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Krill oil ameliorates benign prostatic hyperplasia by regulating G-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers

The Second Asian and Oceanic Congress for Radiation Protection

作者： Ji-Hyun lEE Mee JANG Hyun Ki KIM Su-Jae lEE Yun-sil lEE Sangwoo bAE laboratory of Radiation Effect Korea Institute of Radiological and Medical SciencesSeoul 139-706Korea National Radiation Emergency Medical Center Korea Institute of Radiological and Medical SciencesSeoul 139-706Korea National Radiation Emergency Medical Center Korea Institute of Radiological and Medical SciencesSeoul 139-706Korea laboratory of Radiation Experimental Therapeutics Korea Institute of Radiological and Medical SciencesSeoul 139-706Korea laboratory of Radiation Effect Korea Institute of Radiological and Medical SciencesSeoul 139-706Korea laboratory of Radiation Effect Korea Institute of Radiological and Medical SciencesSeoul 139-706Korea

Exposure of cells to ionizing radiation（IR）results in DNA double strand breakages（DSbs）.Upon DSb formation,cells induce cell cycle arrest,DNA damage repair,and cell *** investigations of cellular radiation response,complexities of the mechanisms limit our understanding of the *** that of the cellular response to low dose ionizing radiation is quite *** we tried screening and isolation of low dose ionizing radiation-induced *** were isolated based on their higher expression following 1cGy gamma irradiation compared to non-irradiated *** of the isolated genes revealed a nucleotide sequence which encodes exonuclease domain highly similar to that of Exonuclease *** vitro analysis of the gene product as a form of recombinant protein exhibited nuclease *** gene product was detected in the nucleus with other apoptotic nucleases such as CAD and AIF following *** nuclease activity and colocalization with other apoptotic nucleases support the notion that the gene product might be involved in IR-induced cell *** data,thus,suggest that the low dose IR-induced gene product acts in concert with other apoptotic nucleases to enhance apoptosis following low-dose ionizing irradiation.

关键词： ionizing radiation induced-genes double strand breakages

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Food Science and Human Wellness 2023年

作者： Hoon Kim Jongyeob Kim byungdoo Hwang Sang Yong Park Ji-Yeon Shin Eun byeol Go Jae sil Kim Youngjin Roh Soon Chul Myung Seok-Joong Yun Yung Hyun Choi Wun-Jae Kim Sung-Kwon Moon Department of biochemistry， College of Oriental Medicine， Dongeui University Institute of Urotech， Cheongju Department of Urology， Chungbuk National University， Cheongju SD biotechnologies， 66 Magojungang 8-ro 1-gil， Gangseo-gu Department of Food and Nutrition， Chung-Ang University Department of Urology， College of Medicine， Chung-Ang University

Krill oil (KO) exhibits various biological activities， such as anti-inflammatory and antitumor effects. However， the inhibitory effects of benign prostatic hyperplasia (bPH) in vitro and in vivo have not yet been studied. This study investigated the anti-bPH effects of KO extracted by an enzymatic hydrolysis method. KO treatment inhibited the proliferation of WMPY-1 and bPH-1 cells by induction of G0/G1phase arrest through the modulation of positive and negative regulators in both prostate cell types. KO treatment stimulated phosphorylation of JNK and p38 signaling. In addition， KO changed the expression of bPH-related markers (5α-reductase， androgen receptor， FGF， bcl-2， and bax) and the activity of the proliferation-mediated NF-κb binding motif. KO-induced levels of proliferation-mediated molecules of prostate cells were attenuated in the presence of siRNA-specific p-38 (si-p38) and JNK (si-JNK). Furthermore， the administration of KO alleviated prostate size and weight and the cell layer thickness of prostate glands in a testosterone enanthate-induced bPH rat model. KO treatment altered the level of dihydrotestosterone in serum and the expression levels of bPH-related markers in prostate tissues. Finally， KO-mediated inhibition of prostatic growth was validated by histological analysis. These results suggest that KO has an inhibitory effect on bPH in prostate cells in vitro and in vivo. Thus， KO might be a potential prophylactic or therapeutic agent for patients with bPH.

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基于内在好奇心与自模仿学习的探索算法

现代电子技术 2024年第16期47卷 137-144页

作者：吕相霖臧兆祥李思博邹耀斌三峡大学水电工程智能视觉监测湖北省重点实验室湖北宜昌443002 三峡大学计算机与信息学院湖北宜昌443002

针对深度强化学习算法在部分可观测环境中面临的稀疏奖励、信息缺失等问题,提出一种结合好奇心模块与自模仿学习的近端策略优化算法。该算法利用随机网络来生成探索过程中的经验样本数据,然后利用优先经验回放技术选取高质量样本,通过... 详细信息

针对深度强化学习算法在部分可观测环境中面临的稀疏奖励、信息缺失等问题,提出一种结合好奇心模块与自模仿学习的近端策略优化算法。该算法利用随机网络来生成探索过程中的经验样本数据,然后利用优先经验回放技术选取高质量样本,通过自模仿学习对优秀的序列轨迹进行模仿,并更新一个新的策略网络用于指导探索行为。在Minigrid环境中设置了消融与对比实验,实验结果表明,所提算法在收敛速度上具有明显优势,并且能够完成更为复杂的部分可观测环境探索任务。

关键词：好奇心模块自模仿学习深度强化学习近端策略优化随机网络优先经验回放

Phenotypic differences between coryneform bacteria isolated from seminal fluid of healthy men and men with chronic prostatitis syndrome

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Asian Journal of Andrology 2009年第4期11卷 517-520页

作者： Iuri b Ivanov Viktor A Gritsenko Michael D Kuzmin Department of Human Microbiology Institute of Cellular and Intracellular Symbiosis Russian Academy of Sciences Orenburg 460056 Russia

We compared the potential phenotypic properties of coryneform bacteria associated with chronic prostatitis syndrome （CPS）, such as secretory inhibitor of lysozyme （sil） and secretory inhibitor of platelet microbicidal protein （SIPMP）. A total of 110 clinical isolates of coryneform bacteria isolated from the seminal fluid of healthy men and men with CPS were tested. SIPMP production was tested by inhibiting platelet microbicidal protein （PMP） bioactivity against bacillus subtilis, and was expressed as percentage of inhibition of PMP bactericidal activity. sil production was tested by inhibiting lysozyme activity against Micrococcus lysodeikticus and was expressed in microgram per millilitre of inactivated lysozyme. A significantly higher proportion of CPS strains （58.7% vs. 19.2 %） was SIPMP-positive compared with non-CPS strains （P 〈 0.01）. Of the CPS strains tested, 77.8% were sil-positive compared with 34% of the non- CPS isolates （P 〈 0.05）. These results suggest that the diagnosis of CPS should not rely solely on classical parameters, for example, the identification and counting of microorganisms, but the functional significance of these parameters must be estimated, possibly by the concentration of different bacterial substrains, detection of opportunistic microorganisms with pathogenic properties, such as pronounced resistance to the cationic antimicrobial peptides, and/or the ability to inhibit the antimicrobial host defence factors.

关键词： Corynebacterium spp lysozyme platelet microbicidal protein prostatitis

Forest management for optimizing soil protection:a landscape-level approach

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Forest Ecosystems 2021年第4期8卷 672-684页

作者： Ana Raquel Rodrigues Susete Marques brigite botequim Marco Marto jose G.borges Forest Research Centre and laboratory TERRA School of AgricultureUniversity of LisbonTapada da Ajuda1349-017 LisbonPortugal

background:Soil erosion is still identified as the main cause of land degradation worldwide,threatening soil functions and driving several research and policy efforts to reverse *** are commonly associated to some of the most successful land-use systems to achieve soil protection goals,but the extent to which forest ecosystems reduce erosion risks can largely depend on management decisions and associated silvicultural *** tools can assist foresters in solving the complex planning problem they face,concerning the demand for different,and often conflicting,ecosystem services.A resource capability model(RCM),based on a linear programming approach,was built and solved for a forest landscape management problem in Northwest Portugal,over a 90-years planning horizon,divided in 10-years ***:Timber provision and soil erosion were found to be in *** management alternatives included in the model were proven to be sufficiently flexible to obtain the desired level of timber yield,both in volume and even distribution along the planning horizon,while ensuring lower levels of soil loss estimates(below 35 Mg·ha^(−1)·year^(−1)).However,under climate change conditions,compatible with an increasing greenhouse gases emission scenario,potential landscape soil erosion may be enhanced up to 46 Mg·ha^(−1)·year^(−1) in critical ***:Soil conservation concerns in landscape-level forest management planning can be addressed by lPbased optimization *** providing an optimal management solution at landscape level,this approach enables a comprehensive analysis of the RCM,possible trade-offs and potential changes towards uncertainties.

关键词： Ecosystem services Erosion Optimization silvicultural practices

阿苯达唑治疗泡球蚴病患者血清中Th1/Th2型细胞因子的变化及临床意义

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中国人兽共患病杂志 2003年第2期19卷 71-73页

作者：李富荣石佑恩史大中 da Vuitton PS Craig 深圳市人民医院(暨南大学医学院第二附属医院)临床医学研究中心深圳518020 华中科技大学同济医学院寄生虫学教研室兰州医学院寄生虫学教研室 Universite de Franch ecomte Division of biological the University of Salford

目的　为探讨泡球蚴病患者经阿苯达唑治疗后 ,机体免疫应答的状态和对病程转归影响。方法　 35例泡球蚴病患者经阿苯达唑治疗 1 2月前后 ,血清中sil - 2R ,IFN -γ ,Il - 4Il - 5 ,Il - 6 ,TNFα,及特异性IgG ,IgE抗体进行检测。结果... 详细信息

目的　为探讨泡球蚴病患者经阿苯达唑治疗后 ,机体免疫应答的状态和对病程转归影响。方法　 35例泡球蚴病患者经阿苯达唑治疗 1 2月前后 ,血清中sil - 2R ,IFN -γ ,Il - 4Il - 5 ,Il - 6 ,TNFα,及特异性IgG ,IgE抗体进行检测。结果　在治疗 1 2月后 ,Th1型细胞因子sil - 2R ,IFN -γ无改变 (P >0 0 5) ,Th2型细胞因子Il - 4显著性下降 (P l - 5在患者中检出率明显降低 (P <0 0 1 ) ,TNFα和IgE水平较治疗前显著性下降 (P <0 0 1 )。结论　泡球蚴病患者治疗后 ,Th2型细胞因子反应减弱。

关键词：阿苯达唑治疗泡球蚴病血清 Th1/Th2型细胞因子

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用人工模拟降雨研究南方低丘土壤的渗透

水土保持学报 1995年第3期9卷 1-8页

作者：吕喜玺史学正于东升中国科学院南京土壤研究所

通过在径流小区上人工模拟降雨，研究了南方主要的低丘土壤的渗透性能。小区设在一均匀的第四纪红色粘土坡面上（坡度约７°）用人工填充研究土壤建成，小区长８ｍ，宽１．５ｍ，填充土壤厚度４０ｃｍ。结果表明，第四纪红粘土发育的红... 详细信息

通过在径流小区上人工模拟降雨，研究了南方主要的低丘土壤的渗透性能。小区设在一均匀的第四纪红色粘土坡面上（坡度约７°）用人工填充研究土壤建成，小区长８ｍ，宽１．５ｍ，填充土壤厚度４０ｃｍ。结果表明，第四纪红粘土发育的红壤（包括网纹土、耕种和荒地红粘土）和花岗岩发育的荒地红壤较红砂岩发育的红壤（包括耕种和荒地２种）和荒地紫色土的渗透速度快，不容易产生径流和侵蚀。

关键词：人工降雨土壤渗透丘陵地

DIODE lASER CYClO-AblATION IN sil- ICONE OIl GlAUCOMA

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国际眼科杂志 2003年第1期3卷 21-22页

作者： S.lake A.Rubinstein b.James Stoke Mandeville Hospital UKStoke Mandeville Hospital UKStoke Mandeville Hospital UK

Ciliary body ablation with the diode laser is well established as a treatment for neovascular and other refractory glaucomas. Glaucoma secondary to intra-ocular silicone oil for vitreo-retinal surgery is one such glaucoma that can be difficult to control. We reviewed a series of cases where cyclodiode laser is applied for silicone oil-induced glaucoma and demonstrate that it is

关键词：硅油性青光眼眼内压升高眼状体缺失二极管激光疗法疗效

含有l1数据保真项的非凸优化脉冲噪声去除模型

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计算机系统应用 2018年第11期27卷 192-197页

作者：陈静思李春云南财经大学云南省经济社会大数据研究院昆明650221 中国科学院大学北京100049 中国科学院计算机网络信息中心北京100190

随着数字图像处理技术的高速发展,图像恢复被广泛应用于医学领域、军事领域、公共防卫领域及农业气象领域.本文综合TVl1、ROF、STVl1(Squares TVl1)、SHI模型,提出了非凸非光滑关于脉冲噪声去除模型,并使用变量分离技术的ADMM算法对模... 详细信息

随着数字图像处理技术的高速发展,图像恢复被广泛应用于医学领域、军事领域、公共防卫领域及农业气象领域.本文综合TVl1、ROF、STVl1(Squares TVl1)、SHI模型,提出了非凸非光滑关于脉冲噪声去除模型,并使用变量分离技术的ADMM算法对模型进行求解,通常情况下,基于梯度的方法不适合非光滑优化,半二次(halfquadratic)和重权最小二乘算法(IRlS)在零点不可微分情况下不能应用到非光滑函数上, Graduated NonConvexity(GNC) algorithms跟踪非光滑和非凸的最小值沿着一系列近似的非光滑能量函数的势能,需要考虑其计算时间.为了处理模型的非凸非光滑项,本文应用多阶凸松弛方法对模型的子问题进行求解,虽然该方法仅导致原始非凸问题的局部最优解,但该局部解是对初始凸松弛的全局解的改进.此外,因为每个阶段都是凸优化问题,所以该方法在计算上是高效的.利用遗传算法对模型参数进行选择,通过在不同图片及不同噪声上的大量实验表明,该模型的鲁棒性、运行时间和ISNR、PSNR都优于其他三个模型.并且该模型能够保持图像的局部信息具有更好的可视化质量.

关键词：图像恢复非凸优化 ADMM 图像处理多阶凸松弛优化方法