检索结果-南通市图书馆

Risk factors for postoperative bile leakage:a retrospective single-center analysis of 411 hepatectomies

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 81-86页

作者： Fabrizio Panaro Lisa Hacina Hassan Bouyabrine Al-Warith Al-Hashmi Astrid Herrero Francis navarro Department of General and Liver Transplant Surgery Montpellier University HospitalCollege of Medicine

BACKGROUND： The primary focus of the study was to ana- lyze the risk factors for bile leakage after hepatectomy for be- nign or malignant tumors. METHODS： A total of 411 patients who had undergone hepa- tectomy between December 2006 and December 2011 were ret- rospectively analyzed. The severity of bile leakage was graded according to the ISGLS classification. Twenty-eight pre- and postoperative parameters were analyzed. RESULTS： The overall bile leakage incidence was 10.2% （42/411）. The severity of the leakage was classified according to the IS- GLS classification. Bile leakage was detected early in case of abdominal drainage （11.4% vs 1.9%, P=0.034）. It prolonged the time of hospitalization （16 vs 9 days, P=0.001）. In all patients, wedge resection was associated with a higher incidence of bile leakage in contrast to anatomical resections （25.6% vs 4.1%, P〈0.0001） regardless of the underlying liver disease. Furthermore, total vascular exclusion increased risk of bile leakage （P=0.008）. CONCLUSIONS： Bile leakage as a major issue after hepatic resection is related to the postoperative morbidity and the hospitalization time. It is associated with non-anatomical re- section and a total vascular exclusion.

关键词： liver resection bile leakage wedge total vascular exclusion

Superattracting cycles for some Newton type iterative methods

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2011年第3期54卷 539-544页

作者： AMAT Sergio BUSQUIER Sonia navarro Emilie PLAZA Sergio Departamento de Matemtica Aplicada y Estadistica Universidad Politécnica de Cartagena Ecole Généraliste d'Ingénieurs de Marseille (EGIM) Departamento de Matemticas Facultad de Ciencias Universidad de Santiago de Chile

The paper is devoted to the analysis of certain dynamical properties of a family of iterative Newton type methods used to find roots of non-linear equations. We present a procedure for constructing polynomials in such a way that superattracting cycles of any prescribed length occur when these iterative methods are applied. This paper completes the study begun in Amat, Bermúclez, Busquier, et al., (2009).

关键词：牛顿迭代法周期动力特性分析迭代方法方程根非线性多项式

Optimized combinations of statins and azoles against Acanthamoeba trophozoites and cysts in vitro

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2019年第6期12卷 283-287页

作者： Ines Sifaoui Carmen M Martín-navarro Atteneri López-Arencibia María Reyes-Batlle Basilio Valladares joséE.Pinero Sutherland K Maciver Jacob Lorenzo-Morales University Institute of Tropical Diseases and Public Health of the Canary Islands University of La LagunaCanary IslandsSpain Centre for Integrative Physiology Biomedical SciencesEdinburgh Medical SchoolUniversity of EdinburghScotlandUK

Objective: To evaluate the combination of several statins(atorvastatin, fluvastatin and simvastatin) and azoles(voriconazole, posaconazole and itraconazole) against Acanthamoeba spp. Methods: The efficiency of the different drug combinations against the trophozoite stage of different Acanthamoeba strains were evaluated by Alamar Blue assay. Effect on the cyst stage was observed by inverted microscope. Cytotoxicity of combinations of azoles and statins was evaluated by measuring the release of lactate dehydrogenase from a murine macrophage cell line. Results: Combinations of any of the tested statins and voriconazole or posaconazole were more efficient in inhibiting Acanthamoeba compared to statins or azoles individually. The drug combinations at the combined inhibitory concentrations 50% showed lower toxicity compared to that of the compounds alone.Conclusions: The combinations of statins together with voriconazole and posaconazole are more efficient than these drugs alone, and these combinations have lower cytotoxicity in mammalian cell lines.

关键词： Keratitis Voriconazole Posaconazole Atorvastatin Fluvastatin Simvastatin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

汽车因安全问题召回各地监管力度不一

商业周刊（中文版） 2021年第17期 8-10页

作者： Andrea navarro Ryan Beene 融汐(译) 不详

大约十年前,高田公司(Takata)问题安全气囊在撞车事故中爆炸的可能性引发了一场全球汽车业历史上最复杂、影响最深远的安全危机。全球大约有1亿辆车因此被召回。但是,来自阿根廷布宜诺斯艾利斯、现年42岁的鲁伊·德里萨尔迪(Ruy Drisal... 详细信息

大约十年前,高田公司(Takata)问题安全气囊在撞车事故中爆炸的可能性引发了一场全球汽车业历史上最复杂、影响最深远的安全危机。全球大约有1亿辆车因此被召回。但是,来自阿根廷布宜诺斯艾利斯、现年42岁的鲁伊·德里萨尔迪(Ruy Drisaldi)直到去年12月才意识到其中的风险,当时在他们位于墨西哥东南部城市梅里达的家附近,他妻子的二手本田CR-V的安全气囊在另一辆车倒车撞上来后发生了爆炸,杀死了他的妻子。

关键词：安全气囊撞车事故汽车业安全危机监管力度召回阿根廷梅里达

Transcatheter aortic valve implantation in very elderly patients： immediate results and medium term follow-up

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2015年第4期12卷 340-345页

作者： Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez josé M Hemández Ramiro Trillo-Nouche César Morís Area del Corazón Hospital Universitario Central de Asturias Av. Roma Oviedo Asturias Spain Department of Cardiology Hospital Universitario Virgen de la Victoria Campus de Teatinos Málaga Spain Department of Cardiology Complejo Hospitalario Universitario de Santiago de Compostela Travesla da Choupana A Coru a Spain

ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter，观察、未来的学习在三所医院里被执行。我们包括了连续很老(>；... 详细信息

ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter，观察、未来的学习在三所医院里被执行。我们包括了连续很老(>；85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老；2.1 年(从 85 ～ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE；11.2% 与 57 (35.6%) 病人得分 ≥；20% 。程序的成功率是 97.5% ，与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±；232.17 天。在后续时期期间， 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥；20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。

关键词：主动脉中老年患者随访植入导管中长死亡率

Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2021年第9期14卷 1489-1507页

作者： Cristina navarro Cristian Mateo-Elizalde Thotegowdanapalya C.Mohan Eduardo Sanchez-Bermejo Oscar Urrutia Maria Nieves Fernandez-Muniz jose M.Garcia-Mina Riansares Munoz Javier Paz-Ares Gabriel Castrillo Antonio Leyva Department of Plant Molecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones CientíficasMadrid 28049Spain Department of Environmental Biology Sciences SchoolUniversity of NavarraPamplona 31008Spain Department of Analytical Chemistry School of Chemical SciencesUniversidad Complutense de MadridMadrid 28040Spain Present address:Department of Biotechnology and Bioinformatics Faculty of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnataka 570015India Present address:S&A Fresh Produce.Brook Farm MardenHereford HR13ETUK Future Food Beacon of Excellence&School of Biosciences University of NottinghamNottingham LE125RDUK

In nature,plants acquire nutrients from soils to sustain growth,and at the same time,they need to avoid the uptake of toxic compounds and/or possess tolerance systems to cope with them.This is particularly challenging when the toxic compound and the nutrient are chemically similar,as in the case of phosphate and arsenate.In this study,we demonstrated that regulatory elements of the phosphate starvation response(PSR)coordinate the arsenate detoxification machinery in the cell.We showed that arsenate repression of the phosphate transporter PHT1;1 is associated with the degradation of the PSR master regulator PHR1.Once arsenic is sequestered into the vacuole,PHR1 stability is restored and PHT1;1 expression is recovered.Furthermore,we identified an arsenite responsive SKP1-like protein and a PHR1 interactor F-box(PHIF1)as constituents of the SCF complex responsible for PHR1 degradation.We found that arsenite,the form to which arsenate is reduced for compartmentalization in vacuoles,represses PHT1;1 expression,providing a highly selective signal versus phosphate to control PHT1;1 expression in response to arsenate.Collectively,our results provide molecular insights into a sensing mechanism that regulates arsenate/phosphate uptake depending on the plant’s detoxification capacity.

关键词： arsenic signaling F-box protein arsenate uptake arsenic detoxification phosphate starvation phytoremediation

Postural control quantification in minimally and moderately impaired persons with multiple sclerosis:The reliability of a posturographic test and its relationships with functional ability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2020年第6期9卷 677-684页

作者： David Barbado Ramon Gomez-Illan Pedro Moreno-navarro Gregori Valero-Conesa Raul Reina Francisco J.Vera-Garcia Department of Sport Sciences Sports Research CentreMiguel Hern_andez University of ElcheElche(Alicante)03202Spain

Background:Postural control has been associated with the functional impairment in persons with multiple sclerosis(pwMS).However,there is a need for reliable methods to assess postural control in early stages of the disease,when subtle changes can be difficult to detect.The aims of this study were to assess the absolute and relative reliability of a standing and a sitting posturographic protocol in minimally(Expanded Disability Status Scale≤2)and moderately(2.5≤Expanded Disability Status Scale≤4)impaired pwMS,and to analyze relationships among postural control and functional mobility and gait performance.Methods:To assess postural control in an upright stance,14 minimally and 16 moderately impaired pwMS performed six 70 s trials in tandem stance,3 with their weaker leg behind(TSWL)and 3 with their stronger leg behind(TSSL).Additionally,participants completed five 70 s trials using an unstable sitting protocol(US)to assess trunk stability.The mean radial errors of TSWL,TSSL,and US trials were calculated as postural control indexes.Furthermore,participants performed the Timed Up and Go test(TUG)and the Timed 25-foot Walk test(T25FW)to measure their functional mobility and gait speed,respectively.Reliability was evaluated using the intraclass correlation coefficient(ICC3,1)and the standard error of measurement(SEM).Analyses of variances were carried out to assess between-group differences.Hedges’g index(dg)was used to estimate the effect size of differences.Pearson correlation analyses(r)were performed to examine the relationships among the postural control and the functional tests.Results:Posturographic tests showed a high reliability in both minimally(0.87≤ICC≤0.92;9.32%≤SEM≤11.76%)and moderately(0.80≤ICC≤0.92;10.33%≤SEM≤15.33%)impaired pwMS.Similarly,T25FW and TUG displayed a high consistency in minimally(0.89≤ICC≤0.94;3.43%≤SEM≤5.17%)and moderately(0.85≤ICC≤0.93;5.57%≤SEM≤6.56%)impaired individuals.Minimally impaired pwMS showed a better performance on the TUG,T25FW,and TSWL than moderately impaired individuals(p

关键词： Balance Consistency of the assessment Core stability Functional mobility

Comment on:simultaneous versus delayed resection for initially resectable synchronous colorectal cancer liver metastases

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2021年第1期10卷 131-133页

作者： Gianluca Cassese Zineb Cherkaoui Francis navarro Patrick Pessaux Division of HBP Surgery and Transplantation Department of SurgerySt.Eloi HospitalMontpellier University Hospital-School of MedicineMontpellierFrance Digestive and Endocrine Surgery Department Nouvel Hôpital CivilStrasbourgFrance Institute of Image Guided Surgery(IHU Strasbourg) StrasbourgFrance INSERM UnitéInserm U1110 Institut de Recherche sur les Maladies Vrales et HépatiquesStrasbourgFrance

We read with great interest the recently published article of Boudjema and collaborators(1).The authors evaluated the safety and efficacy of delayed resection(DR)versus simultaneous resection(SR)for patients with initially resectable synchronous colorectal cancer liver metastases(CRC-SLM).The aforementioned study(METASYNC)was the first randomized controlled trial comparing two resection strategies for CRC-SLM.In the literature,large retrospective studies didn’t seem to favor one type of treatment,particularly when comparisons are based on a propensity match score(2).

关键词： resection colorectal metastases

Thermal Hydraulic Analysis Improvement for the IEA-R1 Research Reactor and Fuel Assembly Design Modification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Nuclear Science and Technology 2018年第2期8卷 54-69页

作者： Pedro Ernesto Umbehaun Walmir Maximo Torres josé Antonio Batista Souza Mitsuo Yamaguchi Antonio Teixeira e Silva Roberto navarro de Mesquita Nikolas Lymberis Scuro Delvonei Alves de Andrade Nuclear and Energy Research Institute (Instituto de Pesquisas Energéticas e Nucleares) S&auml o Paulo Brazil

This paper presents the sequence of activities to improve the thermal hydraulic analysis of the IEA-R1 research reactor to operate in safe conditions after power upgrade from 2 to 5 MW and core size reduction from 30 to 24 fuel assemblies. A realistic analysis needs the knowledge of the actual operation conditions (heat flow, flow rates) beyond the geometric data and the uncertainties associated with manufacturing and measures. A dummy fuel assembly was designed and constructed to measure the actual flow rate through the core fuel assemblies and its pressure drop. First results showed that the flow distribution over the core is nearly uniform. Nevertheless, the values are below than the calculated ones and the core bypass flow rate is greater than those estimated previously. Based on this, several activities were performed to identify and reduce the bypass flow, such as reduction of the flow rate through the sample irradiators, closing some unnecessary secondary holes on the matrix plate, improvement in the primary flow rate system and better fit of the core components on the matrix plate. A sub-aquatic visual system was used as an important tool to detect some bypass flow path. After these modifications, the fuel assemblies flow rate increased about 13%. Additional tests using the dummy fuel assembly were carried out to measure the internal flow distribution among the rectangular channels. The results showed that the flow rate through the outer channels is 10% - 15% lower than the internal ones. The flow rate in the channel formed between two adjacent fuel assemblies is an estimated parameter and it is difficult to measure because this is an open channel. A new thermal hydraulic analysis of the outermost plates of the fuel assemblies takes into account all this information. Then, a fuel design modification was proposed with the reduction of 50% in the uranium quantity in the outermost fuel plates. In order to avoid the oxidation of the outermost plates by high temperature, low flow rate, a reduction of 50% in th

关键词： Nuclear Research Reactor Uranium Reduction Thermal Hydraulic Analysis Flow Measurement Dummy Fuel Assembly