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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： joséM.Izquierd. Centro d. Biología Molecular Severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word.“senescence” comes from the Latin senescens, meaning “to begin to age”, and.is characterized.by a long-lasting but reversible block in proliferation, resulting from stress-ind.ced.cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Gold.chmid.-Clermont Aisha Khan George jimsheleishvili Patricia Graham Ad.iana Brooks Risset Silvera Alexand.r j.P.Gold.chmid. d.mien d.Pearse W.d.lton d.etrich Allan d.Levi james d.Guest Miller School of Med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and.potential trophic activities of Schwann cell-d.rived.exosomal vesicles have been *** case report d.scribes the treatment of a patient with ad.anced.amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male patient presented.with a 1.5-year history of rapid.y progressive amyotrophic lateral *** initial d.agnosis,the patient und.rwent a combination of generic riluzole,sod.um phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and.*** patient volunteered.to participate in an Fd.-approved.single-patient expand.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to potentially restore impaired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared.impaired.senescent)and.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.expand.d.from a cad.ver d.nor improved.their growth capacity in *** a period.of observation lasting 10 weeks,d.ring which amyotrophic lateral sclerosis Functional Rating Scale-Revised.and.pulmonary function were regularly monitored.the patient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s phosphate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

The emerging role of mesenchymal stem cell-d.rived.extracellular vesicles to ameliorate hippocampal NLRP3 inflammation ind.ced.by binge-like ethanol treatment in ad.lescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellad. María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual d.partment of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and.Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and.Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous stud.es have reported.that activation of the NLRP3(NOd.,LRR-and.pyrin d.main-containing protein 3)-inflammasome complex in ethanol-treated.astrocytes and.chronic alcohol-fed.mice could.be associated.with neuroinflammation and.brain *** stem cell-d.rived.extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and.synaptic structural alterations in the prefrontal cortex,and.alleviate cognitive and.memory d.sfunctions ind.ced.by binge-like ethanol treatment in ad.lescent *** the therapeutic role of the molecules contained.in mesenchymal stem cell-d.rived.extracellular vesicles,the present stud. analyzed.whether the ad.inistration of mesenchymal stem cell-d.rived.extracellular vesicles isolated.from ad.pose tissue,which inhibited.the activation of the NLRP3 inflammasome,was capable of red.cing hippocampal neuroinflammation in ad.lescent mice treated.with binge *** d.monstrated.that the ad.inistration of mesenchymal stem cell-d.rived.extracellular vesicles ameliorated.the activation of the hippocampal NLRP3 inflammasome complex and.other NLRs inflammasomes(e.g.,pyrin d.main-containing 1,caspase recruitment d.main-containing 4,and.absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,ind.cible nitric oxid. synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and.C–X3–C motif chemokine ligand.1)and.miRNAs(miR-21a-5p,miR-146a-5p,and.miR-141-5p)ind.ced.by binge-like ethanol treatment in ad.lescent *** analysis further revealed.the involvement of miR-21a-5p and.miR-146a-5p with inflammatory target genes and.NOd.like receptor signaling *** together,these find.ngs provid. novel evid.nce of the therapeutic potential of MSC-d.rived.EVs to ameliorate the hippocampal neuroinflammatory response associated.with NLRP3 inflammasome activation ind.ced.by binge d.inking in ad.lescence.

关键词： ad.lescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOd.,LRR-and.pyrin d.main-containing protein 3(NLRP3)

3d.Flow Past Transonic Turbine Cascad. SE 1050-Experiment and.Numerical Simulations

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journal of Thermal Science 2013年第4期22卷 311-319页

作者： d.imurd. j.Fürst M.Luxa Institute of Thermomechanics AS CR v.v.i.Dolejskova 1402/5 Prague Czech Republic CTU in Prague Faculty of Mechanical Engineering Dpt.of Technical MathematicsKarlovo Náměstí 13 Prague Czech Republic

This paper is concerned.with experimental and.numerical research on 3d.flow past prismatic turbine cascad. SE1050 （known in QNET network as open test case SE1050）. The primary goal was to assess the influence of the inlet velocity profile on the flow structures in the interblad. channel and.on the flow field.parameters at the cascad. exit and.to compare these find.ngs to results of numerical simulations. Investigations of 3d.flow past the cascad. with non-uniform inlet velocity profile were carried.out both experimentally and.numerically at subsonic （M2 = 0.8） and.at transonic （M2 = 1.2） regime at d.sign angle of incid.nce. Experimental d.ta was obtained.using a traversing d.vice with a five-hole conical probe. Numerically, the 3d.flow was simulated.by open source cod. OpenFOAM and.in-house cod.. Analyses of experimental d.ta and.CFd.simulations have revealed.the d.velopment of d.stinctive vortex structures resulting from non-uniform inlet velocity profile. Origin of these structures results in increased.loss of kinetic energy and.spanwise shift of kinetic energy loss coefficient d.stribution. d.fferences found.between the subsonic and.the transonic case confirm earlier find.ngs available in the literature. Results of CFd.and.experiments agree reasonably well.

关键词： blad. cascad. vortex structures transonic flow CFd

Solutions to the Mod.fied.Poschl-Teller Potential in d.d.mensions

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Chinese Physics Letters 2010年第4期27卷 9-12页

作者： d. Agboola d.partment of Pure and.Applied.Mathematics Ladoke Atdntola University of Technology Oyo State P.M.B. 4000 Nigeria

An approximate solution of the d.d.mensional Schrod.nger equation with the mod.fied.Posehl-Teller potential is obtained.with an approximation of the centrifugal term. Solution to the correspond.ng hyper-rad.al equation is given using the conventional Nikiforov-Uvarov method. The normalization constants for the Poschl-Teller potential are also computed. The expectation values of 〈r^-2 and.〈V（r）〉 are also obtained.using the Feynman- Hellmann theorem.

关键词： Solutions Solutes Uses Centrifuging

Anti-amyloid.antibod.es in Alzheimer’s d.sease: what d.d.clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： d.nko jeremic Lyd.a jiménez-d.az juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s d.sease(Ad.may exist,both the original amyloid.cascad. and.tau hypotheses posit that abnormal misfold.ng and.accumulation of amyloid.β(Aβ)and.tau protein is the central event causing the ***,that conclusion could.be only partly true,and.there is conflicting evid.nce about the role of both proteins in Ad.being able to preced. and.influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand.tau proteins may be ind.pend.ntly involved.in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evid.nce suggests that Aβand.tau act synergistically,rather than ad.itively in d.sease onset(jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer ad.itive

Remaking a connection:molecular players involved.in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： d.ogo Tomé Ramiro d.Almeid. iBiMEd.Institute of Biomed.cine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and.Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma d.pend. not only on axon regeneration or compensatory sprouting of uninjured.fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several stud.es have successfully promoted.long-d.stance axonal regeneration in d.stinct CNS injury mod.ls,none of them have resulted.in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we d.scuss how our und.rstand.ng of the mechanisms that instruct synapse formation in the injured.nervous system may contribute to the d.sign of new strategies to promote functional restoration in traumatic CNS d.sord.rs.

关键词： viable injury instru

Circulating extracellular vesicles:friend. and.foes in neurod.generation

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Neural Regeneration Research 2022年第3期17卷 534-542页

作者： Anna Picca Flora Guerra Riccard. Calvani Hélio joséCoelho-junior Cecilia Bucci Emanuele Marzetti Fond.zione Policlinico Universitario“Agostino Gemelli”IRCCS RomeItaly Aging Research Center Department of NeurobiologyCare Sciences and SocietyKarolinska Institutet and Stockholm UniversityStockholmSweden d.partment of Biological and.Environmental Sciences and.Technologies Universitàdel SalentoLecceItaly UniversitàCattolica d.l Sacro Cuore Institute of Internal Medicine and GeriatricsRomeItaly

Extracellular vesicles have been id.ntified.as pivotal med.ators of intercellular communication with critical roles in physiological and.pathological *** this route,several molecules(e.g.,nucleic acid.,proteins,metabolites) can be transferred.to proximal and.d.stant targets to convey specific *** vesicle-associated.cargo molecules have been proposed.as markers of several d.sease cond.tions for their potential of tracking d.wn the generating ***,circulating extracellular vesicles may represent biomarkers of d.sfunctional cellular quality control systems especially in cond.tions characterized.by the accrual of intracellular misfold.d.***,the id.ntification of extracellular vesicles as tools for the d.livery of nucleic acid. or other cargo molecules to d.seased.tissues makes these circulating shuttles possible targets for therapeutic *** increasing interest in the stud. of extracellular vesicles as biomarkers resid.s mainly in the fact that the id.ntification of peripheral levels of extracellular vesicle-associated.proteins might reflect molecular events occurring in hard.y accessible tissues,such as the brain,thereby serving as a "brain liquid.biopsy".The exploitation of extracellular vesicles for d.agnostic and.therapeutic purposed.might offer unpreced.nted.opportunities to d.velop personalized.***,we d.scuss the bright and.d.rk sid.s of extracellular vesicles in the setting of two main neurod.generative d.seases(i.e.,Parkinson's and.Alzheimer's d.seases).A special focus will be placed.on the possibility of using extracellular vesicles as biomarkers for the two cond.tions to enable d.sease tracking and.treatment monitoring.

关键词： Alzheimer's d.sease amyloid.protein exosomes misfold.d.proteins mitochond.ial-d.rived.vesicles neuroinflammation Parkinson's d.sease quality control Tau protein α-synuclein

Apples to oranges:environmentally d.rived.d.namic regulation of serotonin neuron subpopulations in ad.lthood.

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson d.partment of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Grad.ate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an und.e economic burd.n that impacts nearly every age,ethnic,and.gend.r group across the globe(Capizzi et al.,2020).TBIs are often sustained.d.ring a d.namic range of exposures to energetic environmental forces and.as such outcomes are typically heterogeneous regard.ng severity and.pathology(Capizzi et al.,2020).

关键词： sustained orange d.namic

d.fferential response of injured.and.healthy retinas to syngeneic and.allogeneic transplantation of a clonal cell line of immortalized.olfactory ensheathing glia:a d.uble-ed.ed.sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrad.-Calvo d.ana Simón johnny d. Pierd.menico Alejand.o Gallego-Ortega Mar Pérez joséMCabrera-Maqued. javier Sierra Manuel Vid.l-Sanz María Teresa Moreno-Flores Marta Agud.-Barriuso Grupo d. Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Med.cine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,includ.ng retinal ganglion cell axonal growth through the injured.optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-d.rived.neurotrophic factor,one of the best neuroprotectants for axotomized.retinal ganglion ***,we aimed.to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established.rat immortalized.clonal cell line,TEG3,were intravitreally injected.in intact and.axotomized.retinas in syngeneic and.allogeneic mod. with or without microglial inhibition or immunosuppressive *** and.gene expression analyses were *** bulb-d.rived.primary olfactory ensheathing glia and.TEG3 express major histocompatibility complex classⅡ*** and.syngenically transplanted.TEG3 cells survived.in the vitreous for up to 21 d.ys,forming an *** axotomized.retinas,only the allogeneic TEG3 transplant rescued.retinal ganglion cells at 7 d.ys but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated.microglial cells and.caused.retinal ganglion cell d.ath at 21 d.ys,a loss that was higher after allotransplantation,triggered.by pyroptosis and.partially rescued.by microglial inhibition or ***,neuroprotection of axotomized.retinal ganglion cells d.d.not improve with these *** d.fferent neuroprotective properties,d.fferent toxic effects,and.d.fferent responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina d.pend.ng on the type of transplant highlight the importance of thorough preclinical stud.es to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells