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Core promoter: A critical region where the hepatitis B virus makes decisions

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World Journal of Gastroenterology 2014年第2期20卷 425-435页

作者： jorge Quarleri Instituto de Investigaciones Biomédicas en Retrovirus y Sida Universidad de Buenos AiresBuenos Aires C1121ABGArgentina

The core promoter(CP) of the viral genome plays an important role for hepatitis B virus(HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic(pg) RNAs. The CP consists of the upper regulatory region and the basa core promoter(BCP). The CP overlaps with the 3'-end of the X open reading frames and the 5'-end of the precore region,and contains cis-acting elements that can independently direct transcription of the precore mRNA and pgRNA. Its transcription regulation is under strict control of viral and cellular factors. Even though this regulatory region exhibits high sequence conservation,when variations appear,they may contribute to the persistence of HBV within the host,leading to chronic infection and cirrhosis,and eventually,hepatocellular carcinoma. Among CP sequence variations,those occurring at BCP may dysregulate viral gene expression with emphasis in the hepatitis B e antigen,and contribute to disease progression. In this review these molecular aspects and pathologic topics of core promoter are deeply evaluated.

关键词： Hepatitis B virus Core promoter Variants Basal core promoter Transcription regulation

Computing the topology of an arrangement of implicitly defined real algebraic plane curves~§

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1685-1693页

作者： jorge CARAVANTES Laureano GONZALEZ-VEGA Department of Mathematics Statistics and ComputationUniversity of CantabriaSantander39005CantabriaSpain

We introduce a new algebraic approach dealing with the problem of computing the topology of an arrangement of a finite set of real algebraic plane curves presented implicitly. The main achievement of the presented method is a complete avoidance of irrational numbers that appear when using the sweeping method in the classical way for solving the problem at hand. Therefore, it is worth mentioning that the efficiency of the proposed method is only assured for low-degree curves.

关键词： Topology computation Real plane curves Sweeping method

Evidence-Based Complementary and Alternative Medicine Effects of Capybara Oil on Cardiac Remodeling of C57bl/6 Mice

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Journal of Biosciences and Medicines 2024年第5期12卷 213-232页

作者： Rafael M. Almeida Wagner D. Giannetti Guilherme R. Silveira Carolina R. Castilho Renata V. Lisboa Bianca T. Ciambarella Rodrigo N. Ferreira jorge José de Carvalho Laboratory of Ultrastructure and Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Education Center of Valenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Cardiovascular diseases are the main cause of morbidity and mortality in the world, and obesity and the metabolic syndrome are risk factors for its development. One of the therapies to reduce cardiovascular risk is the use of polyunsaturated fatty acids. In Brazil, a source of such acid is the oil extracted from the fat of the capybara. The objective of this work is to study the effects of the capybara oil on lipid and glucose metabolism, as well as its effects on the adipose tissue and cardiac remodeling. We assessed the effects of capybara oil treatment on body mass, lipid and carbohydrate metabolism, systolic blood pressure, adipose tissue and cardiac remodeling, and performed an ultrastructural evaluation of the myocardium in C57Bl/6 mice treated with high-fat diet. Treatment with capybara oil reduced total cholesterol and triglyceride levels, systolic blood pressure, visceral and subcutaneous adipose tissue, and adipocyte diameter. In addition, cardiac remodeling was attenuated, preserving cardiomyocytes, increasing vascularization, reducing cardiomyocyte hypertrophy and the extracellular matrix, and preserving the morphological integrity of mitochondria. Capybara oil has several beneficial effects on the cardiovascular and metabolic system, and further studies are needed to better understand its role in the prevention or treatment of cardiovascular diseases.

关键词： Capybara Oil Cardiac Remodeling Polyunsaturated Fatty Acids Obesity Metabolic Syndrome

Stable Matchings in the Marriage Model with Indifferences

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Journal of the Operations Research Society of China 2021年第3期9卷 593-617页

作者： Noelia Juarez jorge Oviedo Instituto de Matemática Aplicada San Luis IMASLUniversidad Nacional de San Luis and CONICETEjército de los Andes 950D5700HHW San LuisArgentina

For the marriage model with indifferences,we define an equivalence relation over the stable matching *** identify a sufficient condition,the closing property,under which we can extend results of the classical model(without indifferences)to the equivalence classes of the stable matching *** condition allows us to extend the lattice structure over classes of equivalences and the rural hospital theorem.

关键词： Stability Indifferences Lattice structure

Asymptomatic male currently not desiring fertility with bilateral subclinical varicocele found on ultrasound evaluation and borderline semen analysis results

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Asian Journal of Andrology 2016年第2期18卷 315-316页

作者： jorge Hallak Androscience High Complexity Andrology and Research Laboratory in MaleReproductive Health Section of Andrology Division of Urology Department of Surgery Hospital das Clinicas University of Sao Paulo Medical School Sao PauloBrazil Reproductive Toxicology Unit Department of Pathology University of Sao Paulo Medical School Sao Paulo Brazil Department of Pathology University of Sao Paulo Medical School Sao Paulo Brazil.

Varicoceles are a fountain of inspiration for male health providers since times immemorial, and it has haunted men ever since with so many different and multifaceted aspects that even today, basic scientists and andrologists are finding new and exciting discoveries derived from its pathophysiology, clinical outcomes, and consequences. Varicocele is a perfect model to link basic science with technological innovation in diagnostic testing in semen analysis and surgical techniques improving medical practice and improving male reproductive and general health.

关键词： CREATINE-KINASE MEN

Architectural survey of historical buildings:The orders of classical architecture in the Baptistery of Florence

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Frontiers of Architectural Research 2021年第1期10卷 117-133页

作者： jorge Romero School of Architecture Pontifical Catholic University of Ecuador(Iborro Headquarters)IbarraEcuador School of Architecture UIDE Universidad Internacional Del Ecuador(Quito Headquarters)QuitoEcuador

The survey of historic buildings is very important for architectural *** integral survey allows perpetuating the building historical memory,deciphering it for future generations,and recovering it in case of accidental *** Baptistery of Florence survey was done with four measuring methods:the"direct"one,which employs traditional measuring tools;the"indirect"one,which expedites the dimension-gathering process with more preci-sion;and the"photogrammetric"one,which uses snapshots to facilitate the representation process with *** innova tive measuring concept,known here as the"recovery sur-vey",synthetizes graphical reality so that irregularities--due to the project materialization and deterioration over time-disappear;therefore,retrieving the building original ***-umns with their bases,shafts and capitals,as well as entablatures with their architraves,friezes and cornices were under *** three Greek orders(Doric,lonic and Corinthian)together with the two roman orders(Tuscan and Composite)unveiled the classical architecture *** constituents,which reoccur inside and outside the baptistery,were measured as part of these holistic survey and recovery process,to achieve the objective of this research study:the recording of this world historical building through an integral survey and rilievo to decode its significance and symbolism.

关键词： Architectural survey Recovery rilievo Photogrammetric survey Architectural conservation Classical architecture orders Architectural symbolism

Strategic adjustment of copulatory plug size in a nematode

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Current Zoology 2019年第5期65卷 571-577页

作者： jorge Canales-LAZCANO jorge Contreras-GARDUNO Carlos CORDERO Posgrado en Ciencias Biomedicas Institute)de EcologiaUNAMCircuito Exterior S/Nanexo al Jardfn Botanico exteriorCiudad UniversitariaCiudad de MexicoMexico Escuela Nacional de Estudios Superiores Universidad Nacional Autonoma de MexicoUnidad MoreliaAntigua Carretera a Patzcuaro No.8701Col.Ex-Hacienda San Jose de la HuertaMoreliaMichoacanMexico Departamento de Ecologia Evolutiva Instituto de EcologlaUNAMCircuito Exterior S/Nanexo al Jardin Botanico exteriorCiudad UniversitariaCiudad de MexicoMexico

Copulatory plugs(CP)are substances produced during copulation that block the genital openings of the *** several species of Nematoda,males produce CP that are thought to impede female remating and thus sperm *** relatively large size of the CP in several nematodes,and its evolutionary loss in self-fertilizing populations of Caenorhabditis elegans,suggests that CP are costly to *** CP production is costly,the application of basic concepts of strategic ejaculation theory suggests a modulated allocation of CP in response to sperm competition *** hypothesis led us to predict that males perceiving a higher risk of sperm competition will produce larger *** tested these ideas with the entomopathogenic,gonochoristic nematode Rhabditis *** first experiment provides evidence suggesting that production of CP is costly,because the size of CP is negatively affected by stressful conditions(high population density,small male adult size,and suboptimal food type).The results of our second experiment support the prediction that males adjust the size of CP to sperm competition risk:the average size of CP increased as the number of males competing for one female ***,our study supports the idea that in *** the production of CP is costly for males and that the size of the CP produced is influenced by sperm competition risk.

关键词： copulatory plug sexual selection sperm competition strategic ejaculation nematodes

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph Nelson Siewe Fodjo Olivia Kamoen Luis-jorge Amaral Amber Hadermann Chiara Trevisan Mark J.Taylor Julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

A NEW STATISTICAL APPROACH FOR THE ANALYSIS OF UNCERTAIN SYSTEMS

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Journal of Systems Science & Complexity 2009年第1期22卷 1-34页

作者： Xinjia CHEN Kemin ZHOU jorge ARAVENA Department of Electrical Engineering Southern University Baton Rouge LA 70813 USA. Department of Electrical and Computer Engineering Louisiana State University Baton Rouge LA 70803 USA.

This paper addresses the issues of conservativeness and computational complexity of probabilistie robustness analysis. The authors solve both issues by defining a new sampling strategy and robustness measure. The new measure is shown to be much less conservative than the existing one. The new sampling strategy enables the definition of efficient hierarchical sample reuse algorithms that reduce significantly the computational complexity and make it independent of the dimension of the uncertainty space. Moreover, the authors show that there exists a one to one correspondence between the new and the existing robustness measures and provide a computationally simple algorithm to derive one from the other.

关键词： Computational complexity randomized algorithms risk analysis robustness analysis uncertain system.