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Gut microbiome:A revolution in typeⅡdiabetes mellitus

World Journal of Diabetes 2024年第9期15卷 1874-1888页

作者： Madhan Jeyaraman Tejaswin Mariappan Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Gabriel Silva Santos Lucas furtado da fonseca joséfábio lana Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Community Medicine Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia Department of Orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia Department of biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

TypeⅡdiabetes mellitus(T2DM)has experienced a dramatic increase globally across countries of various income levels over the past three *** persistent prevalence of T2DM is attributed to a complex interplay of genetic and environmental *** numerous pharmaceutical therapies have been developed,there remains an urgent need for innovative treatment approaches that offer effectiveness without significant adverse *** this context,the exploration of the gut microbiome presents a promising *** has increasingly shown that the gut microbiome of individuals with T2DM exhibits distinct differences compared to healthy individuals,suggesting its potential role in the disease’s pathogenesis and *** emerging field offers diverse applications,particularly in modifying the gut environment through the administration of prebiotics,probiotics,and fecal microbiome *** interventions aim to restore a healthy microbiome balance,which could potentially alleviate or even reverse the metabolic dysfunctions associated with *** current results from clinical trials have not yet shown dramatic effects on diabetes management,the groundwork has been laid for deeper *** and future clinical trials are critical to advancing our understanding of the microbiome’s impact on *** further elucidating the mechanisms through which microbiome alterations influence insulin resistance and glucose metabolism,researchers can develop more targeted *** potential to harness the gut microbiome in developing new therapeutic strategies offers a compelling prospect to transform the treatment landscape of T2DM,potentially reducing the disease’s burden significantly with approaches that are less reliant on traditional pharmaceuticals and more focused on holistic,systemic health improvements.

关键词： TypeⅡdiabetes Gut microbiome Probiotics Prebiotics fecal microbiota transplantation

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Bone marrow-derived products: A classification proposal – bone marrow aspirate, bone marrow aspirate concentrate or hybrid?

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World Journal of Stem Cells 2020年第4期12卷 241-250页

作者： joseph Purita joséfábio Santos Duarte lana Morey Kolber Bruno Lima Rodrigues Tomas Mosaner Gabriel Silva Santos Carolina Caliari-Oliveira Stephany Cares Huber Institute of Regenerative Medicine Boca RatonFL 33432United States Institute of Bone and Cartilage IndaiatubaSP 13334-170Brazil Department of Physical Therapy Nova Southeastern UniversityFort LauderdaleFL 33314United States University of Campinas CampinasSP 13083-970Brazil In Situ Cell Therapy Ribeirao PretoSP 14056-680Brazil

Degenerative musculoskeletal disorders are one of the top causes of pain and disability in the adult *** available alternatives to mitigate symptoms include conservative treatments such as the administration of pharmacological agents and an educative approach towards lifestyle *** use of certain analgesics,such as opiates and corticosteroids,delivers short term results but do not address the etiological source of pain and ***,prolonged use of such medications may cause additional ***,the demand for musculoskeletal tissue regeneration has led to an alternative approach referred to as“orthobiologics”.This alternative is based on cellular and molecular components capable of inducing and promoting tissue *** marrow(BM)aspirate(BMA)and concentrate are well-known orthobiologics used to treat musculoskeletal *** derived from the BM have been discussed in the literature;however,the lack of standardization regarding collection and processing protocols presents a challenge for generalization of study outcomes and determination of *** BM-derived orthobiologics have not yet been classified,to our knowledge,this manuscript proposes the ACH classification system,which speaks to BMA(A),BMA and concentrate(C)and hybrid(H),which combines A and *** classification proposes and describes 8 parameters that are relevant for the quality of biological *** more parameters used would imply greater characterization and complexity of the evaluation of the biological product *** ACH classification envisages a necessary contribution to the comprehension of both clinical procedures and research outcomes,ultimately ushering in a standardization of best practice.

关键词： Bone-marrow classification Bone-marrow aspirate concentrate Regenerativemedicine Stem cells Musculoskeletal disorders Orthobiologics

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Platelet-rich plasma vs bone marrow aspirate concentrate:An overview of mechanisms of action and orthobiologic synergistic effects

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World Journal of Stem Cells 2021年第2期13卷 155-167页

作者： joséfábio Santos Duarte lana Lucas furtado da fonseca Rafael da Rocha Macedo Tomas Mosaner William Murrell Ashok Kumar joseph Purita Marco Antonio Percope de Andrade Department of Orthopedics The Bone and Cartilage InstituteIndaiatuba 13334-170SPBrazil Department of Orthopedics The Federal University of São PauloSão Paulo 04023-062SPBrazil Department of Orthopedics Rede D’Or Unit IFOR HospitalSão Bernardo do Campo 09715-021SPBrazil Department of Orthopaedics Healthpoint UAEAbu Dhabi 00000United Arab Emirates Department of Orthopaedics My Doc Specialist Medical CentreDubai 00000United Arab Emirates Department of Orthopedics Institute of Regenerative MedicineBoca RatonFL 33432United States Department of Orthopaedic Federal University of Minas GeraisBelo Horizonte 31270-901MGBrazil

The use of orthobiologics as a novel therapy for the treatment of numerous musculoskeletal disorders has increased considerably over the past ***,there are multiple alternatives available as suitable treatments;however,the use of autologous blood-derived products such as platelet-rich plasma(PRP),bone marrow aspirate(BMA)and BMA concentrate(BMAC),specifically,is *** many investigations attempted to demonstrate the effectiveness of these therapies,even with positive results,the literature lacks standardized protocols and overall accuracy in study designs,which leads to variance and difficulty in reproducibility of *** efficacy of PRP for the treatment of cartilage,bone and muscle tissues is well *** BMAC has generated optimistic results for the same purposes,its applicability in clinical trials is still relatively recent when compared to *** products demonstrate the potential to set forth reparative processes,each in their own distinct *** combination of these biological products has been previously proposed,yet little is known about their *** indicates that growth factor,cytokine,and chemokine profiles seen in both PRP and BMAC vary but are likely to work synergistically to enhance musculoskeletal *** products seem to work well without PRP;however,the addition of PRP to BMAC has been shown to act as a rich and natural source of culture medium for stem cells located either peripherally or in the bone marrow ***,additional variables associated with the use of BMAC and PRP in orthopedics must be further evaluated in order to consolidate the efficacy of this therapeutic strategy.

关键词： Orthobiologics Platelet-rich plasma Bone-marrow aspirate Regenerative medicine Musculoskeletal diseases Stem cells

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Gut microbiome and orthopaedic health:Bridging the divide between digestion and bone integrity

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World Journal of Orthopedics 2024年第12期15卷 1135-1145页

作者： Naveen Jeyaraman Madhan Jeyaraman Priya Dhanpal Swaminathan Ramasubramanian Lavanya Ragavanandam Sathish Muthu Gabriel Silva Santos Lucas furtado da fonseca joséfábio lana Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopaedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department of General Medicine Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Pharmacology Faculty of Medicine-Sri Lalithambigai Medical College and HospitalDr MGR Educational and Research InstituteChennai 600095Tamil NaduIndia Department of Orthopaedics Government Medical College and HospitalKarur 639004Tamil NaduIndia Department of biotechnology Karpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia

The gut microbiome,a complex ecosystem of microorganisms in the digestive tract,has emerged as a critical factor in human health,influencing metabolic,immune,and neurological *** review explores the connection between the gut microbiome and orthopedic health,examining how gut microbes impact bone density,joint integrity,and skeletal *** highlights mechanisms linking gut dysbiosis to inflammation in conditions such as rheumatoid arthritis and osteoarthritis,suggesting microbiome modulation as a potential therapeutic *** findings include the microbiome’s role in bone metabolism through hormone regulation and production of short-chain fatty acids,crucial for mineral *** review also considers the effects of diet,probiotics,and fecal microbiota transplantation on gut microbiome composition and their implications for orthopedic *** promising,challenges in translating microbiome research into clinical practice persist,necessitating further exploration and ethical consideration of microbiome-based *** interdisciplinary research aims to link digestive health with musculoskeletal integrity,offering new insights into the prevention and management of bone and joint diseases.

关键词： Gut microbiome Orthopaedic health Bone density Dysbiosis Inflammation Microbiome modulation

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Insights of gut-liver axis in hepatic diseases:Mechanisms,clinical implications,and therapeutic potentials

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第6期15卷 1-17页

作者： Naveen Jeyaraman Madhan Jeyaraman Tejaswin Mariappan Sathish Muthu Swaminathan Ramasubramanian Shilpa Sharma Gabriel Silva Santos Lucas furtado da fonseca joséfábio lana Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Research Methods Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopaedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department of Community Medicine Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia Department of Orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia Department of biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Paediatric Surgery All India Institute of Medical SciencesNew Delhi 110029India

With the rising prevalence of chronic liver diseases worldwide,there exists a need to diversify our artillery to incorporate a plethora of diagnostic and therapeutic methods to combat this ***,the most common causes of liver disease are non-alcoholic fatty liver disease,hepatitis,and alcoholic liver *** of these chronic diseases have the potential to transform into hepatocellular carcinoma with advancing *** this review,we analyse the relationship between the gut and liver and their significance in liver *** two-way relationship has interesting effects on each other in liver *** gut microbiota,through its metabolites,influences the metabolism in numerous *** manipulation of its composition can lead to the discovery of numerous therapeutic potentials that can be applied in the treatment of various liver *** cohort studies with a pan-omics approach are required to understand the association between the gut microbiome and hepatic disease progression through which we can identify effective ways to deal with this issue.

关键词： Gut-liver axis Dysbiosis Liver disease Probiotics fecal microbiota transplantation Precision medicine

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Photobiomodulation therapy for osteoarthritis: Mechanisms of action

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World Journal of Translational Medicine 2022年第3期10卷 29-42页

作者： fábio Pericinoto Giolo Gabriel Silva Santos Victor fontes Pacheco Stephany Cares Huber Kaue franco Malange Bruno Lima Rodrigues fernanda Bassora Tomas Mosaner Gabriel Azzini Lucas Leite Ribeiro Carlos Amilcar Parada joséfábio Santos Duarte lana Department of Physical Therapy Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil biomedical Science Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil Department of Orthopedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170Brazil Neurobiology of Pain and Regenerative Medicine The University of CampinasCampinas 13083-862Brazil Department of Hematology The University of CampinasCampinas 13083-878Brazil

Photobiomodulation(PBM)is a non-invasive therapeutic modality with demonstrated effects in many fields related to regenerative *** the field of orthopedics,in particular,PBM at various wavelengths has demonstrated the capacity to trigger multiple biological effects associated with protective mechanisms in musculoskeletal *** articles cited in this review show that devices operating close to or within the near infrared range at low intensities can provoke responses which favor the shift in the predominant catabolic microenvironment typically seen in degenerative joint diseases,especially osteoarthritis(OA).These responses include proliferation,differentiation and expression of proteins associated with stable cell ***,PBM can also modulate oxidative stress,inflammation and pain by exerting regulatory effects on immune cells and blocking the transmission of pain through sensory neuron fibers,without adverse ***,these effects are essential in order to control the progression of OA,which is in part attributed to exacerbated inflammation and degradative enzymatic reactions which gradually contribute to the destruction of joint *** may offer medical experts ease of application,financial viability,efficacy and lack of serious adverse ***,it may prove to be a suitable ally in the management of mild to moderate degrees of *** review explores and discusses the principal biological mechanisms of PBM and how the produced effects may contribute to the amelioration of osteoarthritic *** was reviewed using PubMed and Google Scholar in order to find studies describing the mechanisms of *** investigation included a combination of nomenclature such as:“photobiomodulation”,“phototherapy”,“laser therapy”,“PBM”,“osteoarthritis”,low level light therapy”,“inflammation”and“cartilage”.We considered only articles written in English,with access to the full text.

关键词： Photobiomodulation Low-level laser therapy Osteoarthritis Inflammation Regenerative medicine

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Platelet-rich plasma application in diabetic ulcers:A review

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World Journal of Dermatology 2022年第1期10卷 1-9页

作者： Victoria Pereira Simão Carolina Souza Cury Gabriel Mota Zamariolli Tavares Gabriel Calixto Ortega Arthur Cichetto Ribeiro Gabriel Silva Santos joséfábio Santos Duarte lana Medical School Centro Universitário LusíadaSantos 11045-101São PauloBrazil biomedical Science Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department ofOrthopedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil

There are 422 million diabetic people in the world.25%of these individuals are diagnosed with diabetic foot ulcer(DfU).20%of patients with DfU will suffer amputation of the lower *** amputation procedures,the mortality rate of patients is over 70%in 5 *** has no cure and,therefore,treatment aims to prevent and treat its *** platelet-rich plasma(PRP)has been shown to be a therapeutic tool for many types of disorders,including the treatment of *** manuscript aims to carry out a review to provide more knowledge about the efficacy and safety of autologous PRP for wound closure in patients with *** majority of studies included in this review state that PRP promotes improvement of DfU lesions by accelerating tissue healing ***,many studies have a small sample size and thus require larger sample range in order to improve robustness of data in the literature.

关键词： Diabetic foot ulcer Platelet-rich plasma Wound healing Tissue regeneration Inflammation

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biofat grafts as an orthobiologic tool in osteoarthritis:An update and classification proposal

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World Journal of Meta-Analysis 2021年第1期9卷 29-39页

作者： Rafael da Rocha Macedo Lucas furtado da fonseca joséfábio Santos Duarte lana Tomas Mosaner joseph Purita MAP de Andrade Luciano Miller Rodrigues Patricio Centurion Department of Orthopedics Rede D’Or unidade IFOR HospitalSão Bernardo do Campo 09715-021São PauloBrazil Department of Orthopedics Escola Paulista de Medicina da Universidade Federal de São PauloSão Paulo 04024-002Brazil Department of Orthopedics The Bone and Cartilage InstituteIndaiatuba 13334-170São PauloBrazil Department of Orthopedics Institute of Regenerative MedicineBoca RatonFL 33432United States Department of Orthopedics Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Orthopedic Department Faculdade de Medicina do ABCSanto André09060-870São PauloBrazil Aesthetic and Reconstructive Plastic Surgery Ricardo Palma UniversityLima 15023Peru

Among degenerative musculoskeletal disorders,osteoarthritis remains one of the main causes of pain and disability in the adult *** available alternatives to alleviate symptoms include conservative treatments such as physical therapy,anti-inflammatory drugs and an educational approach to lifestyle *** use of certain analgesics,such as opiates and corticosteroids offer short-term results but does not address the etiological source of pain and *** addition,prolonged use of such medications can cause additional ***,the demand for regeneration of joint cartilage has led to an alternative approach called"orthobiologics".This alternative is based on cellular and molecular components capable of inducing and promoting tissue *** derived from adipose tissue have been studied as an excellent source of orthobiologics in an attempt to promote joint cartilage ***,the lack of standardization regarding collection and processing protocols presents a challenge for the generalization of study results and determination of *** the best of our knowledge,orthobiologics derived from fat have not yet been ***,this manuscript proposes the HGS classification system which aims to describe certain parameters that are relevant to the quality of organic products regarding harvesting techniques(H),graft type(G),and number of centrifugations(S).The more parameters used would imply greater characterization and complexity of the evaluation of the biological product *** HGS classification may provide a valuable contribution to the understanding of clinical procedures and research results,aiming to ultimately usher in a standardization of optimal practice.

关键词： Orthobiologics Adipose tissue Mesenchymal stem cells Regenerative medicine Musculoskeletal disorders Orthopedics

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Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： joséM.Izquierdo Centro de biología Molecular Severo Ochoa(CBM) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Thermal and salinity effects on locomotor performance of Thoropa taophora tadpoles(Anura,Cycloramphidae)

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Integrative Zoology 2020年第1期15卷 40-54页

作者： Antonio C.GALLO Cinthia ABRASILEIRO fábio Cury DE BARROS joséEduardo DE CARVALHO Department of Ecology and Evolutionary biology Federal University of São PauloDiademaSão PauloBrazil

It is well known that environmental temperature influences several biological functions of ectotherms,notably in *** high permeability of anuran skin,associated with the effect of elevated environmental temperature,potentiates the dehydration process and this combination may restrict locomotor ***pa taophora is an endemic species from the Atlantic Rainforest whose tadpoles are semiterrestrial and predominantly diurnal,and are found in rocky seashores where they are exposed to sea spray and high *** this study we investigated how temperature and salinity conditions affect the locomotor performance in Thoropa taophora *** also assessed how different osmotic concentrations affect the activity of the metabolic pathways that support muscle *** measured the sprint speed of tadpoles of various sizes at different temperatures and salinities in the *** also measured the activity of the enzymes pyruvate kinase(PK),lactate dehydrogenase(LDH)and citrate synthase(CS)in different temperatures and osmotic concentrations,and calculated the thermal sensitivity and the activity constants for each *** results showed that,in general,sprint speed decreased with increasing temperature and ***,whereas the effect of increased salinity was similar in smaller and larger tadpoles,increased temperature had a higher negative impact on sprint speed of larger tadpoles,thus indicating low thermal sensitivity of small *** and LDH thermal sensitivities and LDH constant of activity decreased as the osmolality *** conclusion,the locomotor capacity of tadpoles was decreased by temperature and salinity,which may be related to a decrease in anaerobic metabolism both in terms of sensitivity and total energy turnover through enzymatic *** discuss the ecological consequences,including the potential impacts on predator escape behavior promoted by changes in metabolism and locomotor performance

关键词： amphibians energy metabolism enzyme activity sprint speed

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