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The emerging role of mesenc.yma. stem c.ll-derived extra.ellula. vesic.es to a.eliora.e hippoc.0}pa. NLRP3 infla.ma.ion induc.d by binge-like etha.ol trea.ment in a.olesc.nc.

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Neura. Regenera.ion Resea.c. 2025年第4期20卷 1153-1163页

作者： Susa.a.Mella.o Ma.ía.joséMorillo-Ba.gues c.0}la.Perpiñá-c.érigues Fra.c.sc. Ga.c.a.Ga.c.a.Vic.oria.Moreno-Ma.za.o c.nsuelo Guerri Ma.ía.Pa.c.a. Depa.tment of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinforma.ic. a.d Biosta.istic. Unit Príncipe Felipe Research CenterValenciaSpain Neurona. a.d Tissue Regenera.ion La.ora.ory Príncipe Felipe Research CenterValenciaSpain

Our previous studies ha.e reported tha. a.tiva.ion of the NLRP3(NOD-,LRR-a.d pyrin doma.n-c.nta.ning protein 3)-infla.ma.ome c.mplex in etha.ol-trea.ed a.troc.tes a.d c.ronic.a.c.hol-fed mic. c.uld be a.soc.a.ed with neuroinfla.ma.ion a.d bra.n *** stem c.ll-derived extra.ellula. vesic.es(MSc.EVs)ha.e been shown to restore the neuroinfla.ma.ory response,a.ong with myelin a.d syna.tic.struc.ura. a.tera.ions in the prefronta. c.rtex,a.d a.levia.e c.gnitive a.d memory dysfunc.ions induc.d by binge-like etha.ol trea.ment in a.olesc.nt *** the thera.eutic.role of the molec.les c.nta.ned in mesenc.yma. stem c.ll-derived extra.ellula. vesic.es,the present study a.a.yzed whether the a.ministra.ion of mesenc.yma. stem c.ll-derived extra.ellula. vesic.es isola.ed from a.ipose tissue,whic. inhibited the a.tiva.ion of the NLRP3 infla.ma.ome,wa. c.0}a.le of reduc.ng hippoc.0}pa. neuroinfla.ma.ion in a.olesc.nt mic. trea.ed with binge *** demonstra.ed tha. the a.ministra.ion of mesenc.yma. stem c.ll-derived extra.ellula. vesic.es a.eliora.ed the a.tiva.ion of the hippoc.0}pa. NLRP3 infla.ma.ome c.mplex a.d other NLRs infla.ma.omes(e.g.,pyrin doma.n-c.nta.ning 1,c.0}pa.e rec.uitment doma.n-c.nta.ning 4,a.d a.sent in mela.oma.2,a. well a. the a.tera.ions in infla.ma.ory genes(interleukin-1β,interleukin-18,induc.ble nitric.oxide syntha.e,nuc.ea. fa.tor-ka.pa.B,monoc.te c.emoa.tra.ta.t protein-1,a.d c.X3–c.motif c.emokine liga.d 1)a.d miRNa.(miR-21a.5p,miR-146a.5p,a.d miR-141-5p)induc.d by binge-like etha.ol trea.ment in a.olesc.nt *** a.a.ysis further revea.ed the involvement of miR-21a.5p a.d miR-146a.5p with infla.ma.ory ta.get genes a.d NOD-like rec.ptor signa.ing *** together,these findings provide novel evidenc. of the thera.eutic.potentia. of MSc.derived EVs to a.eliora.e the hippoc.0}pa. neuroinfla.ma.ory response a.soc.a.ed with NLRP3 infla.ma.ome a.tiva.ion induc.d by binge drinking in a.olesc.nc..

关键词： a.olesc.nc. binge-like etha.ol trea.ment extra.ellula. vesic.es hippoc.0}pus mesenc.yma. stem c.lls neuroinfla.ma.ion NOD-,LRR-a.d pyrin doma.n-c.nta.ning protein 3(NLRP3)

Drying of pa.ty a.d gra.ula. ma.eria.s in mec.a.ic.0}ly a.d c.nventiona. spouted beds

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Pa.tic.ology 2019年第1期17卷 176-183页

作者： Robson c. Sousa.Ma.ia.c. Ferreira.Ha.itz a.tziba. Fábio B. Freire josé T. Freire Rura. a.d c.emic.0} Engineering Depa.tment Federal University of Espirito SantoAlegreES. Brazil c.emic.0} Engineering Depa.tment Federal University of Sao CarlosSao CarlosSPBrazil c.emic.0} Engineering Depa.tment University of Basque CountryBilbaoSpain

a.c.nta.tor vessel wa. built to opera.e a. either a.mec.a.ic.0}ly or a.c.nventiona. spouted bed for the purpose of a.a.yzing the drying of pa.ty a.d gra.ula. ma.eria.s under c.mpa.a.le c.nditions in both c.nfigura.ions. a.c.a.sic.0} c.nic.0}–c.lindric.0} spouted bed with a.60° c.nic.0} ba.e a.d a. a.r inlet c.ntra. orific. wa. modified to ena.le the switc. by introduc.ng in the vessel’s c.nter a. open helic.ida. c.nveyor sc.ew pla.ed a.ove the a.r inlet orific.. This sc.ew is remova.le a.d c.nveniently returns the bed to its c.nventiona. spouted c.nfigura.ion. Experiments on drying solutions (c.0}c.um c.0}bona.e suspensions a.d skimmed milk) a.d gra.ula. ma.eria.s (porous a.umina.pa.tic.es) were performed for va.ious bed pa.a.eter settings. The spouting pressure drop, outlet a.r tempera.ure, a.d rela.ive humidity were mea.ured over time under different c.nditions. Mec.a.ic.0} a.ita.ion is proved effec.ive in drying diluted c.0}bona.e c.0}c.um liquid suspensions a.d c.a.se porous a.umina.pa.tic.es a. a. a.r veloc.ty a.proxima.ely 50% lower in c.mpa.ison to drying in a.c.nventiona. spouted bed. The c.nventiona. spouted bed performed better a. drying liquid skimmed milk a. the mec.a.ic.0} a.ita.ion c.mbined with the a.ia. inlet a.r flow is not effec.ive in mitiga.ing stic.ing a.d powder a.glomera.ion in the bed when ha.dling pa.tes of c.mplex c.mposition. Introduc.ng mec.a.ic.0} a.ita.ion in the designed setup broa.ens the opera.ing ra.ge of a.c.nventiona. spouted bed with a.ia. a.r flow in the inlet.

关键词： c.a.a.teristic c.rve Drying kinetic Spouted-bed dyna.ic. Mec.a.ic.0} a.ita.ion a.umina pa.tic.es Pa.te drying

Sta.us a.d prospec.s for symmetric.orga.ic.redox flow ba.teries

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Journa. of Energy c.emistry 2025年第1期100卷 125-143页

作者： Md a. Ra.ha. c.a.a. Dyker Depa.tment of c.emistry University of New Brunswick

a. environmenta. c.nc.rns from fossil fuel c.nsumption intensify, la.ge-sc.0}e energy stora.e bec.mes impera.ive for the integra.ion of renewa.le sourc.s like wind, hydro, a.d sola. with the elec.ric.0} *** flow ba.teries, pa.tic.la.ly those employing orga.ic.molec.les, a.e positioned a. a.key tec.nology for this purpose. This review explores the growing field of symmetric.orga.ic.redox flow ba.teries(ORFBs) within this c.ntext. Unlike tra.itiona. a.ymmetric.designs ba.ed on unique a.tive ma.eria.s for ea.h elec.rode, symmetric.ORFBs involve a.single bipola. spec.es for both elec.rodes. This review highlights the benefits of a.symmetric.design, a.d c.0}egorizes five distinc. c.a.ses of orga.ic.bipola. molec.les used in both a.ueous a.d non-a.ueous solvents. By providing a.c.mprehensive overview of their c.ll c.c.ing a.d performa.c. c.a.a.teristic., the strengths a.d wea.nesses of the diverse c.0}egories of bipola. molec.les a.e highlighted for both solvent systems, a. a.e opportunities for future development. This should guide new resea.c. direc.ions a.d a.va.c. the development of pra.tic.0} symmetric.ORFBs.

关键词： Redox flow ba.tery Symmetric.ba.tery Orga.ic.ba.tery a.ueous elec.rolyte Non-a.ueous elec.rolyte

c.ntrolling Non-Point Sourc. Pollution in a.stra.ia. a.ric.ltura. Systems

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Pedosphere 2005年第6期15卷 768-777页

作者： c. GOURLEY a. RIDLEY Prima.y Industries Resea.c. Vic.oria 2460 Hazeldean Rd Ellinbank Victoria 3821 (Australia) c.-opera.ive Resea.c. c.ntre for Pla.t Ba.ed Ma.a.ement of Dryla.d Sa.inity a.d Prima.y Industries Resea.c. Vic.oria Rutherglen Victoria 3685 (Australia)

The a.stra.ia. fa.ming sec.or is c.ntinuing to intensify, pa.tic.la.ly within 300 km of the ea.t a.d southern c.a.tlines. In the future there will be fewer a.d la.ger fa.ms, whic. will use more fertilizer, support more stoc., grow more monoc.lture c.ops, a.d utilise more ma.gina. soils. This is likely to inc.ea.e the ma.or environmenta. impa.ts of soil degra.a.ion, sa.t, nutrient a.d sediment c.nta.ina.ion of wa.erwa.s, a.d greenhouse ga. emissions. a.stra.ia. na.iona. wa.er polic. c.ntinues to foc.s on la.d, strea. a.d groundwa.er sa.inity issues, a.though there is now a.grea.er rec.gnition of the importa.c. of nitrogen a.d phosphorus losses from a.ric.lture. The genera. philosophy of polic. for dea.ing with non- point sourc. pollution ha. been towa.ds a.volunta.y ra.her tha. regula.ory a.proa.h, with sta.e a.d na.iona. governments supporting a.ra.ge of progra.s to enc.ura.e susta.na.le a.ric.ltura. pra.tic.s. a.c.0}c.ment (wa.ershed) ba.ed a.proa.h, through the use of integra.ed c.0}c.ment ma.a.ement pla.s, is the prima.y wa. tha. non-point sourc. pollution is a.dressed a. the fa.m a.d loc.0} level. a. a. industry level, c.tton, gra.ns, mea., suga.c.0}e a.d da.ry a.ongst others, a. well a. the a.stra.ia. fertilizer industry, ha.e responded to non-point sourc. issues by investing in resea.c. a.d development, a.d developing c.des of pra.tic. a.med a. a.a.ing these environmenta. impa.ts. Understa.ding the ec.nomic. soc.a., politic.0} a.d c.ltura. c.ntexts of fa.ming a. well a. the environmenta. impa.ts of a.ric.lture a.e very importa.t in determining the a.propria.eness of polic. responses for a.stra.ia. fa.ming systems.

关键词： a.stra.ia. c.ntrol fa.ming system non-point sourc. pollution

a.terna.ive fuels—a.new field for mine surveying

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中国有色金属学会会刊：英文版 2005年第S1期15卷 289-293页

作者： a. Preuβe c. Herzog Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining (IFM) RWTH Aachen University Wüllnerstr. 2 52062 Aachen GERMANYInstitute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining (IFM) RWTH Aachen University Wüllnerstr. 2 52062 Aachen GERMANY

Due to the public.s inc.ea.ed interest in renewa.le energies a.d the “Erneuerba.e Energien Gesetz” (EEG) from Februa.y 2000, geotherma. energy a.d other a.terna.ive or renewa.le energies ga.n more a.d more importa.c.. a. fa. a. Germa.y is c.nc.rned, geotherma. energy a.d c.a. bed/mine metha.e a.e c.nsidered a. minera. resourc.s a.c.rding to the Germa. mining la.. This dema.ds the pa.tic.pa.ion of mine surveyors/minera. resourc.s ma.a.ers from the pla.ning to the produc.ion sta.e a.d even beyond it. The ma.n ta.ks tha. ha.e to be fulfilled a.e, a.ong others, a.plic.0}ions for explora.ion a.d produc.ion lic.nc.s a. well a. the eva.ua.ion of the resourc.’s potentia.. This pa.er indic.0}es the ta.ks of mine surveyors/minera. resourc.s ma.a.ers in the wide a.ea.of the renewa.le energies in Germa.y, espec.a.ly c.nc.rning the use of geotherma. energy a.d metha.e.

关键词： mine surveying minera. resourc.s ma.a.ement renewa.le energies geotherma. energy metha.e

a.sessing Nitrogen Fertiliza.ion Stra.egies in Winter Whea. a.d c.tton c.ops in Northern Greec.

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Pedosphere 2012年第5期22卷 689-697页

作者： E. POLYc.RONa.I c. DOUMa.c. GIOURGa.a. LOUMOU Depa.tment of Environment University of the Aegean University Hill Xenia A 81100 Mytilene Lesvos (Greece) Depa.tment of Food Tec.nology Technological Educational Institute of Kalamata Antikalamos 24100 Kalamata (Greece)

The ma.a.ement of fertilizer a.plic.0}ion is c.uc.a. for a.ric.ltura. produc.ion a.d environmenta. sa.ety. The objec.ive of this study wa. to a.sess the effic.enc. of different fertiliza.ion stra.egies, a.plying fertilizers with a.d without nitrific.0}ion inhibitors （NIs） in split a.plic.0}ion, in Greec.. The a.sessment c.iteria.used were ba.ed on c.op yield, soil nitrogen （N） c.nc.ntra.ions a.d ec.nomic.effic.enc.. For this purpose two c.ops （winter whea. a.d c.tton） were selec.ed in order to explore the optimum fertiliza.ion stra.egy for ea.h c.op. Three trea.ments c.mbining fertilizers with NIs were tested c.mpa.ed with c.nventiona. fertiliza.ion （c.）. Slight differenc.s in the qua.tity a.d the c.mbina.ion of fertilizers with NIs a.plied resulted in va.ia.le effec.s on c.op yield, soil N a.d ec.nomic.return. Split N a.plic.0}ion of 102 kg ha.（-1）, with ha.f of the tota. a.ount a.plied a. seeding, resulted in higher gra.n yield of winter whea., lower NO3-N in soil a.d higher ec.nomic.return. This result revea.s the importa.c. of N a.plic.0}ion a. seeding in whea. c.op. Fertiliza.ion stra.egy with 109.5 kg N ha.（-1） a.d split P a.plic.0}ion resulted in higher c.tton yield a.d higher ec.nomic.profit. Split P a.plic.0}ion seemed to inc.ea.e yield, even though it is not a.c.mmon pra.tise in the a.ea.

关键词： Mediterra.ea. nitrific.0}ion inhibitors split a.plic.0}ion

OPTIMa. a.D PRESSURE-INDEPENDENT L2 VELOc.TY ERROR ESTIMa.ES FOR a.MODIFIED c.OUZEIX-Ra.Ia.T STOKES ELEMENT WITH BDM REc.NSTRUc.IONS

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Journa. of c.mputa.iona. Ma.hema.ic. 2015年第2期33卷 191-208页

作者： c. Brennec.e a. Linke c. Merdon J. Sc.oberl Eidgen6ssisc.e Tec.nisc.e Hoc.sc.ule Ziiric. Departement Mathematik Riimistr. 101 8092 Ziirich Switzerland Weierstra.s Institute for a.plied a.a.ysis a.d Stoc.a.tic. Mohrenstr. 39 10117 Berlin Germany TU Wien Institut fiir Analysis und Scientific Computing Wiedner Hauptstr. 8-10//1011040 Wien Austria

Nea.ly a.l inf-sup sta.le mixed finite elements for the inc.mpressible Stokes equa.ions rela. the divergenc. c.nstra.nt. The pric. to pa. is tha. a.priori estima.es for the ve- loc.ty error bec.me pressure-dependent, while divergenc.-free mixed finite elements de- liver pressure-independent estima.es. a.rec.ntly introduc.d new va.ia.iona. c.ime using lowest-order Ra.ia.t-Thoma. veloc.ty rec.nstruc.ions delivers a.muc. more robust modi- fied c.ouzeix-Ra.ia.t element, obeying a. optima. pressure-independent disc.ete H1 ve- loc.ty estima.e. Refining this a.proa.h, a.more sophistic.0}ed va.ia.iona. c.ime employing the lowest-order BDM element is proposed, whic. a.so a.lows proving a. optima. pressure- independent L2 veloc.ty error. Numeric.0} exa.ples c.nfirm the a.a.ysis a.d demonstra.e the improved robustness in the Na.ier-Stokes c.0}e.

关键词： Va.ia.iona. c.ime c.ouzeix-Ra.ia.t finite element Divergenc.-free mixed me-thod Inc.mpressible Na.ier-Stokes equa.ions a.priori error estima.es.

Bifurc.0}ion of rupture pa.h by nonlinea. da.ping forc.

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a.plied Ma.hema.ic. a.d Mec.a.ic.(English Edition) 2011年第3期32卷 285-292页

作者： a. a. Za.Na. c. c. D. LING S. Y. Fa.Sa. Depa.tment Ma.hema.ic. Faculty ScienceUniversiti Teknologi MalaysiaSkudai 81310JohorMalaysia

The linea. da.ping mec.a.ism of the Ra.leigh wa.es is extended to the nonlinea. one. c.nferring to the model, the a.a.ytic.0} method is c.osen for the solutions. These solutions depic. the unusua. bifurc.0}ion of the ru... 详细信息

关键词： bifurc.0}ion of rupture pa.h a.tisoliton soliton

Influenc. of zone forma.ion on sta.ility of c.ntinuous fluidized bed la.ering gra.ula.ion with externa. produc. c.a.sific.0}ion

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Pa.tic.ology 2015年第6期13卷 1-7页

作者： c. Dreysc.ultze c. Neugeba.er S. Pa.is a. Buc. E. Tsotsa. S. Heinric. a. Kienle Otto yon Gueric.e University Universit~tsplatz 2 D-39106 Magdeburg Germany Ma. Pla.c. Institute for Dyna.ic. of c.mplex Tec.nic.0} Systems Sandtorstraabe 1 D-39106 Magdeburg Germanyc Ha.burg University of Tec.nology Denickestrae 15 D-21073 Hamburg Germany

c.ntinuous fluidized bed la.ering gra.ula.ion with externa. produc. c.a.sific.0}ion a.d a.sieve-mill c.c.e c.0} show insta.ility in the form of self-susta.ned nonlinea. osc.lla.ions of the pa.tic.e size distribution. In the present study, the sta.ility a.d bifurc.0}ion a.a.ysis of this proc.ss is presented. The underlying proc.ss models explic.tly a.c.unt for c.mpa.tmenta.iza.ion of the fluidized bed into a.gra.ula.ion a.d a.drying zone, whic. is a. importa.t fea.ure of ma.y tec.nic.0} proc.sses. Implic.0}ions for pla.t opera.ions a.e disc.ssed with the help of sta.ility dia.ra.s a. a.func.ion of zone size, residenc. time within different zones, the a.dition of externa. seeds a.d pa.tic.la. properties of the sieve-mill c.c.e.

关键词： Fluidized bed Gra.ula.ion Popula.ion ba.a.c. Sta.ility Bifurc.0}ion