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Channel Flows in Plate Heat Exchangers with the Aid of Particle Tracking Velocimetry

Open Journal of Fluid Dynamics 2024年第3期14卷 163-183页

作者： Felipe José dos Santos Leonel Edward Beckedorff Kleber Vieira de Paiva jorge luiz goes.oliveira PETROBRASPetrleo Brasileiro S.A. Rio de Janeiro Brazil Institute of Fluid Mechanics and Heat Transfer Technische Universitt Wien Vienna Austria Department of Mobility Engineering Federal University of Santa Catarina Joinville Brazil

Channel flows of Plate Heat Exchangers (PHEs) were assessed by experiments with three different chevron angle arrangements in turbulent regime. Two chevron angles were selected to assess low and high pressure drop channels, besides a third mixed configuration as to achieve in-between results regarding hydraulic performance. Friction factor correlations were provided with the channel Reynolds number ranging from 1175 to 8325. Two-dimensional (2D) mean velocity field was obtained by Particle Tracking Velocimetry (PTV) with Reynolds number equal to 3450. To the best of our knowledge, this is the first experimental study that quantified the complete 2D velocity field of a typical PHE channel. This value allowed comparison with literature results of Plate and Shell Heat Exchanger (PSHE) channels with the same Reynolds number. PSHE mean velocity field is highly heterogeneous as compared to the one obtained for PHE channels. Peak velocity magnitude in the PSHE center is 50% higher than its bulk velocity, whereas this value is only 15% higher in the PHE center. Pressure drop in PHE mixed channels cannot be approximated by averaging chevron angles: furrow flow prevailed in the specified conditions. The axial velocity is asymmetric regarding the vertical plane. Smooth streamlines prevail in the channel inlet. Recirculation zones at the channel exit affect pipe flow in the manifold outlet with swirling flow structures. The necessary length to obtain fully developed pipe flow at the channel outlet was estimated. Significant velocity components occur in the distribution areas and can limit the heat exchanger performance. The results reported herein are essential to understand how the PHE channel geometry affects the velocity field and, therefore, local heat transfer and dissipation processes.

关键词： PHE PTV PSHE Friction Factor Chevron

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MicroRNAs in inflammatory bowel disease:What do we know and what can we expect?

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World Journal of Gastroenterology 2024年第16期30卷 2184-2190页

作者： Ellen Cristina Souza de oliveira Ana Elisa Valencise Quaglio Thais Gagno Grillo luiz Claudio Di Stasi Ligia Yukie Sassaki Department of Internal Medicine Medical SchoolSão Paulo State University(Unesp)Botucatu 18618-686São PauloBrazil Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State University(Unesp)Botucatu 18618-689São PauloBrazil

MicroRNAs(miRNAs),small non-coding RNAs composed of 18–24 nucleotides,are potent regulators of gene expression,contributing to the regulation of more than 30%of protein-coding *** that miRNAs are regulators of inflammatory pathways and the differentiation of intestinal epithelial cells,there is an interest in exploring their importance in inflammatory bowel disease(IBD).IBD is a chronic and multifactorial disease of the gastrointestinal tract;the main forms are Crohn's disease and ulcerative *** studies have investigated the dysregulated expression of miRNAs in IBD,demonstrating their important roles as regulators and potential biomarkers of this *** editorial presents what is known and what is expected regarding miRNAs in *** the important regulatory roles of miRNAs in IBD are clearly established,biomarkers for IBD that can be applied in clinical practice are lacking,emphasizing the importance of further *** regarding the influence of miRNAs on the inflammatory process and the exploration of their role in gene regulation are expected to provide a basis for the use of miRNAs not only as potent biomarkers in IBD but also as therapeutic targets for the control of inflammatory processes in personalized medicine.

关键词： MicroRNAs Inflammatory bowel disease Crohn’s disease Ulcerative colitis Biomarker Therapy

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Mindfulness training in medical education as a means to improve resilience,empathy,and mental health in the medical profession

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World Journal of Psychiatry 2024年第4期14卷 489-493页

作者： Edison Iglesias de oliveira Vidal luiz Fernando Alvarenga Ribeiro Marco Antonio de Carvalho-Filho Fernanda Bono Fukushima Internal Medicine Department Botucatu Medical SchoolSao Paulo State University(UNESP)Botucatu 18618-687SPBrazil Wenckebach Institute for Education and Training LEARN-Lifelong LearningEducation and Assessment Research NetworkUniversity Medical Center GroningenGroningen 9713AVGroningenNetherlands Assertiva Mindfulness Botucatu 18603-970SPBrazil Surgical Specialties and Anesthesiology Department Botucatu Medical SchoolSão Paulo State University(UNESP)Botucatu 18618-687SPBrazil

The high rates of depression,burnout,and increased risk of suicide among medical students,residents,and physicians in comparison with other careers signal a mental health crisis within our *** contend that this crisis coupled with the inadequate acquisition of interpersonal skills during medical education results from the interaction between a challenging environment and the mental capital of ***,we posit that mindfulness-based practices are instrumental for the development of major components of mental capital,such as resilience,flexibility of mind,and learning skills,while also serving as a pathway to enhance empathy,compassion,self-awareness,conflict resolution,and relational ***,the evidence base supporting the effectiveness of mindfulness-based interventions has been increasing over the years,and a growing number of medical schools have already integrated mindfulness into their *** we acknowledge that mindfulness is not a panacea for all educational and mental health problems in this field,we argue that there is currently an unprecedented opportunity to gather momentum,spread and study mindfulness-based programs in medical schools around the world as a way to address some longstanding shortcomings of the medical profession and the health and educational systems upon which it is rooted.

关键词： Mindfulness Medical education Mental capital Mental health Medical students Resilience

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Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel oliveira Carlos Roberto jorge Soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia luiz Felipe S. Teixeira Maria Helena Marumo Bellini Natanael Gomes da Silva luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

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Dehydrated Natural Feed for Cats: Influence on Apparent Digestibility Coefficient, Feces Scores, and Serum Immune, Antioxidant, and Metabolic Biomarkers

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Food and Nutrition Sciences 2024年第7期15卷 594-611页

作者： Bruno Giorgio de oliveira Cécere Guilherme luiz Deolindo Bianca F. Bissacotti Priscila Marquezin Copetti Maria Rosa Chitolina Schetinger Bruna Klein Matheus Delamea Baldissera Thiago Pereira Ribeiro Walter Hugo Cuelho Suarez Daniel Pigatto Monteiro Aleksandro Schafer Da Silva Graduate Multicenter Program in Biochemistry and Molecular Biology University of the State of Santa Catarina Lages Brazil Department of Biochemistry and Molecular Biology Universidade Federal de Santa Maria (UFSM) Santa Maria Brazil Department of Animal Science Universidade Federal de Santa Maria (UFSM) Chapec Brazil Department of Health Science Universidade Franciscana (UFN) Santa Maria Brazil Department of Animal Nutrition Tectron-Tecnologia e Inovao Toledo Brazil

The present study aimed to determine whether natural dehydrated feed (DNF) can replace dry extruded feed while preserving the required daily intake, nutrient digestibility and benefits for immunity and antioxidant response in cats. The animals were divided into two groups of seven animals each. One group received DNF, and the other consumed commercial extruded dry feed (DCF). The experiment lasted 45 days and we measured daily consumption and collected blood and feces samples. The animals in the DNF group showed greater digestibility of fiber and mineral matter than DCF. Cats in the DNF group had a higher volume of feces. DNF cats had lower leukocyte and granulocyte counts and cholesterol levels. Serum enzymatic antioxidant responses and non-enzymatic were higher in DNF cats. Cats in the DNF group showed lower serum acute phase proteins in addition to a tendency toward a higher concentration of transferrin than in the DCF group. Fecal Escherichia coli and total coliform counts of cats fed DNF were higher than DCF. We conclude that the daily consumption of cats is adequate. This feed had greater digestibility of fiber and mineral matter, in addition to an improvement in antioxidant and immunological responses.

关键词： Alternative Feed Antioxidant Companion Animals Health

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ASYMPTOTIC HOMOGENIZATION IN A PARABOLIC SEMILINEAR PROBLEM WITH PERIODIC COEFFICIENTS AND INTEGRABLE INITIAL DATA

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Acta Mathematica Scientia 2013年第5期33卷 1275-1292页

作者： Rogerio luiz Quintino de oliveira JUNIOR Instituto de Matema'tica e Estat' stica Universidade do Estado do R.de Janeiro Rua S ao Francisco Xavier524 - Pavilha o Reitor Joa o Lyra Filho 6oandar bl.B 20559-900 Rio de Janeiro R.J. Brazil

In this paper, we study the large time behavior of solutions of the parabolic semilinear equation δtu-div（a（x）△↓u） = -｜u｜^αu in （0,∞） × R^N, where α 〉 0 is constant and a∈ Cb^1（R^N） is a symmetric periodic matrix satisfying some ellipticity *** an integrable initial data u0 and α ∈ （2/N, 3/N）, we prove that the large time behavior of solutions is given by the solution U（t, x） of the homogenized linear problem δtU-div（a^h△↓U）=0,U（0） = C, where a^h is the homogenized matrix of a（x）, C is a positive constant and δ is the Dirac measure at 0.

关键词： homogenization similinear parabolic equation integrable initial data matrix with periodic coefficient large time behavior

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Dipole (hyper)polarizabilities of neutral silver clusters

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Chinese Physics B 2016年第12期25卷 217-222页

作者： Francisco E jorge luiz G M de Macedo Departarnento de Fisica Universidade Fedoral do Espirito Santo 29060-900 Vitoria Brazil Unidade Academica de Fisica Universidade Federal de Campina Grande 58429-900 Campina Grande Brazil Faculdade de Biotecnologia ICB Universidade Federal do Para 66075-110 Belem Brazil

At the Douglas-Kroll-Hess （DKI4） level, the B3PW91 functional along with the all-eleclron relativistic basis sets of valence triple and quadruple zeta qualities are used to determine the structure, stability, and electronic properties of the small silver clusters （Agn, n ≤ 7）. The results presented in this study are in good agreement with the experimental data and theoretical values obtained at a higher level of theory from the literature. Static polarizability and hyperpolarizability are also reported. It is verified that the mean dipole polarizability per atom exhibits an odd-even oscillation and that the polarizability anisotropy is directly related to the cluster shape. In this article, the first study of hyperpolarizabilities of small silver clusters is presented. Except for the monomer, the second hyperpolarizabilities of the silver clusters are significantly larger than those of the copper clusters.

关键词： B3PW91 functional all-electron basis sets non-relativistic and DKH2 calculations silver clusters,dipole (hyper)polarizabilities

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Meningococcal disease, a clinical and epidemiological review

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1019-1029页

作者： Rodrigo Siqueira Batista Andreia Patricia Gomes jorge luiz Dutra Gazineo Paulo Sergio Balbino Miguel luiz Alberto Santana Lisa oliveira Mauro Geller Laboratorio de Agentes Patogenicos Departamento de Medicina e Enfermagem Universidade Federal de VicosaVicosaMGBrazil Curso de Medicina Faculdade Dinamica do Vale do PirangaPonte NovaMGBrazil Hospital Universitario Clementino Fraga Filho Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Curso de Medicina Centro Universitario Serra dos Orgaos (UNIFESO)TeresopolisRJBrazil School of Medicine New York University–NYUNew YorkUSA Departamento de Genetica Medica Universidade Federal do Rio de Janeiro (UFRJ)Rio de JaneiroRJBrazil

Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa. In Brazil, it is endemic with occasional outbreaks, epidemics and sporadic cases occurring throughout the year, especially in the winter. The major epidemics of the disease occurred in Brazil in the 70's caused by serogroups A and C. Serogroups B, C and Y represent the majority of cases in Europe, the Americas and Australia. However, there has been a growing increase in serogroup W in some areas. The pathogen transmission happens for respiratory route(droplets) and clinically can lead to meningitis and sepsis(meningococcemia). The treatment is made with antimicrobial and supportive care. For successful prevention, we have some measures like vaccination, chemoprophylaxis and droplets' precautions. In this review, we have described and clarify clinical features of the disease caused by N. meningitidis regarding its relevance for healthcare professionals.

关键词： Neisseria meningitidis Bacterial infection Meningococcal disease

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Analysis of the autopsy,toxicological,and psychiatric reports of Portugal’s first major forensic case:partⅢ

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Forensic Sciences Research 2021年第4期6卷 250-272页

作者： Ricardo jorge Dinis-oliveira Department of Public health and Forensic sciences and Medical educationFaculty of MedicineUniversity of PortoPortoPortugal IINFACTS-Institute of research and advanced Training in health sciences and Technologies Department of sciencesUniversity institute of health sciences(IUCS)advanced Polytechnic and University cooperative(CESPU)CRLGandraPortugal UCIBIO-REQUIMTE Laboratory of ToxicologyDepartment of Biological sciencesFaculty of PharmacyUniversity of PortoPortoPortugal

This work presents an odd historical record obtained through more than 14 years of research regarding one of the first major european forensic *** presumed homicide of Mário Guilherme Augusto de Sampaio in 1890 was allegedly perpetrated by his uncle,the prestigious doctor vicente Urbino de *** famous poisoning had international repercussions for decades,with the participation of several forensic experts that made the history of forensic sciences,namely forensic toxicology and *** third work aims to collect,restore,and analyse all the forensic evidence,particularly from the autopsy,toxicological,and psychiatric forensic *** regarding the life of vicente Urbino de Freitas during his exile in Brazil were also recovered,along with a vast and outstanding assortment of forensic medicine photographs from the 19th century.

关键词： Forensic sciences forensic reports alkaloids history of legal medicine Flores Street vicente Urbino de Freitas JoséAntónio de Sampaio Junior Mário Guilherme Augusto de Sampaio

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Analysis of the testimonial evidence of Portugal's first major forensic case:part Ⅱ

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Forensic Sciences Research 2020年第4期5卷 266-285页

作者： Ricardo jorge Dinis-oliveira Department of Public Health and Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies Department of SciencesUniversity Institute of Health Sciences(IUCS)Advanced Polytechnic and University Cooperative(CESPU)CRLGandraPortugal UCIBIO-REQUIMTE Laboratory of Toxicology

The crime possibly perpetrated by a doctor named Vicente Urbino de Freitas in 1890 is one of the most famous cases of poisoning,and it had echoes in the Portuguese and foreign press for several *** prestigious doctor was convicted of the fatal poisoning of his *** also attempted the homicide of two nieces and their mother-in-law,who only escaped because they obstinately refused to comply with the"therapeutics"prescribed by the family *** motive of the crime should have been Vicente Urbino de Freitas'ambition to receive the family inheritance of his wife,the daughter of the well-known mer-chant Jose Antonio Sampaio of Flores Street in *** Urbino de Freitas was con-victed but doubt about his guilt persists for more than a *** second work aimed to collect and analyse all the relevant and contradictory testimonial evidence of the prosecu-tion and defence *** case represents an odd historical record obtained through more than 12years of research on the first major significant Portuguese forensic *** and unprecedented testimonial evidence and photographs were obtained from different countries and then repaired,since these also provide an important historical record of the medical photography.

关键词： History of legal medicine forensic sciences forensic toxicology Vicente Urbino de Freitas Mário Guilherme Augusto de Sampaio testimonial evidence Flores Street

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