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Journal of Sport and Health Science 2019年第1期8卷 23-31页

作者： Eduardo Aguera Salvador Castilla Evelio Luque ignacio Jimena ignacio Ruz-Caracuel Fernando Leiva-Cepas jos Pea Department of Neurology Maimonides Institute for Biomedical Research IMIBIC Reina Sofia University Hospital University of Cordoba Department of Critical Care and Emergency Reina Sofia University Hospital University of Cordoba Department of Morphological Sciences Section of Histology Faculty of Medicine and Nursing Maimonides Institute for Biomedical Research IMIBICReina Sofia University Hospital University of Cordoba

Purpose: The objective of the present study was to determine whether a denervated muscle extract(DmEx) could stimulate satellite cell response in denervated ***: Wistar rats were divided into 4 groups: normal rats, normal rats treated with DmEx, denervated rats, and denervated rats treated with DmEx. The soleus muscles were examined using immunohistochemical techniques for proliferating cell nuclear antigen, desmin, and myogenic differentiation antigen(MyoD), and electron microscopy was used for analysis of the satellite ***: The results indicate that while denervation causes activation of satellite cells, DmEx also induces myogenic differentiation of cells localized in the interstitial space and the formation of new muscle fibers. Although DmEx had a similar effect in nature on innervated and denervated muscles, this response was of greater magnitude in denervated vs. intact ***: Our study shows that treatment of denervated rats with DmEx potentiates the myogenic response in atrophic denervated muscles.

关键词： Muscle atrophy Muscle denervation Muscle extract Myogenic response Satellite cell Skeletal muscle

Sintering study of Ti6Al4V powders with different particle sizes and their mechanical properties

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International Journal of Minerals,Metallurgy and Materials 2018年第12期25卷 1389-1401页

作者： joséLuis Cabezas-Villa joséLemus-ruiz Didier Bouvard Omar Jiménez Héctor Javier Vergara-Hernández Luis Olmos University Michoacana of San Nicolás of Hidalgo IIMMMorelia 58060México University Grenoble Alpes CNRSSIMaPGrenoble 38000France University of Guadalajara Departamento de Ingeniería de ProyectosZapopan 45100México National Technological Institute of Mexico I.T.MoreliaMorelia 58120México University Michoacana of San Nicolás of Hidalgo INICITMorelia 58060México

Ti6Al4V powders with three different particle size distributions(0–20, 20–45, and 45–75 μm) were used to evaluate the effect of the particle size distribution on the solid-state sintering and their mechanical properties. The sintering kinetics was determined by dilatometry at temperatures from 900 to 1260°C. The mechanical properties of the sintered samples were evaluated by microhardness and compression tests. The sintering kinetics indicated that the predominant mechanism depends on the relative density irrespective of the particle size used. The mechanical properties of the sintered samples are adversely affected by increasing pore volume fraction. The elastic Young's modulus and yield stress follow a power law function of the relative density. The fracture behavior after compression is linked to the neck size developed during sintering, exhibiting two different mechanisms of failure: interparticle neck breaking and intergranular cracking in samples with relative densities below and above of 90%, respectively. The main conclusion is that relative density is responsible for the kinetics, mechanical properties, and failure behavior of Ti6 Al4 V powders.

关键词： Ti6Al4V powders dilatometry microhardness sintering kinetics compression failure behavior

Arecaceae fruits:Fatty acids,phenolic compounds and in vitro antitumor activity

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Food Bioscience 2022年第6期50卷 1966-1979页

作者： Abdallah Lahlou Tarik Chileh-Chelh Svetlana Lyashenko Miguel Ángel Rincón-Cervera ignacio Rodríguez-García Rosalía López-ruiz Miguel Urrestarazu joséLuis Guil-Guerrero Food Technology Division ceiA3CIAMBITALUniversity of Almería04120AlmeríaSpain Institute of Nutrition and Food Technology University of Chile7830490MaculSantiagoChile Organic Chemistry Division University of Almería04120AlmeríaSpain Chemical-Physical Department Analytical Chemistry of PollutantsUniversity of Almería04120AlmeríaSpain Production Vegetal División University of Almería04120AlmeríaSpain

Arecaceae fruits are regarded as raw sources of valuable *** this work,several Arecaceae fruits belonging to eleven taxa were screened for fatty acids(FA)by gas chromatography with flame ionization detector and checked for their in vitro antitumor activity against the HT-29 colorectal cancer cells line through the MTT *** parallel use of two chromatography systems,HPLC-DAD and LC-MS,allowed the precise characterization of all phenolic compounds contained in the *** belmoreana had the highest FA amounts(11.7 g/100 g on dry weight);Syagrus romanzoffiana had a relatively high PUFA content(26.3%of total FA);and Butia capitata contains high amounts of medium-chain saturated FA(51.2%).Total phenolics reached 201.8 mg/100 g on dry weight in Phoenix dactylifera *** phenolics,occurred benzoic acids,phenylpropanoic acid,and cinnamic acid *** highlights the great diversity of flavonoids detected as(−)-catechin,quercetin,and kaempferol,as well as phenolic glycosides,such as *** methanol:water(60:40,v/v)extracts of fruits induced dose-and time-dependent inhibitory effects on HT-29 cancer ***,the fruits of Arecaceae taxa evaluated here constitute suitable candidates to be used as functional foods.

关键词： Arecaceae fruits Livistona Phenolics Flavonoids Antitumor activity HT-29 cells

Potential of Nassarius nitidus for monitoring organotin pollution in the lagoon of Bizerta (northern Tunisia)

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Journal of Environmental Sciences 2011年第9期23卷 1551-1557页

作者： Youssef Lahbib Sami Abidli Pablo Rodríguez González josè ignacio Garía Alonso Najoua Trigui-El Menif Department of Biology Laboratory of Environment BiomonitoringGroup of Applied and Fundamental MalacologyFaculty of Sciences of BizertaUniversity of Carthage Department of Physical and Analytical Chemistry Faculty of ChemistryUniversity of Oviedo

Imposex and butyltin burden were assessed in Nassarius nitidus,Bolinus brandaris and Hexaplex trunculus collected at five stations in the Bizerta *** analysis showed that imposex followed type （a） in *** （distal evolution）,against type （d） in the two muricids （proximal evolution）.Imposex indices were higher in sites located nearby sources of tributyltin and *** was the least affected species of the five sites,followed by *** and *** analysis showed lower accumulation in *** followed by *** and *** study has allowed the gathering of data on imposex in a snail studied for the first time in Tunisia （***）.It suggests the possibility of using such snail as a complementary species for organotin monitoring programs in the Mediterranean and further confirmed that *** is the most suitable species for such investigations.

关键词： organotins bio-indicator North Africa

Estrogen and progesterone receptor isoforms expression in the stomach of Mongolian gerbils

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World Journal of Gastroenterology 2008年第37期14卷 5701-5706页

作者： Milena Saqui-Salces Teresa Neri-Gómez Armando Gamboa-Dominguez Guillermo ruiz-Palacios ignacio Camacho-Arroyo Facultad de Química Departamento de Biología Universidad Nacional Autónoma de MéxicoMéxico DF 04510 México Departamento de Patología INCMNSZMéxico DF14000 México Departamento de Infectología INCMNSZMéxico DF 14000 México

AIM: We studied the estrogen receptor (ER) and progesterone receptor (PR) isoforms expression in gastric antrum and corpus of female gerbils and their regulation by estradiol (E2) and progesterone (P4). METHODS: Ovariectomized adult female gerbils were subcutaneously treated with E2, and E2 + P4. Uteri and stomachs were removed, the latter were cut along the greater curvature, and antrum and corpus were excised. Proteins were immunoblotted using antibodies that recognize ER-alpha, ER-beta, and PR-A and PR-B receptor isoforms. Tissues from rats treated in the same way were used as controls. RESULTS: Specific bands were detected for ER-alpha (68 KDa), and PR isoforms (85 and 120 KDa for PR-A and PR-B isoforms, respectively) in uteri, gastric antrum and corpus. We could not detect ER-beta isoform. PR isoforms were not regulated by E2 or P4 in uterus and gastric tissues of gerbils. ER-alpha isoform content was significantly down-regulated by E2 in the corpus, but not affected by hormones in uterus and gastric antrum. CONCLUSION: The presence of ER-alpha and PR isoforms in gerbils stomach suggests that E2 and P4 actions in this organ are in part mediated by their nuclear receptors.

关键词： Estrogen receptor Progesterone receptor isoforms Gerbil Stomach Sex steroid hormones

Depth of closure:New calculation method based on sediment data

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International Journal of Sediment Research 2018年第2期33卷 198-207页

作者： Luis Aragonés jose ignacio Pagán Isabel López josé C.Serra Department of civil engineering University of Alicante Department of transportation ETSI Caminos Polytechnic University of Valencia

Obtaining depth of closure(DoC) in an accurate manner is a fundamental issue for coastal engineering,since good results for coastal structures and beach nourishment depend mainly on DoC. Currently, there are two methods for obtaining the DoC, mathematical formulations and profile surveys. However, these methods can incur important errors if one does not take into account the characteristics and morphology of the area, or if one does not have a sufficiently long time series. In this work the DoC is obtained from the break in the trend of the sediment with the depth, that is, in general with the increase of the depth a decrease in the size of the sediment takes place. However, at one point this tendency changes and the size increases, and then decreases again. When comparing the point where the minimum sediment size occurs before the increase, it is observed that the error incurred is small compared to other methods. If the Standard Deviation of Depth Change(SDDC) method is considered as the most accurate method, the error incurred by the proposed method is less than 7%. In addition, it can be seen that the dispersion of the sediment method always occurs outside the zone of bar movement. Whereas in the methods of profiles survey(using 2 cm precision profiles), sometimes the DoC is obtained within the active zone of bar movement. In addition, where the relative minimum of the median sediment size is found, and the sizes of 0.063 and 0.125 mm predominate in the composition of the sample. Therefore, this new method allows the precise location of the DoC to be obtained in a fast and simple way. Furthermore, this method has the advantage that it is not affected by the modifications that may be experienced by both the study area and the cross-shore beach profile.

关键词： Depth of Closure Median sediment size Profile surveys Profile change GIS

Fibrosing cholestatic hepatitis following cytotoxic chemotherapy for small-cell lung cancer

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World Journal of Gastroenterology 2009年第18期15卷 2290-2292页

作者： Jaime Ceballos-Viro josé M López-Picazo josé L Pérez-Gracia Jesús J Sola Gregorio Aisa ignacio Gil-Bazo Department of Oncology Clínica Universidad de NavarraPio XII 3631008 PamplonaSpain Department of Pathology Clínica Universidad de NavarraPio XII 3631008 PamplonaSpain

Fibrosing cholestatic hepatitis(FCH) is a variant of viral hepatitis reported in hepatitis B virus or hepatitis C virus infected liver,renal or bone transplantation recipients and in leukemia and lymphoma patients after conventional cytotoxic *** constitutes a well-described form of fulminant hepatitis having extensive fibrosis and severe cholestasis as its most characteristic pathological ***,we report a case of a 49-year-old patient diagnosed with small-cell lung cancer who developed this condition following conventional chemotherapy-induced *** is the first reported case in the literature of FCH after conventional chemotherapy for a solid *** addition to a detailed report of the case,a physiopathological examination of this potentially life-threatening condition and its treatment options are discussed.

关键词： Fibrosing cholestatic hepatitis Immunosuppression Chemotherapy Lung cancer Hepatitis Bvirus Lamivudine

Science Letters:Visual odometry for road vehicles—feasibility analysis

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 2017-2020页

作者： SOTELO Miguel-angel GARCíA Roberto PARRA ignacio FERNNDEZ David GAVILN Miguel LVAREZ Sergio NARANJO josé-eugenio Department of Electronics University of Alcalá Alcalá de Henares 28871 Spain Department of Informatics Industrial Automation Institute CSIC Madrid Spain

Estimating the global position of a road vehicle without using GPS is a challenge that many scientists look forward to solving in the near future. Normally, inertial and odometry sensors are used to complement GPS measures in an attempt to provide a means for maintaining vehicle odometry during GPS outage. Nonetheless, recent experiments have demonstrated that computer vision can also be used as a valuable source to provide what can be denoted as visual odometry. For this purpose, vehicle motion can be estimated using a non-linear, photogrametric approach based on RAndom SAmple Consensus (RANSAC). The results prove that the detection and selection of relevant feature points is a crucial factor in the global performance of the visual odometry algorithm. The key issues for further improvement are discussed in this letter.

关键词： 3D visual odometry Ego-motion estimation RAndom SAmple Consensus (RANSAC) Photogrametric approach

Fluoroquinolones for the treatment of latent Mycobacterium tuberculosis infection in liver transplantation

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World Journal of Gastroenterology 2019年第26期25卷 3291-3298页

作者： jose Tiago Silva Rafael San-Juan Mario Fernández-ruiz josé María Aguado Unit of Infectious Diseases Hospital Universitario "12 de Octubre" Instituto de Investigación Hospital "12 de Octubre" (imas12) School of Medicine Universidad Complutense

Solid organ transplantation(SOT)is the best treatment option for end-stage organ *** immunosuppressive agents have reduced the incidence of graft rejection but have increased the risk of infection,particularly due to the reactivation of latent infections due to opportunistic agents such as Mycobacterium *** tuberculosis(TB)after SOT is a significant cause of morbidity and *** cases of posttransplant TB are secondary to reactivation of latent tuberculosis infection(LTBI)due to the effects of long-term immunosuppressive *** minimization strategies have been developed to diagnose LTBI and initiate treatment prior to *** with vitamin B6 supplementation is the treatment of ***,liver transplantation(LT)candidates and recipients have an increased risk of isoniazid-induced liver toxicity,leading to lower treatment completion rates than in other SOT ***(FQs)exhibit good in vitro antimycobacterial activity and a lower risk of drug-induced liver injury than *** the present review,we highlight the disease burden posed by posttransplant TB and summarize the emerging clinical evidence supporting the use of FQs for the treatment of LTBI in LT recipients and candidates.

关键词： Fluoroquinolones Mycobacterium tuberculosis Latent tuberculosis infection Liver transplantation Drug-induced liver graft injury

Relationships between soil pollution by heavy metals and melanin-dependent coloration of a fossorial amphisbaenian reptile

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Integrative Zoology 2022年第4期17卷 596-607页

作者： joséMARTÍN Pablo RECIO Gonzalo RODRÍGUEZ-ruiz Isabel BARJA Eduardo GUTIÉRREZ Luis VGARCÍA Departamento de Ecología Evolutiva Museo Nacional de Ciencias NaturalesCSICMadridSpain Departamento de Zoología Facultad de BiologíaUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain Departamento de Biogeoquímica Ecología Vegetal y MicrobianaInstituto de Recursos Naturales y Agrobiología de SevillaCSICSevillaSpain

Melanin is the basis of coloration in many animals,and although it is often used in communication,thermoregulation,or camouflage,melanin has many other physiological *** example,in polluted habitats,melanin can have a detoxifying *** coloration would help to sequester in the skin the heavy metal contaminants from inside the body,which will be expelled to the exterior when the skin is ***,animals should have evolved more melanic colorations in more polluted habitats(“industrial melanism”hypothesis).We examined whether the fossorial amphisbaenian reptile,Trogonophis wiegmanni,is able to eliminate heavy metals,derived from soil pollution by seagull depositions,through sloughing its *** results suggest a covariation between levels of soil pollution by heavy metals and the concentration of heavy metals in the sloughed skins of *** suggests that amphisbaenians may expel heavy metals from their bodies when they slough the *** also tested whether amphisbaenians inhabiting soils with higher levels of heavy metal pollution had darker(melanin-dependent)body ***,contrary to predictions from the“industrial melanization”hypothesis,we found a negative relationship between soil pollution and proportions of melanic *** contradictory result could,however,be explained because heavy metals have endocrine disruption effects that increase physiological stress,and higher stress levels could result in decreased *** suggest that although amphisbaenians might have some detoxifying mechanism linked to melanin in the skin,this process might be negatively affected by stress and result ineffective under conditions of high soil pollution.

关键词： amphisbaenians coloration fossorial reptiles heavy metals melanin soil pollution