检索结果-南通市图书馆

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

引用

Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Generating oligodendroglia from adult mesenchymal cells for transplantation:cell reprogramming or direct lineage conversion?

引用

Neural Regeneration Research 2023年第7期18卷 1493-1494页

作者： jorge Pascual-gue.ra JoséA.rodrígue.-Navarro Carlos L.Paíno Service of Neurobiology-Research Ramón y Cajal University Hospital-IRYCISMadridSpain Department of Cellular Biology Complutense UniversityMadridSpain

Cell replacement therapy has long been proposed as a treatment for the damaged nervous *** of the most challenging aspects of such a strategy,however,is finding sources of donor cells for *** neural cells are rarely an option as every cell in the nervous system has a defined function that would be lost if that cell was to be *** possibility would be sourcing precursor or differentiated cells from fetal tissues;however,aside from ethical issues,heterologous cells are at risk of immunological rejection in the long *** improvements over the past 15 years have led to the possibility that autologous non-neural cells could be used for cell transplantation through their conversion into neural derivatives.

关键词： neural programming removed

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inferior vena cava filter misplacement with svC perforation

引用

Journal of Interventional Medicine 2023年第3期6卷 140-142页

作者： Alexis Eliseo Santos rodrígue. jorge Lopera Civil Hospital of Morelia Dr.Migue. Silva Mexico The University of Texas Health Science Center at San Antonio USA

*** The use of inferior vena cava(IVC)filters had been increasingly growing in the last few *** Food and Drug Administration(FDA)approved the use of retrieval filters,so they can be removed once the risk of venous thromboembolism has *** commits the interventional radiologist in knowing the retrieval techniques and how to manage a complex retrieval process,even though the retrieval rates remain significantlylow.

关键词： removed retrieval vena

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of vaccine rollout strategies for emerging infectious diseases:A model-based approach including protection attitudes

引用

Infectious Disease Modelling 2023年第4期8卷 1032-1049页

作者： Mauricio Paton Juan M.Acuna jorge.rodrígue. Department of Chemical Engineering College of EngineeringKhalifa UniversitySAN Campus PO Box 127788Abu DhabiUnited Arab Emirates Department of Epidemiology and Public Health College of Medicine.Khalifa UniversityPO Box 127788Abu DhabiUnited Arab Emirates

Vaccine allocation strategies become crucial during vaccine shortages,especially in the face of potential outbreaks of new infectious diseases,as witnessed during the COVID-19 *** address this,a specialized compartmental model is created,which simulates an emerging infectious disease similar to *** model divides the population into different age groups and is used to compare various vaccine prioritisation approaches,aiming to minimize the total number of *** model is an improvement upon previous ones as it incorporates essential behavioural factors and is adapted to account for the protective effects of vaccination against both disease infection and *** takes into account human behaviors such as mask-wearing and social distancing by utilizing specific parameters related to self-protection,awareness levels,and the frequency of daily person-to-person interactions within each age ***,a novel method for dynamic vaccine prioritisation was introduced in this *** approach is model-independent and relies on the dynamic R *** is the first time such a method has been developed,offering a decision-making approach that is not tied to any specific *** innovation provides a flexible and adaptable strategy for determining vaccine priorities based on real-time data and the current state of the *** findings reveal crucial insights into vaccine allocation *** the daily rollout rates are fast(0.75%or higher)and children are eligible for vaccination,prioritising groups with high daily person-to-person interactions can lead to substantial reductions in total fatalities(up to approximately 40%lower).On the other hand,if rollout rates are slower and overall vaccination coverage is high,focusing on vaccinating elders emerges as the most effective strategy,resulting in up to approximately 10%fewer ***,the scenario changes significantly when children are not eligible for vaccination

关键词： behaviour slower utilizing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Variable exponent Hardy spaces associated with discrete Laplacians on graphs

引用

Science China Mathematics 2019年第1期62卷 73-124页

作者： Víctor Almeida jorge J.Betancor AlejANDro J.Castro Lourdes rodrígue.-Mesa Departamento de Análisis Matemático Universidad de La Laguna Department of Mathematics Nazarbayev University

In this paper we develop the theory of variable exponent Hardy spaces associated with discrete Laplacians on infinite graphs. Our Hardy spaces are defined by square integrals, atomic and molecular decompositions. Also we study boundedness properties of Littlewood-Paley functions, Riesz transforms, and spectral multipliers for discrete Laplacians on variable exponent Hardy spaces.

关键词： graphs discrete Laplacian Hardy spaces variable exponent square functions spectral multipliers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Grey Wolf Optimization Based Tuning of Terminal Sliding Mode Controllers for a Quadrotor

引用

Computers, Materials & Continua 2021年第8期68卷 2265-2282页

作者： Rabii Fessi Hegazy Rezk Soufiene Bouallègue Research Laboratory in Automatic Control(LARA) National Engineering School of Tunis(ENIT)University of Tunis EL MANARTunis1002Tunisia College of Engineering at Wadi Addawaser Prince Sattam Bin Abdulaziz UniversityAl-Kharj11911Saudi Arabia Department of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61517Egypt High Institute of Industrial Systems of Gabès(ISSIG) University of GabèsGabès6011Tunisia

The research on Unmanned Aerial Vehicles(UAV)has intensified considerably thanks to the recent growth in the fields of advanced automatic control,artificial intelligence,and *** this paper,a Grey Wolf Optimization(GWO)algorithm is proposed and successfully applied to tune all effective parameters of Fast Terminal Sliding Mode(FTSM)controllers for a quadrotor UAV.A full control scheme is first established to deal with the coupled and underactuated dynamics of the *** for altitude,attitude,and position dynamics become separately designed and *** work around the repetitive and time-consuming trial-error-based procedures,all FTSM controllers’parameters for only altitude and attitude dynamics are systematically tuned thanks to the proposed GWO *** a hard and complex tuning task is formulated as a nonlinear optimization problem under operational *** performance and robustness of the GWO-based control strategy are compared to those based on homologous metaheuristics and standard terminal sliding mode *** simulations are carried out to show the effectiveness and superiority of the proposed GWO-tuned FTSM controllers for the altitude and attitude dynamics’stabilization and *** statistical analyses revealed that the GWO algorithm is more competitive with high performance in terms of fastness,non-premature convergence,and research exploration/exploitation capabilities.

关键词： Quadrotor cascade control fast terminal sliding mode control grey wolf optimizer nonparametric Friedman analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improving automatic climate control with decision support techniques to minimize disease effects in greenhouse tomatoes

引用

Information Processing in Agriculture 2017年第1期4卷 50-63页

作者： Joaquın Canadas jorge Antonio Sanchez-Molina Francisco rodrıgue. Isabel Marıa del Aguila Department of Informatics University of Almerı´a04120 Almerı´aSpain The Agrifood Campus of International Excellence(ceiA3)Spain

Crop growth in greenhouses is basically determined by the climate variables in the environment and by the amounts of water and fertilizers supplied by *** management of these factors depends on the expertise of agricultural technicians and farmers,usually assisted by control systems installed within the *** this context,decision support features enable us to incorporate invaluable human experience so thatwe can take quick and effective decisions to ensure efficient crop *** work describes a real-time decision support system for greenhouse tomatoes that supports decisions at three stages–the supervision stage identifies climate sensor faults,the control stage maintains climate variables at setpoints,and the strategic stage identifies diseases affecting the crop and changes climate variables accordingly to minimize *** DSS was implemented by integrating a real-time rule-based tool into the control *** results show that the system increases climate control effectiveness,while providing support in preventing diseaseswhich are difficult to *** system was tested by simulating the appearance of the disease and observing the real *** main contribution has been to demonstrate that production rules,which aremature and well-known in the artificial intelligence domain,can act as a shared technology for the whole *** means that fault detection,temperature control and disease monitoring features are not dealt with in isolation.

关键词： Greenhouse crop growth Decision support systems Climate control Disease management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Control Strategy for a Quadrotor Based on a Memetic Shuffled Frog Leaping Algorithm

引用

Computers, Materials & Continua 2021年第6期67卷 4081-4100页

作者： Nour Ben Ammar Hegazy Rezk Soufiene Bouallègue Research Laboratory in Automatic Control(LARA) National Engineering School of Tunis(ENIT)University of Tunis EL MANARLe BelvédèreTunis1002Tunisia College of Engineering at Wadi Addawaser Prince Sattam Bin Abdulaziz UniversityAl-Kharj11911Saudi Arabia Department of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61517Egypt High Institute of Industrial Systems of Gabès(ISSIG) University of GabèsGabès6011Tunisia

This work presents a memetic Shuffled Frog Leaping Algorithm(SFLA)based tuning approach of an Integral Sliding Mode Controller(ISMC)for a quadrotor type of Unmanned Aerial Vehicles(UAV).Based on the Newton–Euler formalism,a nonlinear dynamic model of the studied quadrotor is firstly established for control design *** the main parameters of the ISMC design are the gains of the sliding surfaces and signum functions of the switching control law,which are usually selected by repetitive and time-consuming trials-errors based procedures,a constrained optimization problem is formulated for the systematically tuning of these unknown *** time-domain operating constraints,such an optimization-based tuning problem is effectively solved using the proposed SFLA metaheuristic with an empirical comparison to other evolutionary computation-and swarm intelligence-based algorithms such as the Crow Search Algorithm(CSA),Fractional Particle Swarm Optimization Memetic Algorithm(FPSOMA),Ant Bee Colony(ABC)and Harmony Search Algorithm(HSA).Numerical experiments are carried out for various sets of algorithms’parameters to achieve optimal gains of the sliding mode controllers for the altitude and attitude dynamics *** studies revealed that the SFLA is a competitive and easily implemented algorithm with high performance in terms of robustness and non-premature *** results verified that the proposed metaheuristicsbased approach is a promising alternative for the systematic tuning of the effective design parameters in the integral sliding mode control framework.

关键词： Quadrotor modeling integral sliding mode control gains tuning advanced metaheuristics memetic algorithms shuffled frog leaping algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relativistic charged stellar modeling with a perfect fluid sphere

引用

Communications in Theoretical Physics 2023年第9期75卷 113-121页

作者： Joaquin Estevez-Delgado Joel Arturo rodrígue. Ceballos jorge Mauricio Paulin-Fuentes JoséVega Cabrera Antonio Rendón Romero Facultad de Ciencias Físico Matemáticas de la Universidad Michoacana de San Nicolás de Hidalgo Edificio BCiudad UniversitariaMorelia MichoacánCP 58040Mexico Facultad de Químico Farmacobiología de la Universidad Michoacana de San Nicolás de Hidalgo Tzintzuntzan No.173Col.MatamorosMorelia MichoacánC.P.58240Mexico División Académica de Ciencias Básicas de la Universidad Juárez Autónoma de Tabasco Carretera Cunduacán-Jalpa Km.1Col.La Esmeralda86690CunduacánTabascoMexico Facultad de Ingenieria Mecanica de la Universidad Michoacana de San Nicolás de Hidalgo Edificio W Ciudad UniversitariaCP 58030Morelia MichoacánMexico

In this report we present the generalization of a solution to Einstein's equations with perfect fluid for the case of Einstein–Maxwell with perfect *** effect of the charge is reflected by a parameter,ν,and its interval is determined by the positivity condition from the pressure in the interior of the *** is shown that the solution is stable according to the Zeldovich criteria as well as in relation to the criteria of the adiabatic *** compactness,u=GM/c^(2)R,of this charged model is greater than it is for the chargeless case as a result of the effect of the presence of the *** allows it to represent stars with a high compactness,in particular a graphic analysis is presented for the star SAX J1808.4-3658 with mass M=1.435M_(⊙)and radius R=7.07 *** these data and employing the solution,we obtain that the total maximum charge for the star is Q=2.4085×10^(20)C.

关键词： general relativity exact solutions charged fluid stars models

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-Canonical Functions of the E2F/DP Pathway with Emphasis in Plants

引用

Phyton-International Journal of Experimental Botany 2021年第2期90卷 307-330页

作者： Víctor A.Sánchez-Camargo Samantha Romero-rodrígue. jorge M.Vázquez-Ramos Facultad de Química Departamento de BioquímicaUniversidad Nacional Autónoma de MéxicoAvenida Universidad y CopilcoCiudad de México04510México Plant Development and(Epi)Genetics Group Swammerdam Institute for Life SciencesUniversiteit van AmsterdamAmsterdam1098XHNetherlands

The E2F/DP pathway is a widely conserved regulatory mechanism in pluricellular *** family of E2F and DP transcription factors was originally described having a role in the transition from the G1 to the S phase of the cell ***,the discovery of hundreds of possible gene targets and their involvement in many other biochemical processes,soon showed that they participated in cell development and differentiation,chromatin remodeling,DNA repair and *** E2F/DP transcription factors can act as either activators or repressors of transcription depending on their association to other regulatory proteins,particularly the retinoblastoma protein,or even depending to their protein structure that can define their *** plants the E2F/DP pathway also regulates endoreduplication,a process present along the life cycle,from organ elongation to root differentiation and *** transcription factors also help plant cells to respond to environmental disturbances such as those caused by different types of radiation,or by *** review focuses on the“so called”non-canonical functions of the E2F/DP family proteins in animal and plant cells,that are in fact essential activities that connect regulatory circuits among multiple metabolic pathways by means of their atypical functions.

关键词： E2F DP transcription factors atypical functions plant cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：