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Gene expression changes in spleens of the wildlife reservoir species,Eurasian wild boar(Sus scrofa),naturally infected with Brucella suis biovar 2

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Journal of Genetics and Genomics 2010年第11期37卷 725-736页

作者： Ruth C.Galindo Pilar m.muoz maría J.de miguel Clara m.marin Javier Labairu miguel Revilla josé m.Blasco Christian Gortazar josé de la Fuente Instituto de Investigación en Recursos Cinegéticos IREC(CSIC-UCLm-JCCm) Unidad de Sanidad Animal Centro de Investigación y Tecnología Agroalimentaria(CITA) ITG Ganadero Avda. Serapio Huici 2231610 VillabaNavarraSpain Departamento de Patología Animal Facultad de VeterinariaUniversity of Zaragoza Department of Veterinary Pathobiology Center for Veterinary Health SciencesOklahoma State University

Brucella suis is responsible for swine brucellosis worldwide. Of the five different B. suis biovars （by.）, bv. 2 appears restricted to Europe where it is frequently isolated from wild boar and hares, can infect pigs and can cause human brucellosis. In this study, the differ- ential gene expression profile was characterized in spleens of Eurasian wild boar naturally infected with B. suis bv. 2. Of the 20,201 genes analyzed in the microarray, 633 and 1,373 were significantly （fold change 〉 1.8; P 〈 0.01） upregulated and downregulated, respectively, in infected wild boar. The analysis was focused on genes that were over represented after conditional test for biological process gene ontology. Upregulated genes suggested that B. suis bv. 2 infection induced cell maturation, migration and/or proliferation in infected animals. The genes downregulated in infected wild boar impaired the activity of several important cellular metabolic pathways such as metabolism, cytoskeleton organization and biogenesis, immune response and lysosomal function and vesicle-mediated transport. In addition, the response to stress, sperm fertility, muscle development and apoptosis seemed to be also impaired in infected animals. These results suggested that B. suis bv. 2 may use strategies similar to other smooth brucellae to facilitate intracellular multiplication and the development of chronic infections. To our knowledge, this is the first report of the analysis of gene expression profile in hosts infected with B. suis bv. 2, which is important to understand the molecular mechanisms at the host-pathogen interface in the main reservoir species with possible implications in the zoonotic cycle of the pathogen.

关键词： Brucella suis boar genomics microarray systems biology

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Peripheral refraction of myopic eyes with spectacle lenses correction and lens free emmetropes during accommodation

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Eye and Vision 2021年第1期8卷 454-461页

作者： António Queirós Alejandro Cerviño josémanuel González‑méijome Clinical&Experimental Optometry Research Lab(CEORLab) Center of Physics(Optometry)University of MinhoCampus de Gualtar4710‑057 BragaPortugal Optometry Research Group Department of Optics and Optometry and Vision SciencesUniversity of ValenciaValenciaSpain

Purpose:To measure axial and off-axis refraction patterns in myopic eyes with spectacle lenses correction and lens free emmetropes in young healthy subjects at different target distances from 2.00 m(0.50 D)to 0.20 m(5.00 D)in terms of sphere,astigmatism,and spherical equivalent ***:Refraction was measured at the center,20 and 40 degrees from the line of sight both nasally and temporally in 15 emmetropic and 25 myopic young healthy subjects with an open field,binocular,infrared autorefractor(Grand Seiko WAm-5500,Hiroshima,Japan).Fixation target was a maltese cross set at 2.00,0.50,0.33 and 0.20 m from the corneal *** in off-axis refraction with accommodation level were normalized with respect to distance axial values and compared between myopic eyes with spectacle lenses correction and lens free ***:Off-axis refraction in myopic eyes with spectacle lenses correction was significantly more myopic in the temporal retina compared to lens free emmetropes except for the closest target *** off-axis refractive error changed significantly with accommodation when compared to axial refraction particularly in the myopic *** change in the negative direction was due to changes in the spherical component of refraction that became more myopic relative to the center at the 0.20 m distance as the J0 component of astigmatism was significantly reduced in both emmetropes and myopes for the closest ***:Accommodation to very near targets(up to 0.20 m)makes the off-axis refraction of myopes wearing their spectacle correction similar to that of lens free emmetropes.A significant reduction in off-axis astigmatism was also observed for the 0.20 m distance.

关键词： Off-axis refraction Refractive error Accommodation myopia progression

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Exploring the potential for an evolutionarily conserved role of the taste 1 receptor gene family in gut sensing mechanisms of fish

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Animal Nutrition 2022年第4期11卷 293-308页

作者： Anna Rita Angotzi Esther Leal Sara Puchol josé m. Cerdá-Reverter Sofia morais Department of Fish Physiology and Biotechnology Instituto de Acuicultura de Torre de la SalIATS-CSICTorre la Sal s/nRibera de Cabanes12595 CastellonSpain Lucta S.A. Innovation DivisionAnimal Science UnitUAB Research Park08193 BellaterraSpain

In this study,we investigated the transcriptional spatio-temporal dynamics of the taste 1 receptor(T1R)gene family repertoire in seabream(Sparus aurata[sa]),during larval ontogeny and in adult *** early larval development,sa T1R expression arises heterochronously,*** extraoral taste-related perception in the gastrointestinal tract(GIT)anticipates first exogenous feeding(at 9 days post hatching[dph]),followed by the buccal/intraoral perception from 14 dph onwards,supporting the hypothesis that the early onset of the molecular machinery underlying sa T1R expression in the GIT is not induced by food but rather genetically *** adulthood,we characterized the expression patterns of sa T1R within specific tissues(n=4)distributed in oropharingeal,GIT and brain regions substantiating their functional versatility as chemosensory signaling players to a variety of biological functions beyond oral taste ***,we provided for the first time direct evidences in fish for m RNA coexpression of a subset of sa T1R genes(mostly sa T1R3,*** common subunit of the heterodimeric T1R complexes for the detection of“sweet”and“umami”substances),with the selected gut peptides ghrelin(ghr),cholecystokinin(cck),hormone peptide yy(pyy)and proglucagon(pg).Each peptide defines the enteroendocrine cells(ECCs)identity,and establishes on morphological basis,a direct link for T1R chemosensing in the regulation of fish digestive ***,we analyzed the spatial gene expression patterns of 2 taste signaling components functionally homologous to the mammalian G(i)a subunit gustducin,namely sa G(i)a1 and sa G(i)a2,and demonstrated their co-localization with the sa T1R3in EECs,thus validating their direct involvement in taste-like transduction mechanisms of the fish *** conclusion,data provide new insights in the evolutionary conservation of gut sensing in fish suggesting a conserved role for nutrient sensors modulating entero-endocrine secretion.

关键词： Taste 1 receptor Fish larvae Gut nutrient sensing Gut peptides G(i)alpha protein subunits 1 and 2

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Spatial analysis and structure of a cross-timber stand in the TallGrass Prairie Preserve (Pawhuska, Oklahoma)

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Journal of Forestry Research 2013年第1期24卷 47-52页

作者： josé Ramón Arévalo Departamento de Ecología Facultad de BiologíaUniversidad de La LagunaLa Laguna 38206Spain

I analyzed the spatial distribution and structure of trees in a cross timber forest in the Tallgrass Prairie Preserve （Pawhuska, Oklahoma, USA）. I mapped and measured diameter of all stems, saplings （〉1.5 m tall） and dead trees in a 4-ha plot. The stand was dominated by Quercus stellata and Q. marilandica. In total, I mapped 7,636 trees, consisting of 6,785 Q. stellata, 846 Q. marilandica, 2 Celtis occidentalis, 1 Fraxinus pensilvanica and 2 Prunus americana. For saplings, I mapped 54 Q. stellata and 21 Q. marilandica. The size class distribution of the two dominant species did not differ. The dominant mortality class was “standing dead”, while I only found saplings less than 2 m tall. The spatial distribution of the species indicated segregation in the use of the environment, generating a clumped univariate distribution of stems of the same species within radii of 30 m, but repulsion outside 30 m. This segregation can be explained by the different ecological requirements of each species.

关键词： conservation point pattern analysis Quercus stellata Q.marilandica size class distribution

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Fibrosing cholestatic hepatitis following cytotoxic chemotherapy for small-cell lung cancer

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World Journal of Gastroenterology 2009年第18期15卷 2290-2292页

作者： Jaime Ceballos-Viro josé m López-Picazo josé L Pérez-Gracia Jesús J Sola Gregorio Aisa Ignacio Gil-Bazo Department of Oncology Clínica Universidad de NavarraPio XII 3631008 PamplonaSpain Department of Pathology Clínica Universidad de NavarraPio XII 3631008 PamplonaSpain

Fibrosing cholestatic hepatitis(FCH) is a variant of viral hepatitis reported in hepatitis B virus or hepatitis C virus infected liver,renal or bone transplantation recipients and in leukemia and lymphoma patients after conventional cytotoxic *** constitutes a well-described form of fulminant hepatitis having extensive fibrosis and severe cholestasis as its most characteristic pathological ***,we report a case of a 49-year-old patient diagnosed with small-cell lung cancer who developed this condition following conventional chemotherapy-induced *** is the first reported case in the literature of FCH after conventional chemotherapy for a solid *** addition to a detailed report of the case,a physiopathological examination of this potentially life-threatening condition and its treatment options are discussed.

关键词： Fibrosing cholestatic hepatitis Immunosuppression Chemotherapy Lung cancer Hepatitis Bvirus Lamivudine

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A Proof of Wedderburn＇s Theorem

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Algebra Colloquium 2015年第4期22卷 603-606页

作者： josé Antonio Cuenca mira Departamento de álgebra Geometría y Topología Facultad de Ciencias Universidad de Málaga 29071 Málaga Spain

In this note we first introduce the finite weak Herstein condition, which is a property that holds for every finite field. For a field F satisfying the finite weak Herstein condition, we then characterize whether all the finite-dimensional division F-algebras are commutative. This gives an alternate proof of Wedderburn＇s Theorem.

关键词： division algebra finite-dimensional algebra finite field Galois extension

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Assessing tree crown fire damage integrating linear spectral mixture analysis and supervised machine learning on Sentinel-2 imagery

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International Journal of Digital Earth 2023年第1期16卷 3162-3198页

作者： Giandomenico De Luca Giuseppe modica Joao m.N.Silva Salvatore Praticò josém.C.Pereira Dipartimento di Agrari1 Universitàdegli Studi Mediterranea di Reggio Calabri1Reggio Calabri1Italy Dipartimento di Scienze veterinarie Universitàdegli Studi di Messin1Messin1Italy Forest Research Centre School of AgricultureUniversity of LisbonLisbonPortugal

Crown fire damage is a mixture of three principal fire-related components:charred material,scorched foliage,and unaltered green *** study estimated the abundance of these physical alterations in two immediate post-fire mediterranean forest contexts(Portugal and Italy)by applying linear spectral mixture analysis(LSmA)on Sentinel-2 *** tree crowns fire damage was subsequently mapped,integrating fractional abundance information in a random forest(RF)algorithm,comparing the accuracy resulting from the adoption of generic or image spectral libraries as the primary investigative *** image-derived endmembers resulted in more effectiveness in terms of fire-related components abundance quantification(LmSAderived RmSEmembers or image endmembers derived information was *** environmental heterogeneity of the two study areas affected the fire severity gradients,with a prevalence of the charred(PT)(45–46%)and green class(IT)(44–53%).Post-fire temporal monitoring was initialized by applying the proposed strategies,and the preliminary results showed a positive recovery trend in forest vegetation from the first year following the fire event,with a reduced charcoal predominance and an increasing proportion of green components.

关键词： Post-fire assessment fire severity post-fire vegetation recovery random forest(RF) scikit-learn fraction image extraction spectral unmixing endmembers crown fire damage mapping fully constrained least squares pixel purity index

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On the Performance of the Energy Detector Subject to Impulsive Noise in κ-μ, α-μ, and η-μ Fading Channels

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Tsinghua Science and Technology 2017年第4期22卷 360-367页

作者： jos V.m.Cardoso Wamberto J.L.Queiroz Hang Liu marcelo S.Alencar Department of Electrical Engineering Federal University of Campina Grande Department of Electrical Engineering and Computer Science The Catholic University of America

This paper presents a unified theoretical analysis of the energy detection of Gaussian and m-PSK signals in κ-μ,α-μ,and η-μ fading channels at the output of an energy detector subject to impulsive noise（Bernoulli-Gaussian model）. As a result, novel, simple, and accurately approximated expressions for the probability of detection are derived. more precisely, the generalized Gauss-Laguerre quadrature is applied to approximate the probability of detection as a simple finite sum. monte Carlo simulations corroborate the accuracy and precision of the derived approximations. The results are further extended to cooperative energy detection with hard decision combining information.

关键词： spectrum sensing energy detector fading channel impulsive noise

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Plant cell wall-mediated disease resistance:Current understanding and future perspectives

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molecular Plant 2024年第5期17卷 699-724页

作者： Antonio molina Lucıa Jorda miguel Angel Torres marina martın-Dacal Diego jose Berlanga Patricia Fernandez-Calvo Elena Gomez-Rubio Sonsoles martın-Santamarıa Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento de Biotecnologıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro de Investigaciones Biologicas margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain misión Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond their function as structural barriers,plant cell walls are essential elements for the adaptation of plants to environmental *** walls are dynamic structures whose composition and integrity can be altered in response to environmental challenges and developmental *** wall changes are perceived by plant sensors/receptors to trigger adaptative responses during development and upon stress *** cell wall damage caused by pathogen infection,wounding,or other stresses leads to the release of wall molecules,such as carbohydrates(glycans),that function as damage-associated molecular patterns(DAmPs).DAmPs are perceived by the extracellular ectodomains(ECDs)of pattern recognition receptors(PRRs)to activate pattern-triggered immunity(PTI)and disease ***,glycans released from the walls and extracellular layers of microorganisms interacting with plants are recognized as microbe-associated molecular patterns(mAmPs)by specific ECD-PRRs triggering PTI *** number of oligosaccharides DAmPs/mAmPs identified that are perceived by plants has increased in recent ***,the structural mechanisms underlying glycan recognition by plant PRRs remain ***,this knowledge is mainly focused on receptors of the Lysm-PRR family,which are involved in the perception of various molecules,such as chitooligosaccharides from fungi and lipo-chitooligosaccharides(i.e.,Nod/mYC factors from bacteria and mycorrhiza,respectively)that trigger differential physiological ***,additional families of plant PRRs have recently been implicated in oligosaccharide/polysaccharide *** include receptor kinases(RKs)with leucine-rich repeat and malectin domains in their ECDs(LRR-mAL RKs),Catharanthus roseus RECEPTOR-LIKE KINASE 1-LIKE group(CrRLK1L)with malectin-like domains in their ECDs,as well as wall-associated kinases,lectin-RKs,and *** characterization of structural basis of glycans recogniti

关键词： Arabidopsis thaliana cell wall damage-associated molecular patterns DAmPs disease resistance glycans oligosaccharides pattern-triggered immunity PTl pattern recognition receptor PRRs

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Three-dimensional organ modeling based on deformable surfaces applied to radio-oncology

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第6期11卷 407-417页

作者： Gloria BUENO Oscar DéNIZ Jesús SALIDO Carmen CARRASCOSA josé m. DELGADO Grupo de Visióny Sistemas Inteligentes Universidad de Castilla-La Mancha E.T.S. Ingenieros Industriales Avda. Camilo José Cela 3. 13071 Ciudad Real Spain Hospital General de Ciudad Real Tomelloso s/n. 13005 Ciudad Real Spain Instituto Oncológico (Grupo ImO) modesto Lafuente 14 28010 Madrid Spain

This paper describes a method based on an energy minimizing deformable model applied to the 3D biomechanical modeling of a set of organs considered as regions of interest (ROI) for radiotherapy. The initial model consists of a quadratic surface that is deformed to the exact contour of the ROI by means of the physical properties of a mass-spring system. The exact contour of each ROI is first obtained using a geodesic active contour model. The ROI is then parameterized by the vibration modes resulting from the deformation process. Once each structure has been defined, the method provides a 3D global model including the whole set of ROIs. This model allows one to describe statistically the most significant variations among its structures. Statistical ROI variations among a set of patients or through time can be analyzed. Experimental results are presented using the pelvic zone to simulate anatomical variations among structures and its application in radiotherapy treatment planning.

关键词： 3D biomechanical organ modeling Energy minimizing deformable model Finite element model Geodesic active contour Radiotherapy treatment planning

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