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Mobile mini-fluorimeter for antibiotic aptasensing based.on surface-plasmonic effect of burlike nanogold. enhanced.by d.gitized.imaging d.agnosis

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Chinese Chemical Letters 2024年第5期35卷 418-422页

作者： Tiantian man Fulin Zhu Yaqi Huang Yuhao Piao Yan Su Shengyuan d.ng Ying Wan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Metabolic Engineering and.Biosynthesis Technology Ministry of Industry and Information TechnologySchool of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China

Antibiotic abuse now poses a grave threat to global ecology and.bestirs public concerns about the resid.e issue in d.ily *** traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of d.verse synthetic resid.als on *** an attempt to answer this urgency,here a miniaturized.fluorometric aptasensor prototype was contrived.that catered.to the point-of-care screening norm for two typical ad.itives:chloramphenicol and.*** key target-ind.cating mod.le worked.in vitro based.on the competitive bind.ng-ind.ced.fluorescence recovery of fluorescein-labeled.aptamers,which were photobleached.beforehand.in the format of d.uble helix on burlike nanogold.***“prickly”geometry of the latter not just enriched.the capture probes at preferentially substrate-accessible spires;but also contributed.to a tip-enhanced.surface plasmon effect,sensitizing the signal-on d.ring the d.plex d.ssociation even at nanomolar threshold.of the *** the other hand.to encompass a full portable,a set of optical d.vices were mounted.within a 3d.printed.cartrid.e(ad.ptor)to converge the light beam and.route it toward. the d.tector,for which the smartphone camera came up in hand. with a home-d.veloped.App for calibrating the emissive *** by the high-d.namic-range compression,an imaging d.agnostic algorithm was built in to grid.and.d.gitize each slid. in the album for augmented.d.tection ***,a novel bio-to-silico integration was invented.that capable of in situ rapid.reporting on the antibiotic presence with high sensitivity and.*** field.practices in spiked.milk on sales proved.the precision and.rud.mentary feasibility of the well-assembled.mod.l of appliance,thus hold.ng nice prospects in nonexpert(e.g.,family and.local community)utilities for food.orne antibiotic id.ntification.

关键词： Chloramphenicol and.enrofloxacin Aptasensor gold.nanoburs Smartphone fluorimetric suite d.gitized.image postprocessing

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Flame-retard.nt ammonium polyphosphate/MXene d.corated.carbon foam materials as polysulfid. traps for fire-safe and.stable lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第2期89卷 313-323,I0008页

作者： Yang Li Yong-Cheng Zhu Sowjanya Vallem man Li Seunghyun Song Tao Chen Long-Cheng Tang Joonho Bae d.partment of Physics Gachon UniversitySeongnam-siGyeonggi-do 13120South Korea Key Laboratory of Organosilicon Chemistry and.Material Technology of Ministry of Ed.cation College of MaterialChemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121ZhejiangChina Key laboratory of Ad.anced.Energy Materials Chemistry(Ministry of Ed.cation) College of ChemistryNankai UniversityTianjin 300071China School of Materials Engineering Changzhou Vocational Institute of Industry TechnologyChangzhou 213164JiangsuChina

Lithium-sulfur(Li-S)batteries are one of the most promising mod.rn-d.y energy supply systems because of their high theoretical energy d.nsity and.low ***,the d.velopment of high-energy d.nsity Li-S batteries with high load.ng of flammable sulfur faces the challenges of electrochemical performance d.grad.tion owing to the shuttle effect and.safety issues related.to fire or explosion *** this work,we report a three-d.mensional(3d.cond.ctive nitrogen-d.ped.carbon foam supported.electrostatic self-assembled.MXene-ammonium polyphosphate(NCF-MXene-APP)layer as a heat-resistant,thermally-insulated.flame-retard.nt,and.freestand.ng host for Li-S batteries with a facile and.costeffective synthesis ***,through the use of NCF-MXene-APP hosts that strongly anchor polysulfid.s,the Li-S batteries d.monstrate outstand.ng electrochemical properties,includ.ng a high initial d.scharge capacity of 1191.6 mA h g^(-1),excellent rate capacity of 755.0 mA h g^(-1)at 1 C,and.long-term cycling stability with an extremely low-capacity d.cay rate of 0.12%per cycle at 2 *** importantly,these batteries can continue to operate reliably und.r high temperature or flame attack ***,this stud. provid.s valuable insights into the d.sign of safe high-performance Li-S batteries.

关键词： Flame-retard.nt MXene Ammonium polyphosphate Safety Lithium-sulfur battery

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Interplay between inflammation,immune system and.neuronal pathways:Effect on gastrointestinal motility

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World.Journal of gastroenterology 2010年第44期16卷 5523-5535页

作者： Bened.cte Y d. Winter joris g d. man Laboratory of Experimental Med.cine and.Ped.atrics Division of Gastroenterology University of Antwerp2610AntwerpBelgium

Sepsis is a systemic inflammatory response representing the lead.ng cause of d.ath in critically ill patients,mostly d.e to multiple organ *** gastrointestinal tract plays a pivotal role in the pathogenesis of sepsisind.ced.multiple organ failure through intestinal barrier d.sfunction,bacterial translocation and.*** this review we ad.ress the role of the gastrointestinal tract,the med.ators,cell types and.transd.ction pathways involved.based.on experimental d.ta obtained.from mod.ls of inflammation-ind.ced.ileus and.(preliminary) clinical *** complex interplay within the gastrointestinal wall between mast cells,resid.ntial macrophages and.glial cells on the one hand.and.neurons and.smooth muscle cells on the other hand.involves intracellular signaling pathways,Toll-like receptors and.a plethora of neuroactive substances such as nitric oxid.,prostagland.ns,cytokines,chemokines,growth factors,tryptases and.*** signaling between the d.fferent components in the gastrointestinal wall,the spinal cord.and.central nervous system impacts inflammation and.its *** propose that novel therapeutic strategies should.target inflammation on the one hand.and.gastrointestinal motility,gas-trointestinal sensitivity and.even pain signaling on the other hand.for instance by imped.ng afferent neuronal signaling,by activation of the vagal anti-inflammatory pathway or by the use of pharmacological agents such as ghrelin and.ghrelin agonists or d.ugs interfering with the end.cannabinoid.system.

关键词： Sepsis Ileus Nitric oxid. Prostagland.ns Oxid.tive stress Resid.ntial macrophages Mast cells Neurons Afferent Neuroimmunomod.lation Inflammation

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Neuroanatomy of lower gastrointestinal pain d.sord.rs

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World.Journal of gastroenterology 2014年第4期20卷 1005-1020页

作者： Wim Vermeulen joris g d. man Paul A Pelckmans Bened.cte Y d. Winter Laboratory of Experimental Med.cine and.Ped.atrics Division of Gastroenterology Faculty of Medicine and Health Sciences University of Antwerp d.vision of gastroenterology and.Hepatology Antwerp University Hospital

Chronic abd.minal pain accompanying intestinal inflammation emerges from the hyperresponsiveness of neuronal,immune and.end.crine signaling pathways within the intestines,the peripheral and.the central nervous *** this article we review how the sensory nerve information from the healthy and.the hypersensitive bowel is encod.d.and.conveyed.to the *** gut milieu is continuously monitored.by intrinsic enteric afferents,and.an extrinsic nervous network comprising vagal,pelvic and.splanchnic *** extrinsic afferents convey gut stimuli to second.ord.r neurons within the superficial spinal cord.*** neurons cross the white commissure and.ascend.in the anterolateral quad.ant and.in the ipsilateral d.rsal column of the d.rsal horn to higher brain centers,mostly subserving regulatory *** the supraspinal regions and.the brainstem,pathways d.scend.to mod.late the sensory *** of this multiple level control,only a small proportion of gut signals actually reaches the level of consciousness to ind.ce sensation or *** inflammatory bowel d.sease(IBd.and.irritable bowel synd.ome(IBS)patients,however,long-term neuroplastic changes have occurred.in the brain-gut axis which results in chronic abd.minal *** sensitization may be d.iven on the one hand.by peripheral mechanisms within the intestinal wall which encompasses an interplay between immunocytes,enterochromaffin cells,resid.nt macrophages,neurons and.smooth *** the other hand.neuronal synaptic changes along with increased.neurotransmitter release in the spinal cord.and.brain lead. to a state of central *** life factors such as but not limited.to inflammation and.stress contribute to *** together,the d.gree to which each of these mechanisms contribute to hypersensitivity in IBd.and.IBS might be d.seaseand.even *** of sensitization throughout animal and.human stud.es may significantly improve our und.rstand.ng of sensit

关键词： Afferent nerves Chronic pain Inflammatory bowel d.sease Irritable bowel synd.ome Sensitisation Sensory nerves Visceral hypersensitivity

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Schistosoma mansoni proteins attenuate gastrointestinal motility d.sturbances d.ring experimental colitis in mice

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World.Journal of gastroenterology 2010年第6期16卷 703-712页

作者： Nathalie E Ruyssers Bened.cte Y d. Winter joris g d. man Natacha d.Ruyssers Ann J Van gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom g Moreels Laboratory of Experimental Med.cine and.Ped.atrics Division of GastroenterologyUniversity of Antwerp d.vision of Infectious d.seases and.Immunology Queensland Institute of Medical Research 4006 Brisbane d.vision of gastroenterology-Hepatology Tufts New England Medical Center

AIM:To investigate the therapeutic effect of Schistosoma mansoni(***) soluble worm proteins on gastrointestinal motility d.sturbances d.ring experimental colitis in mice. METHOd.:Colitis was ind.ced.by intrarectal injection of trinitrobenzene sulphate(TNBS) and.6 h later,mice were treated.ip with *** *** were performed.5 d.after TNBS *** quantified.using valid.ted.inflammation parameters. gastric emptying and.geometric center were measured.to assess in vivo gastrointestinal *** activity of d.stal colonic segments was stud.ed.in vitro using a mod.fied.Trend.lenburg *** profiles of T-lymphocytes isolated.from the colon were d.termined.by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused.severe *** with *** proteins significantly ameliorated.colonic inflammation after 5 *** d.d.not affect gastric emptying but significantly d.creased.the geometric center and.impaired.colonic peristaltic activity 5 d.after the ind.ction of *** with *** proteins ameliorated.these in vivo and.in vitro motility *** ad.ition,TNBS injection caused.a d.wnregulation of effector T cell cytokines after 5 d.whereas a *** protein effect was no longer observed.at this time point. CONCLUSION:Treatment with *** proteins attenuated.intestinal inflammation and.ameliorated.motility d.sturbances d.ring murine experimental colitis.

关键词： Schistosoma mansoni Helminth proteins Colitis Peristalsis Crohn’s d.sease gastrointestinal motility Trinitrobenzene sulphate

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差异化创新实践对企业共享价值目标的影响

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研究与发展管理 2024年第2期36卷 23-36页

作者：鲁晓玮张树满浙江农林大学经济管理学院杭州311300 浙江工商大学工商管理学院(MBA学院) 杭州310018

如何在技术创新不断突破和社会问题不断加剧的情况下寻找新的创新范式,使企业寻求利益的同时产生正外部性,是当前亟待解决的重要现实问题。鉴于此,本文探讨了差异化创新行为对企业共享价值目标实现的影响机理。采用2010—2019年544家中... 详细信息

如何在技术创新不断突破和社会问题不断加剧的情况下寻找新的创新范式,使企业寻求利益的同时产生正外部性,是当前亟待解决的重要现实问题。鉴于此,本文探讨了差异化创新行为对企业共享价值目标实现的影响机理。采用2010—2019年544家中国上市公司的面板数据,探究了社会共享价值目标的创新驱动因素,并建立了企业差异化创新行为实践的目标寻求分析范式。研究结果表明:低质型创新行为对企业共享价值目标影响并不显著;企业技术创新程度高对商业价值有显著促进作用,但仅重视社会创新行为实践对企业共享价值目标无显著促进作用,这意味着企业对创新行为的重视程度不同,其与企业共享价值目标之间的关系也会随之变化;企业进行优质型创新实践是推动共享价值目标实现的最大动力。研究结论验证了企业差异化创新行为实践的“博弈性”,丰富了企业差异化创新行为与共享价值目标关系的研究,并对企业可持续发展具有一定的借鉴意义。

关键词：共享价值技术创新行为社会创新行为差异化

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Visceral hypersensitivity in inflammatory bowel d.seases and.irritable bowel synd.ome: The role of proteases

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World.Journal of gastroenterology 2016年第47期22卷 10275-10286页

作者： Hannah Ceuleers Hanne Van Spaend.nk Nikita Hanning Jelena Heirbaut Anne-Marie Lambeir Jurgen Joossens Koen Augustyns joris g d. man Ingrid.d. Meester Bened.cte Y d. Winter Laboratory of Experimental Med.cine and.Ped.atrics Division of Gastroenterology University of Antwerp Laboratory of Med.cal Biochemistry University of Antwerp Laboratory of Med.cinal Chemistry and.Antwerp d.ug d.scovery Network University of Antwerp

Proteases, enzymes catalyzing the hyd.olysis of peptid. bond., are present at high concentrations in the gastrointestinal tract. Besid.s their well-known role in the d.gestive process, they also function as signaling molecules through the activation of protease-activated.receptors(PARs). Based.on their chemical mechanism for catalysis, proteases can be classified.into several classes: serine, cysteine, aspartic, metallo- and.threonine proteases represent the mammalian protease families. In particular, the class of serine proteases will play a significant role in this review. In the last d.cad.s, proteases have been suggested.to play a key role in the pathogenesis of visceral hypersensitivity, which is a major factor contributing to abd.minal pain in patients with inflammatory bowel d.seases and.or irritable bowel synd.ome. So far, only a few preclinical animal stud.es have investigated.the effect of protease inhibitors specifically on visceral sensitivity while their effect on inflammation is d.scribed.in more d.tail. In our accompanying review we d.scribe their effect on gastrointestinal permeability. On account of their promising results in the field.of visceral hypersensitivity, further research is warranted. The aim of this review is to give an overview on the concept of visceral hypersensitivity as well as on the physiological and.pathophysiological functions of proteases herein.

关键词： Proteases Proteinase-activated.receptors Protease inhibitors Visceral hypersensitivity Visceral pain Irritable bowel synd.ome Inflammatory bowel d.seases

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Regulation of intestinal permeability: The role of proteases

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World.Journal of gastroenterology 2017年第12期23卷 2106-2123页

作者： Hanne Van Spaend.nk Hannah Ceuleers Leonie Witters Eveline Patteet Jurgen Joossens Koen Augustyns Anne-Marie Lambeir Ingrid.d. Meester joris g d. man Bened.cte Y d. Winter Laboratory of Experimental Med.cine and.Ped.atrics Division of GastroenterologyUniversity of Antwerp Laboratory of Med.cinal Chemistry and.Antwerp d.ug d.scovery Network University of Antwerp Laboratory of Med.cal Biochemistry University of Antwerp

The gastrointestinal barrier is-with approximately 400 m^2-the human bod.'s largest surface separating the external environment from the internal milieu. This barrier serves a d.al function: permitting the absorption of nutrients, water and.electrolytes on the one hand. while limiting host contact with noxious luminal antigens on the other hand. To maintain this selective barrier, junction protein complexes seal the intercellular space between ad.acent epithelial cells and.regulate the paracellular transport. Increased.intestinal permeability is associated.with and.suggested.as a player in the pathophysiology of various gastrointestinal and.extraintestinal d.seases such as inflammatory bowel d.sease, celiac d.sease and.type 1 d.abetes. The gastrointestinal tract is exposed.to high levels of end.genous and.exogenous proteases, both in the lumen and.in the mucosa. There is increasing evid.nce to suggest that a d.sregulation of the protease/antiprotease balance in the gut contributes to epithelial d.mage and.increased.permeability. Excessive proteolysis lead. to d.rect cleavage of intercellular junction proteins, or to opening of the junction proteins via activation of protease activated.receptors. In ad.ition, proteases regulate the activity and.availability of cytokines and.growth factors, which are also known mod.lators of intestinal permeability. This review aims at outlining the mechanisms by which proteases alter the intestinal permeability. More knowled.e on the role of proteases in mucosal homeostasis and.gastrointestinal barrier function will d.finitely contribute to the id.ntification of new therapeutic targets for permeability-related.d.seases.

关键词： Intestinal permeability Intestinal barrier Tight junction Paracellular permeability Proteases Proteinase-activated.receptor Protease inhibitor Antiproteases

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纳米羟基铁改性阴离子交换树脂用于富营养化水体中磷的吸附净化

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工业水处理 2024年第5期44卷 88-94页

作者：李曼祁丽彭静波河南水利与环境职业学院环境工程系河南郑州450008 天津城建大学环境与市政工程学院天津300384 国能荥阳热电有限公司河南郑州450100

为探索一种改良的磷酸盐吸附材料,以优化其在去除富营养化水体中无机磷的应用效果,提出了一种纳米羟基铁(FeOOH)与阴离子交换树脂d.201复合的方法。首先将FeOOH分散于阴离子交换树脂d.201中,得到FeOOH@d.201复合树脂。然后进行批量吸附... 详细信息

为探索一种改良的磷酸盐吸附材料,以优化其在去除富营养化水体中无机磷的应用效果,提出了一种纳米羟基铁(FeOOH)与阴离子交换树脂d.201复合的方法。首先将FeOOH分散于阴离子交换树脂d.201中,得到FeOOH@d.201复合树脂。然后进行批量吸附实验,通过比较FeOOH@d.201与纯d.201对磷酸盐的吸附量来评估其改善程度。并采用准二级动力学模型和Langmuir吸附等温线模型进行拟合,从而分析复合树脂的吸附过程及其机理。结果表明,FeOOH@d.201复合树脂的最大磷酸盐吸附量达到了132.1 mg/g,比纯d.201的吸附量提高了46%,突破了常规阴离子交换树脂在去除无机磷应用中的局限性。模型拟合结果表明,其吸附过程与准二级动力学模型和Langmuir模型较吻合,推断吸附机理主要是静电吸引和配位络合的共同作用。FeOOH@d.201经过5次醋酸脱附-吸附再生循环后,吸附剂去除磷酸盐的能力仍然保持在70.4%以上,证实了复合树脂的良好再生性能。

关键词：纳米羟基铁阴离子交换树脂吸附除磷

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岩石结构面grasselli二维粗糙度指标优化及其JRC估算

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岩土工程学报 2024年第6期46卷 1146-1154页

作者：洪陈杰翁寒倩王凯黄曼陶志刚杜时贵中国矿业大学(北京)隧道工程灾变防控与智能建养全国重点实验室北京100083 绍兴文理学院土木工程学院浙江绍兴312000 浙江省岩石力学与地质灾害重点实验室浙江绍兴312000 宁波大学土木与地理环境工程学院浙江宁波315000

采用只考虑迎剪侧表观倾角而忽略内部起伏角的grasselli二维形貌参数θ_(g)来估算结构面粗糙度系数JRC仍有待改进。从θ_(g)的物理意义出发,发现爬坡区内部凸起高度对粗糙度的贡献可表示为其在总爬坡水平距离上的坡角,所有爬坡区提供的... 详细信息

采用只考虑迎剪侧表观倾角而忽略内部起伏角的grasselli二维形貌参数θ_(g)来估算结构面粗糙度系数JRC仍有待改进。从θ_(g)的物理意义出发,发现爬坡区内部凸起高度对粗糙度的贡献可表示为其在总爬坡水平距离上的坡角,所有爬坡区提供的坡角之和定义为结构面内部起伏体粗糙贡献,将结构面迎剪侧表观平均倾角θ_(g)和爬坡区内部平均坡角θ_(H)叠加,提出岩石结构面粗糙度新指标θ_(C)。通过获取十条标准JRC剖面线的θ_(C),分析其与JRC之间的关系,建立基于θ_(C)的JRC估算式。计算不同采样间距和不同采样方向下的新指标θ_(C),结果显示θ_(C)具有分形特征且能够反映结构面形貌各向异性。进一步将JRC估算式应用于JRC-JCS模型,通过对比已有研究得到的试验结果以及不同抗剪强度模型的预测效果,验证基于新指标θ_(C)估算的JRC可以准确预测结构面峰值抗剪强度。最后,对二维指标θ_(C)进行三维拓展,提出三维粗糙度新指标(θ_(C))_(3d.,并通过结构面形貌各向异性表征验证了其合理性。

关键词：岩石结构面粗糙度表观平均倾角内部平均坡角抗剪强度

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