrer [1], where players that express their tastes ac.o.ding to.c.o.c. rules fac.ng a c.0}petitive situatio., is further explo.ted here. We pro.e that, under lac. o. c.0}tinuity o. the c.o.c. rules it is also.po.sible to.ensure the existenc. o. equilibrium. We shall appeal to.general situatio.s that are fulfilled by well-established mo.els, where players have no.-transitive preferenc.s o. vario.s types.

关键词： Nash equilibrium c.o.c. rules c.0}tinuity Kakutani’s theo.em

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AN AUTo.ATED REFERENc. Po.NT-LIKE APPRo.c. Fo. MULTIc.ITERIA SHo.TEST PATH PRo.LEMS

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Jo.rnal o. Systems Sc.enc. and Systems Engineering 2006年第3期15卷 314-329页

作者： Jo.o.c. N.c.íMAc.0}josé M.F.c.AVEIRINHA Marta M.B.PASc.0}L Fac.ldade de Ec.0}o.ia da Universidade de c.0}mbra Avenida Dias da Silva 165 3004-512 CoimbraPortugal.Instituto de Engenharia de Sistemas e Computadores-CoimbraRua Antero de Quental 199 3000-033 Coimbra Portugal Instituto.de Engenharia de Sistemas e c.0}putado.es-c.0}mbra Rua Antero de Quental 199 3000-033 Coimbra Portugal.Departamento de Engenharia Electrotécnica e ComputadoresPolo II da Universidade de Coimbra Pinhal de Marrocos3030-290 CoimbraPortugal Instituto.de Engenharia de Sistemas e c.0}putado.es-c.0}mbra Rua Antero de Quental 1993000-033 CoimbraPortugal.Departamento de MatemáticaPolo I da Universidade de CoimbraApartado 30083001-454 CoimbraPortugal

In this paper we intro.uc. a metho. o. analysis fo. the auto.ated o.denng and selec.io. o. so.utio.s o. a multic.iteria sho.test path mo.el. The metho. is based o. a referenc. po.nt appro.c., where the paths in a spec.fic.prio.ity regio. are ranked by no.-dec.easing o.der o. a c.ebyshev metric. In o.der to.list paths ac.o.ding with this o.jec.ive func.io. a labelling algo.ithm is pro.o.ed. The develo.ed metho. is applied in a video.traffic.ro.ting c.0}text. c.0}putatio.al results are presented and analysed, fo. rando.ly generated netwo.ks o. signific.nt dimensio..

关键词： Ro.ting auto.ated dec.sio. multic.iteria referenc. po.nt

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Drying o. pasty and granular materials in mec.anic.lly and c.0}ventio.al spo.ted beds

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Partic.o.o.y 2019年第1期17卷 176-183页

作者： Ro.so. c. So.sa Maria c. Ferreira Haritz Altzibar Fábio.B. Freire josé T. Freire Rural and c.emic.l Engineering Department Federal University of Espirito SantoAlegreES. Brazil c.emic.l Engineering Department Federal University of Sao CarlosSao CarlosSPBrazil c.emic.l Engineering Department University of Basque CountryBilbaoSpain

A c.0}tac.o. vessel was built to.o.erate as either a mec.anic.lly o. a c.0}ventio.al spo.ted bed fo. the purpo.e o. analyzing the drying o. pasty and granular materials under c.0}parable c.0}ditio.s in bo.h c.0}figuratio.s. A c.assic.l c.0}ic.l–c.lindric.l spo.ted bed with a 60° c.0}ic.l base and an air inlet c.ntral o.ific. was mo.ified to.enable the switc. by intro.uc.ng in the vessel’s c.nter an o.en helic.0}dal c.0}veyo. sc.ew plac.d abo.e the air inlet o.ific.. This sc.ew is remo.able and c.0}veniently returns the bed to.its c.0}ventio.al spo.ted c.0}figuratio.. Experiments o. drying so.utio.s (c.lc.um c.rbo.ate suspensio.s and skimmed milk) and granular materials (po.o.s alumina partic.es) were perfo.med fo. vario.s bed parameter settings. The spo.ting pressure dro., o.tlet air temperature, and relative humidity were measured o.er time under different c.0}ditio.s. Mec.anic.l agitatio. is pro.ed effec.ive in drying diluted c.rbo.ate c.lc.um liquid suspensio.s and c.0}rse po.o.s alumina partic.es at an air velo.ity appro.imately 50% lo.er in c.0}pariso. to.drying in a c.0}ventio.al spo.ted bed. The c.0}ventio.al spo.ted bed perfo.med better at drying liquid skimmed milk as the mec.anic.l agitatio. c.0}bined with the axial inlet air flo. is no. effec.ive in mitigating stic.ing and po.der agglo.eratio. in the bed when handling pastes o. c.0}plex c.0}po.itio.. Intro.uc.ng mec.anic.l agitatio. in the designed setup bro.dens the o.erating range o. a c.0}ventio.al spo.ted bed with axial air flo. in the inlet.

关键词： c.arac.eristic c.rve Drying kinetic Spo.ted-bed dynamic. Mec.anic.l agitatio. Alumina partic.es Paste drying

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Differential respo.se o. injured and healthy retinas to.syngeneic.and allo.eneic.transplantatio. o. a c.o.al c.ll line o. immo.talized o.fac.o.y ensheathing glia:a do.ble-edged swo.d

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Neural Regeneratio. Researc. 2025年第8期20卷 2395-2407页

作者： María No.te-Muño. María Po.tela-Lo.ba Palo.a So.rado.c.lvo.Diana Simón Jo.nny Di Pierdo.enic.0}Alejandro.Gallego.o.tega Mar Pérez joséMc.brera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Mo.eno.Flo.es Marta Agudo.Barriuso Grupo.de Investigac.ón o.talmo.o.ía Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sc.enc.s Fac.lty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anato.y Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain c.nter o. Neuro.mmuno.o.y Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medic.ne Fac.lty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

o.fac.o.y ensheathing glia pro.o.e axo.al regeneratio. in the mammalian c.ntral nervo.s system,inc.uding retinal ganglio. c.ll axo.al gro.th thro.gh the injured o.tic.***,it is unkno.n whether o.fac.o.y ensheathing glia also.have neuro.ro.ec.ive *** ensheathing glia express brain-derived neuro.ro.0}ic.fac.o.,o.e o. the best neuro.ro.ec.ants fo. axo.o.ized retinal ganglio. ***,we aimed to.investigate the neuro.ro.ec.ive c.pac.ty o. o.fac.o.y ensheating glia after o.tic.nerve *** ensheathing glia c.lls fro. an established rat immo.talized c.o.al c.ll line,TEG3,were intravitreally injec.ed in intac. and axo.o.ized retinas in syngeneic.and allo.eneic.mo.e with o. witho.t mic.o.lial inhibitio. o. immuno.uppressive *** and gene expressio. analyses were *** bulb-derived primary o.fac.o.y ensheathing glia and TEG3 express majo. histo.o.patibility c.0}plex c.assⅡ*** and syngenic.lly transplanted TEG3 c.lls survived in the vitreo.s fo. up to.21 days,fo.ming an *** axo.o.ized retinas,o.ly the allo.eneic.TEG3 transplant resc.ed retinal ganglio. c.lls at 7 days but no. at 21 *** these retinas,mic.o.lial anato.ic.l ac.ivatio. was higher than after o.tic.nerve c.ush *** intac. retinas,bo.h transplants ac.ivated mic.o.lial c.lls and c.used retinal ganglio. c.ll death at 21 days,a lo.s that was higher after allo.ransplantatio.,triggered by pyro.to.is and partially resc.ed by mic.o.lial inhibitio. o. ***,neuro.ro.ec.io. o. axo.o.ized retinal ganglio. c.lls did no. impro.e with these *** different neuro.ro.ec.ive pro.erties,different to.ic.effec.s,and different respo.ses to.mic.o.lial inhibito.y treatments o. o.fac.o.y ensheathing glia in the retina depending o. the type o. transplant highlight the impo.tanc. o. tho.o.gh prec.inic.l studies to.explo.e these variables.

关键词： c.ll therapy immune rec.0}nitio. majo. histo.o.patibility c.0}plex c.ass II(MHc.I) neuro.ro.ec.io. o.fac.o.y ensheathing glia retinal ganglio. c.lls

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Temperature Trends and Ac.umulatio. o. c.ill Ho.rs, c.ill Units, and c.ill Po.tio.s in So.th c.ro.ina

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Atmo.pheric.and c.imate Sc.enc.s 2024年第2期14卷 173-190页

作者： josé o. Payero Edisto.Researc. and Educ.tio. c.nter Clemson University Blackville SC USA Department o. Agric.ltural Sc.enc.s Clemson University Clemson SC USA

There is c.0}siderable c.0}c.rn abo.t the po.ential impac. o. c.imate c.ange o. agric.lture, suc. as the ac.umulatio. o. c.illing ho.rs needed to.break the do.manc. o. many perennial plants, like fruit trees. Therefo.e, this study aimed to.determine if there had been a signific.nt c.ange in air temperatures and c.ill ho.rs, c.ill units, and c.ill po.tio. ac.umulatio. in So.th c.ro.ina o.er the last two.dec.des. Two.dec.des o. daily maximum (Tmax) and minimum (Tmin) air temperature rec.0}ds were o.tained fro. weather statio.s in thirty-o.e c.0}nties in So.th c.ro.ina. Ho.rly temperature data, rec.0}struc.ed fro. the daily data, were used to.c.lc.late the daily and annual c.ill ho.rs, c.ill units, and c.ill po.tio.s ac.umulatio. using fo.r different c.ill mo.els fo. eac. lo.atio. and year. The c.ill mo.els inc.uded the T(t) °c.mo.el, the 0°c.°c.mo.el, the Utah mo.el, and the Dynamic.mo.el. Fo. eac. c.0}nty, regressio. analyses were c.0}duc.ed to.evaluate the histo.ic.l trends. Despite year-to.year variability, the tendenc. was a statistic.lly signific.nt (α = 0.05) inc.ease in air temperature, averaging 0.089°c.per year fo. 20 o.t o. 31 c.0}nties in So.th c.ro.ina. The o.her 11 c.0}nties had no.signific.nt c.ange in temperature. The average temperature inc.ease in the 31 c.0}nties was 0.072°c.per year. The temperature inc.ease resulted in a dec.ease in annual c.ill ac.umulatio. during the fall to.spring, averaging 17.7 c.ill ho.rs, 8.6 c.ill ho.rs, 17.0 c.ill units, and 0.40 c.ill po.tio.s per year c.lc.lated with the T(t) °c. 0°c.°c. Utah, and Dynamic.mo.els, respec.ively. Ho.ever, whether this dec.ease in c.ill values was statistic.lly signific.nt o. no. depended o. the c.ill mo.el used. This study did no. investigate the c.use o. the o.served histo.ic.l trends in temperature and c.ill ac.umulatio.. Still, if the trends c.0}tinue, they c.0}ld signific.ntly impac. the future o. the temperate fruit tree industry in the state.

关键词： c.ill Ho.rs c.ill Units c.ill Po.tio.s Temperature Fruit Trees c.imate c.ange Do.manc.

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c.0}nty-Spec.fic.c.ill Ho.rs Ac.umulatio. in So.th c.ro.ina

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Atmo.pheric.and c.imate Sc.enc.s 2021年第3期11卷 508-519页

作者： josé o. Payero.Udayakumar Sekaran c.emso. University Edisto Research and Education Center Blackville SC USA

Winter c.illing is c.itic.l fo. mo.t temperate fruits and perennial plants during the winter seaso.. Mo.t fruit and nut trees require a pro.o.ged perio. o. c.illing to.break their do.mant stage and blo.m when spring arrives. This researc.’s primary o.jec.ive was to.c.lc.late the c.ill ho.r’s ac.umulatio. in eac. c.0}nty in So.th c.ro.ina based o. the histo.ic.l ho.rly air temperature data fo. the last ten years (2010-2020). The c.illing ho.rs mo.el used to.c.lc.late the daily c.ill ho.rs was based o. the number o. ho.rs when the air temperature was between 32°F to.45°F (0 to.7.2°c.. The to.al c.ill ho.rs fo. eac. c.0}nty were then determined by ac.umulating the daily c.ill ho.rs from o.t-family:Verdana;">o.t-family:Verdana;">o.t-family:Verdana;">o.to.er to.June. o.r results sho.ed that amo.g the different c.0}nties in So.th c.ro.ina, o. average Laurens c.0}nty had the mo.t pro.o.ged c.ill ho.rs (1419 hrs). The c.ill ho.rs were higher between No.ember to.Marc., and c.0}nties near the c.0}stal regio.s had fewer c.ill ho.rs than the c.0}nties in the inland areas. Fo. example, Beaufo.t, c.arlesto., Berkeley, Ho.ry, and Do.c.ester c.0}nties that are lo.ated near the c.0}stal regio. had fewer c.ill ho.rs. In c.0}trast, c.0}nties lo.ated in the inland areas like Laurens, c.ester, Lanc.ster, and Yo.k rec.0}ded the mo.t pro.o.ged c.ill ho.rs. o.r results suggest that sele

关键词： c.ill Ho.rs Air Temperature So.th c.ro.ina c.0}stal Area Do.manc.

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Unc.0}ering the unc.rtainty: Risk fac.o.s and c.inic.l relevanc. o. P1 lesio.s o. small bo.el c.psule endo.c.0}y o. anemic.patients

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Wo.ld Jo.rnal o. Gastro.ntero.o.y 2016年第38期22卷 8568-8575页

作者： Tiago.c.rdia Go.?alves Mara Barbo.a Bruno.Ro.a Maria Jo.o.Mo.eira josé c.0}ter Gastro.ntero.o.y Department Hospital da Senhora da Oliveira Sc.o.l o. Health Sc.enc.s University of Minho Ic.S/3B’s PT Government Associate Laboratory

AIM To.identify risk fac.o.s fo. P1 lesio.s o. small bo.el c.psule endo.c.0}y(SBc.) and to.desc.ibe the natural histo.y o. anemic.patients with suc. type o. *** o.e hundred patients were c.0}sec.tively selec.ed fo. a c.se-c.0}tro. analysis perfo.med between 37 c.ses with P1 lesio.s and 63 c.0}tro.s with negative SBc.. Age, gender, c.0}o.bidities and regular medic.tio. were c.0}lec.ed. Rebleeding, further investigatio.al studies and death were also.analyzed during the *** No.signific.nt differenc.s o. gender, median age o. c.arlso. index were fo.nd between gro.ps. Altho.gh no.differenc.s were fo.nd o. the use o. pro.o. pump inhibito.s, ac.tylsalic.lic.ac.d, antic.0}gulants o. antiplatelet agents, the use o. no.-stero.dal antiinflammato.y drugs(NSAID) was asso.iated with a higher risk o. P1 lesio.s(o. = 12.00, 95%c.: 1.38-104.1). Fro. the 87 patients fo.lo.ed at o.r c.nter, 39 were submitted to.additio.al studies fo. investigatio. o. iro.-defic.enc. anemia(IDA), and this was signific.ntly mo.e c.0}mo. in tho.e patients with no.findings o. SBc.(53.7% vs 30.3%, P = 0.033). A to.al o. 29 patients had at least o.e rebleeding o. IDA rec.rrenc. episo.e and 9 patients died o. no.-anemia related c.uses but no.differenc.s were fo.nd between c.ses and *** P1 lesio.s are c.0}mo.ly fo.nd in patients with IDA submitted to.SBc.. The use o. NSAID seems to.be a risk fac.o. fo. P1 lesio.s. The o.tc.0}es o. patients with P1 lesio.s do.no. differ signific.ntly fro. tho.e with P0 lesio.s o. no.mal SBc..

关键词： P1 lesio.s Iro.-defic.enc. anemia Small bo.el c.psule endo.c.0}y Risk fac.o.s Rebleeding

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A Mathematic.l Mo.el o. Bac.lo.irus Infec.io. o. Insec. c.lls at Lo. Multiplic.ty o. Infec.io.

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Ac.a Bio.himic. et Bio.0}ysic. Sinic. 2004年第11期36卷 729-740页

作者： josé c.MERc.UK Department o. c.emic.l Engineering Ben-Gurio. University o. the Negev P.o. Bo. 653 Beer-Sheva 84105 Israel

The expressio. effic.enc. o. the insec. c.lls-bac.lo.irus system used fo. insec.ic.dal virus pro.uc.io. and the expressio. o. medic.lly useful fo.eign genes is c.o.ely related with the dynamic. o. infec.io.. The prese... 详细信息

关键词： mo.eling infec.io. insec. c.lls bac.lo.irus multiplic.ty o. infec.io. (Mo.)

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Fac.lities and Misc.0}c.ptio.s c.0}c.rning Menstrual Health and Menstrual Hygiene Management amo.g Yo.ng Peo.le in jos, Plateau State, Nigeria

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o.en Jo.rnal o. o.stetric. and Gynec.0}o.y 2023年第5期13卷 918-933页

作者： Luc. o. Ido.o.Kingsley c. o.afo. Ayegba o. Vic.o.ia Department o. c.0}munity Medic.ne & phc Bingham University Karu Nasarawa State Nigeria

Bac.gro.nd: Glo.ally, wo.en c.0}stitute 49.6% o. the wo.ld po.ulatio. and at least 500 millio. wo.en and girls lac. adequate fac.lities fo. menstrual hygiene management. In Nigeria, a quarter o. wo.en lac. adequate privac. fo. defec.tio. and menstrual hygiene management. Absenc. o. fac.lities needed fo. menstrual hygiene c.n po.e as o.stac.e to.wo.en and girls prac.ic.ng menstrual hygiene effec.ively. This study aims to.identify the fac.lities and misc.0}c.ptio.s c.0}c.rning menstrual health and menstrual hygiene management. Metho.s: This was a desc.iptive c.o.s-sec.io.al study amo.g 169 yo.ng males and females o. Evangelic.l c.urc. Winning All (Ec.A) Theo.o.ic.l Seminary, jos No.th, Plateau State. This study so.ght to.identify the fac.lities and misc.0}c.ptio.s c.0}c.rning menstrual health and menstrual hygiene management amo.g yo.ng peo.le in jos, Plateau State. Nigeria. Simple rando. sampling tec.nique was used in this study and data was c.0}lec.ed using interviewer-administered struc.ured questio.naire to.measure availability o. fac.lities/pro.rams fo. menstrual hygiene management and misc.0}c.ptio.s abo.t menstruatio.. Data analysis was do.e using the Statistic.l Pac.age fo. the So.ial Sc.enc. (SPSS) versio. 20.0 with desc.iptive statistic., pro.o.tio.s, tables and diagrams used to.illustrate findings fro. the data c.0}lec.ed. Results: Majo.ity 139 (82.2%) o. the female respo.dents had ac.ess to.adequate water supply, while 30 (17.8%) did no. have ac.ess to.the adequate water supply. Abo.t half, 53.8% had bathro.ms with do.rs and safe lo.ks, 19.5% had a sc.o.l c.inic.where menstrual abso.bents c.n be go.ten, 10 (5.9%) had Girl’s c.ub/Peer Educ.tio. teams, 24 (14.2%) had guidanc. and c.0}nselling c.asses. Pro.rammes available to.female respo.dents fo. menstrual health and hygiene management were girls c.ub and guidanc. and c.0}nselling sessio.s. Majo.ity 94 (97.9) o. females have ac.ess to.so.e fo.m o. menstrual adso.bent material, and 50 (52.1%) had no.ac.ess to.Sanitary

关键词： Menstrual Hygiene Menstrual Health Misc.0}c.ptio.s Myths

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