Interplay between inflammation,immune system and neuronal pathways:Effect on gastrointestinal motility

作     者：Benedicte Y De Winter Joris G De Man 

作者机构：Laboratory of Experimental Medicine and PediatricsDivision of Gastroenterology University of Antwerp2610AntwerpBelgium 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第44期

页      面：5523-5535页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Sepsis Ileus Nitric oxide Prostaglandins Oxidative stress Residential macrophages Mast cells Neurons Afferent Neuroimmunomodulation Inflammation 

摘      要：Sepsis is a systemic inflammatory response representing the leading cause of death in critically ill patients,mostly due to multiple organ *** gastrointestinal tract plays a pivotal role in the pathogenesis of sepsisinduced multiple organ failure through intestinal barrier dysfunction,bacterial translocation and *** this review we address the role of the gastrointestinal tract,the mediators,cell types and transduction pathways involved,based on experimental data obtained from models of inflammation-induced ileus and (preliminary) clinical *** complex interplay within the gastrointestinal wall between mast cells,residential macrophages and glial cells on the one hand,and neurons and smooth muscle cells on the other hand,involves intracellular signaling pathways,Toll-like receptors and a plethora of neuroactive substances such as nitric oxide,prostaglandins,cytokines,chemokines,growth factors,tryptases and *** signaling between the different components in the gastrointestinal wall,the spinal cord and central nervous system impacts inflammation and its *** propose that novel therapeutic strategies should target inflammation on the one hand and gastrointestinal motility,gas-trointestinal sensitivity and even pain signaling on the other hand,for instance by impeding afferent neuronal signaling,by activation of the vagal anti-inflammatory pathway or by the use of pharmacological agents such as ghrelin and ghrelin agonists or drugs interfering with the endocannabinoid system.