检索结果-南通市图书馆

Commentary:mammokine directs beige adipocytes to reserve energy for milk production in breast

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第3期14卷 1472-1476页

作者： lina Tang Jianping Ye metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Research Center for Basic medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Beige/brown adipocytes play a crucial role in regulating the body’s overall energy *** thermogenic function is under the influence of various tissues,including the brain,muscles,and ***,the breast tissue is not in th... 详细信息

关键词： Beige Breast Epitheliail cells scRNA-seq Thermogenesis

Research on Alliance Decision of Dual-Channel Remanufacturing Supply Chain Considering Bidirectional Free-Riding and Cost-Sharing

在线全文

学校读者我要写书评

暂无评论

Computer modeling in Engineering & Sciences 2024年第9期140卷 2913-2956页

作者： lina Dong Yeming Dai School of Business Qingdao UniversityQingdaoChina

This study delves into the formation dynamics of alliances within a closed-loop supply chain(CLSC)that encom-passes a manufacturer,a retailer,and an e-commerce *** leverages Stackelberg game for this exploration,contrasting the equilibrium outcomes of a non-alliance model with those of three differentiated alliance *** non-alliance model acts as a crucial benchmark,enabling the evaluation of the motivations for various supply chain entities to engage in alliance *** analysis is centered on identifying the most effective alliance strategies and establishing a coordination within these *** thoroughly investigate the consequences of diverse alliance behaviors,bidirectional free-riding and cost-sharing,and the resultant effects on the optimal decision-making among supply chain *** findings underscore several pivotal insights:(1)The behavior of alliances within the supply chain exerts variable impacts on the optimal pricing and demand of its *** comparison to the non-alliance(D)model,the manufacturer-retailer(mR)and manufacturer-e-commerce platform(mE)alliances significantly lower both offline and online resale prices for new and remanufactured *** adjustment leads to an enhanced demand for products via the mR alliance’s offline outlets and the mE alliance’s online platforms,thereby augmenting the profits for those within the ***,retailer-e-commerce platform(ER)alliance tends to increase the optimal retail price and demand across both online and offline *** specific conditions,alliance behavior can also increase the profits of non-alliance members,and the profits derived through alliance channels also exceed those from non-alliance channels.(2)The prevalence of bidirectional free-riding behavior largely remains constant across different alliance *** these models,bidirectional free-riding typically elevates the equilibrium prices in offline channel while negatively affe

关键词： Dual-channel remanufacturing supply chain alliance remanufactured products bidirectional free-riding cost-sharing

Harnessing bacteria for tumor therapy:Current advances and challenges

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第2期35卷 97-106页

作者： lina Guo Jinsong Ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Changsha medical University Academician WorkstationChangsha 410219China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

After a century of standstill,bacteria-based tumor therapy has resurged recently benefiting from the revolution of tumor immunotherapy,which provides unique solutions to tackle the obstacles of traditional tumor *** and facultative anaerobes with active tropism can selectively colonize at tumor sites and suppress tumor growth via different mechanisms,serving as attractive tools for tumor treatment either as a monotherapy or combining with other therapies for synergistic anti-tumor *** this critical review,we introduce the recent advances of bacteria-based tumor therapy from the following ***,the general properties of bacteria are reviewed emphasizing on their structural components related to tumor immunotherapy,and the main bacteria that have been used in tumor therapy are ***,the benefits of bacteria for tumor therapy are illustrated,such as tumor targetability,deep penetration,and facile genetic engineering for attenuation,enhanced efficacy,as well as ***,anti-tumor mechanisms of bacteria are summarized,which refer to intrinsic tumoricidal activities,immune activation,bacteria metabolism,and their capability to regulate gut microbiota ***,bacteria could act as carriers to deliver various types of therapeutics to achieve combination therapy with improved *** addition,several challenges for anti-tumor applications of bacteria are discussed regarding the delivery,efficacy and safety issues,and potential solutions are also ***,the possible improvements and perspectives are discussed in the end,which provide a guideline for the design of advanced bacteria-based tumor therapeutics in the future.

关键词： Bacteria Tumor targeting Immunotherapy Combination therapy Genetic engineering Surface decoration

An Uncertainty Evaluation on the ΔK_(th) and ΔK_(IC) of Fine-grained Isotropic Graphite

在线全文

学校读者我要写书评

暂无评论

Acta mechanica Solida Sinica 2024年第3期37卷 478-486页

作者： Yantian Zhang lina Zhu Ruiguo Yan Xishu Wang Department of Engineering mechanics Tsinghua UniversityBeijing100084China Wheel-Rail Center Tianjin Research Institute for Advanced EquipmentTsinghua UniversityTianjin300300China

This paper intensively explores the critical issues related to the quantitative and accurate evaluations of FCG behavior in the early stage,macro fatigue fracture toughness,and the critical crack size for damage tolerance in nuclear *** address these issues,scale-span FCG tests were carried out using two typical specimens,CT and SEm in-situ *** results indicate that the FCG threshold and the effective FCG length have a significant correlation with the modified maximum loop stress theory for a mixed I/II *** particular,the effective FCG length(a_(eq))and the applied stress threshold of polycrystalline graphite are important parameters for fatigue damage tolerance design in engineering *** influencing factors of ΔK_(th,eq) and a_(eq) were discussed in detail using the mixed I/II mode,*** addition,the scattered values of ΔK_(IC) for this graphite can be quantitatively estimated using the Weibull distribution *** predicated parameters and experimental results demonstrate a strong correlation.

关键词： Nuclear graphite mixed I/II mode Fatigue crack Fatigue crack growth threshold Fatigue fracture toughness

H∞ Robustness for Distributed Control in Autonomous microgrids Considering Cyber Disturbances

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2024年第2期10卷 696-706页

作者： Ge Cao Guannan Lou Wei Gu lina Sheng School of Electrical Engineering Southeast UniversityNanjing 210096China

The physical connections and logical relationships between microgrids and communication networks allow microgrids to develop into typical cyber-physical systems(CPSs).With the extensive use of open communication mechanisms,the impact of cyber disturbances in public communication networks cannot be *** this paper,a parameter optimal method for a distributed secondary controller based on the robust control theory and consensus algorithm is presented to enhance the robustness of a secondary control system under data disturbance,parameter perturbation,and time ***,a distributed secondary control strategy of microgrids is demonstrated that coordinates frequency and voltage restoration and power ***,considering the impact of cyber events on the secondary control,a distributed robust controller gain design method is proposed to satisfy the H∞ performance *** solution of the distributed robust control is transformed into a linear matrix in equation problem and latency margin is simultaneously ***,a test microgrid CPS is simulated with and without time delay to investigate the impact of cyber events on system operational states and the effectiveness and robustness of the proposed method.

关键词： Cyber disturbance cyber-physical lsystem distributed control microgrid robust H∞control

Synthesis of multifunctional additives for solid propellants:Structure,properties and mechanism

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第3期33卷 308-316页

作者： Pingan Zhang lina Sun Jianmin Yuan Jianru Deng College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082PR China College of material Science and Engineering Hunan UniversityChangsha 410082PR China Hu Bei Sanjiang Aerospace Jianghe Chemical Technology Co. LtdYichang 444200PR China

To simplify the composite propellant formulation and address the current issue of the single-functionality present in existing additives,the multi-cyano,amine-based polybutadiene(AEHTPB-CN)was prepared based on AEHTPB by adopting appropriate synthesis *** replacing 10% of HTPB binder in the propellant formulation,it can effectively enhance the interfacial bond strength between the propellant binder matrix and solid fillers(AP(ammonium perchlorate)and RDX(cyclotrimethylene-trinitramine)),the mechanical properties of the HTPB/AP/RDX/Al propellant were superior to blank control propellant with an improvement of 35.4% in tensile strength,62.0% enhancement in elongation at break,and reduce the propellant burn rate by 10.7% with any energy *** function mechanism of AEHTPB-CN was systematically elucidated through experiments and computer simulation *** results show that the tertiary amine group in AEHTPB-CN can react with AP to form ammonium ionic bonds,and the hydroxyl and cyano groups can form hydrogen bonding interactions with AP,which enables AEHTPB-CN to be firmly adsorbed on the AP surface through chemical and physical *** RDX,the interfacial bonding effect of AEHTPB-CN is attributed to their ability to form C-H···N≡C weak hydrogen bonding interaction between the cyano group and RDX methylene group.

关键词： Hydroxyl-terminated polybutadiene(HTPB) HTPB propellant Chemical modification Bonding agent mechanism

mutations in Ras homolog family member A in patients with peripheral T-cell lymphoma and implications for personalized medicine

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & medicine 2024年第9期21卷 754-768页

作者： lina Hu Xuanye Zhang Shengbing Zang Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Pathology Sun Yat-sen University Cancer Center Department of medical Oncology Sun Yat-sen University Cancer Center

Genome sequencing has revealed frequent mutations in Ras homolog family member A(RHOA) among various cancers with unique aberrant profiles and pathogenic effects, especially in peripheral T-cell lymphoma(PTCL). The discrete positional distribution and types of RHOA amino acid substitutions vary according to the tumor type, thereby leading to different functional and biological properties, which provide new insight into the molecular pathogenesis and potential targeted therapies for various tumors. However, the similarities and discrepancies in characteristics of RHOA mutations among various histologic subtypes of PTCL have not been fully elucidated. Herein we highlight the inconsistencies and complexities of the type and location of RHOA mutations and demonstrate the contribution of RHOA variants to the pathogenesis of PTCL by combining epigenetic abnormalities and activating multiple downstream pathways. The promising potential of targeting RHOA as a therapeutic modality is also outlined. This review provides new insight in the field of personalized medicine to improve the clinical outcomes for patients.

关键词： Drug target Ras homolog family member A mutation pathogenesis peripheral T-cell lymphoma personalized medicine

PdCu alloy anchored defective titania for photocatalytic conversion of carbon dioxide into methane with 100% selectivity

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第4期91卷 254-265页

作者： lina Zhang Sajjad Hussain Qiuye Li Jianjun Yang National&Local Joint Engineering Research Center for Applied Technology of Hybrid Nanomaterials Henan UniversityKaifeng 475004HenanChina

The photoreduction of CO_(2)into CH_(4)with simultaneous high activity and selectivity is a promising strategy to increase energy supply and alleviate global ***,the absence of the active sites that is responsible for the adsorption and activation of CO_(2)and the generation of CO and H2via side reactions often lead to poor efficiency and low selectivity of the ***,Cu,Pd,and PdCu metal clusters cocatalyst-anchored defective TiO_(2)nanotubes(Cu/TiO_(2)-SBO,Pd/TiO_(2)-SBO,and Pd1Cu1/TiO_(2)-SBO)were designed via a simple solution impregnation reduction and applied for photocatalytic conversion of CO_(2)to CH_(4).The Pd1Cu1/TiO_(2)-SBO photocatalyst exhibits excellent catalytic performance among the other catalysts for photoreduction of CO_(2)into CH_(4).more interestingly,the product selectivity of CH_(4)reaches up to 100%with a rate of 25μmol g^(-1)h^(-1).In-situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)and density functional theory(DFT)simulations indicate that the main reasons for the high selectivity of CH_(4)are attributed to the PdCu alloy and oxygen vacancies,which jointly enhance the photoinduced carrier separation and lower energy barriers of key ***,due to the tunable d-band center of the Cu site in the PdCu alloy,the generated intermediates can be well prevented from poisoning and promoted to participate in further ***,the current study will provide insight into the development of new,highly selective photocatalysts for the visible light-catalytic reduction of CO_(2)into CH_(4).

关键词： PdCu alloy Defective TiO_(2) Photoreduction of CO_(2) Photocatalytic mechanism

LRChain:data protection and sharing method of learning archives based on consortium blockchain

在线全文

学校读者我要写书评

暂无评论

The Journal of China Universities of Posts and Telecommunications 2024年第4期31卷 28-42页

作者： Lan lina Gao Yuhan Shi Ruisheng Wu Fenfen School of Humanities Beijing University of Posts and TelecommunicationsBeijing 100876China School of Cyberspace Security Beijing University of Posts and TelecommunicationsBeijing 100876China Key Laboratory of Trustworthy Distributed Computing and Service Beijing University of Posts and TelecommunicationsMinistry of EducationBeijing 100876China

Learning archives management in traditional systems faces challenges such as inadequate security,weak tamper resistance,and limited sharing *** address these issues,this paper proposes LRChain,a method based on consortium blockchain,for lifelong learning archives data protection and *** employs a combination of on-chain and off-chain cooperative storage using a consortium chain and inter planetary file system(IPFS)to enhance data security and *** also enables fine-grained verification of learning archives through selective disclosure principles,ensuring privacy protection of sensitive ***,an attributebased encryption(ABE)algorithm is utilized to establish authorized access control for learning archives,facilitating safe and trusted *** evaluations and security analyses demonstrate that this method exhibits decentralization,strong security,tamper resistance,and performs well,effectively meeting the requirements for secure sharing of learning archive data.

关键词： learning archives consortium blockchain collaborative storage secure sharing