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Genes & Diseases 2024年第4期11卷 106-108页

作者： Gloria Garavito-De Egea Alex Dominguez-Vargas Jorg e l.Velez Gustavo Aroca luis Fagng Elkin Navarro-Quiroz Zilac Espitaleta Kenny Del Toro-Camargo Leticia Martinez-Ariza Tatiana Gonzalez-Vargas Susana Garcia Mauricio Arcos-Burgos Eduardo Egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune diseases(AIDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph Nelson Siewe Fodjo Olivia Kamoen luis-jorge Amaral Amber Hadermann Chiara Trevisan Mark J.Taylor Julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

Prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma:Review and bibliometric

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iLIVER 2024年第1期3卷 52-61页

作者： Pamela Scarlett Espinoza Loyola Diana Laura Muratalla Bautista Karen Adela Hernández Bautista Elizabeth Gil White JoséAntonio González Moreno Daniel Angel Torres del Real Víctor Manuel Páez Zayas Carla Escorza-Molina Fernando Mondragón Rodríguez Omar Vásquez Gómez luis jorge Fernández López Paul Santiago Mogrovejo Vázquez Isidoro Aczel Sánchez-Cedillo Víctor Jose Visag Castillo Social Service Internship Universidad Nacional Autónoma de MéxicoMexico City 04510Mexico Social Service Internship Universidad AnahuacMexico City 04510Mexico Department of Surgery Division of Transplantation Surgery Hospital General de MéxicoMexico City 06720Mexico Departament of Gastroenterology Division of HepatologyHospital General de MéxicoMexico City 06720Mexico Departmanet of Anesthesiology Hospital General de MéxicoMexico City 06720Mexico

Hepatocellular carcinoma(HCC)is one of the most common cancers in the world and is one of the leading indications for liver transplantation,liver transplantation is the gold standard treatment for end stage liver *** is based up on radiological characteristics and rarely biopsy *** treatment must be individualized to each patient to improve recurrences and *** this article,we focus on the different selection criteria for liver *** study aimed to investigate the distribution laws and research frontiers of international literature,so as to present holistic bibliometric evaluation of the studies on 5-year survival and disease-free recurrence in 5 years,according to hepatocarcinoma criteria for liver *** paper aims to review and analyze 5-year survival and disease-free recurrence based on hepatocarcinoma criteria for liver *** systematically examines and summarizes distribution characteristics and research frontiers through bibliometric analysis.A bibliographic search was implemented in PubMed/Medline,Clinical Key,Science Direct and Index Medicus with MESH terms,from the year 1996–*** selected for transplantation using the Metroticket 2.0(MT2)criteria had the highest overall survival along with patients selected for transplantation using the Milan Criteria had the best 5-year disease-free *** Metroticket 2.0 criteria(MT2)and Milan Criteria(MC)have shown the most favorable post-transplant outcomes for patients with hepatocellular carcinoma(HCC).However,MC demonstrated the best 5-year disease-free recurrence rate,underscoring the significance of taking into account tumor morphology and biology when determining the eligibility of HCC patients for liver *** distribution characteristics and research frontiers by bibliometrics concerning prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma the collaboration

关键词： Hepatocellular carcinoma Liver transplantation Survival Criteria Recurrence Bibliometrics

Optimization of a Single Flash Geothermal Power Plant Powered by a Trans-Critical Carbon Dioxide Cycle Using Genetic Algorithm and Nelder-Mead Simplex Method

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Energy Engineering 2023年第2期120卷 263-275页

作者： Yashar Aryanfar jorge luis García Alcaraz Department of Electric Engineering and Computation Autonomous University of Ciudad JuárezCiudad JuárezChihuahuaMéxico Department of Industrial Engineering and Manufacturing Autonomous University of Ciudad JuárezCiudad JuárezChihuahuaMéxico

The usage of renewable energies,including geothermal energy,is expanding rapidly *** low efficiency of geothermal cycles has consistently highlighted the importance of recovering heat loss for these *** paper proposes a combined power generation cycle(single flash geothermal cycle with trans-critical CO_(2) cycle)and simulates in the EES(Engineering Equation Solver)*** results show that the design parameters of the proposed system are significantly improved compared to the BASIC single flash ***,the proposed approach is optimized using the genetic algorithm and the Nelder-Mead Simplex *** pressure,steam turbine output pressure,and CO_(2) turbine inlet pressure are three assumed variable parameters,and exergy efficiency is the target *** the default operating mode,the system exergy efficiency was 32%,increasing to 39%using the genetic algorithm and 37%using the Nelder-Mead method.

关键词： Optimization geothermal genetic algorithm Nelder-Mead simplex exergy efficiency

Role of platelets and breast cancer stem cells in metastasis

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World Journal of Stem Cells 2020年第11期12卷 1237-1254页

作者： Gretel Mendoza-Almanza luis Burciaga-Hernandez Vilma Maldonado jorge Melendez-Zajgla jorge Olmos CONACYT Universidad Autónoma de Zacatecas.Zacatecas 98060Mexico Maestría en Ciencias Biomédicas Universidad Autónoma de ZacatecasZacatecas 98160Mexico Laboratorio de Epigenética Instituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Génómica funcional del cáncer Instituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Biotecnología Marina Centro de Investigación Científica y de Estudios Superiores de EnsenadaEnsenada 22860Mexico

The high mortality rate of breast cancer is mainly caused by the metastatic ability of cancer cells,resistance to chemotherapy and radiotherapy,and tumor regression *** recent years,it has been shown that the presence of breast cancer stem cells is closely associated with the migration and metastatic ability of cancer cells,as well as with their resistance to chemotherapy and *** tumor microenvironment is one of the main molecular factors involved in cancer and metastatic processes development,in this sense it is interesting to study the role of platelets,one of the main communicator cells in the human body which are activated by the signals they receive from the microenvironment and can generate more than one *** can ingest and release RNA,proteins,cytokines and growth *** the platelets interact with the tumor microenvironment,they are called"tumor-educated platelets."Tumor-educated platelets transport material from the tumor microenvironment to sites adjacent to the tumor,thus helping to create microenvironments conducive for the development of primary and metastatic *** has been observed that the clone capable of carrying out the metastatic process is a cancer cell with stem cell *** stem cells go through a series of processes,including epithelial-mesenchymal transition,intravasation into blood vessels,movement through blood vessels,extravasation at the site of the establishment of a metastatic focus,and site ***-educated platelets support all these processes.

关键词： Breast cancer stem cells Platelets Metastasis Tumor microenvironment Epithelial-mesenchymal transition

Crohn's disease in one mixed-race population in Brazil

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World Journal of Gastroenterology 2007年第33期13卷 4489-4492页

作者： Genoile Oliveira santana Luiz Guilherme Costa Lyra Tamara Celi Almeida santana Lidiane Bianca dos Reis jorge Carvalho Guedes Maria Betania Toralles André Castro Lyra Gastrohepatology Unit Federal University of Bahia Brazil Gastrohepatology Unit Hospital San Rafael BahiaBrazil Gastrohepatology Unit Federal University of Bahia Brazil Department of Medicine Federal University of Bahia Brazil Gastrohepatology Unit Hospital San Rafael BahiaBrazil Department of Medicine Federal University of Bahia Brazil Gastrohepatology Unit Federal University of Bahia Brazil Department of Medicine Federal University of Bahia Brazil Genetic Unit Federal University of Bahia Brazil

AIM： To evaluate the classification and severity of Crohn＇s disease in different racial groups. METHODS： Patients with Crohn＇s disease from the outpatient clinic of the University Hospital Prof. Edgard Santos were enrolled in the study. This hospital is a reference centre for inflammatory bowel disease. Race was determined using self-identification. The Vienna＇s classification was applied for all subjects. The severity of Crohn＇s disease was determined according to the number of surgical procedures, hospital admissions in the last year and treatment with steroids and immunosuppressors. Statistical analysis was calculated using t test for means,χ^2 or F for proportions. A P value 〈 0.05 was considered to be significant. RESULTS： Sixty-five patients were enrolled. Non-white patients were more frequently diagnosed with Crohn＇s disease in the age less than 40 years than white patients. The behaviour of disease was similar in both groups with a high frequency of the penetrating form. There was a tendency for non-white patients to have a greater frequency of hospital admissions in the last year compared to white subjects. Non-whites also had a higher rate of colonic and upper gastrointestinal involvement, and were also more frequently on treatment with immunossupressors than white patients although this difference was not statistically significant. CONCLUSION： Non-white patients with Crohn＇s disease had an earlier diagnosis and appeared to have had a more severe disease Dresentation than white patients.

关键词： Racial group Brazil Race Inflammatory bowel disease Crohn's disease

Portal Venous Thrombosis and Splenic Hemangioma, Secondary to Acute Pancreatitis: Case Report

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Open Journal of Gastroenterology 2024年第1期14卷 11-17页

作者： Gustavo Adolfo Hernández Valdez Harvey Yair Zamora Veliz Estefany Gilberty Mendoza Verdin Quitzia Mayanim Rentería Fonseca Itzel Velázquez Viniegra Janette Alejandra Gamiño Gutierrez Diana Rita Velázquez Jimenez Florencio Favian Andrade luis Fernando Baez Bustos jorge Morales Rojas María Jacqueline Martínez Tejeda Graciela Gaddy Robles Martínez Juan Antonio Contreras Escamilla Departamento de Medicina Interna ISSSTE Tepic General Hospital APP Tepic Nayarit México General Surgery Department ISSSTE Tepic General Hospital APP Tepic Nayarit México Hospital Civil Fray Antonio Alcalde Guadalajara Jalisco México

We present an unusual case of portal vein thrombosis with a splanchnic hemangioma secondary to acute biliary pancreatitis. We report a 45-year-old patient, who has systemic arterial hypertension in treatment, was admitted for abdominal pain in the epigastrium, with irradiation to the right hypochondrium, accompanied by nausea and vomiting of 10 occasions of bile content, physical examination with pain in the right hypochondrium, Murphy positive. We have laboratory studies with a lipase of 788, so a diagnosis of pancreatitis is made with an etiology to be determined. The laboratories suggestive of acute biliary pancreatitis (lipase 788.71);an imaging study was subsequently performed (ultrasonography) with the result of stone in the common bile duct. A laparoscopy was performed with relative improvement, so he was discharged and returned 20 days after surgery due to abdominal pain of the same intensity in the left hypochondrium. Ending his hospitalization with a splenectomy for splenic hemangioma with portal vein thrombosis.

关键词： Pancreatitis Esplenic Hemangioma Esplenectomy Portal Vein Thrombosis Surgery

Pharmacological treatments of presbyopia:a review of modern perspectives

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Eye and Vision 2017年第1期4卷 14-17页

作者： Antonio Renna jorge L.Alió luis Felipe Vejarano Vissum Alicante AlicanteSpain Studi Medici Renna MelendugnoLecceItaly Universidad Miguel Hernandez Calle Cabañal 103016 AlicanteSpain Vissum Instituto Oftalmologico de Alicante AlicanteSpain Fundación Oftalmológica Vejarano PopayanColombia Universidad del Cauca PopayanColombia

Introduction:Presbyopia affects people from the 4^(th) decade of life and is characterized by accommodative loss that leads to negative effects on vision-targeted health-related quality of life.A non-invasive pharmacological treatment providing near-lenses independence would be a truly groundbreaking approach in the treatment of *** purpose of this review is to analyze the emerging pharmacological solutions proposed to address ***:Several ophthalmic eye drops compounds solutions have been described in peer-reviewed papers or presented in ophthalmological tabloids and *** topical treatment deals with drug combinations aimed to modify one or more factors involved in the accommodative process and have been proposed to be instilled either monocularly or *** remains unclear how much each drug in the final combined form is involved in the achievement of the outcome and contributes to ***:Despite the lack of a completely well understood mechanism,pharmacological control of presbyopia seems to be a possible and very attractive alternative for presbyopic *** studies mentioned in this review are to be considered pilot investigations as they involve either a small number of subjects or are single case *** studies are needed to confirm which will be the more effective pharmacological compound for the treatment of presbyopia.

关键词： Presbyopia Ageing Near vision Glasses Multifocality Accommodation Pharmacological therapy Eyedrops

Comparing surgical efficiencies between phacoemulsification systems: a single surgeon retrospective study of 2000 eyes

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International Journal of Ophthalmology(English edition) 2022年第4期15卷 581-585页

作者： luis Escaf-Jaraba jorge Escobar-DiazGranados Bartolomé Valdemarín Clínica Oftalmológica del Caribe Barranquilla 080003Colombia Universidad Simón Bolívar Barranquilla 080004Colombia

AIM: To compare under similar conditions intraoperative surgical efficiencies metrics between an active fluidics and a gravity based phacoemulsification ***: Adult patients who were diagnosed with a cataract that compromised visual acuity inferior to 20/40 were included in the study. Patients were excluded from the study if they had a history of severe retinal disorders, clinically significant corneal endothelial dystrophy or history of corneal disease. All phacoemulsification surgeries were performed by a single surgeon. Both phacoemulsification systems used the 0.9 mm 45-degree aspiration bypass system Intrepid Balanced tip and the 0.9 mm Intrepid Ultra infusion sleeve. All cataracts were classified using the Lens Opacities Classification System III, cumulative dissipated energy(CDE) and aspiration fluids were measured in each ***: Totally 2000 eyes were included in the study. Phacoemulsification was performed in 1000(50%) eyes with an active fluid dynamics system and in 1000(50%) eyes with a gravity-based fluidic system. Mean CDE until fracture of the lens was 1.1 and 1.9 percent-seconds and total mean CDE used was 5.6 and 7.2 percent-seconds using an active fluidics dynamics system and gravity-based fluidic system, respectively(P<0.001). Mean aspiration fluids used were 70 m L using an active fluidics dynamics system and 85 m L using a gravity-based fluidic system(P<0.001).CONCLUSION: This study evidences that surgeries performed under similar conditions(same surgeon, phaco tip and sleeve) with the active fluidics dynamics system required significantly lower CDE and aspiration fluids.

关键词： ophthalmology phacoemulsification surgical ef ficiencies cumulative dissipated energy aspiration fluids

Capillary hydrodynamic fractionation of hydrophobic colloids:Errors in the estimated particle size distribution

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Particuology 2014年第6期12卷 97-105页

作者： luis A.Clementi Zohartze Artetxe Ziortza Aguirreurreta Amaia Agirre Jose R.Leiza luis M.Gugliotta jorge R.Vega INTEC(CONICET and Universidad Nacional del Litoral) FRSF-UTN(Facultad Regional Santa Fe-Universidad Tecnologica Nacional) POLYMAT Kimika Aplikatua SailaKimika Zientzien FakultateaUniversity of the Basque Country UPV/EHUJoxe Mari Korta Zentroa

Capillary hydrodynamic fractionation（CHDF） with turbidity detection at a single wavelength is an analytical technique that is often used for sizing the sub-micrometric particles of hydrophobic *** article investigates three sources of errors that affect the particle size distribution（PSD） estimated by CHDF：diameter calibration errors,uncertainties in the particle refractive index（PRI）,and instrumental broadening（IB）.The study is based on simulated and experimental examples that involve unimodal and bimodal *** errors in the diameter calibration curve can produce important deviations in the number average diameter due to systematic shifts suffered by the PSD *** uncertainties in the PRI are unimportant in the analysis of unimodal PSDs,but in the specific case of bimodal PSDs,errors in the PRI can strongly affect the estimated number concentration of each *** typical IB correction（based on the IB function estimated from narrow standards） produces slightly erroneous average diameters but can lead to PSDs with underestimated widths and distorted *** practice,the three investigated sources of errors can be present simultaneously,and uncertainties in the average diameters,the shape and width of the PSD,and the number concentration of the PSD modes are unavoidable.

关键词： Particle size distribution Capillary hydrodynamic fractionation Nanoparticle Particle refractive index Instrumental broadening