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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez joséMCabrera-Maqueda Javier Sierra manuel Vidal-Sanz María Teresa moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Stress,Burnout,and Resilience:Are Teachers at Risk?

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International Journal of Mental Health Promotion 2023年第2期25卷 207-222页

作者： joséLuis moreno-Lucas Juan Pedro Martínez-Ramón Francisco manuel Morales-Rodríguez Cecilia Ruiz-Esteban e Inmaculada Méndez Department of Developmental and Educational Psychology Campus of Excellence Mare NostrumUniversity of MurciaEspinardoMurcia30100Spain Department of Developmental and Educational Psychology University Campus of CartujaUniversity of GranadaGranada18071Spain

It is increasingly common to find alarming news related to tragic events occurring in schools around the *** able to deal with these situations without getting hurt is a task not suitable for *** general,teachers are the ones who must deal with this type of situation in addition to other daily problems that appear in any classroom that make the level of stress to which they are subjected can become *** research aims to know the current situation of teachers in a region of southeastern Spain in terms of their level of work stress,resilience,and other associated variables,for which an ex post facto quantitative approach study was *** this purpose,an ad hoc sociodemographic questionnaire,and questions based on the Teaching and Learning International Survey of the Organization for Economic Co-Operation and Development,the Maslach Burnout Inventory,and the Brief Resilient Coping Scale were *** participating sample consisted of 470 *** main findings were that 6%of teachers had burnout(high emotional exhaustion,high cynicism,and low professional effectiveness simultaneously).Resilience correlated inversely with stress,emotional exhaustion,cynicism,excessive teaching,and difficulty maintaining classroom *** conclusion,knowing the needs of teachers allows us to reflect on what kind of prevention and intervention programs are necessary to improve the well-being of teachers and thus improve the quality of education.

关键词： Burnout coping resilience stress teacher

Combined Radiometric Analysis Related to Guava Leaf Phenology in Response to Soil Application of Paclobutrazol (PBZ)

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International Journal of Geosciences 2022年第8期13卷 681-694页

作者： Victor manuel Rodríguez-moreno Victor manuel Rodríguez-moreno josé Saúl Padilla-Ramírez Guillermo Medina-García Arturo Reyes-González Experimental Field Station “Pabellón” Km 32.5 highway Ags-Zac Pabellón de Arteaga Aguascalientes México Experimental Field Station “Zacatecas” Km 24.5 highway Zacatecas-Fresnillo Calera de Victor Rosales Zac. México Experimental Field Station “La Laguna” Boulevard José Santos Valdez 1200 Pte Matamoros Coahuila México

The leaf-response to three-soil applied treatments of Paclobutrazol (PBZ;1000, 2000 and 0 ppm-control) was studied in a high-density plantation of eight guava (Psidium guajava) genotypes trees. All materials were prunned in vase form, with two to three major branches, yearly prunning for triggering the annual production cycle, and average height of 2.0 m. The dataset comprises fourth radiometric indices highly related to plant physiological activities. The dataset model took into account data collection dates, guava genotypes, and the positional effect of sun radiation on leaves based on their proximity to the canopy level and downward to the base of the woody seasonal-branch. Unexpectedly, there were no significant differences (NS) in PBZ treatments for genotypes, leaf position and radiometric indices. Analysis of the radiometric indices data revealed that anthocyanin (ARI index) and chlorophyll (PRI index) have a strong inverse relationship. Significant differences (P ≤ 0.05) were found between guava genotypes, and anthocyanin content;these results show that guava genotypes have varied responses, which could derive in their classification based-on drought resistance or low water requirements, however, it is important to note that additional research is required to determine the scope of these indications.

关键词： Radiometric Indices PBZ Guava High-Density Plantation Climate Change

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天人相参与《难经》独取寸口的理论研究

天人相参与《难经》独取寸口的理论研究

作者：马努（manuel josé moreno González）北京中医药大学

学位级别：硕士

西班牙语是世界通用语言之一，是联合国6种工作语言之一。它是世界上使用国家最多的语言，有21个国家(欧洲1个，非洲1个，拉丁美洲19个)以西班牙语为官方语言，人口共计约有3亿5千2百万。此外，在美国西南各州和菲律宾还有数百万人讲西... 详细信息

西班牙语是世界通用语言之一，是联合国6种工作语言之一。它是世界上使用国家最多的语言，有21个国家(欧洲1个，非洲1个，拉丁美洲19个)以西班牙语为官方语言，人口共计约有3亿5千2百万。此外，在美国西南各州和菲律宾还有数百万人讲西班牙语。西班牙语的重要位置是毋庸质疑的。中国与西班牙和拉丁美洲之间的交往可以追溯到16世纪中期。当时中国商人和西班牙人在菲律宾群岛进行贸易，形成了一条中国-菲律宾-墨西哥的海上贸易之路，史称“太平洋丝绸之路”。近年以来，将中医的典籍翻译各国文字的国家开始增加。但到目前为止，西班牙语界之中医经典的翻译只出了几本。其中：两种《内经》，为从法文或英文转译过来;一种《内经》和一种《难经》，为综合多种英译本翻译而来，另一种版本的《内经》总共翻译了162篇中的42篇，而《难经》为从王洪图、烟建华《难经(白话本)》1988年的版本翻译而来。这些翻译著作起到了传播中医的作用，引起了许多外国学者对中医的兴趣，这些贡献是不可忽视的，但本人在考察这些著作的过程中，认为上述译本没有达到语言翻译的基本要求和特点及中医古汉语特点的原貌。为了使更多的外国学者对中医有比较正确的认识，能够更好的运用和研究中医，需要掌握更严格的翻译方法和完整的中医概念。为保持信息的可靠性，本人认为翻译原文的四个基本特点应为： * 语言清楚， * 句子简洁，简要， * 词汇准确，精确， * 符合中医特点。语言是随着民族文化的发展而产生的，因此，本人认为尊重民族语言，保持语言原貌，民族精神，先民思想等为翻译者不可不尊的原则。单词为语言交往的基本单位。为了澄清初步问题，词汇的精确性和准确性，木人在翻译《难经》的过程中无法避免一些概念的基本问题与研究。解决中医概念的基本问题就是解决中医关于生命的根本来源，变化与消亡的基本内容。由于各个时代的思想文化的差异、社会环境的变迁及疾病谱的改变，中医理论中出现了不同认识，探讨学派的思想文化根源，与其影响基本概念的形成和定义对中医学或某个著作的研究是非常有意义的。秦汉时代为统一国家，统一思想的一个非常重要的历史阶段。他不只统一这两个方面，还是统一度量衡，文字等，的一个关键阶段。因此统一文字与概念是在同一思想的基础上形成的，《难经》就在一个这样的统一思想的背景下产生的，可以视为一部阶段总结性的著作。为了进一步探讨《难经》的一些概念问题，本人想从当时文化背景的影响，去研究《难经》对一些思想与概念的认识和强调。无论在何种文化背景之下，一本著作的头一句话或头一个章节通常是整体思想的关键，我

关键词：独取寸口脉动肺朝百脉寅时寅月八风之邪

气候波动与土地利用变化对西班牙比利牛斯山脉中部径流影响的评价

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AMBIO－人类环境杂志 2003年第4期32卷 283-286页

作者： Santiago Beguería Juan I.López-moreno Adrián Lorente manuel Seeger josé M.García-Ruiz 闵庆文比利牛斯生态研究所大学地理学

在地中海国家扩大灌溉土地的面积,应当考虑气候与土地利用变化对水资源的影响。本文利用降水和温度资料,分析了20世纪中叶以来西班牙比利牛斯山脉中部流域径流的变化趋势。降水与径流之间关系的年变化表明,径流在所研完期间的后半时段... 详细信息

在地中海国家扩大灌溉土地的面积,应当考虑气候与土地利用变化对水资源的影响。本文利用降水和温度资料,分析了20世纪中叶以来西班牙比利牛斯山脉中部流域径流的变化趋势。降水与径流之间关系的年变化表明,径流在所研完期间的后半时段相对较低,这一趋势与土地利用变化一致。在月水平上,降水量在10月、4月和7月明显增加,而在3月则有下降:温度在1月和2月有所增加,而在4月则趋于下降。但过去50年间径流在大部分月份中呈显著下降趋势,土地利用和植被覆盖的变化是解释年平均径流下降大约30%的惟一非气候因素。

关键词：气候波动土地利用西班牙比利牛斯山脉径流植被覆盖

Prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma:Review and bibliometric

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iLIVER 2024年第1期3卷 52-61页

作者： Pamela Scarlett Espinoza Loyola Diana Laura Muratalla Bautista Karen Adela Hernández Bautista Elizabeth Gil White joséAntonio González moreno Daniel Angel Torres del Real Víctor manuel Páez Zayas Carla Escorza-Molina Fernando Mondragón Rodríguez Omar Vásquez Gómez Luis Jorge Fernández López Paul Santiago Mogrovejo Vázquez Isidoro Aczel Sánchez-Cedillo Víctor jose Visag Castillo Social Service Internship Universidad Nacional Autónoma de MéxicoMexico City 04510Mexico Social Service Internship Universidad AnahuacMexico City 04510Mexico Department of Surgery Division of Transplantation Surgery Hospital General de MéxicoMexico City 06720Mexico Departament of Gastroenterology Division of HepatologyHospital General de MéxicoMexico City 06720Mexico Departmanet of Anesthesiology Hospital General de MéxicoMexico City 06720Mexico

Hepatocellular carcinoma(HCC)is one of the most common cancers in the world and is one of the leading indications for liver transplantation,liver transplantation is the gold standard treatment for end stage liver *** is based up on radiological characteristics and rarely biopsy *** treatment must be individualized to each patient to improve recurrences and *** this article,we focus on the different selection criteria for liver *** study aimed to investigate the distribution laws and research frontiers of international literature,so as to present holistic bibliometric evaluation of the studies on 5-year survival and disease-free recurrence in 5 years,according to hepatocarcinoma criteria for liver *** paper aims to review and analyze 5-year survival and disease-free recurrence based on hepatocarcinoma criteria for liver *** systematically examines and summarizes distribution characteristics and research frontiers through bibliometric analysis.A bibliographic search was implemented in PubMed/Medline,Clinical Key,Science Direct and Index Medicus with MESH terms,from the year 1996–*** selected for transplantation using the Metroticket 2.0(MT2)criteria had the highest overall survival along with patients selected for transplantation using the Milan Criteria had the best 5-year disease-free *** Metroticket 2.0 criteria(MT2)and Milan Criteria(MC)have shown the most favorable post-transplant outcomes for patients with hepatocellular carcinoma(HCC).However,MC demonstrated the best 5-year disease-free recurrence rate,underscoring the significance of taking into account tumor morphology and biology when determining the eligibility of HCC patients for liver *** distribution characteristics and research frontiers by bibliometrics concerning prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma the collaboration

关键词： Hepatocellular carcinoma Liver transplantation Survival Criteria Recurrence Bibliometrics